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Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 04/2016, Volume 60, Issue 4, pp. 2281 - 2291
Deciphering the mode of action (MOA) of new antibiotics discovered through phenotypic screening is of increasing importance. Metabolomics offers a potentially... 
TARGET | NATURAL-PRODUCT | THYMIDYLATE KINASE | BIOSYNTHESIS | ESCHERICHIA-COLI | ALANINE LIGASE | D-CYCLOSERINE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | STAPHYLOCOCCUS-AUREUS | MASS-SPECTROMETRY | PATHOGENS | Acyltransferases - antagonists & inhibitors | Metabolomics | Nucleoside-Phosphate Kinase - genetics | Ceftazidime - pharmacology | Escherichia coli - drug effects | Humans | Triclosan - metabolism | Triclosan - pharmacology | Acyltransferases - metabolism | Threonine - metabolism | Acyltransferases - genetics | Fosfomycin - metabolism | Pyrimidines - metabolism | DNA, Bacterial - antagonists & inhibitors | Ceftazidime - metabolism | Cell Wall - drug effects | Terpenes - antagonists & inhibitors | Terpenes - metabolism | Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology | Mass Spectrometry | Escherichia coli - metabolism | HEK293 Cells | Chromatography, Liquid | Hydroxamic Acids - pharmacology | Fosfomycin - analogs & derivatives | Carbonyl Cyanide m-Chlorophenyl Hydrazone - metabolism | Gene Expression | DNA, Bacterial - biosynthesis | Fosfomycin - pharmacology | Nucleoside-Phosphate Kinase - antagonists & inhibitors | Anti-Bacterial Agents - metabolism | Adenosine - pharmacology | Cell Wall - chemistry | Pyrimidines - pharmacology | Threonine - analogs & derivatives | Hydroxamic Acids - metabolism | Threonine - pharmacology | Metabolome - drug effects | Escherichia coli - genetics | Cell Wall - metabolism | Adenosine - metabolism | Anti-Bacterial Agents - pharmacology | Nucleoside-Phosphate Kinase - metabolism
Journal Article
Water Research, ISSN 0043-1354, 09/2012, Volume 46, Issue 13, pp. 4226 - 4234
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 12/2017, Volume 336, pp. 49 - 54
Triclosan (TCS), a member of the class of compounds called pharmaceutical and personal care products (PPCPs), is a broad antibacterial and antifungal agent... 
HPG axis | Triclosan | Aromatase | Sex steroid | Female Yellow River carp | ENDOCRINE-DISRUPTING CHEMICALS | ZEBRAFISH DANIO-RERIO | LONG-TERM EXPOSURE | FATHEAD MINNOWS | FLUVIATILIS | TOXICITY | VITELLOGENIN | GENE-EXPRESSION | FISH | PITUITARY-GONAD AXIS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Receptors, Estrogen - metabolism | Gonads - drug effects | Aromatase - metabolism | Triclosan - toxicity | RNA, Messenger - metabolism | Hormones - genetics | Fish Proteins - genetics | Testosterone - metabolism | Aromatase - genetics | Time Factors | Female | Hepatopancreas - metabolism | Carps - metabolism | Estradiol - metabolism | Hypothalamo-Hypophyseal System - drug effects | Receptors, Estrogen - genetics | Vitellogenins - metabolism | Hepatopancreas - drug effects | Gonadotropin-Releasing Hormone - genetics | Gonadotropins, Pituitary - metabolism | RNA, Messenger - genetics | Fish Proteins - metabolism | Estrogens - toxicity | Gonadotropins, Pituitary - genetics | Hypothalamo-Hypophyseal System - metabolism | Endocrine Disruptors - toxicity | Reproduction - drug effects | Gonads - metabolism | Animals | Hormones - metabolism | Gonadotropin-Releasing Hormone - metabolism | Carps - genetics | Testosterone | Toiletries | Enzymes | Carp | Pituitary hormones | RNA | Fishes | Personal care industry | Phenols | Estradiol | Index Medicus
Journal Article
Toxicology Letters, ISSN 0378-4274, 12/2018, Volume 299, pp. 76 - 85
This study combined metabonomics with molecular biology techniques to identify differential endogenous substances produced by triclocarban (TCC) that affect... 
Triclocarban | Glycolysis | Metabonomics | TCA cycle | UNITED-STATES | RAT | ANTIMICROBIAL TRICLOCARBAN | MUSCLE | METHYL-TRICLOSAN | ENVIRONMENTAL FATE | WASTE-WATER | 3,4,4'-TRICHLOROCARBANILIDE | TOXICOLOGY | NORTH TEXAS | EXPOSURE | Index Medicus
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 5/2019, Volume 56, Issue 5, pp. 3113 - 3131
Triclocarban is a phenyl ether that has recently been classified as a contaminant of emerging concern. Evidence shows that triclocarban is present in human... 
Triclocarban | Neurology | Neurosciences | Biomedicine | Neurobiology | DNA methylation | Sumoylation | Cell Biology | Apoptosis | Primary neurons | FETAL EXPOSURE | TRICLOSAN | POPULATION | ACTIVATION | INVOLVEMENT | NEUROPROTECTIVE ACTION | NEUROSCIENCES | ER-ALPHA | BETA | ARYL-HYDROCARBON RECEPTOR | EXPRESSION | L-Lactate Dehydrogenase - metabolism | Reactive Oxygen Species - metabolism | Receptors, Aryl Hydrocarbon - antagonists & inhibitors | Apoptosis - drug effects | Caspase 3 - metabolism | Membrane Potential, Mitochondrial - drug effects | RNA, Messenger - metabolism | Sumoylation - drug effects | DNA (Cytosine-5-)-Methyltransferases - metabolism | Carbanilides - toxicity | Receptors, Aryl Hydrocarbon - metabolism | Epigenesis, Genetic - drug effects | Neurons - metabolism | Neurons - drug effects | bcl-2-Associated X Protein - genetics | RNA, Messenger - genetics | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Histone Deacetylases - metabolism | Hippocampus - pathology | Animals | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Staining and Labeling | Mice | DNA Methylation - drug effects | Sirtuins - metabolism | RNA, Small Interfering - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Sirtuins | Biodegradation | Histone deacetylase | Bax protein | Neurons | Fetuses | Nervous system | Antagonists | Gene expression | Embryos | Neurological diseases | Proteins | SUMO protein | Neurotoxicity | Developmental stages | Contaminants | Proteasomes | Epigenetics | Methylation | Localization | Deoxyribonucleic acid--DNA
Journal Article
Chemosphere, ISSN 0045-6535, 09/2017, Volume 183, pp. 257 - 265
Journal Article
Environmental Science & Technology, ISSN 0013-936X, 06/2011, Volume 45, Issue 12, pp. 5395 - 5402
Journal Article