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Publication DateNATURE REVIEWS GENETICS, ISSN 1471-0056, 08/2017, Volume 18, Issue 8, pp. 454 - 454
Some common inherited diseases are caused by nucleotide repeat expansions, whereby disease occurs only when the number of repeats exceeds a critical threshold....
GENETICS & HEREDITY | Trinucleotide repeats | Genetic disorders | Research | Gene mutations | RNA | Ribonucleic acid--RNA | Genetics
GENETICS & HEREDITY | Trinucleotide repeats | Genetic disorders | Research | Gene mutations | RNA | Ribonucleic acid--RNA | Genetics
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Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in fragile X syndrome
Science, ISSN 0036-8075, 2014, Volume 343, Issue 6174, pp. 1002 - 1005
Epigenetic gene silencing is seen in several repeat-expansion diseases. In fragile X syndrome, the most common genetic form of mental retardation, a CGG...
IN-VITRO | METHYLATION | INSTABILITY | FULL MUTATION | GENE | NONCODING RNAS | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | EXPRESSION | FMR1 LOCUS | LONG | Fragile X Syndrome - genetics | Cell Line | Embryonic Stem Cells - metabolism | RNA, Small Interfering - genetics | Humans | RNA, Messenger - genetics | Gene Silencing | Mice, SCID | Trinucleotide Repeats - genetics | Promoter Regions, Genetic - genetics | DNA Methylation | Animals | Mice, Inbred NOD | Fragile X Mental Retardation Protein - genetics | Mice | Neurons - metabolism | Nuclear Proteins - genetics | Gene silencing | Epigenetic inheritance | Messenger RNA | Genetic research | Genetic aspects | Fragile X syndrome | Research | Health aspects | Epigenetics | Genetic disorders | Ribonucleic acid--RNA | Gene expression | Mental retardation | Index Medicus
IN-VITRO | METHYLATION | INSTABILITY | FULL MUTATION | GENE | NONCODING RNAS | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | EXPRESSION | FMR1 LOCUS | LONG | Fragile X Syndrome - genetics | Cell Line | Embryonic Stem Cells - metabolism | RNA, Small Interfering - genetics | Humans | RNA, Messenger - genetics | Gene Silencing | Mice, SCID | Trinucleotide Repeats - genetics | Promoter Regions, Genetic - genetics | DNA Methylation | Animals | Mice, Inbred NOD | Fragile X Mental Retardation Protein - genetics | Mice | Neurons - metabolism | Nuclear Proteins - genetics | Gene silencing | Epigenetic inheritance | Messenger RNA | Genetic research | Genetic aspects | Fragile X syndrome | Research | Health aspects | Epigenetics | Genetic disorders | Ribonucleic acid--RNA | Gene expression | Mental retardation | Index Medicus
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Loading RightsPLoS ONE, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, pp. e49083 - e49083
Fuchs endothelial corneal dystrophy (FECD) is a common, familial disease of the corneal endothelium and is the leading indication for corneal transplantation....
