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trehalose (531) 531
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animals (266) 266
biochemistry & molecular biology (237) 237
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PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 4, p. e60933
...]pyrimidine-3-carboxamide (THPP) and N-benzyl-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] (Spiro) analogues were recently identified against Mycobacterium tuberculosis and Mycobacterium bovis BCG through a high-throughput whole-cell screening campaign... 
CANDIDATE | SQ109 | IDENTIFICATION | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | Pyrazoles - therapeutic use | Antitubercular Agents - chemistry | Humans | Drug Resistance, Bacterial | Spiro Compounds - therapeutic use | Tuberculosis - microbiology | Chromatography, Thin Layer | Mycobacterium tuberculosis - drug effects | Microbial Sensitivity Tests | Pyrazoles - chemistry | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Tuberculosis - drug therapy | Pyrazoles - pharmacokinetics | Spiro Compounds - chemistry | Antitubercular Agents - therapeutic use | Disease Models, Animal | Pyrazoles - pharmacology | Bacterial Proteins - antagonists & inhibitors | Cord Factors | Microbial Viability - drug effects | Bridged Bicyclo Compounds, Heterocyclic - chemistry | Antitubercular Agents - pharmacology | Rats | Genotype | Treatment Outcome | Mutation - genetics | Mycobacterium tuberculosis - isolation & purification | Spiro Compounds - pharmacokinetics | Hep G2 Cells | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Antitubercular Agents - pharmacokinetics | Dogs | Bacterial Proteins - metabolism | Mice | Kinetics | Spiro Compounds - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - pharmacokinetics | Mycobacterium tuberculosis - genetics | Pyrimidines | Tuberculosis | Genomics | Nucleotide sequencing | Drug therapy | Patient compliance | DNA sequencing | Trehalose | Medical treatment | Lung diseases | BCG | Cytotoxicity | Genomes | Drug resistance | Mutants | Gene sequencing | Chemistry | Lungs | Resistant mutant | Bacteria | Mutation | Piperidine
Journal Article
Carbohydrate Polymers, ISSN 0144-8617, 03/2018, Volume 183, pp. 110 - 122
•Trehalose-type diblock methylcellulose analogues were synthesized via Huisgen 1,3-dipolar cycloaddition... 
Diblock copolymer | Methylcellulose | Polysaccharides | Surface activity | End-functionalization | Thermo-reversible supramolecular hydrogels | OXIDATION | POLYMER SCIENCE | ACID | GELS | CHEMISTRY, ORGANIC | MODEL | CHEMISTRY, APPLIED | CELLULOSE | DERIVATIVES
Journal Article
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2016, Volume 14, Issue 36, pp. 8598 - 8609
.... Recently, detectable trehalose analogues have gained attention as probes for studying trehalose metabolism and as potential diagnostic imaging agents for mycobacterial infections... 
NMR | TRANSPORTER | CRYSTAL-STRUCTURE | TUBERCULOSIS | BIOSYNTHESIS | DYNAMICS | CHEMISTRY, ORGANIC | ALPHA,ALPHA-TREHALOSE | COUPLING-CONSTANTS | EPIDEMIOLOGY | CORD FACTOR
Journal Article
Chembiochem : a European journal of chemical biology, ISSN 1439-7633, 2019, Volume 20, Issue 10, pp. 1282 - 1291
.... We recently described an alkyne‐modified TMM analogue (O‐AlkTMM‐C7) which, in conjunction with click chemistry, acted as a chemical reporter for mycoloylation in intact... 
