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Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2017, Volume 474, Issue 11, pp. 1867 - 1877
Until recently, one of the major limitations of hydrogen/deuterium exchange mass spectrometry (HDX-MS) was the peptide-level resolution afforded by proteolytic... 
ACTIVATION | AMIDE HYDROGENS | PROTEIN | HDX-MS | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTRAMOLECULAR MIGRATION | KINASE | IDENTIFICATION | CAPTURE DISSOCIATION | BINDING | Oligonucleotides - genetics | Oligonucleotides - chemistry | Class Ia Phosphatidylinositol 3-Kinase - metabolism | Electron Transport | Molecular Weight | Humans | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Oligonucleotides - antagonists & inhibitors | Signal Processing, Computer-Assisted | Binding Sites | Peptide Fragments - genetics | Drug Evaluation, Preclinical - methods | Triazines - metabolism | Triazines - pharmacology | Indazoles - chemistry | Enzyme Inhibitors - metabolism | Purines - metabolism | Enzyme Inhibitors - pharmacology | Models, Molecular | Indazoles - metabolism | Recombinant Fusion Proteins - chemistry | Sulfonamides - pharmacology | Class Ia Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Indazoles - pharmacology | Oligonucleotides - metabolism | Peptide Fragments - chemistry | Class I Phosphatidylinositol 3-Kinases | Purines - chemistry | Peptide Fragments - antagonists & inhibitors | Protein Conformation | Quinazolinones - chemistry | Quinazolinones - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Recombinant Fusion Proteins - metabolism | Quinolines - pharmacology | Antineoplastic Agents - metabolism | Tandem Mass Spectrometry | Class Ia Phosphatidylinositol 3-Kinase - chemistry | Deuterium Exchange Measurement | Triazines - chemistry | Antineoplastic Agents - pharmacology | Class Ia Phosphatidylinositol 3-Kinase - genetics | Quinazolinones - pharmacology | Peptide Fragments - metabolism | Reproducibility of Results | Sulfonamides - chemistry | Purines - pharmacology | Quinolines - chemistry | Phosphatidylinositol 3-Kinases - chemistry | Antineoplastic Agents - chemistry | Phosphatidylinositol 3-Kinases - genetics | Quinolines - metabolism | Sulfonamides - metabolism | ETD | PI3K
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2014, Volume 9, Issue 11, p. e112271
The herbicides ametryn and clomazone are widely used in sugarcane cultivation, and following microbial degradation are considered as soil and water... 
HERBICIDE | CATALASE | SUPEROXIDE | BIODEGRADATION | GLUTATHIONE | INDUCED OXIDATIVE STRESS | MULTIDISCIPLINARY SCIENCES | SOIL BACTERIUM | 16S RIBOSOMAL-RNA | DEGRADING BACTERIA | TRANSFERASE | Glutathione Peroxidase - metabolism | Triazines - metabolism | Reactive Oxygen Species - metabolism | Glutathione - metabolism | Glutathione Reductase - metabolism | Soil Microbiology | Antioxidants - metabolism | Isoxazoles - metabolism | Glutathione Transferase - metabolism | Phylogeny | Catalase - metabolism | Soil Pollutants - metabolism | Pseudomonas - drug effects | Pseudomonas - enzymology | Lipid Peroxidation - drug effects | RNA, Ribosomal, 16S - genetics | Oxidative Stress - drug effects | Oxazolidinones - metabolism | Herbicides - metabolism | Pseudomonas - genetics | Pseudomonas - metabolism | Superoxide Dismutase - metabolism | Antioxidants | Herbicides | RNA | Glutathione transferase | Analysis | Bacteria | Superoxide | Soil microbiology | Oxidative stress | rRNA 16S | Hydrogen peroxide | Lipid peroxidation | Superoxide dismutase | Biochemistry | Soil pollution | Gene sequencing | Microorganisms | Agrochemicals | Catalase | Glutathione reductase | Soil water | Pseudomonas aeruginosa | Soil bacteria | Sugarcane | Strains (organisms) | Glutathione | Soil contamination | Peroxidation | Biodegradation | Enzymes | Cultivation | Pesticides | Soil degradation | Sediment pollution | Metabolism | Contaminants | Environmental degradation | Microbial degradation | Water pollution | Weeds
Journal Article
Cell death & disease, ISSN 2041-4889, 08/2017, Volume 8, Issue 8, pp. e3001 - e3001
Recent studies reported the important role of autophagy in follicular development. However, the underlying molecular mechanisms remain elusive. In this study,... 