PATHOGENESIS | APOPTOSIS | CTG REPEAT | UNFOLDED PROTEIN RESPONSE | MENTAL-RETARDATION | ENDOTHELIAL DYSTROPHY | MULTIDISCIPLINARY SCIENCES | INHERITANCE | PITT-HOPKINS-SYNDROME | MISSENSE MUTATIONS | HAPLOINSUFFICIENCY | Blotting, Southern | Fuchs' Endothelial Dystrophy - genetics | Genetic Predisposition to Disease | Reproducibility of Results | Transcription Factor 4 | Humans | Middle Aged | Molecular Sequence Data | Male | Transcription Factors - genetics | Sequence Analysis, DNA | Case-Control Studies | Genome, Human - genetics | Microsatellite Repeats - genetics | Base Sequence | Alleles | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Aged, 80 and over | Trinucleotide Repeat Expansion - genetics | Female | Aged | Chromosomes, Human, Pair 18 - genetics | Genetic aspects | Single nucleotide polymorphisms | Genes | Analysis | Cornea | Transcription factors | Laboratories | Intellectual disabilities | Pathogenesis | Transplantation | Biochemistry | Single-nucleotide polymorphism | Kinases | Gene sequencing | Proteins | Primers | DNA repeat expansion | Southern blotting | Expansion | Chromosomes | Deoxyribonucleic acid--DNA | Edema | Health risks | Data processing | Patients | Endothelium | White blood cells | Corneal dystrophy | Dystrophy | Genetic testing | Molecular biology | DNA sequencing | Apoptosis | Polymorphism | Index Medicus | Deoxyribonucleic acid | DNA
PATHOGENESIS | APOPTOSIS | CTG REPEAT | UNFOLDED PROTEIN RESPONSE | MENTAL-RETARDATION | ENDOTHELIAL DYSTROPHY | MULTIDISCIPLINARY SCIENCES | INHERITANCE | PITT-HOPKINS-SYNDROME | MISSENSE MUTATIONS | HAPLOINSUFFICIENCY | Blotting, Southern | Fuchs' Endothelial Dystrophy - genetics | Genetic Predisposition to Disease | Reproducibility of Results | Transcription Factor 4 | Humans | Middle Aged | Molecular Sequence Data | Male | Transcription Factors - genetics | Sequence Analysis, DNA | Case-Control Studies | Genome, Human - genetics | Microsatellite Repeats - genetics | Base Sequence | Alleles | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Aged, 80 and over | Trinucleotide Repeat Expansion - genetics | Female | Aged | Chromosomes, Human, Pair 18 - genetics | Genetic aspects | Single nucleotide polymorphisms | Genes | Analysis | Cornea | Transcription factors | Laboratories | Intellectual disabilities | Pathogenesis | Transplantation | Biochemistry | Single-nucleotide polymorphism | Kinases | Gene sequencing | Proteins | Primers | DNA repeat expansion | Southern blotting | Expansion | Chromosomes | Deoxyribonucleic acid--DNA | Edema | Health risks | Data processing | Patients | Endothelium | White blood cells | Corneal dystrophy | Dystrophy | Genetic testing | Molecular biology | DNA sequencing | Apoptosis | Polymorphism | Index Medicus | Deoxyribonucleic acid | DNA
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Loading RightsCell, ISSN 0092-8674, 09/2018, Volume 175, Issue 1, pp. 224 - 238.e15
More than 25 inherited human disorders are caused by the unstable expansion of repetitive DNA sequences termed short tandem repeats (STRs). A fundamental...
trinucleotide repeat expansion disorders | subTADs | genome instability | short tandem repeats | fragile X syndrome | 3D genome folding | TADs | topologically associating domains | higher-order chromatin architecture | LINEAGE COMMITMENT | CTG REPEAT | HUMAN GENOME | DNA METHYLATION | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FRAGILE-X-SYNDROME | CTCF | HUNTINGTONS-DISEASE | TRINUCLEOTIDE REPEATS | MYOTONIC-DYSTROPHY | CELL BIOLOGY | Humans | CCCTC-Binding Factor - genetics | Trinucleotide Repeat Expansion - physiology | Chromatin Assembly and Disassembly - genetics | Fragile X Mental Retardation Protein - physiology | Male | Fragile X Mental Retardation Protein - metabolism | CCCTC-Binding Factor - physiology | Disease - etiology | Chromatin - physiology | Adult | Female | Fragile X Syndrome - genetics | Cell Line | Brain - cytology | Disease - genetics | Fragile X Syndrome - metabolism | Microsatellite Repeats - physiology | CpG Islands - physiology | Genome, Human - genetics | Microsatellite Repeats - genetics | DNA - genetics | Brain - pathology | CpG Islands - genetics | Trinucleotide Repeat Expansion - genetics | Fragile X Mental Retardation Protein - genetics | Chromatin - genetics | Chromatin Assembly and Disassembly - physiology | Epigenetic inheritance | Medical colleges | Anopheles | Chromatin | Genomics | Plants | Nucleotide sequencing | DNA sequencing | Index Medicus
