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Chemico-Biological Interactions, ISSN 0009-2797, 2010, Volume 184, Issue 3, pp. 376 - 387
Steatosis is the first step in the development of non-alcoholic fatty liver disease (NAFLD). However, the mechanisms involved in its pathogenesis are not fully... 
Cultured human hepatocytes | HepG2 | NAFLD | Fatty acids | Nuclear receptor ligands | Steatosis | RAT-LIVER | LIPID-METABOLISM | PROLIFERATOR-ACTIVATED RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RETINOIC ACID RECEPTORS | PREGNANE-X-RECEPTOR | PPAR GAMMA 1 | NONALCOHOLIC FATTY LIVER | CONSTITUTIVE ANDROSTANE RECEPTOR | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | TOXICOLOGY | DRUG-METABOLISM | Vitamin A - pharmacology | Farnesol - pharmacology | Humans | Hepatocytes - metabolism | PPAR gamma - metabolism | Terpenes - pharmacology | Phloroglucinol - pharmacology | Indoles - pharmacology | Hepatocytes - drug effects | Cholesterol - analogs & derivatives | Fatty Liver - metabolism | Bridged Bicyclo Compounds - pharmacology | Androstenols - pharmacology | Cells, Cultured | Receptors, Cytoplasmic and Nuclear - genetics | Calcifediol - pharmacology | Fatty Liver - drug therapy | Hep G2 Cells | Pregnenediones - pharmacology | PPAR gamma - agonists | Tamoxifen - pharmacology | Cholesterol - pharmacology | Ligands | Phloroglucinol - analogs & derivatives | Selective Estrogen Receptor Modulators - pharmacology | Receptors, Cytoplasmic and Nuclear - metabolism | Phosphates | Cell research | Corticosteroids | Liver diseases | Estrogen | Albumin | Triglycerides | Hepatoma | Retinoids | Tamoxifen | Messenger RNA | Synthesis | Choline | Physiological aspects | Progesterone | Rifampin | Protein binding
Journal Article
Annual Review of Medicine, ISSN 0066-4219, 02/2001, Volume 52, Issue 1, pp. 503 - 517
"Atypical" antipsychotics represent a new generation of antipsychotics with a significantly lower incidence of extrapyramidal side effects (EPS), as well as... 
clozapine | serotonin | dopamine | psychosis | Psychosis | Dopamine | Clozapine | Serotonin | RISPERIDONE | FIRST-EPISODE SCHIZOPHRENIA | SERUM TRIGLYCERIDE LEVELS | DIABETES-MELLITUS | MEDICINE, GENERAL & INTERNAL | D-2 RECEPTOR OCCUPANCY | WEIGHT-GAIN | TARDIVE-DYSKINESIA | OLANZAPINE | RESISTANT SCHIZOPHRENIA | Clozapine - therapeutic use | Dibenzothiepins - therapeutic use | Sulpiride - pharmacology | Humans | Thiazoles - therapeutic use | Schizophrenic Psychology | Sulpiride - analogs & derivatives | Clozapine - pharmacology | Dibenzothiazepines - therapeutic use | Risperidone - therapeutic use | Antipsychotic Agents - therapeutic use | Schizophrenia - physiopathology | Receptors, Dopamine D2 - drug effects | Indoles - pharmacology | Imidazoles - therapeutic use | Pirenzepine - pharmacology | Haloperidol - pharmacology | Sulpiride - therapeutic use | Dibenzothiazepines - pharmacology | Pirenzepine - therapeutic use | Quetiapine Fumarate | Pirenzepine - analogs & derivatives | Risperidone - pharmacology | Haloperidol - therapeutic use | Serotonin Antagonists - therapeutic use | Dopamine Antagonists - therapeutic use | Treatment Outcome | Imidazoles - pharmacology | Piperazines - therapeutic use | Serotonin Antagonists - pharmacology | Piperazines - pharmacology | Benzodiazepines | Dopamine Antagonists - pharmacology | Receptors, Dopamine D4 | Indoles - therapeutic use | Dibenzothiepins - pharmacology | Thiazoles - pharmacology | Antipsychotic Agents - pharmacology | Schizophrenia - drug therapy | Drug Monitoring
Journal Article
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 12/2012, Volume 696, Issue 1-3, pp. 194 - 202
Dipeptidyl peptidase-4 (DPP-4) inhibitors have been demonstrated to improve glycemic control, in particular postprandial hyperglycemic control, in patients... 
