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Nature Medicine, ISSN 1078-8956, 2014, Volume 20, Issue 4, pp. 425 - 429
Journal Article
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, ISSN 0363-6119, 01/2013, Volume 304, Issue 1, pp. R23 - R32
The interaction between adenosine and soluble epoxide hydrolase (sEH) in vascular response is not known. Therefore, we hypothesized that lack of sEH in mice... 
Relaxation | CYP2J5-epoxgenase;ω-hydroxylase | receptor | Soluble epoxide hydrolase | Contraction | Adenosine A | Epoxide Hydrolases - physiology | Adenosine-5'-(N-ethylcarboxamide) - pharmacology | Butyrates - pharmacology | Male | Receptor, Adenosine A2A - physiology | Lauric Acids - pharmacology | Vasodilation - genetics | 8,11,14-Eicosatrienoic Acid - analogs & derivatives | Adenosine A2 Receptor Agonists - pharmacology | Urea - analogs & derivatives | Female | Benzamides - pharmacology | Oxygenases - physiology | Vasodilation - physiology | 8,11,14-Eicosatrienoic Acid - pharmacology | Adamantane - analogs & derivatives | NG-Nitroarginine Methyl Ester - pharmacology | Adamantane - pharmacology | Triazines - pharmacology | Phenethylamines - pharmacology | Vasodilator Agents - pharmacology | Enzyme Inhibitors - pharmacology | Gene Silencing | Adenosine - pharmacology | Pyrimidines - pharmacology | Epoxide Hydrolases - genetics | Triazoles - pharmacology | Adenosine A2 Receptor Antagonists - pharmacology | PPAR gamma - physiology | Animals | Adenosine - analogs & derivatives | Benzoates - pharmacology | Mice | Phenylurea Compounds - pharmacology | Pyridines - pharmacology | Vasodilation - drug effects | Urea - pharmacology | Index Medicus | adenosine A2a receptor | CYP2J5-epoxgenase | ω-hydroxylase | relaxation | contraction | Cardiovascular and Renal Integration | soluble epoxide hydrolase | adenosine A1 receptor
Journal Article
Chemical Research in Toxicology, ISSN 0893-228X, 09/2008, Volume 21, Issue 9, pp. 1814 - 1822
In vitro covalent binding assessments of drugs have been useful in providing retrospective insights into the association between drug metabolism and a... 
ACYL GLUCURONIDES | CHEMISTRY, MEDICINAL | PROTEIN | RAT | REACTIVE METABOLITES | TIENILIC ACID | HEPATIC-NECROSIS | BIOACTIVATION | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | MASS-SPECTROMETRY | TOXICOLOGY | HUMAN URINE | Buspirone - chemistry | Raloxifene Hydrochloride - pharmacology | Thiazoles - metabolism | Acetaminophen - metabolism | Humans | Microsomes, Liver - metabolism | Indomethacin - metabolism | Simvastatin - pharmacology | Diclofenac - chemistry | Thiazines - metabolism | Propranolol - pharmacology | Toxicity Tests - methods | Binding Sites | Simvastatin - metabolism | Microsomes, Liver - chemistry | Indomethacin - pharmacology | Paroxetine - metabolism | Raloxifene Hydrochloride - metabolism | Triazoles - metabolism | Ticrynafen - metabolism | Paroxetine - pharmacology | Diclofenac - metabolism | Paroxetine - chemistry | Diphenhydramine - pharmacology | Diclofenac - pharmacology | Triazoles - chemistry | Buspirone - metabolism | Ticrynafen - pharmacology | Structure-Activity Relationship | Buspirone - pharmacology | Hepatocytes - metabolism | Dose-Response Relationship, Drug | Carbamazepine - chemistry | Diphenhydramine - metabolism | Acetaminophen - pharmacology | Microsomes, Liver - drug effects | Propranolol - metabolism | Carbamazepine - metabolism | Thiazines - pharmacology | Molecular Structure | Drug Evaluation, Preclinical | Hepatocytes - drug effects | Carbamazepine - pharmacology | Simvastatin - chemistry | Acetaminophen - chemistry | Ticrynafen - chemistry | Propranolol - chemistry | Diphenhydramine - chemistry | Thiazines - chemistry | Triazoles - pharmacology | Indomethacin - chemistry | Thiazoles - chemistry | Thiazoles - pharmacology | Raloxifene Hydrochloride - chemistry | Index Medicus
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 01/2013, Volume 344, Issue 1, pp. 23 - 32
Journal Article
Journal Article
Journal Article
Cancer Letters, ISSN 0304-3835, 2016, Volume 383, Issue 2, pp. 309 - 317
Abstract In previous studies we demonstrated that targeting the nuclear exporter protein exportin-1 (CRM1/XPO1) by a selective inhibitor of nuclear export... 
