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Cancer Discovery, ISSN 2159-8274, 04/2017, Volume 7, Issue 4, pp. 400 - 409
Entrectinib, a potent oral inhibitor of the tyrosine kinases TRKA/B/C, ROS1, and ALK, was evaluated in two phase I studies in patients with advanced or... 
REARRANGEMENT | ONCOGENE | ONCOLOGY | ANALOG SECRETORY CARCINOMA | LANDSCAPE | KINASE FUSIONS | SARCOMAS | ETV6-NTRK3 GENE FUSION | CRIZOTINIB | GENOMIC ALTERATIONS | CLINICAL-RESPONSE | Benzamides - pharmacokinetics | Colorectal Neoplasms - genetics | Humans | Middle Aged | Receptor, trkA - antagonists & inhibitors | Male | Receptor, trkB - genetics | Indazoles - administration & dosage | Protein Kinase Inhibitors - adverse effects | Mammary Analogue Secretory Carcinoma - genetics | Dose-Response Relationship, Drug | Benzamides - administration & dosage | Membrane Glycoproteins - antagonists & inhibitors | Receptor, trkC - genetics | Anaplastic Lymphoma Kinase | Melanoma - genetics | Colorectal Neoplasms - drug therapy | Receptor, trkB - antagonists & inhibitors | Aged, 80 and over | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Adult | Female | Benzamides - adverse effects | Carcinoma, Non-Small-Cell Lung - pathology | Crizotinib | Protein Kinase Inhibitors - pharmacokinetics | Proto-Oncogene Proteins - antagonists & inhibitors | Pyridines - administration & dosage | Carcinoma, Non-Small-Cell Lung - genetics | Receptor, trkC - antagonists & inhibitors | Melanoma - pathology | Mammary Analogue Secretory Carcinoma - drug therapy | Membrane Glycoproteins - genetics | Protein Kinase Inhibitors - administration & dosage | Sequestosome-1 Protein - genetics | Pyrazoles - administration & dosage | Indazoles - pharmacokinetics | Receptor Protein-Tyrosine Kinases - genetics | Oncogene Proteins, Fusion - genetics | Melanoma - drug therapy | Adolescent | Receptor, trkA - genetics | Oncogene Proteins, Fusion - antagonists & inhibitors | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Indazoles - adverse effects | Colorectal Neoplasms - pathology | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
Neuron, ISSN 0896-6273, 2002, Volume 35, Issue 1, pp. 65 - 76
Nerve growth factor (NGF) induces dramatic axon growth from responsive embryonic peripheral neurons. However, the roles of the various NGF-triggered signaling... 
SIGNAL-TRANSDUCTION | PROTEIN-KINASE-B | NEURITE OUTGROWTH | PHOSPHATIDYLINOSITOL 3-KINASE | BAX-DEFICIENT MICE | SYMPATHETIC NEURONS | SURVIVAL SIGNALS | NERVE GROWTH | PC12 CELLS | PHOSPHOINOSITIDE 3-KINASE | NEUROSCIENCES | ras Proteins - genetics | Mitogen-Activated Protein Kinase Kinases - genetics | ras Proteins - metabolism | Male | Ganglia, Spinal - cytology | Phosphatidylinositol 3-Kinases - metabolism | MAP Kinase Kinase 1 | Cell Differentiation - genetics | Mitogen-Activated Protein Kinase Kinases - metabolism | Cell Size - genetics | Receptor, trkC - genetics | Gene Expression - physiology | Female | Fetus | Protein-Serine-Threonine Kinases - metabolism | Neurons, Afferent - cytology | Nerve Growth Factor - metabolism | Proto-Oncogene Proteins c-raf - genetics | Ganglia, Spinal - embryology | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Signal Transduction - genetics | Proto-Oncogene Proteins - deficiency | bcl-2-Associated X Protein | Receptor Protein-Tyrosine Kinases - metabolism | Mice, Knockout | Phosphatidylinositol 3-Kinases - genetics | Proto-Oncogene Proteins c-akt | Animals | Growth Cones - metabolism | Growth Cones - ultrastructure | Receptor Protein-Tyrosine Kinases - genetics | Receptor, trkA - metabolism | Proto-Oncogene Proteins c-raf - deficiency | Receptor, trkA - genetics | Mitogen-Activated Protein Kinases - genetics | Mice | Neurons, Afferent - metabolism | Proto-Oncogene Proteins c-bcl-2 | Receptor, trkC - metabolism | Ganglia, Spinal - metabolism | Mitogen-Activated Protein Kinases - metabolism | Signal transduction | Kinases | Neurons | Rodents
Journal Article
Nature Cell Biology, ISSN 1465-7392, 03/2007, Volume 9, Issue 3, pp. 324 - 330
The mitogen-activated protein kinase (MAPK) network is a conserved signalling module that regulates cell fate by transducing a myriad of growth-factor signals.... 
