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International Journal of Oncology, ISSN 1019-6439, 12/2013, Volume 43, Issue 6, pp. 1787 - 1798
Journal Article
Circulation research, ISSN 0009-7330, 2005, Volume 96, Issue 1, pp. 119 - 126
Remodeling of small arteries is essential in the long-term regulation of blood pressure and blood flow to specific organs or tissues. A large part of the... 
Vascular remodeling | Tissue transglutaminase | Vasoconstriction | Blood flow | INDUCED ACTIVATION | APOPTOSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | RESISTANCE ARTERIES | CROSS-LINKING | SPASM | tissue transglutaminase | vascular remodeling | FLOW | STRUCTURAL-CHANGES | ADAPTATION | PERIPHERAL VASCULAR DISEASE | vasoconstriction | HYPERTENSION | HEMATOLOGY | blood flow | Norepinephrine - pharmacology | GTP-Binding Proteins - pharmacology | Mesenteric Arteries - physiology | Cross-Linking Reagents - pharmacology | Endothelin-1 - pharmacology | Transglutaminases - pharmacology | Transglutaminases - genetics | Nitroprusside - pharmacology | Hemorheology | Cadaverine - pharmacology | GTP-Binding Proteins - genetics | Vasoconstriction - physiology | Enzyme Induction - drug effects | Cystamine - pharmacology | Female | Nitric Oxide Donors - pharmacology | Myocytes, Smooth Muscle - cytology | Organ Culture Techniques | Muscle, Skeletal - blood supply | Tretinoin - pharmacology | Vasoconstrictor Agents - pharmacology | Extracellular Matrix Proteins - chemistry | GTP-Binding Proteins - physiology | Guinea Pigs | Vasodilator Agents - pharmacology | Gels | Cell Size - drug effects | Transglutaminases - biosynthesis | Rats | Nitric Oxide - physiology | Papaverine - pharmacology | Arteries - drug effects | Vasoconstriction - drug effects | Extracellular Matrix Proteins - drug effects | Extracellular Matrix - ultrastructure | Animals | Arteries - enzymology | Coronary Vessels - cytology | Vasomotor System - physiology | Collagen | Biotin - pharmacology | Transglutaminases - physiology | GTP-Binding Proteins - biosynthesis | Amines - pharmacology | Mesenteric Arteries - enzymology | Sus scrofa | Biotin - analogs & derivatives
Journal Article
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 08/2004, Volume 24, Issue 8, pp. 1454 - 1459
OBJECTIVE—Neural apoptosis-regulated convertase (NARC)-1 is the newest member of the proprotein convertase family implicated in the cleavage of a variety of... 
HepG2 | QPCR | Primary hepatocytes | Cholesterol | SRE | CELLS | ELEMENT-BINDING PROTEIN-2 | primary hepatocytes | AUTOSOMAL-DOMINANT HYPERCHOLESTEROLEMIA | LOW-DENSITY-LIPOPROTEIN | NUCLEAR RECEPTOR LXR | TARGET GENES | PATHWAY | LIVER | cholesterol | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | EXPRESSION | Consensus Sequence | Lovastatin - pharmacology | Species Specificity | Humans | Regulatory Sequences, Nucleic Acid | Homeostasis | Lovastatin - analogs & derivatives | Hepatocytes - metabolism | Simvastatin - pharmacology | Promoter Regions, Genetic - genetics | Quinolines - pharmacology | RNA, Messenger - biosynthesis | Cell Line - drug effects | Base Sequence | Liver X Receptors | Serine Endopeptidases - genetics | Orphan Nuclear Receptors | Proprotein Convertases | Sp1 Transcription Factor - physiology | Hepatocytes - drug effects | Heptanoic Acids - pharmacology | Tretinoin - pharmacology | Mevalonic Acid - pharmacology | Cell Line - metabolism | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Serine Endopeptidases - biosynthesis | Receptors, Cytoplasmic and Nuclear - drug effects | Rats | Hydroxymethylglutaryl CoA Reductases - physiology | Reverse Transcriptase Polymerase Chain Reaction | Hydroxycholesterols - pharmacology | Sequence Homology, Nucleic Acid | Gene Expression Regulation - drug effects | Mevalonic Acid - analogs & derivatives | Atorvastatin Calcium | Pyrroles - pharmacology | Sequence Alignment | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Cholesterol - pharmacology | Mice | Pyridines - pharmacology | Cholesterol - biosynthesis | Sterol Regulatory Element Binding Protein 2 | Proprotein Convertase 9
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 04/2005, Volume 25, Issue 17, pp. 4279 - 4287
The mechanism by which physiological synaptic NMDA receptor activity promotes neuronal survival is not well understood. Here, we show that that an episode of... 
