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Journal Article
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2017, Volume 474, Issue 17, pp. 2993 - 3010
Arthritis is a chronic inflammatory disease which reduces the life quality of affected individuals. Therapeutic tools used for treating inflammatory pain are... 
RHEUMATOID-ARTHRITIS | ACTIVATION | BETA-SITOSTEROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | INVOLVEMENT | LUPEOL | RATS | RECEPTOR | HYPERALGESIA | MECHANISMS | OSTEOARTHRITIS | Viscosity | Plant Extracts - chemistry | Acute Pain - drug therapy | Arthritis, Experimental - drug therapy | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Male | Pentacyclic Triterpenes - analysis | Administration, Cutaneous | Plant Extracts - administration & dosage | Stigmasterol - administration & dosage | Drug Storage | Sitosterols - analysis | Stigmasterol - therapeutic use | Analgesics, Non-Narcotic - adverse effects | Buddleja - growth & development | Brazil | Sitosterols - adverse effects | Plant Leaves - chemistry | Sitosterols - administration & dosage | Gels | Hot Temperature - adverse effects | Administration, Oral | Stigmasterol - analysis | Drug Stability | Sitosterols - therapeutic use | Stigmasterol - adverse effects | Analgesics, Non-Narcotic - administration & dosage | Analgesics, Non-Narcotic - therapeutic use | Buddleja - chemistry | Pentacyclic Triterpenes - administration & dosage | Pentacyclic Triterpenes - therapeutic use | Pentacyclic Triterpenes - adverse effects | Ethnopharmacology | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Plant Leaves - growth & development | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Mice | Plant Extracts - therapeutic use | Analgesics, Non-Narcotic - chemistry | Plant Extracts - adverse effects
Journal Article
Planta Medica, ISSN 0032-0943, 10/2007, Volume 73, Issue 13, pp. 1331 - 1357
Abstract The biosynthesis of leukotrienes (LTs) is initiated by the transformation of free arachidonic acid to LTA 4 by 5-lipoxygenase (5-LO). Subsequent... 
Review | Inhibitors | Leukotrienes | Natural compounds | 5-Lipoxygenase | Inflammation | Leukocytes | Plants | Arachidonic acid | arachidonic acid | CELLULAR ACTION MECHANISMS | natural compounds | inhibitors | INDUCED CA2+ MOBILIZATION | CYTOSOLIC PHOSPHOLIPASE A | ANTIINFLAMMATORY ACTIVITY | CHEMISTRY, MEDICINAL | LEUKOTRIENE BIOSYNTHESIS INHIBITOR | ARACHIDONIC-ACID METABOLISM | HUMAN POLYMORPHONUCLEAR LEUKOCYTES | leukotrienes | PLANT SCIENCES | IN-VITRO | SELECTIVE INHIBITOR | inflammation | INTEGRATIVE & COMPLEMENTARY MEDICINE | plants | BETA-BARREL DOMAIN | leukocytes | PHARMACOLOGY & PHARMACY | Humans | Triterpenes - therapeutic use | Coumarins - administration & dosage | Leukotrienes - biosynthesis | Quinones - therapeutic use | Lipoxygenase Inhibitors - therapeutic use | Sesquiterpenes - administration & dosage | Coumarins - therapeutic use | Flavonoids - therapeutic use | Sesquiterpenes - therapeutic use | Lipoxygenase Inhibitors - administration & dosage | Plant Extracts - administration & dosage | Phenols - therapeutic use | Flavonoids - administration & dosage | Polyphenols | Alkaloids - administration & dosage | Alkaloids - therapeutic use | Phenols - administration & dosage | Quinones - administration & dosage | Phytotherapy | Plant Extracts - therapeutic use | Triterpenes - administration & dosage | Plants, Medicinal | Evaluation | Synthesis | Physiological aspects | Development and progression | Health aspects | Structure-activity relationships (Biochemistry) | Materia medica, Vegetable | Plant extracts
Journal Article
Journal Article
Clinical Pharmacokinetics, ISSN 0312-5963, 06/2009, Volume 48, Issue 4, pp. 211 - 241
More than 20 individual and fixed-dose combinations of antiretrovirals are approved for the treatment of human immunodeficiency virus (HIV) infection. However,... 
Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | PHARMACOKINETIC INTERACTION | CCR5 ANTAGONIST | PROTEASE INHIBITOR | IN-VITRO | TREATMENT-NAIVE | IMMUNODEFICIENCY-VIRUS TYPE-1 | ANTIVIRAL ACTIVITY | PHARMACOLOGY & PHARMACY | CLINICAL PHARMACOKINETICS | NEGATIVE HEALTHY-VOLUNTEERS | HIGH GENETIC BARRIER | Anti-HIV Agents - pharmacology | HIV Integrase Inhibitors - pharmacology | Drugs, Investigational - pharmacology | Triterpenes - pharmacology | Humans | Drugs, Investigational - pharmacokinetics | Reverse Transcriptase Inhibitors - pharmacology | Succinates - pharmacokinetics | HIV Integrase Inhibitors - administration & dosage | Reverse Transcriptase Inhibitors - administration & dosage | Anti-HIV Agents - administration & dosage | HIV Protease Inhibitors - pharmacology | Reverse Transcriptase Inhibitors - pharmacokinetics | Succinates - administration & dosage | Drug Interactions | HIV Protease Inhibitors - pharmacokinetics | Molecular Structure | Receptors, Chemokine - antagonists & inhibitors | Drug Therapy, Combination | HIV Integrase Inhibitors - pharmacokinetics | HIV Protease Inhibitors - administration & dosage | Acquired Immunodeficiency Syndrome - drug therapy | Anti-HIV Agents - pharmacokinetics | Drugs, Investigational - administration & dosage | Triterpenes - pharmacokinetics | Succinates - pharmacology | Triterpenes - administration & dosage | Antiviral agents | Complications and side effects | Drug interactions | Dosage and administration | Research | Drug therapy | HIV infection | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2013, Volume 8, Issue 8, p. e72817
Previously we have reported that, cycloart-23-ene-3 beta, 25-diol (called as B2) and L-glutamine stimulated glucagon like peptide-1 (GLP-1) (7-36) amide... 
MICE | MODEL | INHIBITOR | GLUTATHIONE | MULTIDISCIPLINARY SCIENCES | LIVER | Triazoles - administration & dosage | Diabetes Mellitus, Experimental - drug therapy | Triterpenes - pharmacology | Streptozocin | Glycated Hemoglobin A - metabolism | Pyrazines - administration & dosage | Triterpenes - therapeutic use | Colon - drug effects | Body Weight - drug effects | Glucagon-Like Peptide 1 - blood | Male | Pyrazines - therapeutic use | Insulin - blood | Glucagon-Like Peptide 1 - secretion | Diabetes Mellitus, Experimental - blood | Glutamine - pharmacology | Sitagliptin Phosphate | Triazoles - therapeutic use | Biomarkers - metabolism | Niacinamide | Pancreas - drug effects | Pancreas - pathology | Rats | Pancreas - metabolism | Rats, Sprague-Dawley | Colon - metabolism | Feeding Behavior - drug effects | Triazoles - pharmacology | Animals | Glutamine - administration & dosage | Staining and Labeling | Lipid Metabolism - drug effects | Glutamine - therapeutic use | Drinking Behavior - drug effects | Oxidative Stress - drug effects | Blood Glucose - metabolism | Pyrazines - pharmacology | Triterpenes - administration & dosage | NADPH | Drugs | Oxidative stress | Glucagon | Body weight | Amino acids | Glucose | Rodents | Hemoglobin | Physiology | Bioindicators | Water intakes | Pancreas | Food | Nutrition | Secretion | Diabetes mellitus | Histology | Pharmacology | Insulin | Studies | Food intake | Pharmacy | Biomarkers | Water intake | Nicotinamide | Diabetes | Glutamine
Journal Article
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 10/2012, Volume 144, Issue 1, pp. 195 - 200
Celastrol is a natural compound extracted from the traditional Chinese medicinal herb, Thunder God Vine (TGV). Owing to its potential anti-inflammatory and... 
Bioavailability | Pharmacokinetics | LC–MS/MS | Celastrol | Gender difference | LC-MS/MS | DRUG | CHEMISTRY, MEDICINAL