Hematology, Oncology and Palliative Medicine | NHL | XPO1 | Selective inhibitors of nuclear export | SINE | CRM1 | Exportin-1 | SURVIVAL | DRUG-RESISTANCE | MODEL | CANCER | STRATEGIES | ONCOLOGY | LINE | CHOP | PROTEINS | Vincristine - pharmacology | TOR Serine-Threonine Kinases - metabolism | Transcription Factor RelA - antagonists & inhibitors | Apoptosis - drug effects | Humans | Lymphoma, Non-Hodgkin - enzymology | Lymphoma, Non-Hodgkin - pathology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | TOR Serine-Threonine Kinases - antagonists & inhibitors | Dexamethasone - pharmacology | Time Factors | Oxadiazoles - pharmacology | Acrylamides - pharmacology | Lymphoma, Non-Hodgkin - drug therapy | Cell Survival - drug effects | Hydrazines - pharmacology | Everolimus - pharmacology | Mice, SCID | Mice, Inbred ICR | Drug Synergism | Triazoles - pharmacology | Xenograft Model Antitumor Assays | Animals | Karyopherins - metabolism | Signal Transduction - drug effects | Transcription Factor RelA - metabolism | Tumor Burden - drug effects | Active Transport, Cell Nucleus - drug effects | Cyclophosphamide - pharmacology | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Cell Line, Tumor | Prednisone - pharmacology | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Karyopherins - antagonists & inhibitors | Doxorubicin - pharmacology | Receptors, Cytoplasmic and Nuclear - metabolism | International trade | Cyclophosphamide | Care and treatment | Dexamethasone | Analysis | Lymphomas | Prednisone | Exports | Steroids | Cancer | Drugs | TOR protein | Animal models | Laboratories | Toxicity | Xenotransplantation | Clinical trials | Cytotoxicity | Kinases | Experiments | Anticancer properties | Proteins | Cell growth | Antitumor agents | Cell cycle | Xenografts | Biocompatibility | Localization | Drug dosages | NF-κB protein | Chronic lymphatic leukemia | Hematology | Pharmacology | Chemical compounds | Patients | Lymphoma | Nuclear transport | Studies | Inhibitors | Response rates | In vivo methods and tests | Apoptosis | Index Medicus
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 03/2008, Volume 73, Issue 3, pp. 789 - 800
In addition to being an important receptor in leukocyte activation and mobilization, CCR5 is the essential coreceptor for human immunodeficiency virus (HIV). A... 