Type 2 diabetes | Glucagon-like peptide-1 | Postprandial hyperglycemia | Teneligliptin | Dyslipidemia | Dipeptidyl peptidase-4 | MYOCARDIAL-INFARCTION | ENDOTHELIAL DYSFUNCTION | PRECLINICAL PROFILE | ISCHEMIC-HEART-DISEASE | IMPROVED GLUCOSE-TOLERANCE | IV INHIBITOR | CARDIOVASCULAR-DISEASE | BETA-CELL DYSFUNCTION | PHARMACOLOGY & PHARMACY | SLOW-BINDING INHIBITOR | Hypertriglyceridemia - drug therapy | Pyrazoles - therapeutic use | Nitriles - pharmacology | Rats, Wistar | Dipeptidyl-Peptidase IV Inhibitors - therapeutic use | Dipeptidyl Peptidase 4 - blood | Glucagon-Like Peptide 1 - blood | Male | Insulin - blood | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Hyperglycemia - drug therapy | Pyrrolidines - pharmacology | Sitagliptin Phosphate | Thiazolidines - pharmacology | Adamantane - analogs & derivatives | Pyrazoles - pharmacology | Hypoglycemic Agents - therapeutic use | Adamantane - pharmacology | Blood Glucose - analysis | Rats | Hypolipidemic Agents - pharmacology | Hypertriglyceridemia - blood | Hypoglycemic Agents - pharmacology | Thiazolidines - therapeutic use | Rats, Zucker | Triazoles - pharmacology | Animals | Hyperglycemia - blood | Hypolipidemic Agents - therapeutic use | Diabetes Mellitus, Type 2 - drug therapy | Pyrazines - pharmacology | Hyperglycemia | Peptides | Triglycerides | Glucose | Fatty acids | Dextrose
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 2017, Volume 312, Issue 2, pp. H289 - H304
High consumption of simple sugars causes adverse cardiometabolic effects. We investigated the mechanisms underlying the metabolic and vascular effects of... 
Insulin resistance | Glucose | Liver | Fructose | Adiponectin | TRIGLYCERIDE TRANSFER PROTEIN | adiponectin | glucose | FRUCTOSE-FED RATS | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | ENDOTHELIAL DYSFUNCTION | liver | LIQUID FRUCTOSE | VASCULAR DYSFUNCTION | fructose | HYPERPOLARIZING FACTOR | HEPATIC INSULIN-RESISTANCE | FRUCTOKINASE EXPRESSION | NITRIC-OXIDE | PERIPHERAL VASCULAR DISEASE | ARTIFICIALLY-SWEETENED BEVERAGES | insulin resistance | PPAR alpha - drug effects | Phosphorylation | Aorta - metabolism | Nitroprusside - pharmacology | Carrier Proteins - drug effects | Phenylephrine - pharmacology | Liver - drug effects | Fructose - pharmacology | Carnitine O-Palmitoyltransferase - metabolism | Adiponectin - metabolism | Carnitine O-Palmitoyltransferase - drug effects | Female | Aorta - physiopathology | Nitric Oxide Donors - pharmacology | Nitric Oxide Synthase Type III - metabolism | Real-Time Polymerase Chain Reaction | Bradykinin - pharmacology | Vasoconstrictor Agents - pharmacology | Vasodilator Agents - pharmacology | Dietary Sucrose - pharmacology | Signal Transduction | Acetylcholine - pharmacology | Aorta - drug effects | Liver - metabolism | Rats | Glucose - pharmacology | Energy Intake | Rats, Sprague-Dawley | Blotting, Western | Triglycerides - metabolism | Insulin - metabolism | Animals | Carrier Proteins - metabolism | Lipogenesis - drug effects | Lipid Metabolism - drug effects | PPAR alpha - metabolism | Nitric Oxide Synthase Type III - drug effects | Physiological aspects | Aorta | Health aspects | Sugar | Proteïnes de la sang | Resistència a la insulina | Fetge | Fructosa | Disorders of metabolism | Glucosa | Trastorns del metabolisme | Blood proteins
Journal Article