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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2014, Volume 111, Issue 48, pp. 17272 - 17277
VEGF-B primarily provides neuroprotection and improves survival in CNS-derived neurons. However, its actions on the peripheral nervous system have been less... 
Sensation | Debridement | Cornea | Neurites | Neurons | Nerves | Peripheral nerves | Mice | Epithelium | Nerve regeneration | Nerve injury | Neuronal growth | VEGF-B | neuronal growth | cornea | nerve injury | ANGIOGENESIS | PERMEABILITY | ENDOTHELIAL-GROWTH-FACTOR | MULTIDISCIPLINARY SCIENCES | ISCHEMIA | DEFICIENT MICE | KNOCKOUT MICE | RECOVERY | DISPLAY | PATHWAY | DISEASE | Neurites - physiology | Receptors, Notch - metabolism | Nerve Regeneration - physiology | Cell Survival - genetics | Phosphatidylinositol 3-Kinases - metabolism | Peripheral Nerves - drug effects | Cornea - drug effects | Peripheral Nerve Injuries - physiopathology | Neurons - physiology | Neurons - metabolism | Neurons - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Neurites - drug effects | Nerve Regeneration - genetics | Cell Survival - drug effects | Trigeminal Ganglion - cytology | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Peripheral Nerves - pathology | Blotting, Western | Mice, Knockout | Peripheral Nerves - physiopathology | Vascular Endothelial Growth Factor B - pharmacology | Animals | Signal Transduction - drug effects | Vascular Endothelial Growth Factor B - metabolism | Nerve Regeneration - drug effects | Cornea - innervation | Vascular Endothelial Growth Factor B - genetics | Cell Proliferation - drug effects | Cornea - physiopathology | Peripheral Nerve Injuries - genetics | Microscopy, Fluorescence | Sensory receptors | Vascular endothelial growth factor | Health aspects | Nervous system | Cell growth | Rodents | Index Medicus | Biological Sciences
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 45, pp. 18486 - 18499
The cornea is densely innervated to sustain the integrity of the ocular surface. Corneal nerve damage produced by aging, diabetes, refractive surgeries, and... 
EXPERIMENTAL SURGERY | phospholipase A | cornea | BIOCHEMISTRY & MOLECULAR BIOLOGY | brain-derived neurotrophic factor (BDNF) | neuropeptides | SPINAL-CORD | NGF | IDENTIFICATION | SENSORY NEURONS | PEDF | adipose triglyceride lipase | Sema7A | DRY EYE | INFLAMMATION | PEDF PLUS DHA | GROWTH-FACTOR | DHA | C-JUN | lipid signaling | Male | Receptors, Neuropeptide - metabolism | Eye Proteins - agonists | Trigeminal Ganglion - drug effects | Neuroprotective Agents - metabolism | Enzyme Inhibitors - administration & dosage | Nerve Growth Factors - pharmacology | Neuroprotective Agents - pharmacology | Cornea - pathology | Eye Proteins - antagonists & inhibitors | Organ Culture Techniques | Docosahexaenoic Acids - therapeutic use | Trigeminal Ganglion - pathology | Nerve Tissue Proteins - agonists | Trigeminal Nerve Injuries - drug therapy | Enzyme Inhibitors - pharmacology | Injections, Intraperitoneal | Nerve Growth Factors - administration & dosage | Serpins - pharmacology | Nerve Growth Factors - therapeutic use | Eye Proteins - metabolism | Nerve Regeneration - drug effects | Cornea - innervation | Eye Proteins - pharmacology | Neuroprotective Agents - therapeutic use | Administration, Ophthalmic | Cornea - physiology | Cornea - drug effects | Eye Proteins - administration & dosage | Receptors, Neuropeptide - agonists | Eye Proteins - genetics | Drug Therapy, Combination | Neuroprotective Agents - administration & dosage | Trigeminal Ganglion - physiology | Nerve Tissue Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Receptors, Neuropeptide - antagonists & inhibitors | Trigeminal Nerve - pathology | Eye Proteins - therapeutic use | Serpins - therapeutic use | Docosahexaenoic Acids - administration & dosage | Nerve Tissue Proteins - genetics | Serpins - administration & dosage | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Trigeminal Nerve - drug effects | Trigeminal Nerve - physiology | Animals | Phenylurea Compounds - administration & dosage | Phenylurea Compounds - pharmacology | Models, Neurological | Docosahexaenoic Acids - metabolism | Index Medicus | Neurobiology
Journal Article
Neuroscience, ISSN 0306-4522, 2004, Volume 127, Issue 2, pp. 481 - 496
We investigated the CNS delivery of insulin-like growth factor-I (IGF-I), a 7.65 kDa protein neurotrophic factor, following intranasal administration and the... 