Neuroprotection | CREB | Calcium | NMDA receptors | Ca | CaM kinase | Apoptosis | CREB PHOSPHORYLATION | calcium | apoptosis | KINASE-B | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | CEREBELLAR GRANULE CELLS | GLYCOGEN-SYNTHASE KINASE-3-BETA | IN-VITRO | SIGNALING PATHWAY | neuroprotection | GENE-EXPRESSION | TRANSCRIPTION FACTOR | Muscimol - pharmacology | Gene Expression - drug effects | Apoptosis - drug effects | Calcium - metabolism | Calcium Signaling - physiology | Neurons - cytology | Phosphatidylinositol 3-Kinases - metabolism | Dose-Response Relationship, Drug | Cell Nucleus - metabolism | Drug Interactions | Neuroprotective Agents - pharmacology | Transfection - methods | Time Factors | Gene Expression - physiology | Neurons - physiology | Tetrodotoxin - pharmacology | Neurons - drug effects | Oncogene Protein v-akt - metabolism | Tretinoin - pharmacology | Animals, Newborn | Blotting, Western - methods | GABA Agonists | Enzyme Inhibitors - pharmacology | Sodium Channel Blockers - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Bicuculline - pharmacology | Ceramides - pharmacology | GABA Antagonists - pharmacology | Cyclic AMP Response Element-Binding Protein - genetics | Animals | Calcium Signaling - drug effects | Green Fluorescent Proteins - biosynthesis | Cyclic AMP Response Element-Binding Protein - metabolism | Apoptosis - physiology | Cell Nucleus - drug effects | Dizocilpine Maleate - pharmacology | In Vitro Techniques | Hippocampus | Cellular | Molecular
Journal Article
EMBO molecular medicine, ISSN 1757-4684, 2015, Volume 7, Issue 4, pp. 394 - 410
Drugs targeting atrial-specific ion channels, Kv1.5 or Kir3.1/3.4, are being developed as new therapeutic strategies for atrial fibrillation. However, current... 
atrial cardiomyocytes | COUP‐TF | atrial fibrillation | arrhythmias | ion channels | Ion channels | COUP-TF | Atrial fibrillation | Arrhythmias | Atrial cardiomyocytes | FIBRILLATION | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | COUP-TFII | MYOCYTES | ACETYLCHOLINE | RETINOIC-ACID | GUIDELINES | RECTIFIER K+ CURRENT | DIFFERENTIATION | DEVELOPMENTAL EXPRESSION | Atrial Fibrillation - pathology | Drug Evaluation, Preclinical - methods | Gene Expression | Heart Atria - pathology | Atrial Fibrillation - drug therapy | Humans | Heart Atria - metabolism | Pluripotent Stem Cells - metabolism | Pluripotent Stem Cells - pathology | Atrial Fibrillation - metabolism | Myocytes, Cardiac - pathology | Models, Biological | Myocytes, Cardiac - metabolism | Kv1.5 Potassium Channel - antagonists & inhibitors | Kv1.5 Potassium Channel - biosynthesis | Drug Delivery Systems - methods | G Protein-Coupled Inwardly-Rectifying Potassium Channels - biosynthesis | G Protein-Coupled Inwardly-Rectifying Potassium Channels - antagonists & inhibitors | Potassium Channel Blockers - pharmacology | Embryonic stem cells | Analysis | Anti-arrhythmia drugs | Heart cells | Tretinoin | Drugs | Heart | Cell culture | Flow cytometry | Cardiac arrhythmia | Animal models | Transcription factors | Arrhythmia | Genes | Stem cell transplantation | Action potential | Drug delivery | Experiments | Fibrillation | Physiology | Potassium channels (voltage-gated) | Pharmaceutical industry | Data analysis | Potassium channels (inwardly-rectifying) | Research & development--R&D | Cardiomyocytes | Pharmacology | Cell lines | Stem cells | Ventricle | Retinoic acid | Pluripotency
Journal Article
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 2015, Volume 16, Issue 11, pp. 26667 - 26676
Protein transduction using cell-penetrating peptides (CPPs) is useful for the delivery of large protein molecules, including some transcription factors. This... 