trinucleotide repeat expansion disorders | subTADs | genome instability | short tandem repeats | fragile X syndrome | 3D genome folding | TADs | topologically associating domains | higher-order chromatin architecture | LINEAGE COMMITMENT | CTG REPEAT | HUMAN GENOME | DNA METHYLATION | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FRAGILE-X-SYNDROME | CTCF | HUNTINGTONS-DISEASE | TRINUCLEOTIDE REPEATS | MYOTONIC-DYSTROPHY | CELL BIOLOGY | Humans | CCCTC-Binding Factor - genetics | Trinucleotide Repeat Expansion - physiology | Chromatin Assembly and Disassembly - genetics | Fragile X Mental Retardation Protein - physiology | Male | Fragile X Mental Retardation Protein - metabolism | CCCTC-Binding Factor - physiology | Disease - etiology | Chromatin - physiology | Adult | Female | Fragile X Syndrome - genetics | Cell Line | Brain - cytology | Disease - genetics | Fragile X Syndrome - metabolism | Microsatellite Repeats - physiology | CpG Islands - physiology | Genome, Human - genetics | Microsatellite Repeats - genetics | DNA - genetics | Brain - pathology | CpG Islands - genetics | Trinucleotide Repeat Expansion - genetics | Fragile X Mental Retardation Protein - genetics | Chromatin - genetics | Chromatin Assembly and Disassembly - physiology | Epigenetic inheritance | Medical colleges | Anopheles | Chromatin | Genomics | Plants | Nucleotide sequencing | DNA sequencing | Index Medicus
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Antisense Transcription and Heterochromatin at the DM1 CTG Repeats Are Constrained by CTCF
Molecular Cell, ISSN 1097-2765, 2005, Volume 20, Issue 3, pp. 483 - 489
Prior studies of the locus have shown that the CTG repeats are a component of a CTCF-dependent insulator element and that repeat expansion results in...
METHYLATION | DMAHP | GENE | RNA | CHROMATIN | REDUCES EXPRESSION | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | EXPANSION | LOCUS | MYOTONIC-DYSTROPHY | CELL BIOLOGY | Insulator Elements - genetics | Chromosomal Proteins, Non-Histone - metabolism | Homeodomain Proteins - metabolism | Humans | Cells, Cultured | Repressor Proteins - genetics | RNA, Antisense - biosynthesis | DNA-Binding Proteins - genetics | Trinucleotide Repeats - genetics | Promoter Regions, Genetic - genetics | Homeodomain Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | DNA-Binding Proteins - metabolism | Histones - genetics | Heterochromatin - metabolism | CCCTC-Binding Factor | Protein Binding | Histones - metabolism | Transcription, Genetic - genetics | Methylation | Repressor Proteins - metabolism | Fibroblasts - metabolism | Quantitative Trait Loci - genetics | RNA, Antisense - genetics | Cell research | Genetic disorders | Lysine | Oncology, Experimental | Nucleosomes | Antisense RNA | Research | Universities and colleges | Cancer | Index Medicus
METHYLATION | DMAHP | GENE | RNA | CHROMATIN | REDUCES EXPRESSION | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | EXPANSION | LOCUS | MYOTONIC-DYSTROPHY | CELL BIOLOGY | Insulator Elements - genetics | Chromosomal Proteins, Non-Histone - metabolism | Homeodomain Proteins - metabolism | Humans | Cells, Cultured | Repressor Proteins - genetics | RNA, Antisense - biosynthesis | DNA-Binding Proteins - genetics | Trinucleotide Repeats - genetics | Promoter Regions, Genetic - genetics | Homeodomain Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | DNA-Binding Proteins - metabolism | Histones - genetics | Heterochromatin - metabolism | CCCTC-Binding Factor | Protein Binding | Histones - metabolism | Transcription, Genetic - genetics | Methylation | Repressor Proteins - metabolism | Fibroblasts - metabolism | Quantitative Trait Loci - genetics | RNA, Antisense - genetics | Cell research | Genetic disorders | Lysine | Oncology, Experimental | Nucleosomes | Antisense RNA | Research | Universities and colleges | Cancer | Index Medicus
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Loading RightsMolecular Cell, ISSN 1097-2765, 07/2009, Volume 35, Issue 1, pp. 82 - 92
Large-scale expansions of DNA repeats are implicated in numerous hereditary disorders in humans. We describe a yeast experimental system to analyze large-scale...