ACTIVATION | PROTEIN | SPECIFICITY | PHOSPHORYLATION | DYNAMICS | RAF-1 | CASCADE | IDENTIFICATION | SIGNAL-REGULATED KINASE | TRANSIENT | CELL BIOLOGY | RNA, Small Interfering - genetics | MAP Kinase Signaling System - physiology | Tetradecanoylphorbol Acetate - pharmacology | Receptor, trkA - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - metabolism | PC12 Cells | MAP Kinase Kinase 1 - genetics | Flow Cytometry | Mitogen-Activated Protein Kinase 1 - genetics | Phosphorylation - drug effects | Cell Differentiation - physiology | Proto-Oncogene Proteins B-raf - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Proto-Oncogene Proteins c-raf - genetics | Nerve Growth Factor - pharmacology | Rats | MAP Kinase Kinase 1 - metabolism | Protein Kinase C - antagonists & inhibitors | Proto-Oncogene Proteins c-raf - metabolism | Animals | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Cell Differentiation - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Models, Biological | Proto-Oncogene Proteins B-raf - genetics | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Epidermal Growth Factor - pharmacology | Cell Cycle - drug effects | Monte Carlo Method | Mitogen-Activated Protein Kinase 1 - metabolism | Cell proliferation | Evaluation | Pheochromocytoma | Physiological aspects | Cell differentiation | Properties | Protein kinases | Growth factors
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2011, Volume 6, Issue 11, p. e28280
5-Hydroxy-3,6,7,8,3',4'-hexamethoxyflavone (5-OH-HxMF), a hydroxylated polymethoxyflavone, is found exclusively in the Citrus genus, particularly in the peels... 
SIGNAL-TRANSDUCTION | PHEOCHROMOCYTOMA CELLS | DEPENDENT TRANSCRIPTION | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | IMPROVES MEMORY IMPAIRMENT | LONG-TERM POTENTIATION | HYDROXYLATED POLYMETHOXYFLAVONES | TRANSCRIPTIONAL REGULATION | NERVE GROWTH-FACTOR | MOLECULAR-MECHANISMS | Citrus - chemistry | Flavones - chemistry | GAP-43 Protein - genetics | RNA, Messenger - metabolism | PC12 Cells | Nerve Growth Factors - pharmacology | Phosphorylation - drug effects | Cyclic AMP - metabolism | Flavones - pharmacology | Neurites - drug effects | Cyclic AMP-Dependent Protein Kinases - metabolism | GAP-43 Protein - metabolism | Naphthols - pharmacology | RNA, Messenger - genetics | Rats | Nerve Growth Factors - chemistry | Neurites - metabolism | Enzyme Activation - drug effects | Cell Shape - drug effects | Gene Expression Regulation - drug effects | Organophosphates - pharmacology | Animals | Receptor, trkA - metabolism | Signal Transduction - drug effects | Models, Biological | Cyclic AMP Response Element-Binding Protein - metabolism | Citrus | Citrus fruits | Neurons | Genes | Nerve growth factor | Genetic aspects | Cyclic adenylic acid | Genetic transcription | Protein kinases | Protein binding | Phosphates | Protein kinase A | Protein kinase C | Phosphorylation | Complex formation | Calcium | Leukemia | Kinases | Proteins | Adenylate cyclase | Signal transduction | Rodents | Calcium-binding protein | TrkA protein | Ca2+/calmodulin-dependent protein kinase | TrkA receptors | Inhibition | Localization | Growth factors | c-Fos protein | Fos gene | Calmodulin | GAP-43 protein | Axonogenesis | Cyclic AMP | Cyclic AMP response element-binding protein | Gene expression | 1-Phosphatidylinositol 3-kinase | Signaling | Flavonoids | Phytochemicals | Inhibitors | Pharmacy | Morphology | Pheochromocytoma cells | Naphthol | Molecular biology | Alzheimers disease | Apoptosis
Journal Article
Journal Article
Nature, ISSN 0028-0836, 02/2004, Volume 427, Issue 6977, pp. 843 - 848
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e35826
Receptor tyrosine kinase signaling cooperates with WNT/beta-catenin signaling in regulating many biological processes, but the mechanisms of their interaction... 