AMINO-TERMINAL DOMAIN | PROTEIN | ENTRY | CORECEPTOR | RECEPTOR ANTAGONISTS | IMMUNODEFICIENCY-VIRUS TYPE-1 | ANTI-HIV-1 ACTIVITY | PHARMACOLOGY & PHARMACY | HIGHLY POTENT | INHIBITOR | BINDING | Anti-HIV Agents - pharmacology | Benzoates - metabolism | Humans | Receptors, CCR5 - genetics | Piperazines - chemistry | Pyrimidines - metabolism | Receptors, CCR5 - metabolism | Piperidines - pharmacology | Amides - metabolism | Anti-HIV Agents - metabolism | Radioligand Assay | Binding Sites | Amides - pharmacology | Anti-HIV Agents - classification | Amino Acid Sequence | Piperidines - metabolism | Models, Molecular | Pyrimidines - pharmacology | HIV Fusion Inhibitors - pharmacology | Piperazines - pharmacology | Triazoles - metabolism | Anti-HIV Agents - chemistry | Amides - chemistry | Benzoates - pharmacology | Hydrophobic and Hydrophilic Interactions | Receptors, CCR5 - chemistry | Quaternary Ammonium Compounds - pharmacology | Cricetulus | Triazoles - chemistry | Benzoates - chemistry | Cyclohexanes - pharmacology | Molecular Sequence Data | Piperazines - metabolism | Quaternary Ammonium Compounds - chemistry | Pyrimidines - chemistry | Cyclohexanes - metabolism | Transfection | Inhibitory Concentration 50 | Cyclohexanes - chemistry | Molecular Structure | Membrane Fusion - drug effects | Spiro Compounds - chemistry | CCR5 Receptor Antagonists | CHO Cells | Protein Structure, Tertiary | Cricetinae | Piperidines - chemistry | Mutagenesis, Site-Directed | Protein Structure, Secondary | HIV-1 - drug effects | Static Electricity | Sequence Homology, Amino Acid | Triazoles - pharmacology | Animals | Quaternary Ammonium Compounds - metabolism | Spiro Compounds - pharmacology | Spiro Compounds - metabolism | Index Medicus
Journal Article
The Journal of Sexual Medicine, ISSN 1743-6095, 12/2012, Volume 9, Issue 12, pp. 3028 - 3040
The efficacy of phosphodiesterase type 5 inhibitors (PDE5i) in treating lower urinary tract symptoms is supported by the extremely high expression and activity... 
Bladder | PDE5 | Vardenafil | PHOSPHODIESTERASE-5 INHIBITORS | FUNCTIONAL-ACTIVITY | NITRIC-OXIDE SYNTHASE | DETRUSOR SMOOTH-MUSCLE | CGMP-BINDING | LOWER URINARY-TRACT | BENIGN PROSTATIC HYPERPLASIA | IN-VITRO | UROLOGY & NEPHROLOGY | SEXUAL DYSFUNCTION | EXPRESSION | Estradiol - blood | Estrogens - pharmacology | Nitriles - pharmacology | Aromatase Inhibitors - pharmacology | Male | Nitroprusside - pharmacology | RNA, Messenger - metabolism | Sulfones - pharmacology | Testosterone - pharmacology | Muscle, Smooth - drug effects | Female | Nitric Oxide Donors - pharmacology | Testosterone - blood | Phosphodiesterase 5 Inhibitors - pharmacology | Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism | Progesterone - pharmacology | Estradiol - pharmacology | Gene Expression | Triazines - pharmacology | Ovariectomy | Urinary Bladder - metabolism | Progestins - pharmacology | Rats | Imidazoles - pharmacology | Piperazines - pharmacology | Rats, Sprague-Dawley | Triazoles - pharmacology | Animals | Androgens - pharmacology | Sex Factors | Vardenafil Dihydrochloride | Cyclic Nucleotide Phosphodiesterases, Type 5 - genetics | Urinary Bladder - drug effects | Muscle Relaxation - drug effects | Testosterone | Enzymes | Genes | Phenols | Sodium nitroferricyanide | Cyanides | Estradiol | Cyclic guanylic acid | Index Medicus
Journal Article
Cancer Discovery, ISSN 2159-8274, 2014, Volume 4, Issue 7, pp. 816 - 827
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 10/2011, Volume 55, Issue 10, pp. 4652 - 4658
Journal Article
Journal Article