DNA | HUMDISEASE | CAG REPEAT | HUMAN-DISEASE | GENETIC INSTABILITY | SOMATIC INSTABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | REPLICATION IN-VIVO | TRIPLET-REPEATS | MISMATCH-REPAIR | SACCHAROMYCES-CEREVISIAE | S-PHASE CHECKPOINT | TRINUCLEOTIDE REPEATS | CELL BIOLOGY | Gene Expression Regulation, Fungal | Introns - genetics | Humans | RNA, Messenger - genetics | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Trinucleotide Repeats - genetics | Friedreich Ataxia - genetics | Yeasts - genetics | Plasmids - genetics | DNA Replication - genetics | Trinucleotide Repeat Expansion - genetics | Iron-Binding Proteins - genetics | Proteins | Friedreich's ataxia | Genetic disorders | Analysis | Ataxia | Universities and colleges | Index Medicus
DNA | HUMDISEASE | CAG REPEAT | HUMAN-DISEASE | GENETIC INSTABILITY | SOMATIC INSTABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | REPLICATION IN-VIVO | TRIPLET-REPEATS | MISMATCH-REPAIR | SACCHAROMYCES-CEREVISIAE | S-PHASE CHECKPOINT | TRINUCLEOTIDE REPEATS | CELL BIOLOGY | Gene Expression Regulation, Fungal | Introns - genetics | Humans | RNA, Messenger - genetics | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Trinucleotide Repeats - genetics | Friedreich Ataxia - genetics | Yeasts - genetics | Plasmids - genetics | DNA Replication - genetics | Trinucleotide Repeat Expansion - genetics | Iron-Binding Proteins - genetics | Proteins | Friedreich's ataxia | Genetic disorders | Analysis | Ataxia | Universities and colleges | Index Medicus
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Loading RightsGenes and Development, ISSN 0890-9369, 2015, Volume 29, Issue 10, pp. 1006 - 1017
Secondary structure-forming DNA sequences such as CAG repeats interfere with replication and repair, provoking fork stalling, chromosome fragility, and...
