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Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 12/2006, Volume 58, Issue 6, pp. 826 - 834
Cellular uptake of hydrophilic antifolates proceeds via the reduced folate carrier whereas lipophilic antifolates enter cells by diffusion. Recently we have... 
Efflux | Chemotherapy | Lipophilic antifolates | Drug resistance | ABC transporter | TRANSPORTER | METHOTREXATE | efflux | CANCER CELL-LINE | chemotherapy | P-GLYCOPROTEIN | TRIMETREXATE | lipophilic antifolates | PROTEIN BCRP/ABCG2 | GENE | ONCOLOGY | DIHYDROFOLATE-REDUCTASE | PHARMACOLOGY & PHARMACY | drug resistance | MUTATIONS | MULTIDRUG-RESISTANCE | Folic Acid Antagonists - chemistry | Heterocyclic Compounds, 3-Ring - metabolism | Paclitaxel - pharmacology | Humans | Cell Survival - genetics | Neoplasm Proteins - antagonists & inhibitors | Doxorubicin - chemistry | Pyrimethamine - pharmacology | Neoplasm Proteins - metabolism | Pyrimidines - chemistry | Dose-Response Relationship, Drug | Paclitaxel - chemistry | Cisplatin - chemistry | Lipids - chemistry | Transfection | ATP-Binding Cassette Transporters - genetics | Pyrimethamine - analogs & derivatives | ATP-Binding Cassette Transporters - metabolism | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Biological Transport - drug effects | Biological Transport - genetics | Molecular Structure | Neoplasm Proteins - genetics | Quinazolines - chemistry | Pyrimethamine - chemistry | ATP Binding Cassette Transporter, Subfamily G, Member 2 | Cell Line | Cell Survival - drug effects | Trimetrexate - chemistry | Cisplatin - pharmacology | Pyrimidines - pharmacology | Trimetrexate - pharmacology | Antineoplastic Agents - chemistry | Mutation - genetics | Drug Resistance, Neoplasm - genetics | Fluorouracil - chemistry | Cell Proliferation - drug effects | Fluorouracil - pharmacology | Quinazolines - pharmacology | Folic Acid Antagonists - pharmacology | Indoles - chemistry | Doxorubicin - pharmacology | ATP-Binding Cassette Transporters - antagonists & inhibitors
Journal Article
Biochemistry, ISSN 0006-2960, 02/2016, Volume 55, Issue 7, pp. 1107 - 1119
Mycobacterium tuberculosis (Mtb) Rv2671 is annotated as a 5-amino-6-ribitylamino-2,4­(1H,3H)-pyrimidinedione 5′-phosphate (AROPP) reductase (RibD) in the... 
RIBOFLAVIN | BIFUNCTIONAL DEAMINASE | TRANSITION STRUCTURES | CRYSTAL-STRUCTURE | BIOSYNTHESIS | REFSEQ | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | KINETIC MECHANISM | ANTIFOLATE | HYDRIDE TRANSFER | Folic Acid Antagonists - chemistry | Trimethoprim - chemistry | Antitubercular Agents - chemistry | Trimethoprim - pharmacology | Tetrahydrofolate Dehydrogenase - chemistry | Molecular Conformation | Bacterial Proteins - chemistry | Drug Resistance, Bacterial | Phylogeny | Trimethoprim - metabolism | Mycobacterium tuberculosis - drug effects | NADP - chemistry | Enzyme Inhibitors - chemistry | NADP - metabolism | Trimetrexate - metabolism | Recombinant Proteins - metabolism | Bacterial Proteins - antagonists & inhibitors | Catalytic Domain | Enzyme Inhibitors - metabolism | Nucleotide Deaminases - chemistry | Trimetrexate - chemistry | Nucleotide Deaminases - metabolism | Antitubercular Agents - pharmacology | Bacterial Proteins - genetics | Enzyme Inhibitors - pharmacology | Models, Molecular | Recombinant Proteins - chemistry | Trimetrexate - pharmacology | Tetrahydrofolate Dehydrogenase - metabolism | Tetrahydrofolates - metabolism | Folic Acid Antagonists - metabolism | Nucleotide Deaminases - antagonists & inhibitors | Nucleotide Deaminases - genetics | Mycobacterium tuberculosis - enzymology | Aminosalicylic Acid - pharmacology | Bacterial Proteins - metabolism | Ligands | Tetrahydrofolates - chemistry | Kinetics | Antitubercular Agents - metabolism | Folic Acid Antagonists - pharmacology | Mycobacterium tuberculosis - growth & development | Tetrahydrofolate Dehydrogenase - genetics | Mycobacterium tuberculosis | Bacterial proteins | Research | Catalysis | Dihydrofolate reductase | Chemical properties | Structure
Journal Article
Parasitology Research, ISSN 0932-0113, 5/2008, Volume 102, Issue 6, pp. 1227 - 1234
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2006, Volume 14, Issue 24, pp. 8608 - 8621
In order to produce potent new leads for anticancer drugs, a new series of quinazoline analogs was designed to resemble methotrexate (MTX, ) structure features... 