INSULIN | MECHANISM | BIOLOGY | DYSPLASIA | MUTATIONS | WNT | FGFR3 | CANCER | LRP6 | Phosphorylation | Humans | Gene Expression Regulation | Phosphatidylinositol 3-Kinases - metabolism | Glycogen Synthase Kinase 3 - metabolism | Wnt Proteins - metabolism | Receptor Protein-Tyrosine Kinases | beta Catenin - metabolism | Proto-Oncogene Proteins c-akt - genetics | beta Catenin - genetics | Phosphatidylinositol 3-Kinases - genetics | Low Density Lipoprotein Receptor-Related Protein-6 - genetics | Low Density Lipoprotein Receptor-Related Protein-6 - metabolism | MAP Kinase Signaling System - genetics | Wnt Proteins - genetics | Glycogen Synthase Kinase 3 - genetics | Wnt Signaling Pathway - genetics | HEK293 Cells | Mitogen-Activated Protein Kinases - genetics | Proto-Oncogene Proteins c-akt - metabolism | Mitogen-Activated Protein Kinases - metabolism | Wnt protein | AKT protein | Biology | Kinases | Throat cancer | Proteins | Signal transduction | β-catenin | Immunology | TrkA protein | Protein-tyrosine kinase receptors | Physiology | Standard deviation | Protein-tyrosine kinase | Fibroblast growth factor receptor 2 | Tyrosine | Epidermal growth factor receptors | Extracellular signal-regulated kinase | MAP kinase | Biophysics | Cadherin | Biological activity | 1-Phosphatidylinositol 3-kinase | Golgi apparatus | Medicine | Signaling | Low density lipoprotein receptors | Mutation | Prostate cancer | Fibroblast growth factor receptors | Tumors
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 12/2006, Volume 26, Issue 23, pp. 8942 - 8952
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 9/1999, Volume 146, Issue 5, pp. 955 - 966
In this report, we have examined the mechanisms whereby neurotrophins and neural activity coordinately regulate neuronal survival, focussing on sympathetic... 