blood–brain barrier | drug delivery | neurotrophic factor | Alzheimer's disease | stroke | cerebrospinal fluid | blood-brain barrier | HRP | IGF | AUC | CSF | horseradish peroxidase | area under the concentration-time curve | extracellular signal-regulated protein kinase | ERK | CHLAMYDIA-PNEUMONIAE | CIRCULATING IGF-I | ALZHEIMERS-DISEASE | CEREBROSPINAL-FLUID | HORSERADISH-PEROXIDASE | NEUROSCIENCES | BINDING-PROTEINS | NASAL CAVITY | METASTATIC GLIOBLASTOMA-MULTIFORME | CENTRAL-NERVOUS-SYSTEM | CERVICAL LYMPH-NODES | Trigeminal Nerve - metabolism | Iodine Radioisotopes | Spinal Cord - drug effects | Spinal Cord - metabolism | Male | Olfactory Nerve - drug effects | Brain - metabolism | Dose-Response Relationship, Drug | Olfactory Nerve - cytology | Reaction Time - drug effects | Insulin-Like Growth Factor I - administration & dosage | Blood-Brain Barrier - physiology | Lymph Nodes - drug effects | Spinal Cord - cytology | Olfactory Pathways - drug effects | Olfactory Nerve - metabolism | Brain - cytology | Olfactory Pathways - metabolism | Lymph Nodes - metabolism | Rats | Reaction Time - physiology | Administration, Intranasal | Blood-Brain Barrier - drug effects | Rats, Sprague-Dawley | Brain - drug effects | Insulin-Like Growth Factor I - pharmacokinetics | Trigeminal Nerve - drug effects | Animals | Cerebrospinal Fluid - metabolism | Signal Transduction - drug effects | Olfactory Pathways - cytology | Signal Transduction - physiology | Insulin-Like Growth Factor I - metabolism | Trigeminal Nerve - cytology | Index Medicus
Journal Article
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 2009, Volume 37, Issue 2, pp. 370 - 383
Abstract Transgenic mice expressing the human superoxide dismutase 1 (SOD-1) mutant at position 93 (G93A) develop a phenotype resembling amyotrophic lateral... 
