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Evaluation of antidiabetic activity of Ginkgo biloba in streptozotocin induced diabetic rats, 12/2005
The objective of the study was to evaluate the antidiabetic activity of Ginkgo Biloba   and to probe into its mechanism of action. Methods. Albino wistar rats... 
Ginkgo biloba, Antidiabetic, Antioxidant, Troglitazone
Journal
Cancer Research, ISSN 0008-5472, 09/2003, Volume 63, Issue 17, pp. 5274 - 5280
The molecular genetics underlying thyroid carcinogenesis is not clear. Recent identification of a PAX8-peroxisome proliferator-activated receptor gamma (PPAR... 
troglitazone
Journal Article
Brain Research, ISSN 0006-8993, 01/2002, Volume 924, Issue 2, pp. 229 - 236
Both excitotoxicity and apoptosis contribute to neuronal loss in various neurodegenerative diseases such as Alzheimer's disease as well as stroke, and a drug... 
troglitazone
Journal Article
Toxicology, ISSN 0300-483X, 10/2001, Volume 167, Issue 1, pp. 83 - 98
Troglitazone is a thiazolidinedione insulin sensitizer drug for the treatment of type 2 non-insulin-dependent diabetes mellitus (NIDDM). Based on an increasing... 
troglitazone
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 01/2001, Volume 76, Issue 2, pp. 383 - 390
Troglitazone (TGZ), an antidiabetic drug that improves insulin-resistance in the peripheral tissues, was tested for neurotrophic activity in motoneurones and... 
troglitazone
Journal Article
BREAST CANCER RESEARCH AND TREATMENT, ISSN 0167-6806, 10/2017, Volume 165, Issue 3, pp. 517 - 527
40% of triple-negative breast cancer (TNBC) do not express claudin-1, a major constituent of tight junction. Patients with these "claudin-1-low" tumors present... 
MIGRATION | ACTIVATION | SENSITIVITY | TROGLITAZONE | Claudin-1 | LINES | Triple-negative breast cancer | Troglitazone derivatives | ONCOLOGY | OCCLUDIN | PPAR-GAMMA AGONISTS | EXPRESSION | Apoptosis
Journal Article
Chemical Research in Toxicology, ISSN 0893-228X, 01/2001, Volume 14, Issue 1, pp. 62 - 70
Therapy with the oral antidiabetic agent troglitazone (Rezulin) has been associated with cases of severe hepatotoxicity and drug-induced liver failure, which... 
troglitazone
Journal Article
Calcified Tissue International, ISSN 0171-967X, 07/2001, Volume 69, Issue 1, pp. 46 - 50
Aging is associated with decreased trabecular bone mass and increased adipocyte formation in bone marrow. As osteoblasts and adipocytes share common precursor... 
Troglitazone
Journal Article
Theriogenology, ISSN 0093-691X, 01/2020, Volume 142, pp. 276 - 283
Journal Article
Drug Safety, ISSN 0114-5916, 01/2001, Volume 24, Issue 2, pp. 149 - 154
To investigate whether there were any cases of liver function abnormalities possibly associated with troglitazone use in general practice in England. A... 
troglitazone
Journal Article
Drugs, ISSN 0012-6667, 03/1999, Volume 57, Issue 3, pp. 409 - 438
Troglitazone is the first of a new group of oral antidiabetic drugs, the thiazolidinediones, and is indicated for the treatment of patients with type 2... 
Reviews-on-treatment | Drug-interactions | Antihyperglycaemics, therapeutic-use | Clinical-pharmacokinetics | Troglitazone, pharmacodynamics | Type-2-diabetes-mellitus, treatment | Glibenclamide, therapeutic-use | Troglitazone, adverse-reactions | Lipid-metabolism | Troglitazone, therapeutic-use | Troglitazone, general | Troglitazone, pharmacokinetics | Insulin, therapeutic-use | Troglitazone, drug-interactions | Drug-evaluations | POLYCYSTIC-OVARY-SYNDROME | thiazolidinediones | 10-YEAR FOLLOW-UP | ORAL ANTIDIABETIC AGENT | OBESE SUBJECTS | pharmacodynamics | URINARY-EXCRETION | IMPAIRED GLUCOSE-TOLERANCE | troglitazone | diabetes mellitus | INDUCED INSULIN-RESISTANCE | C57BL/KSJ-DB/DB MICE | WERNERS-SYNDROME | pharmacokinetics | PHARMACOLOGY & PHARMACY | TOXICOLOGY | insulin resistance | therapeutic use | NIDDM SUBJECTS | Hypoglycemic Agents - therapeutic use | Area Under Curve | Humans | Half-Life | Thiazoles - therapeutic use | Thiazoles - adverse effects | Diabetes Mellitus, Type 2 - epidemiology | Hypoglycemic Agents - pharmacology | Randomized Controlled Trials as Topic | Chromans - adverse effects | Animals | Diabetes Mellitus, Type 2 - physiopathology | Drug Interactions | Chromans - pharmacology | Chromans - therapeutic use | Glucose - metabolism | Glyburide - therapeutic use | Adult | Aged | Thiazoles - pharmacology | Diabetes Mellitus, Type 2 - drug therapy | Hypoglycemic Agents - adverse effects | Thiazolidinediones
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 10/2017, Volume 142, pp. 168 - 193
Diabetes mellitus is a chronic disease characterized by hyperglycemia, insulin resistance and hyperlipidemia. Glitazones or thiazolidinediones (TZD) are drugs... 
