X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (839) 839
animals (738) 738
humans (682) 682
tripartite motif proteins (562) 562
ubiquitin-protein ligases - metabolism (513) 513
mice (445) 445
muscle proteins - metabolism (363) 363
ubiquitin-protein ligases - genetics (343) 343
male (335) 335
cell biology (295) 295
biochemistry & molecular biology (292) 292
repressor proteins - metabolism (256) 256
tripartite motif-containing protein 28 (254) 254
muscle proteins - genetics (240) 240
proteins (233) 233
skp cullin f-box protein ligases - metabolism (216) 216
female (214) 214
muscle, skeletal - metabolism (211) 211
cell line (202) 202
expression (197) 197
signal transduction (186) 186
transcription factors - metabolism (184) 184
rats (183) 183
repressor proteins - genetics (172) 172
gene-expression (171) 171
gene expression (165) 165
ubiquitin (162) 162
phosphorylation (158) 158
tripartite motif proteins - metabolism (157) 157
atrophy (156) 156
skp cullin f-box protein ligases - genetics (154) 154
article (152) 152
protein binding (142) 142
cell line, tumor (141) 141
muscle, skeletal - pathology (139) 139
skeletal-muscle (137) 137
dna-binding proteins - metabolism (128) 128
rna, messenger - metabolism (128) 128
muscular atrophy - metabolism (126) 126
transcription factors - genetics (126) 126
activation (123) 123
mice, inbred c57bl (121) 121
ubiquitination (121) 121
hek293 cells (118) 118
nuclear proteins - metabolism (118) 118
physiology (118) 118
research (116) 116
proteolysis (115) 115
physiological aspects (107) 107
gene expression regulation (106) 106
research article (102) 102
tripartite motif proteins - genetics (102) 102
ligases (99) 99
oncology (99) 99
muscles (98) 98
multidisciplinary sciences (97) 97
muscular atrophy - pathology (96) 96
biology (94) 94
cancer (94) 94
dna-binding proteins - genetics (92) 92
cells, cultured (90) 90
genes (90) 90
protein (89) 89
analysis (88) 88
transcription factors (88) 88
zinc-finger proteins (87) 87
genetic aspects (86) 86
health aspects (85) 85
ubiquitin ligases (85) 85
skeletal muscle (84) 84
apoptosis (83) 83
disease models, animal (83) 83
muscle fibers, skeletal - metabolism (82) 82
amino acid sequence (81) 81
hela cells (81) 81
molecular sequence data (80) 80
carrier proteins - metabolism (79) 79
mice, knockout (79) 79
proteasome endopeptidase complex - metabolism (79) 79
gene (78) 78
muscle, skeletal - drug effects (78) 78
adult (76) 76
degradation (76) 76
medicine (75) 75
middle aged (75) 75
rats, sprague-dawley (75) 75
blotting, western (74) 74
nuclear proteins - genetics (74) 74
e3 ubiquitin ligase (72) 72
immunology (72) 72
rodents (72) 72
ubiquitin ligase (72) 72
nf-kappa-b (71) 71
cells (70) 70
musculoskeletal system (70) 70
mutation (70) 70
ubiquitin - metabolism (70) 70
foxo transcription factors (68) 68
transfection (68) 68
viruses (68) 68
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Trends in Biochemical Sciences, ISSN 0968-0004, 04/2017, Volume 42, Issue 4, pp. 297 - 311
Tripartite motif (TRIM) family proteins, most of which have E3 ubiquitin ligase activities, have various functions in cellular processes including... 
proteasome | cancer | autophagy | immunity | TRIM | ubiquitin | U-BOX | ANTIVIRAL RESPONSE | TARGETING TAB2 | IFN-BETA PRODUCTION | NEGATIVE REGULATION | UBIQUITIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | RING FINGER | INNATE IMMUNE | NF-KAPPA-B | MOTIF | Tripartite Motif Proteins - metabolism | Autophagy | Carcinogenesis | Immunity | Humans | Ubiquitin | Protein-protein interactions | Index Medicus
Journal Article
Cell Host & Microbe, ISSN 1931-3128, 11/2017, Volume 22, Issue 5, pp. 627 - 638.e7
TRIM25 is an E3 ubiquitin ligase that activates RIG-I to promote the antiviral interferon response. The NS1 protein from all strains of influenza A virus binds... 
