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Biochemical Journal, ISSN 0264-6021, 12/2012, Volume 448, Issue 2, pp. 213 - 220
To investigate the range of autoinhibitory mechanisms used by TKDs (tyrosine kinase domains) from the insulin receptor family of RTKs (receptor tyrosine... 
X-ray crystallography | Insulin receptor kinase | Autoinhibition | Receptor tyrosine kinase (RTK) | Receptor tyrosine kinase-like orphan receptor 2 (Ror2) | Tropomyosin receptor kinase A (TrkA) | ALK | ACTIVATION | CRYSTAL-STRUCTURE | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CATALYTIC DOMAIN | autoinhibition | receptor tyrosine kinase-like orphan receptor 2 (Ror2) | CANCER | ANAPLASTIC LYMPHOMA KINASE | insulin receptor kinase | receptor tyrosine kinase (RTK) | MUTATIONS | INHIBITOR | tropomyosin receptor kinase A (TrkA) | EGF RECEPTOR | Neoplasms - metabolism | Humans | Receptor, trkA - antagonists & inhibitors | Crystallography, X-Ray | Antigens, CD - genetics | Antigens, CD - metabolism | Neoplasms - genetics | Receptor, Insulin - genetics | Protein Structure, Quaternary | Antigens, CD - chemistry | Recombinant Proteins - metabolism | Amino Acid Sequence | Catalytic Domain | Recombinant Proteins - antagonists & inhibitors | Receptor Tyrosine Kinase-like Orphan Receptors - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Receptor, Insulin - antagonists & inhibitors | Amino Acid Motifs | Receptor Tyrosine Kinase-like Orphan Receptors - antagonists & inhibitors | Receptor Tyrosine Kinase-like Orphan Receptors - chemistry | Receptor, trkA - metabolism | Receptor, Insulin - chemistry | Receptor, trkA - chemistry | Receptor, trkA - genetics | Receptor Tyrosine Kinase-like Orphan Receptors - genetics | Receptor, Insulin - metabolism | Mutation | Enzyme Activation - genetics | In Vitro Techniques | ALK, anaplastic lymphoma kinase | FGFR, fibroblast growth factor receptor | Trk, tropomyosin receptor kinase | C-lobe, C-terminal lobe | EGFR, epidermal growth factor receptor | TKD, tyrosine kinase domain | DTT, dithiothreitol | NSCLC, non-small-cell lung cancer | TCEP, tris-(2-carboxyethyl)phosphine | COSMIC, Catalogue Of Somatic Mutations In Cancer | Ni-NTA, Ni2+-nitrilotriacetate | N-lobe, N-terminal lobe | RTK, receptor tyrosine kinase | CDK, cyclin-dependent kinase | IGF1R, insulin-like growth factor 1 receptor | MuSK, muscle-specific kinase | IRK, insulin receptor kinase | Ror, receptor tyrosine kinase-like orphan receptor
Journal Article
Handbook of experimental pharmacology, ISSN 0171-2004, 2014, Volume 220, pp. 103 - 119
The tropomyosin-related tyrosine kinase (Trk) receptors were initially described as a family of growth factor receptors required for neuronal survival. They... 
Signaling endosome | Neurotrophins | Trk receptors | Survival | Neurite outgrowth | Apoptosis | Axonal Transport | Receptor, trkA - physiology | Animals | Receptor, trkB - chemistry | Receptor, trkC - physiology | Signal Transduction | Neuronal Plasticity | Humans | Receptor, trkA - chemistry | Receptor, trkB - physiology | Receptor, trkC - chemistry
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2011, Volume 6, Issue 9, p. e25097
Background: Neurotrophin receptors were initially identified in neural cells. They were recently detected in some cancers in association with invasiveness, but... 
MULTIPLE-MYELOMA | RECEPTOR TRKB | HUMAN NEUROBLASTOMA-CELLS | HEPATOCELLULAR-CARCINOMA | PANCREATIC-CANCER | PROSTATE-CANCER | IN-VIVO | BIOLOGY | FACTOR ACTIVATION | KINASE-B | NERVE GROWTH-FACTOR | Brain-Derived Neurotrophic Factor - genetics | Apoptosis - drug effects | Humans | Adaptor Proteins, Vesicular Transport - genetics | Apoptosis - genetics | Receptor, trkB - genetics | Receptors, Nerve Growth Factor - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Brain-Derived Neurotrophic Factor - pharmacology | Receptor, trkC - genetics | Receptor, trkB - antagonists & inhibitors | Brain-Derived Neurotrophic Factor - metabolism | Cell Membrane - metabolism | Colorectal Neoplasms - metabolism | Enzyme-Linked Immunosorbent Assay | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Receptors, Nerve Growth Factor - genetics | Indole Alkaloids - pharmacology | Fluorescent Antibody Technique | Cell Line, Tumor | Cell Proliferation - drug effects | Carbazoles - pharmacology | Receptor, trkB - metabolism | Receptor, trkC - metabolism | Cell proliferation | Brain | Colorectal carcinoma | Colorectal cancer | Nerve growth factor | Neuroblastoma | Kinases | Neurotrophin 3 | Tissues | Ovarian cancer | Metastases | Proteins | Receptors | Cell growth | Penicillin | Tumor necrosis factor-TNF | TrkA protein | TrkA receptors | Autocrine signalling | Neurotrophins | Protein-tyrosine kinase | Tyrosine | Starvation | Cell survival | Secretion | Neurons | Invasiveness | Pharmacology | Survival | Patients | Neurotrophin receptors | Brain-derived neurotrophic factor | Medical prognosis | Cell lines | Affinity | TrkB receptors | Spinal cord injuries | Receptor mechanisms | Transporter | Cytoplasm | Tumors | Apoptosis | Cancer | Cell Membrane | Receptor, trkB | Receptor, trkC | Cell Proliferation | Cellular Biology | Adaptor Proteins, Vesicular Transport | Indole Alkaloids | Receptors, Nerve Growth Factor | Life Sciences | Carbazoles | Brain-Derived Neurotrophic Factor | Colorectal Neoplasms
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 03/2012, Volume 227, Issue 3, pp. 1017 - 1025
Neurotrophins (NTs) belong to a family of growth factors that play a critical role in the control of skin homeostasis. NTs act through the low‐affinity... 