NUTRIENT DEPRIVATION | CANCER-CELLS | APOPTOSIS | SIGNALING PATHWAY | MITOCHONDRIAL AUTOPHAGY | GROWTH-FACTORS | MTOR PATHWAY | GENE-EXPRESSION | MURINE OVARY | HYPOXIA | CELL BIOLOGY | Protein Kinases - metabolism | RNA, Small Interfering - genetics | Protein Kinases - genetics | Progesterone Reductase - metabolism | TOR Serine-Threonine Kinases - metabolism | Multienzyme Complexes - metabolism | Mitochondrial Proteins - genetics | Autophagy - drug effects | Granulosa Cells - drug effects | Granulosa Cells - metabolism | Cell Hypoxia | Follicle Stimulating Hormone - pharmacology | Chloroquine - pharmacology | TOR Serine-Threonine Kinases - genetics | Cobalt - pharmacology | Gene Expression Regulation, Developmental | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Mitochondrial Proteins - metabolism | Female | Membrane Proteins - metabolism | Autophagy - genetics | Steroid Isomerases - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - agonists | Follicle Stimulating Hormone - metabolism | Triazines - pharmacology | Signal Transduction | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Membrane Proteins - genetics | Steroid Isomerases - metabolism | Mitochondrial Proteins - antagonists & inhibitors | Ubiquitin-Protein Ligases - metabolism | Morpholines - pharmacology | Multienzyme Complexes - genetics | Progesterone Reductase - genetics | Mice, Inbred ICR | Animals | Inhibins - metabolism | Membrane Proteins - antagonists & inhibitors | Beclin-1 - genetics | Cell Proliferation - drug effects | Inhibins - genetics | Mice | Primary Cell Culture | Beclin-1 - metabolism | Ubiquitin-Protein Ligases - genetics | Granulosa Cells - cytology | RNA, Small Interfering - metabolism | Original
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2017, Volume 114, Issue 5, pp. E761 - E770
Although immunotherapy by PD-1 blockade has dramatically improved the survival rate of cancer patients, further improvement in efficacy is required to reduce... 
Mitochondria | PGC-1α | Immune metabolism | Cancer immunotherapy | PD-1 | PGC-1 alpha | mitochondria | MULTIDISCIPLINARY SCIENCES | CANCER-IMMUNOTHERAPY | DILATED CARDIOMYOPATHY | PROTEIN-SYNTHESIS | EFFECTOR | RESPONSES | MEMORY | IMMUNE CHECKPOINT BLOCKADE | ENERGY HOMEOSTASIS | cancer immunotherapy | immune metabolism | TUMOR MICROENVIRONMENT | PD-1-DEFICIENT MICE | Neoplasms - metabolism | Thiophenes - therapeutic use | AMP-Activated Protein Kinases - metabolism | Reactive Oxygen Species - metabolism | TOR Serine-Threonine Kinases - metabolism | Triazines - therapeutic use | Antibodies, Monoclonal - therapeutic use | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Pyrones - pharmacology | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism | Morpholines - therapeutic use | Cytokines - immunology | T-Lymphocytes, Cytotoxic - immunology | Triazines - pharmacology | Antibodies, Monoclonal - pharmacology | Mice, Inbred C57BL | Oxygen Consumption | Morpholines - pharmacology | Programmed Cell Death 1 Receptor - metabolism | Thiophenes - pharmacology | Mitochondria - metabolism | Lymph Nodes - immunology | Mitochondria - drug effects | Mice, Knockout | Neoplasms - drug therapy | Animals | T-Lymphocytes, Cytotoxic - metabolism | Neoplasms - immunology | Cell Line, Tumor | Pyrones - therapeutic use | Mice, Inbred BALB C | Programmed Cell Death 1 Receptor - immunology | Programmed Cell Death 1 Receptor - genetics | Care and treatment | T cells | Health aspects | Immunotherapy | Methods | Cancer | Biological Sciences | PNAS Plus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 20, pp. 7880 - 7891
Cyanuric acid is a metabolic intermediate of s-triazines, such as atrazine (a common herbicide) and melamine (used in resins and plastics). Cyanuric acid is... 
bacteria | transamidosome | PSEUDOMONAS SP | AMIDOHYDROLASE | xenobiotic | Pseudomonas | protein complex | AMIDASE DOMAIN | enzyme structure | CLONING | small protein | complex | SEQUENCE | GENES | low-molecular-weight protein | enzyme | protein evolution | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLASMID | enzyme catalysis | biuret | ALLOPHANATE HYDROLASE | REFINEMENT | bacterial metabolism | cyanuric acid | triazine | SUPERFAMILY | amidase | Organophosphates - metabolism | Herbicides - chemistry | Protein Multimerization | Bacterial Proteins - chemistry | Substrate Specificity | Crystallography, X-Ray | Isoenzymes - chemistry | Pseudomonas - enzymology | Isoenzymes - metabolism | Enzyme Inhibitors - chemistry | Cloning, Molecular | Escherichia coli - metabolism | Triazines - chemistry | Protein Interaction Domains and Motifs | Herbicides - metabolism | Amidohydrolases - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Protein Conformation, alpha-Helical | Triazines - metabolism | Catalytic Domain | Gene Expression | Enzyme Inhibitors - metabolism | Genetic Vectors - chemistry | Isoenzymes - genetics | Operon | Amidohydrolases - genetics | Bacterial Proteins - genetics | Genetic Vectors - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Amidohydrolases - chemistry | Hydrolysis | Sequence Homology, Amino Acid | Sequence Alignment | Protein Conformation, beta-Strand | Escherichia coli - genetics | Protein Binding | Bacterial Proteins - metabolism | Organophosphates - chemistry | Kinetics | Pseudomonas - chemistry | Evolution, Molecular | Editors' Picks
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 4, p. e19329
One of the major causes of chemotherapy failure in cancer treatment is multidrug resistance (MDR) which is mediated by the ABCB1/P-glycoprotein. Previously,... 