nuclear TRIM25 | viral RNA synthesis | Influenza virus | viral ribonucleoproteins | CELLS | UBIQUITIN LIGASE | POLYMERASE | RIG-I | MICROBIOLOGY | NS1 PROTEINS | B VIRUS | A VIRUS | VIROLOGY | STRUCTURAL BASIS | NUCLEOPROTEIN | ANTIVIRAL ACTIVITY | PARASITOLOGY | Transcription, Genetic - drug effects | DEAD Box Protein 58 - metabolism | Humans | Influenza A Virus, H3N2 Subtype - metabolism | Ubiquitin-Protein Ligases - antagonists & inhibitors | Antiviral Agents - metabolism | RNA, Messenger - metabolism | Ubiquitination | SUMO-1 Protein - genetics | HEK293 Cells | Ribonucleoproteins - drug effects | Influenza A virus - pathogenicity | RNA, Viral - metabolism | A549 Cells | Cell Line | Influenza, Human - metabolism | Virus Replication - drug effects | Tripartite Motif Proteins - antagonists & inhibitors | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Tripartite Motif Proteins - genetics | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Host-Pathogen Interactions | Transcription Factors - metabolism | Carrier Proteins - genetics | Carrier Proteins - metabolism | Influenza A virus - metabolism | Ubiquitin-Protein Ligases - drug effects | Interferons - metabolism | Protein Binding | Viral Nonstructural Proteins - metabolism | SUMO-1 Protein - metabolism | Tripartite Motif Proteins - metabolism | RNA, Viral - drug effects | Ubiquitin-Protein Ligases - genetics | Viral Nonstructural Proteins - antagonists & inhibitors | Influenza viruses | Ubiquitin | Synthesis | Messenger RNA | RNA | Developmental biology | Ligases | Influenza | Interferon | Biological response modifiers
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2017, Volume 292, Issue 24, pp. 10180 - 10196
We have previously shown that dysbindin is a potent inducer of cardiomyocyte hypertrophy via activation of Rho-dependent serum-response factor (SRF) signaling.... 
COACTIVATOR HTIF1 | SCHIZOPHRENIA-RELATED PROTEIN | NUCLEAR RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARDIAC-HYPERTROPHY | IN-VIVO | TRIPARTITE MOTIF | SERUM RESPONSE FACTOR | FAMILY PROTEINS | MUSCLE RING FINGER-1 | E3 UBIQUITIN LIGASE | Serum Response Factor - agonists | Serum Response Factor - genetics | Cardiomyopathy, Dilated - pathology | Rats, Wistar | Serum Response Factor - antagonists & inhibitors | Humans | Ubiquitin-Protein Ligases - antagonists & inhibitors | Recombinant Fusion Proteins - metabolism | Dystrophin-Associated Proteins - genetics | Dystrophin-Associated Proteins - metabolism | RNA Interference | Dystrophin-Associated Proteins - chemistry | Proteolysis | HEK293 Cells | Protein Stability | Peptide Fragments - genetics | Animals, Newborn | Recombinant Proteins - metabolism | Peptide Fragments - metabolism | Myocytes, Cardiac - cytology | Signal Transduction | Serum Response Factor - metabolism | Tripartite Motif Proteins - antagonists & inhibitors | Cardiomyopathy, Hypertrophic - metabolism | Carrier Proteins - antagonists & inhibitors | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Rats | Recombinant Proteins - chemistry | Tripartite Motif Proteins - genetics | Transcription Factors - antagonists & inhibitors | Recombinant Fusion Proteins - chemistry | Transcription Factors - genetics | Cardiomyopathy, Dilated - metabolism | Transcription Factors - metabolism | Carrier Proteins - genetics | Myocytes, Cardiac - pathology | Peptide Fragments - chemistry | Animals | Carrier Proteins - metabolism | Myocytes, Cardiac - metabolism | Tripartite Motif Proteins - metabolism | Ubiquitin-Protein Ligases - genetics | Dysbindin | Apoptosis | Cardiomyopathy, Hypertrophic - pathology | Molecular Bases of Disease | cardiac signaling | cardiomyocyte | TRIM24 | apoptosis | SRF-signaling | cardiac hypertrophy | cardiomyopathy | dysbindin | TRIM32 | X-linked inhibitor of apoptosis protein (XIAP)
Journal Article
Journal Article
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 04/2017, Volume 66, Issue 2, pp. 270 - 284.e13
During microRNA (miRNA) biogenesis, two endonucleolytic reactions convert stem-loop-structured precursors into mature miRNAs. These processing steps can be... 
TRIM71 | ZC3H10 | regulation of microRNA biogenesis | siRNA pool | LIN28 | microRNA-guided gene silencing | RNA pull-down | ZC3H7 | RNA processing | RNA binding proteins | TARGET | SEQUENCE DETERMINANTS | RECOGNITION | LIN28-LET-7 PATHWAY | URIDYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-REGULATION | SECONDARY STRUCTURE | HNRNP A1 | PRE-MICRORNA | DROSOPHILA | CELL BIOLOGY | RNA Precursors - chemistry | RNA-Binding Proteins - genetics | RNA Precursors - biosynthesis | Humans | Databases, Genetic | Structure-Activity Relationship | RNA, Messenger - biosynthesis | Transfection | MCF-7 Cells | RNA Interference | HEK293 Cells | Transcription, Genetic | Proteomics - methods | DEAD-box RNA Helicases - metabolism | Genomics - methods | Nucleic Acid Conformation | Binding Sites | A549 Cells | Ribonuclease III - metabolism | RNA Processing, Post-Transcriptional | Jurkat Cells | RNA, Messenger - genetics | Gene Expression Regulation | Ubiquitin-Protein Ligases - metabolism | Tripartite Motif Proteins - genetics | MicroRNAs - biosynthesis | RNA Precursors - genetics | Hep G2 Cells | Sequence Analysis, RNA | CRISPR-Cas Systems | Protein Binding | High-Throughput Nucleotide Sequencing | MicroRNAs - genetics | Tripartite Motif Proteins - metabolism | HeLa Cells | Ubiquitin-Protein Ligases - genetics | MicroRNAs - chemistry | RNA-Binding Proteins - metabolism | Biosynthesis | MicroRNA | Binding proteins | Mass spectrometry | Analysis | Protein binding | Messenger RNA | Genetic engineering
Journal Article
Journal Article
Cell Stem Cell, ISSN 1934-5909, 09/2016, Volume 19, Issue 3, pp. 341 - 354
Journal Article
by Kang, SH and Lee, HA and Kim, M and Lee, E and Sohn, UD and Kim, I
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, ISSN 0193-1849, 06/2017, Volume 312, Issue 6, pp. E495 - E507
Cushing's syndrome is caused by overproduction of the adrenocorticotropic hormone (ACTH), which stimulates the adrenal grand to make cortisol. Skeletal muscle... 