Neurology | Choline acetyl transferase | Amyotrophic lateral sclerosis | Lithium | Synaptic boutons | Transgenic G93A mouse | Brainstem motor neurons | ADULT RATS | CELLS IN-VITRO | NITRIC-OXIDE SYNTHASE | CU/ZN SUPEROXIDE-DISMUTASE | SPINAL-CORD | AMYOTROPHIC-LATERAL-SCLEROSIS | NEUROSCIENCES | DIFFERENTIAL VULNERABILITY | HYPOGLOSSAL NERVE ANASTOMOSIS | NEURON DEGENERATION | DISEASE PROGRESSION | Neuroprotective Agents - therapeutic use | Amyotrophic Lateral Sclerosis - physiopathology | Humans | Nerve Degeneration - physiopathology | Vagus Nerve - drug effects | Facial Nerve - drug effects | Male | Cytoprotection - physiology | Amyotrophic Lateral Sclerosis - drug therapy | Brain Stem - drug effects | Choline O-Acetyltransferase - metabolism | Motor Neurons - pathology | Vagus Nerve - pathology | Hypoglossal Nerve - drug effects | Lithium - therapeutic use | Neuroprotective Agents - pharmacology | Cranial Nerves - pathology | Brain Stem - pathology | Nerve Degeneration - prevention & control | Cytoprotection - drug effects | Trigeminal Nerve - physiopathology | Disease Models, Animal | Biomarkers - metabolism | Drug Administration Schedule | Lithium - pharmacology | Biomarkers - analysis | Axons - drug effects | Trigeminal Nerve - pathology | Mice, Transgenic | Treatment Outcome | Brain Mapping - methods | Vagus Nerve - physiopathology | Hypoglossal Nerve - pathology | Motor Neurons - metabolism | Cranial Nerves - drug effects | Amyotrophic Lateral Sclerosis - pathology | Trigeminal Nerve - drug effects | Animals | Axons - pathology | Choline O-Acetyltransferase - analysis | Cranial Nerves - physiopathology | Brain Stem - physiopathology | Mice | Facial Nerve - pathology | Hypoglossal Nerve - physiopathology | Facial Nerve - physiopathology | Nerve Degeneration - drug therapy | Superoxide dismutase | Superoxide | Neurons | Analysis | Choline | Index Medicus
Journal Article
Journal of Neurophysiology, ISSN 0022-3077, 01/2007, Volume 97, Issue 1, pp. 692 - 700
Early in development, cortical networks generate particular patterns of activity that participate in cortical development. The dominant pattern of electrical... 
HIPPOCAMPAL SLICES | PHYSIOLOGY | GLUTAMATE-RECEPTOR BLOCKADE | GABAERGIC INHIBITION | DEVELOPING NEOCORTEX | SOMATOSENSORY CORTEX | NEURAL ACTIVITY | EXCITATORY ACTIONS | NEUROSCIENCES | THALAMOCORTICAL SYNAPSES | CORTICAL CIRCUITS | GIANT DEPOLARIZING POTENTIALS | Synaptic Transmission - physiology | Rats, Wistar | Somatosensory Cortex - growth & development | gamma-Aminobutyric Acid - metabolism | Neuronal Plasticity - drug effects | Male | Nerve Net - drug effects | Biological Clocks - drug effects | Neural Inhibition - physiology | Neuronal Plasticity - physiology | Female | Synaptic Transmission - drug effects | Afferent Pathways - drug effects | Action Potentials - drug effects | Receptors, AMPA - metabolism | Animals, Newborn | Nerve Net - growth & development | Neurons, Afferent - drug effects | Afferent Pathways - growth & development | Trigeminal Nerve - growth & development | GABA-A Receptor Antagonists | Somatosensory Cortex - drug effects | Interneurons - drug effects | Rats | Excitatory Amino Acid Antagonists - pharmacology | Neurons, Afferent - physiology | GABA Antagonists - pharmacology | Action Potentials - physiology | Trigeminal Nerve - drug effects | Animals | Interneurons - metabolism | Biological Clocks - physiology | Vibrissae - physiology | Glutamic Acid - metabolism | Receptors, GABA-A - metabolism | Neural Inhibition - drug effects | Index Medicus | Neural Inhibition | Interneurons | Receptors, GABA-A | Cellular Biology | Synaptic Transmission | Action Potentials | Life Sciences | Neurons, Afferent | Biological Clocks | Receptors, AMPA | Afferent Pathways | gamma-Aminobutyric Acid | Vibrissae | Somatosensory Cortex | Glutamic Acid | Neuronal Plasticity | Nerve Net | Trigeminal Nerve | Excitatory Amino Acid Antagonists | GABA Antagonists
Journal Article
Journal Article
Nature Neuroscience, ISSN 1097-6256, 06/2015, Volume 18, Issue 6, pp. 844 - 854
Journal Article
Journal Article
Journal of Neurophysiology, ISSN 0022-3077, 08/2017, Volume 118, Issue 2, pp. 1198 - 1209
Journal Article