MIGRATION | IN-VITRO | PHYSIOLOGY | DENDRITIC CELLS | MYOFIBROBLAST | TISSUE-REPAIR | SKIN | RECEPTORS | NGF | EXPRESSION | NERVE GROWTH-FACTOR | CELL BIOLOGY | Brain-Derived Neurotrophic Factor - genetics | Fibroblasts - secretion | Receptor, trkA - physiology | Receptor, trkC - physiology | Receptor, Nerve Growth Factor - genetics | Receptor, trkC - secretion | Fibroblasts - physiology | Myofibroblasts - physiology | Humans | Receptor, trkB - secretion | Receptor, trkB - physiology | Cell Survival - genetics | Male | Myofibroblasts - secretion | Nerve Growth Factors - metabolism | Receptor, trkB - genetics | Cell Differentiation - genetics | Receptor, trkC - genetics | Brain-Derived Neurotrophic Factor - physiology | Guided Tissue Regeneration - methods | Wound Healing - genetics | Dermis - cytology | Nerve Growth Factors - physiology | Cell Differentiation - physiology | Cell Survival - physiology | Nerve Growth Factors - secretion | Cells, Cultured | Receptor, Nerve Growth Factor - physiology | Foreskin | Dermis - secretion | Myofibroblasts - cytology | Receptor, trkA - genetics | Fibroblasts - cytology | Wound Healing - physiology | Dermis - physiology | Receptor, trkA | Receptor, trkB | Receptor, trkC | Cell Survival | Dermis | Wound Healing | Receptor, Nerve Growth Factor | Life Sciences | Immunology | Nerve Growth Factors | Brain-Derived Neurotrophic Factor | Fibroblasts | Cell Differentiation | Myofibroblasts | Guided Tissue Regeneration
Journal Article
Cancer Discovery, ISSN 2159-8274, 04/2017, Volume 7, Issue 4, pp. 400 - 409
Entrectinib, a potent oral inhibitor of the tyrosine kinases TRKA/B/C, ROS1, and ALK, was evaluated in two phase I studies in patients with advanced or... 
REARRANGEMENT | ONCOGENE | ONCOLOGY | ANALOG SECRETORY CARCINOMA | LANDSCAPE | KINASE FUSIONS | SARCOMAS | ETV6-NTRK3 GENE FUSION | CRIZOTINIB | GENOMIC ALTERATIONS | CLINICAL-RESPONSE | Benzamides - pharmacokinetics | Colorectal Neoplasms - genetics | Humans | Middle Aged | Receptor, trkA - antagonists & inhibitors | Male | Receptor, trkB - genetics | Indazoles - administration & dosage | Protein Kinase Inhibitors - adverse effects | Mammary Analogue Secretory Carcinoma - genetics | Dose-Response Relationship, Drug | Benzamides - administration & dosage | Membrane Glycoproteins - antagonists & inhibitors | Receptor, trkC - genetics | Anaplastic Lymphoma Kinase | Melanoma - genetics | Colorectal Neoplasms - drug therapy | Receptor, trkB - antagonists & inhibitors | Aged, 80 and over | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Adult | Female | Benzamides - adverse effects | Carcinoma, Non-Small-Cell Lung - pathology | Crizotinib | Protein Kinase Inhibitors - pharmacokinetics | Proto-Oncogene Proteins - antagonists & inhibitors | Pyridines - administration & dosage | Carcinoma, Non-Small-Cell Lung - genetics | Receptor, trkC - antagonists & inhibitors | Melanoma - pathology | Mammary Analogue Secretory Carcinoma - drug therapy | Membrane Glycoproteins - genetics | Protein Kinase Inhibitors - administration & dosage | Sequestosome-1 Protein - genetics | Pyrazoles - administration & dosage | Indazoles - pharmacokinetics | Receptor Protein-Tyrosine Kinases - genetics | Oncogene Proteins, Fusion - genetics | Melanoma - drug therapy | Adolescent | Receptor, trkA - genetics | Oncogene Proteins, Fusion - antagonists & inhibitors | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Indazoles - adverse effects | Colorectal Neoplasms - pathology | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
Cell, ISSN 0092-8674, 2001, Volume 106, Issue 5, pp. 619 - 632
Journal Article
Journal Article
Journal Article
FEBS Letters, ISSN 0014-5793, 10/2008, Volume 582, Issue 23-24, pp. 3325 - 3329
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2014, Volume 111, Issue 52, pp. 18661 - 18666
Lung adenocarcinomas harboring activating mutations in the epidermal growth factor receptor (EGFR) represent a common molecular subset of non-small cell lung... 