Chromosome fragility | Repeat expansion | Nuclear pore | CAG repeats | Slx5/Slx8 | Nuclear organization | UBIQUITIN E3 LIGASE | DNA-DAMAGE RESPONSE | HUMAN-CELLS | TEMPLATE EXCHANGE | DEVELOPMENTAL BIOLOGY | GENOME STABILITY | DOUBLE-STRAND BREAK | SACCHAROMYCES-CEREVISIAE | TRINUCLEOTIDE REPEATS | CELL BIOLOGY | repeat expansion | GENETICS & HEREDITY | chromosome fragility | nuclear organization | HOMOLOGOUS RECOMBINATION | REPLICATION-FORK REVERSAL | nuclear pore | Saccharomyces cerevisiae - physiology | Recombination, Genetic | Saccharomyces cerevisiae - genetics | S Phase | Saccharomyces cerevisiae Proteins - metabolism | Sumoylation | DNA Repair - genetics | Saccharomyces cerevisiae Proteins - genetics | Nuclear Pore - metabolism | Trinucleotide Repeats - genetics | Protein Transport | Genetic aspects | Research | Nucleotide sequence | Genetic regulation | Brewer's yeast | Recombinant molecules | Index Medicus | Slx5 | Research Paper | Slx8
Chromosome fragility | Repeat expansion | Nuclear pore | CAG repeats | Slx5/Slx8 | Nuclear organization | UBIQUITIN E3 LIGASE | DNA-DAMAGE RESPONSE | HUMAN-CELLS | TEMPLATE EXCHANGE | DEVELOPMENTAL BIOLOGY | GENOME STABILITY | DOUBLE-STRAND BREAK | SACCHAROMYCES-CEREVISIAE | TRINUCLEOTIDE REPEATS | CELL BIOLOGY | repeat expansion | GENETICS & HEREDITY | chromosome fragility | nuclear organization | HOMOLOGOUS RECOMBINATION | REPLICATION-FORK REVERSAL | nuclear pore | Saccharomyces cerevisiae - physiology | Recombination, Genetic | Saccharomyces cerevisiae - genetics | S Phase | Saccharomyces cerevisiae Proteins - metabolism | Sumoylation | DNA Repair - genetics | Saccharomyces cerevisiae Proteins - genetics | Nuclear Pore - metabolism | Trinucleotide Repeats - genetics | Protein Transport | Genetic aspects | Research | Nucleotide sequence | Genetic regulation | Brewer's yeast | Recombinant molecules | Index Medicus | Slx5 | Research Paper | Slx8
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Loading RightsThe American Journal of Human Genetics, ISSN 0002-9297, 11/2017, Volume 101, Issue 5, pp. 700 - 715
Short tandem repeats (STRs) are hyper-mutable sequences in the human genome. They are often used in forensics and population genetics and are also the...
microsatellites | population genetics | short tandem repeats | genetic disorder | genotyping | genome sequencing | trinucleotide repeat expansion | INDELS | MUTATION-RATE | GENE | VARIANTS | EXPANSIONS | GENETICS & HEREDITY | PERSONAL GENOMES | SEQUENCING DATA | RAPID DETECTION | Humans | Middle Aged | Male | Genome, Human - genetics | Microsatellite Repeats - genetics | Genetics, Population - methods | Adolescent | Alleles | Adult | Female | Polymorphism, Genetic - genetics | Software | High-Throughput Nucleotide Sequencing - methods | Child | Sequence Analysis, DNA - methods | Index Medicus
microsatellites | population genetics | short tandem repeats | genetic disorder | genotyping | genome sequencing | trinucleotide repeat expansion | INDELS | MUTATION-RATE | GENE | VARIANTS | EXPANSIONS | GENETICS & HEREDITY | PERSONAL GENOMES | SEQUENCING DATA | RAPID DETECTION | Humans | Middle Aged | Male | Genome, Human - genetics | Microsatellite Repeats - genetics | Genetics, Population - methods | Adolescent | Alleles | Adult | Female | Polymorphism, Genetic - genetics | Software | High-Throughput Nucleotide Sequencing - methods | Child | Sequence Analysis, DNA - methods | Index Medicus
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Loading RightsPLoS Genetics, ISSN 1553-7390, 02/2013, Volume 9, Issue 2, pp. e1003280 - e1003280
Expansions of trinucleotide CAG/CTG repeats in somatic tissues are thought to contribute to ongoing disease progression through an affected individual's life...