Antitumor activity | DHFR inhibitors | 4(3 H)-Quinazolinone | Molecular modeling studies | 4(3H)-Quinazolinone | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG DISCOVERY | METHOTREXATE | CHEMISTRY, ORGANIC | NATIONAL-CANCER-INSTITUTE | 4(3H)-quinazolinone | TRIMETREXATE | PNEUMOCYSTIS-CARINII | antitumor activity | PHARMACOLOGY | molecular modeling studies | BIOLOGICAL EVALUATION | FORCE-FIELD | PART 2 | CYTOTOXICITY | Methotrexate - pharmacology | Folic Acid Antagonists - chemistry | Lung Neoplasms - drug therapy | Liver - enzymology | Tetrahydrofolate Dehydrogenase - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Lung Neoplasms - pathology | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Cattle | Enzyme Inhibitors - chemistry | Antineoplastic Agents - pharmacology | Molecular Structure | Folic Acid Antagonists - chemical synthesis | Quinazolinones - pharmacology | Tumor Cells, Cultured - drug effects | Enzyme Inhibitors - pharmacology | Models, Molecular | Antineoplastic Agents - chemistry | Breast Neoplasms - drug therapy | Quinazolinones - chemical synthesis | Animals | Breast Neoplasms - pathology | Cell Proliferation - drug effects | Quinazolinones - chemistry | Folic Acid Antagonists - pharmacology | Models | Dihydrofolate reductase | Analysis | Pharmacy
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2000, Volume 275, Issue 40, pp. 30855 - 30863
We have studied the molecular basis for the resistance of human CEM leukemia cells to GW1843, a thymidylate synthase inhibitor. GW1843-resistant cells... 
THYMIDYLATE SYNTHASE INHIBITORS | HAMSTER OVARY CELLS | LOW PH | METHOTREXATE TRANSPORT | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESISTANCE | TUMOR-CELLS | L1210 CELLS | MAMMALIAN-CELLS | FOLIC-ACID | MEMBRANE-TRANSPORT | Folic Acid - pharmacology | Humans | Isoindoles | Polymorphism, Single-Stranded Conformational | Biological Transport | Time Factors | DNA Mutational Analysis | Antimetabolites, Antineoplastic - pharmacology | Cell Membrane - metabolism | Leukemia - genetics | Chlorides - pharmacology | Enzyme Inhibitors - pharmacology | Recombinant Proteins - chemistry | Folic Acid - pharmacokinetics | Blotting, Western | Cell Division - drug effects | Membrane Proteins | Drug Resistance, Neoplasm - genetics | Kinetics | Mutation | Quinazolines - pharmacology | Folic Acid Antagonists - pharmacology | Methotrexate - pharmacology | Blotting, Southern | Exons | Leukemia - metabolism | Dose-Response Relationship, Drug | Transfection | Inhibitory Concentration 50 | Carrier Proteins - chemistry | Indoles - pharmacology | Tumor Cells, Cultured | Quinazolines - chemistry | Methotrexate - chemistry | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Folic Acid - analogs & derivatives | Mutagenesis, Site-Directed | Protein Structure, Secondary | Folic Acid - chemistry | Trimetrexate - pharmacology | Reduced Folate Carrier Protein | Carrier Proteins - genetics | Blotting, Northern | Folic Acid Antagonists - metabolism | Membrane Transport Proteins | Folic Acid - metabolism | Thymidylate Synthase - antagonists & inhibitors | DNA, Complementary - metabolism | Indoles - chemistry | Leucovorin - pharmacology
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