Genes | Epidermal cells | Cell lines | Open reading frames | Growth factor receptors | Viability | Genetic mutation | Genetic screening | Cells | Lung neoplasms | ORF | Epidermal growth factor receptor | Non-small cell lung cancer | non-small cell lung cancer | TARGETED THERAPY | WILD-TYPE | GEFITINIB | epidermal growth factor receptor | MULTIDISCIPLINARY SCIENCES | ACQUIRED-RESISTANCE | KINASE INHIBITORS | TYROSINE KINASES | GROWTH-FACTOR RECEPTOR | ERLOTINIB RESISTANCE | MUTATIONS | C-SRC | Receptor, Epidermal Growth Factor - genetics | Receptor, trkB | Humans | Membrane Glycoproteins - biosynthesis | Receptor Protein-Tyrosine Kinases - biosynthesis | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Receptor, Fibroblast Growth Factor, Type 1 - genetics | MAP Kinase Signaling System | Proto-Oncogene Proteins c-mos - genetics | Receptor, trkA - biosynthesis | Protein-Tyrosine Kinases - genetics | Protein-Tyrosine Kinases - biosynthesis | Proto-Oncogene Proteins c-raf - biosynthesis | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Receptor, Epidermal Growth Factor - biosynthesis | Lung Neoplasms - enzymology | Proto-Oncogene Proteins c-raf - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Membrane Glycoproteins - genetics | Receptor, Fibroblast Growth Factor, Type 2 - biosynthesis | Gene Expression Regulation, Enzymologic | Receptor Protein-Tyrosine Kinases - genetics | Cell Line, Tumor | Receptor, trkA - genetics | Carcinoma, Non-Small-Cell Lung - enzymology | Proto-Oncogene Proteins c-mos - biosynthesis | Receptor, Fibroblast Growth Factor, Type 1 - biosynthesis | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Protein research | Oncology, Experimental | Genetic aspects | Research | Lung cancer, Non-small cell | Gene expression | Cancer | Biological Sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2014, Volume 9, Issue 12, p. e115140
Tyro3, Axl and Mertk (TAM) receptor tyrosine kinases play multiple functional roles by either providing intrinsic trophic support for cell growth or regulating... 
NERVOUS-SYSTEM | AXL | MULTIDISCIPLINARY SCIENCES | APOPTOTIC CELLS | ADULT HIPPOCAMPAL NEUROGENESIS | TYROSINE KINASES | TRK RECEPTORS | NEUROTROPHINS | MER | NGF | TYRO-3 FAMILY | Cell Proliferation | Receptor Protein-Tyrosine Kinases - biosynthesis | Apoptosis - genetics | Recombinant Proteins | Proto-Oncogene Proteins - biosynthesis | Neurogenesis - genetics | Receptor, trkA - biosynthesis | c-Mer Tyrosine Kinase | Brain-Derived Neurotrophic Factor - biosynthesis | Proto-Oncogene Proteins - metabolism | Receptors, Nerve Growth Factor - biosynthesis | Cell Survival | Receptor, trkB - biosynthesis | Cells, Cultured | Proto-Oncogene Proteins - genetics | Hippocampus - cytology | Nerve Growth Factors - biosynthesis | Receptor Protein-Tyrosine Kinases - metabolism | Mice, Knockout | Hippocampus - metabolism | Animals | Receptor Protein-Tyrosine Kinases - genetics | Receptor, trkC - biosynthesis | Mice | Neural Stem Cells - metabolism | Brain | Nerve growth factor | Tubulins | Cell differentiation | Neurons | Stem cells | Cell proliferation | Neurosciences | Neurobiology | Central nervous system | Nervous system | Kinases | Neurogenesis | Neuronal-glial interactions | Axl protein | Proteins | Signal transduction | Receptors | Cell activation | Cell growth | Tubulin | Rodents | TrkA protein | Protein-tyrosine kinase receptors | TrkA receptors | Neurotrophins | Growth factors | Tyrosine | Cell survival | Immune response | Axonogenesis | Inflammation | Gene expression | Survival | Medicine | Brain-derived neurotrophic factor | Neural stem cells | TrkB receptors | Differentiation | Hippocampus | Apoptosis
Journal Article