PLURIPOTENT STEM-CELLS | DM1 TRANSGENIC MICE | MYOTONIC-DYSTROPHY TYPE-1 | MISMATCH-REPAIR SYSTEM | DNA-LIGASE I | MOUSE MODEL | GENETICS & HEREDITY | KNOCK-IN MICE | DENTATORUBRAL-PALLIDOLUYSIAN ATROPHY | CTG TRIPLET REPEAT | TRINUCLEOTIDE REPEAT | Genomic Instability | Myotonic Dystrophy - metabolism | Humans | Trinucleotide Repeats - genetics | Corpus Striatum - metabolism | Nerve Tissue Proteins - genetics | Polymorphism, Genetic | Nerve Tissue Proteins - metabolism | Proteins - genetics | Animals | Huntington Disease - genetics | Myotonic Dystrophy - genetics | Trinucleotide Repeat Expansion - genetics | MutS Homolog 3 Protein | Neostriatum - metabolism | Mice | Protein Stability | Disease Models, Animal | Physiological aspects | Genetic aspects | Disease susceptibility | Research | Huntington's chorea | Genetic polymorphisms | Heart | Huntingtons disease | Medical research | Neuromuscular diseases | Genetic disorders | Disease | Protein folding | Genes | DNA methylation | Genetics | Deoxyribonucleic acid--DNA | Binding sites | Index Medicus | Deoxyribonucleic acid | DNA
PLURIPOTENT STEM-CELLS | DM1 TRANSGENIC MICE | MYOTONIC-DYSTROPHY TYPE-1 | MISMATCH-REPAIR SYSTEM | DNA-LIGASE I | MOUSE MODEL | GENETICS & HEREDITY | KNOCK-IN MICE | DENTATORUBRAL-PALLIDOLUYSIAN ATROPHY | CTG TRIPLET REPEAT | TRINUCLEOTIDE REPEAT | Genomic Instability | Myotonic Dystrophy - metabolism | Humans | Trinucleotide Repeats - genetics | Corpus Striatum - metabolism | Nerve Tissue Proteins - genetics | Polymorphism, Genetic | Nerve Tissue Proteins - metabolism | Proteins - genetics | Animals | Huntington Disease - genetics | Myotonic Dystrophy - genetics | Trinucleotide Repeat Expansion - genetics | MutS Homolog 3 Protein | Neostriatum - metabolism | Mice | Protein Stability | Disease Models, Animal | Physiological aspects | Genetic aspects | Disease susceptibility | Research | Huntington's chorea | Genetic polymorphisms | Heart | Huntingtons disease | Medical research | Neuromuscular diseases | Genetic disorders | Disease | Protein folding | Genes | DNA methylation | Genetics | Deoxyribonucleic acid--DNA | Binding sites | Index Medicus | Deoxyribonucleic acid | DNA
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Loading RightsBrain Research, ISSN 0006-8993, 08/2018, Volume 1693, Issue Pt A, pp. 43 - 54
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset inherited neurodegenerative disorder characterized by progressive intention tremor, gait...
RAN translation | RNA gelation | Microsatellite expansion | FMR1 | FXTAS | PREMUTATION CARRIERS | CGG REPEATS | NEUROSCIENCES | TREMOR/ATAXIA SYNDROME | MEDIATED NEURODEGENERATION | IN-VIVO | MITOCHONDRIAL DYSFUNCTION | INTRANUCLEAR INCLUSIONS | FMR1 MESSENGER-RNA | ARGININE-RICH PEPTIDES | MYOTONIC-DYSTROPHY | Fragile X Syndrome - genetics | Ataxia - physiopathology | Gene Expression Regulation - genetics | Fragile X Syndrome - physiopathology | Humans | Trinucleotide Repeat Expansion - physiology | Fragile X Mental Retardation Protein - physiology | Neurodegenerative Diseases - genetics | Tremor - physiopathology | Trinucleotide Repeats - genetics | 5' Untranslated Regions | Tremor - genetics | Trinucleotide Repeat Expansion - genetics | Fragile X Mental Retardation Protein - genetics | Mutation | Ataxia - genetics | Proteins | Nervous system diseases | Codon | Tremor | Analysis | Ataxia | Genetic translation | Protein binding