glucocorticoid receptor | PHYSIOLOGY | PROTEIN | ANTAGONIST | skeletal muscle atrophy | COMPONENTS | Cushing's syndrome | AUTOPHAGY | FOXO TRANSCRIPTION FACTORS | HYPERTROPHY | GLUCOCORTICOID-RECEPTOR | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | forkhead box O3 | CROSSTALK | UP-REGULATION | Receptors, Glucocorticoid - antagonists & inhibitors | Cushing Syndrome - physiopathology | SKP Cullin F-Box Protein Ligases - genetics | Ubiquitin-Protein Ligases - antagonists & inhibitors | Male | Muscle, Skeletal - metabolism | Receptors, Glucocorticoid - metabolism | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Cushing Syndrome - metabolism | Promoter Regions, Genetic - drug effects | Receptors, Glucocorticoid - agonists | Forkhead Box Protein O3 - genetics | Chromatin Immunoprecipitation | Cushing Syndrome - pathology | RNA Interference | Muscle, Skeletal - drug effects | Muscle Proteins - metabolism | Forkhead Box Protein O3 - antagonists & inhibitors | Muscle Proteins - antagonists & inhibitors | Muscular Atrophy - etiology | Disease Models, Animal | Cell Line | Tripartite Motif Proteins - antagonists & inhibitors | Ubiquitin-Protein Ligases - metabolism | Tripartite Motif Proteins - agonists | Tripartite Motif Proteins - genetics | SKP Cullin F-Box Protein Ligases - metabolism | SKP Cullin F-Box Protein Ligases - antagonists & inhibitors | Rats, Sprague-Dawley | Forkhead Box Protein O3 - metabolism | Hormone Antagonists - pharmacology | Forkhead Box Protein O3 - agonists | Gene Expression Regulation - drug effects | Muscle Proteins - genetics | Response Elements - drug effects | Muscle Proteins - agonists | Animals | Active Transport, Cell Nucleus - drug effects | Muscle Fibers, Skeletal - pathology | Glucocorticoids - pharmacology | Genes, Reporter - drug effects | Tripartite Motif Proteins - metabolism | Muscle, Skeletal - pathology | Ubiquitin-Protein Ligases - genetics | Muscles | Physiological aspects | Atrophy, Muscular | Cushing syndrome
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2016, Volume 291, Issue 23, pp. 12184 - 12194
Skeletal muscle atrophy promotes muscle weakness, limiting activities of daily living. However, mechanisms underlying atrophy remain unclear. Here, we show... 
HYPERTROPHY | MYOSTATIN GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CAPILLARY-ELECTROPHORESIS | RECEPTOR | MICE | FOXO TRANSCRIPTION FACTORS | F-BOX PROTEIN | MASS-SPECTROMETRY | GROWTH-FACTOR-I | SCF UBIQUITIN LIGASE | Receptor, IGF Type 1 - metabolism | Insulin-Like Growth Factor I - pharmacology | SKP Cullin F-Box Protein Ligases - genetics | Amino Acids, Branched-Chain - metabolism | Muscle Denervation | Muscle, Skeletal - innervation | Muscle, Skeletal - metabolism | Smad3 Protein - metabolism | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Smad3 Protein - genetics | Smad2 Protein - genetics | Muscle Proteins - metabolism | Myostatin - genetics | Restraint, Physical - adverse effects | Myostatin - metabolism | Muscular Atrophy - etiology | Cell Line | Muscular Atrophy - metabolism | Smad2 Protein - metabolism | Ubiquitin-Protein Ligases - metabolism | Tripartite Motif Proteins - genetics | Mice, Transgenic | SKP Cullin F-Box Protein Ligases - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Receptor, IGF Type 1 - genetics | Blotting, Western | Mice, Knockout | Muscle Proteins - genetics | Animals | Glucose - metabolism | Muscle Fibers, Skeletal - cytology | Tripartite Motif Proteins - metabolism | Muscle, Skeletal - pathology | Ubiquitin-Protein Ligases - genetics | Insulin-Like Growth Factor I - metabolism | Molecular Bases of Disease | SMAD transcription factor | metabolism | muscle atrophy | myostatin | muscle
Journal Article