bioorthogonal chemistry | trehalose | imaging | mycobacteria | chemical reporters | O-MYCOLOYLATED PROTEINS | VISUALIZATION | OUTER-MEMBRANE | WALL | CHEMISTRY, MEDICINAL | MYCOLIC ACIDS | TUBERCULOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOSYNTHESIS | CYCLOADDITIONS | ANTIGEN | DIMYCOLATE | Fluorescent Dyes - chemical synthesis | Fluorescent Dyes - chemistry | Alkynes - chemical synthesis | Mycobacterium smegmatis - chemistry | Click Chemistry | Cord Factors - chemical synthesis | Cord Factors - chemistry | Fluorescent Dyes - metabolism | Alkynes - chemistry | Cord Factors - metabolism | Bacillus subtilis - chemistry | Acyltransferases - metabolism | Escherichia coli - chemistry | Azides - chemistry | Cell Membrane - chemistry | Corynebacterium - chemistry | Cell Engineering - methods | Alkynes - metabolism | Mycobacterium tuberculosis - chemistry | Cell Membrane - metabolism | Molecular Structure | Azides - metabolism | Azides - chemical synthesis | Proteins | Physiological aspects | Permeability | Antigens | Carbohydrates | Trehalose | Fluorescence | Labelling | Mycolic acids | Biosynthesis | Metabolism | Drug development | Cell surface | Immunological tolerance | Substrates | Engineering | Organic chemistry | Tuberculosis | Dependence | Chemical synthesis | Alkynes | mycolic acid | Corynebacterineae | mycomembrane | chemical reporter
Journal Article
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2018, Volume 293, Issue 8, pp. 2755 - 2769
.... We previously reported the discovery of a new class of cyclipostins and cyclophostin (CyC) analogs exhibiting potent activity against Mycobacterium tuberculosis both in vitro and in infected macrophages... 
CELL-WALL COMPONENTS | INACTIVATION | HYDROLASES | COMPLEX | PROTEIN | DISRUPTION | BIOGENESIS | MECHANISM | BIOSYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENVELOPE | Acyltransferases - antagonists & inhibitors | Acylation - drug effects | Antitubercular Agents - chemistry | Molecular Conformation | Crystallography, X-Ray | Acyltransferases - metabolism | Acyltransferases - genetics | Antigens, Bacterial - genetics | Mycobacterium tuberculosis - drug effects | Organophosphorus Compounds - metabolism | Recombinant Fusion Proteins - metabolism | Mycobacterium tuberculosis - cytology | Enzyme Inhibitors - chemistry | Organophosphorus Compounds - pharmacology | Binding Sites | Mycobacterium tuberculosis - metabolism | Bacterial Proteins - antagonists & inhibitors | Catalytic Domain | Enzyme Inhibitors - metabolism | Microbial Viability - drug effects | Antitubercular Agents - pharmacology | Bacterial Proteins - genetics | Enzyme Inhibitors - pharmacology | Models, Molecular | Organophosphorus Compounds - chemistry | Recombinant Fusion Proteins - chemistry | Serine - chemistry | Bacterial Proteins - metabolism | Ligands | Mutation | Antitubercular Agents - metabolism | Antigens, Bacterial - metabolism | Amino Acid Substitution | Mycobacterium tuberculosis - growth & development | Life Sciences | Human health and pathology | Infectious diseases | Biochemistry, Molecular Biology | Biomolecules | Pharmacology | Pharmaceutical sciences | inhibition mechanism | triacylglycerol | Microbiology | Mycobacterium tuberculosis | Ag85 complex | crystal structure | cyclophostin | cell wall | trehalose monomycolate | trehalose dimycolate | cyclipostins
Journal Article
Bioorganic & medicinal chemistry, ISSN 0968-0896, 07/2020, Volume 28, Issue 14, p. 115564
... production in human peripheral blood mononuclear cells. The preliminary biological characterization of the designed analogs presented in this paper should aid... 
Trehalose diester | Tuberculosis | Brartemicin | Adjuvant | Mincle | Vaccine | Trehalose dimycolate | TH-17 | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | BCG | PREVENTION | CHEMISTRY, ORGANIC | SAFE | IL-23 | T-CELL RESPONSES | IL-17 | CORD FACTOR
Journal Article