RAN translation | RNA gelation | Microsatellite expansion | FMR1 | FXTAS | PREMUTATION CARRIERS | CGG REPEATS | NEUROSCIENCES | TREMOR/ATAXIA SYNDROME | MEDIATED NEURODEGENERATION | IN-VIVO | MITOCHONDRIAL DYSFUNCTION | INTRANUCLEAR INCLUSIONS | FMR1 MESSENGER-RNA | ARGININE-RICH PEPTIDES | MYOTONIC-DYSTROPHY | Fragile X Syndrome - genetics | Ataxia - physiopathology | Gene Expression Regulation - genetics | Fragile X Syndrome - physiopathology | Humans | Trinucleotide Repeat Expansion - physiology | Fragile X Mental Retardation Protein - physiology | Neurodegenerative Diseases - genetics | Tremor - physiopathology | Trinucleotide Repeats - genetics | 5' Untranslated Regions | Tremor - genetics | Trinucleotide Repeat Expansion - genetics | Fragile X Mental Retardation Protein - genetics | Mutation | Ataxia - genetics | Proteins | Nervous system diseases | Codon | Tremor | Analysis | Ataxia | Genetic translation | Protein binding
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Loading RightsNature Neuroscience, ISSN 1097-6256, 2014, Volume 17, Issue 5, pp. 694 - 703
Huntington's disease (HD) is characterized by striatal medium spiny neuron (MSN) dysfunction, but the underlying mechanisms remain unclear. We explored roles...
GLUTAMATE TRANSPORT | STRIATAL ASTROCYTES | MUTANT HUNTINGTIN | IN-VIVO | CENTRAL-NERVOUS-SYSTEM | RECTIFYING K+ CHANNEL | KNOCK-OUT | NEUROLOGICAL SYMPTOMS | EXPRESSION | NEUROSCIENCES | TRANSGENIC MICE | Neurons - pathology | Locomotion - genetics | Age Factors | Humans | Huntington Disease - pathology | Green Fluorescent Proteins - genetics | Trinucleotide Repeats - genetics | Hindlimb Suspension - physiology | HEK293 Cells | Huntington Disease - mortality | Neurons - metabolism | Nuclear Proteins - genetics | Huntington Disease - physiopathology | Disease Models, Animal | Green Fluorescent Proteins - metabolism | Corpus Striatum - physiopathology | Mice, Inbred C57BL | Mice, Transgenic | Potassium Channels, Inwardly Rectifying - genetics | Nerve Tissue Proteins - genetics | Huntingtin Protein | Animals | Potassium Channels, Inwardly Rectifying - deficiency | Survival Analysis | Huntington Disease - genetics | Mice | In Vitro Techniques | Astrocytes - metabolism | Development and progression | Ion channels | Huntington's chorea | Astrocytes | Health aspects | Index Medicus
GLUTAMATE TRANSPORT | STRIATAL ASTROCYTES | MUTANT HUNTINGTIN | IN-VIVO | CENTRAL-NERVOUS-SYSTEM | RECTIFYING K+ CHANNEL | KNOCK-OUT | NEUROLOGICAL SYMPTOMS | EXPRESSION | NEUROSCIENCES | TRANSGENIC MICE | Neurons - pathology | Locomotion - genetics | Age Factors | Humans | Huntington Disease - pathology | Green Fluorescent Proteins - genetics | Trinucleotide Repeats - genetics | Hindlimb Suspension - physiology | HEK293 Cells | Huntington Disease - mortality | Neurons - metabolism | Nuclear Proteins - genetics | Huntington Disease - physiopathology | Disease Models, Animal | Green Fluorescent Proteins - metabolism | Corpus Striatum - physiopathology | Mice, Inbred C57BL | Mice, Transgenic | Potassium Channels, Inwardly Rectifying - genetics | Nerve Tissue Proteins - genetics | Huntingtin Protein | Animals | Potassium Channels, Inwardly Rectifying - deficiency | Survival Analysis | Huntington Disease - genetics | Mice | In Vitro Techniques | Astrocytes - metabolism | Development and progression | Ion channels | Huntington's chorea | Astrocytes | Health aspects | Index Medicus
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