Depolarization | Phosphorylation | Receptors | Calcium | Neurons | Adenoviruses | Antibodies | Physiological regulation | Cells | Phosphatidylinositols | Mitogen-activated protein kinase | Nerve growth factor | Calcium/calmodulin-dependent protein kinase II | Ras | Sympathetic neurons | MOLECULAR MECHANISMS | PROTEIN-KINASE-B | calcium/calmodulin-dependent protein kinase II | ras | DEPENDENT SURVIVAL | CALCIUM CHANNELS | sympathetic neurons | NERVE GROWTH-FACTOR | CELL BIOLOGY | mitogen-activated protein kinase | MEMBRANE DEPOLARIZATION | SIGNAL-TRANSDUCTION | nerve growth factor | INDEPENDENT PATHWAYS | MEDIATED SURVIVAL | Receptor, trkA | Apoptosis - drug effects | Protein-Tyrosine Kinases - metabolism | Receptor Protein-Tyrosine Kinases - physiology | Receptors, Nerve Growth Factor - physiology | Neurons - cytology | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Nerve Growth Factors - pharmacology | Mitogen-Activated Protein Kinase Kinases | Potassium Chloride - pharmacology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Phosphorylation - drug effects | Neurons - drug effects | Calcium-Calmodulin-Dependent Protein Kinase Type 2 | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Receptors, Nerve Growth Factor - antagonists & inhibitors | Animals, Newborn | Membrane Potentials - drug effects | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Proto-Oncogene Proteins - antagonists & inhibitors | Sympathetic Nervous System - cytology | Cells, Cultured | Rats | Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors | Enzyme Activation - drug effects | Membrane Potentials - physiology | Rats, Sprague-Dawley | Drug Synergism | Proto-Oncogene Proteins c-akt | Animals | Signal Transduction - drug effects | Neurons - enzymology | Proto-Oncogene Proteins - physiology | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Nervous system, Sympathetic | Physiological aspects | Genetic aspects | Cellular signal transduction | Research | Developmental neurology | Cytochemistry | Protein kinases | Mitogens | Cancer | calcium | sympathetic | calmodulin-dependent protein kinase II | Original | neurons
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2015, Volume 10, Issue 11, p. e0143852
Understanding the mechanisms in the generation of neural stem cells from pluripotent stem cells is a fundamental step towards successful management of... 
HUMAN ES | RETINOIC ACID | NUCLEAR-FACTOR | MULTIDISCIPLINARY SCIENCES | SWITCH CONTROLS | TRANSCRIPTION | GROWTH | NEURONS | RECEPTOR | PROLIFERATION | DIFFERENTIATION | Tyrosine 3-Monooxygenase - metabolism | Retinoid X Receptor alpha - metabolism | TOR Serine-Threonine Kinases - metabolism | Homeodomain Proteins - metabolism | Humans | tau Proteins - metabolism | Stem Cells - cytology | Stem Cells - metabolism | Dopaminergic Neurons - cytology | Morphogenesis | Cell Differentiation - genetics | Multiprotein Complexes - metabolism | Parkinson Disease - metabolism | Trophoblasts - cytology | Proto-Oncogene Proteins c-akt - metabolism | Calcium Signaling | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Disease Models, Animal | Cell Line | Nuclear Pore Complex Proteins - metabolism | Gene Expression Regulation | Axons - metabolism | Rats | Receptors, Retinoic Acid - metabolism | Parkinson Disease - genetics | Glycogen Synthase Kinase 3 - metabolism | beta Catenin - metabolism | Protein Transport | Transcription Factors - metabolism | Cyclic AMP Response Element-Binding Protein - genetics | Tyrosine 3-Monooxygenase - genetics | Animals | Receptor, trkA - metabolism | Signal Transduction - drug effects | Cell Differentiation - drug effects | Models, Biological | Cyclic AMP Response Element-Binding Protein - metabolism | Protein Binding | Stem Cells - drug effects | GTP-Binding Proteins - metabolism | Stem cell research | Analysis | Influence | Cellular signal transduction | G proteins | Research | Gene expression | Flow cytometry | Parkinson's disease | Substantia nigra | Genes | Stem cell transplantation | Kinases | Tyrosine 3-monooxygenase | Proteins | β-catenin | Signal transduction | Pathways | Rodents | TrkA protein | TrkA receptors | Movement disorders | Dopamine receptors | Tyrosine | Dopamine | Neurodegenerative diseases | Neurons | Axonogenesis | Hydroxylase | Implantation | Progenitor cells | Neurological diseases | Regeneration | Signaling | Brain-derived neurotrophic factor | Microscopy | Stem cells | Regulatory mechanisms (biology) | Cells (biology) | Epigenetics | Neural stem cells | Protein interaction | Differentiation | Retinoic acid | Pluripotency
Journal Article
Accounts of Chemical Research, ISSN 0001-4842, 10/2001, Volume 34, Issue 10, pp. 826 - 835
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2017, Volume 292, Issue 14, pp. 5748 - 5759
Journal Article