Induced pluripotent stem cell | Pancreatic differentiation | Protein transduction | Poly-arginine | Cell-penetrating peptide | TRANSCRIPTION FACTORS | PROGENITOR CELLS | protein transduction | FUNCTIONAL-NEURONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DIRECT CONVERSION | cell-penetrating peptide | CHEMISTRY, MULTIDISCIPLINARY | poly-arginine | PROTEIN TRANSDUCTION DOMAIN | IN-VITRO | induced pluripotent stem cell | MYOGENIC DIFFERENTIATION | INSULIN-PRODUCING CELLS | GENERATION | pancreatic differentiation | ARGININE-RICH PEPTIDES | Homeodomain Proteins - metabolism | Humans | Maf Transcription Factors, Large - metabolism | Cell-Penetrating Peptides - pharmacology | Insulin-Secreting Cells - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Maf Transcription Factors, Large - genetics | Basic Helix-Loop-Helix Transcription Factors - pharmacology | Nerve Tissue Proteins - pharmacology | Trans-Activators - genetics | Veratrum Alkaloids - pharmacology | Insulin-Secreting Cells - cytology | Trans-Activators - pharmacology | Homeodomain Proteins - pharmacology | Induced Pluripotent Stem Cells - cytology | Induced Pluripotent Stem Cells - metabolism | Tretinoin - pharmacology | Cell-Penetrating Peptides - genetics | Maf Transcription Factors, Large - pharmacology | Gene Expression | Basic Helix-Loop-Helix Transcription Factors - genetics | Induced Pluripotent Stem Cells - drug effects | Glucagon-Like Peptide 1 - pharmacology | Cinnamates - pharmacology | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Cellular Reprogramming - drug effects | Nerve Tissue Proteins - metabolism | Animals | Insulin-Secreting Cells - drug effects | Cell Differentiation - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Trans-Activators - metabolism | Mice | Niacinamide - pharmacology | Cell-Penetrating Peptides - metabolism | Peptides | Signal transduction | Stem cells
Journal Article
Nature neuroscience, ISSN 1546-1726, 2004, Volume 7, Issue 9, pp. 1003 - 1009
Although it has long been known that cultured embryonic stem cells can generate neurons, the lineage relationships with their immediate precursors remain... 
DIRECTED DIFFERENTIATION | NERVOUS-SYSTEM | IN-VITRO DIFFERENTIATION | DOPAMINERGIC-NEURONS | RADIAL GLIA | HIPPOCAMPAL-NEURONS | ES CELLS | PRECURSOR CELLS | EXPRESSION | NEUROSCIENCES | NEURAL DIFFERENTIATION | Homeodomain Proteins - metabolism | Repressor Proteins | Membrane Potentials - radiation effects | Glial Fibrillary Acidic Protein - metabolism | Drug Interactions | Time Factors | Neurons - metabolism | Indoles | Tetrodotoxin - pharmacology | Receptors, AMPA - metabolism | Tretinoin - pharmacology | Membrane Potentials - drug effects | Synaptophysin | Glutamic Acid - pharmacology | Paired Box Transcription Factors | Fatty Acid-Binding Protein 7 | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Bicuculline - pharmacology | Blotting, Western | GABA Antagonists - pharmacology | Immunohistochemistry - methods | Patch-Clamp Techniques | Embryo, Mammalian - cytology | Mice | Fatty Acid-Binding Proteins | Nestin | Neurogranin | Neurons - cytology | Receptors, Nerve Growth Factor - metabolism | Quinoxalines - pharmacology | Neurons - classification | Tubulin - metabolism | Neurons - drug effects | Cell Differentiation - physiology | Electric Stimulation - methods | Cell Differentiation - radiation effects | Valine - analogs & derivatives | Cells, Cultured | Stem Cells - radiation effects | Calmodulin-Binding Proteins - metabolism | PAX6 Transcription Factor | Receptor, Nerve Growth Factor | Cell Lineage - physiology | Nerve Tissue Proteins - metabolism | Animals | Carrier Proteins - metabolism | Cell Count - methods | Receptor, trkA - metabolism | Cell Differentiation - drug effects | Stem Cells - drug effects | Neuroglia - metabolism | Stem Cells - physiology | Valine - pharmacology | Eye Proteins | Intermediate Filament Proteins - metabolism | Care and treatment | Physiological aspects | Nervous system | Degeneration | Genetic aspects | Research | Cell differentiation | Embryonic stem cells | Identification and classification
Journal Article