CELLS | HUMAN P-GLYCOPROTEIN | MRP1 ABCC1 | BIOLOGY | SUBFAMILY-B MEMBER-1 | REVERSES MULTIDRUG-RESISTANCE | MOLECULAR-BASIS | BINDING | CANCER | MODULATION | CHEMOTHERAPY | Phosphodiesterase 5 Inhibitors - chemistry | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Imidazoles - chemistry | Piperazines - metabolism | Carbolines - metabolism | Piperazines - chemistry | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Sulfones - pharmacology | Carbolines - chemistry | Sulfones - chemistry | Phosphodiesterase 5 Inhibitors - metabolism | Triazines - chemistry | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Gene Expression Regulation, Neoplastic - drug effects | Phosphodiesterase 5 Inhibitors - pharmacology | Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism | Imidazoles - metabolism | Triazines - metabolism | Triazines - pharmacology | KB Cells | Adenosine Triphosphatases - metabolism | Models, Molecular | Sulfones - metabolism | Imidazoles - pharmacology | Piperazines - pharmacology | Adenosine Triphosphatases - antagonists & inhibitors | Tadalafil | Vardenafil Dihydrochloride | Adenosine Triphosphatases - chemistry | Protein Conformation | ATP Binding Cassette Transporter, Sub-Family B | Carbolines - pharmacology | Drug Resistance, Neoplasm - drug effects | Drug resistance in microorganisms | Chemotherapy | Drug therapy | Adenosine triphosphatase | Cancer | Drugs | Biotechnology | Laboratories | Toxicity | Leukemia | Brain cancer | Clinical trials | Cytotoxicity | Oncology | Biology | Metastasis | Drug resistance | Kinases | Cancer therapies | Proteins | Antitumor agents | Paclitaxel | P-Glycoprotein | Pharmaceutical sciences | Phosphodiesterase | Efflux | Medical research | Incubation | Multidrug resistance | Glycoprotein | Glycoproteins | Permeability | Substrates | Brain research | Inhibitors | Pharmacy | Cell lines | Transporter | Apoptosis
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 01/2015, Volume 54, Issue 5, pp. 1578 - 1582
Cumulative evidence strongly supports that the amyloid and tau hypotheses are not mutually exclusive, but concomitantly contribute to neurodegeneration in... 
enzymes | neurochemistry | drug discovery | drug design | heterocycles | Neurochemistry | Enzymes | Heterocycles | Drug design | Drug discovery | ACID | GLYCOGEN-SYNTHASE KINASE-3 | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | Index Medicus | Drugs | Brain | Inhibitors | Pathways | Strategy | Assessments | Alzheimer's disease
Journal Article
Journal Article
Environmental Science and Pollution Research, ISSN 0944-1344, 12/2016, Volume 23, Issue 23, pp. 24289 - 24297
The sensitivity of early life stages of common carp (Cyprinus carpio L.) to chronic exposure to single and combined environmental concentrations of the... 
Environment, general | Environmental Health | Ecotoxicology | Antioxidant enzymes | Terbuthylazine-desethyl | Environment | Fish | Atrazine 2-hydroxy | Waste Water Technology / Water Pollution Control / Water Management / Aquatic Pollution | Terbuthylazine 2-hydroxy | Environmental Chemistry | Atmospheric Protection/Air Quality Control/Air Pollution | RIVER WATER | OXIDATIVE STRESS | LONG-TERM EXPOSURE | PROMETRYNE | PESTICIDES | ENVIRONMENTAL SCIENCES | TERBUTHYLAZINE | DEGRADATION-PRODUCTS | ANTIOXIDANT RESPONSE | ORGANIC CONTAMINANTS | Liver - pathology | Glutathione - metabolism | Glutathione Reductase - metabolism | Antioxidants - metabolism | Embryo, Nonmammalian - metabolism | Triazines - toxicity | Embryo, Nonmammalian - drug effects | Liver - embryology | Atrazine - metabolism | Liver - drug effects | Lipid Peroxidation - drug effects | Herbicides - metabolism | Superoxide Dismutase - metabolism | Carps - metabolism | Triazines - metabolism | Glutathione Transferase - metabolism | Thiobarbituric Acid Reactive Substances - metabolism | Herbicides - toxicity | Carps - embryology | Catalase - metabolism | Water Pollutants, Chemical - metabolism | Animals | Embryo, Nonmammalian - enzymology | Water Pollutants, Chemical - toxicity | Atrazine - toxicity | Oxidative Stress - drug effects | Antioxidants | Metabolites | Glutathione transferase | Liver | Fishes | Aquaculture industry | Environmental aspects | Superoxide | Research institutes | Atrazine | Studies | Environmental science | Effects | Pesticides
Journal Article