Molecular dynamics | Rosiglitazone | Docking | 15d-PGJ2 | Pioglitazone | Troglitazone
Journal Article
NEW ENGLAND JOURNAL OF MEDICINE, ISSN 0028-4793, 02/2006, Volume 354, Issue 7, pp. 731 - 739
  Given its rarity, drug-related hepatotoxicity may not be seen during the initial clinical trials of a new medication. After approval, when many more patients... 
INDUCED HEPATITIS | UNITED-STATES | MEDICINE, GENERAL & INTERNAL | MEDICAL PROGRESS | ADVERSE REACTIONS | DISEASE | TROGLITAZONE | RISK | CAUSALITY ASSESSMENT | FAILURE | INDUCED LIVER-INJURY | Pharmaceutical industry | Medical research | Liver
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 06/2010, Volume 636, Issue 1-3, p. 198
Aberrant activation of the Wnt/[beta]-catenin signaling pathway plays a crucial role in oncogenesis of various human malignancies. It has been demonstrated... 
Tyrosine | Thiazolidinediones | Troglitazone
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 05/2002, Volume 109, Issue 10, pp. 1345 - 1350
Lipodystrophy is a rare disorder that is characterized by selective loss of subcutaneous and visceral fat and is associated with hypertriglyceridemia,... 
DIABETES-MELLITUS | MEDICINE, RESEARCH & EXPERIMENTAL | THERAPY | SPECTROSCOPY | FREE FATTY-ACIDS | GLUCOSE | IN-VIVO | HUMANS | TROGLITAZONE
Journal Article
HEPATOLOGY, ISSN 0270-9139, 01/2004, Volume 39, Issue 1, pp. 188 - 196
Nonalcoholic steatohepatitis (NASH) is a common chronic liver disease for which there is no known effective therapy. A proportion of patients with NASH... 
METFORMIN | ADIPOCYTES | FATTY LIVER-DISEASE | GLUCOSE | RESISTANCE | TROGLITAZONE | NATURAL-HISTORY | GASTROENTEROLOGY & HEPATOLOGY | INSULIN SENSITIVITY | ASSOCIATION | CRYPTOGENIC CIRRHOSIS
Journal Article
Analytical Chemistry, ISSN 0003-2700, 06/2017, Volume 89, Issue 11, pp. 6257 - 6264
To date, the main limitations for LC-MS-based untargeted lipidomics reside in the lack of adequate computational and cheminformatics tools that are able to... 
CHEMISTRY, ANALYTICAL | TROGLITAZONE HEPATOTOXICITY | LIVER-INJURY | METABOLISM | DISEASE | MULTIVARIATE-ANALYSIS | IDENTIFICATION | SPECTRA | MASS-SPECTROMETRY | ELECTROSPRAY-IONIZATION | LIPIDS
Journal Article
Hepatology, ISSN 0270-9139, 2003, Volume 38, Issue 4, pp. 1008 - 1017
Insulin resistance (IR) commonly is associated with nonalcoholic steatoliepatitis (NASH). To establish whether IR causes NASH, this study was undertaken to... 
THIAZOLIDINEDIONE | OBESITY | PIOGLITAZONE | SENSITIVITY CHECK INDEX | PROLIFERATOR-ACTIVATED RECEPTORS | DISEASE | FATTY LIVER | TROGLITAZONE | STELLATE CELL ACTIVATION | GASTROENTEROLOGY & HEPATOLOGY | INSULIN SENSITIVITY
Journal Article
CHEMICAL RESEARCH IN TOXICOLOGY, ISSN 0893-228X, 07/2019, Volume 32, Issue 7, pp. 1423 - 1431
Idiosyncratic drug reactions (IDRs) significantly increase the risk of failure in drug development. The major IDR leading to drug candidate failure is... 
COMPLEX I | OXIDATION | CHEMISTRY, MEDICINAL | NECROSIS | TROGLITAZONE | ANIMAL-MODEL | MICE | TOXICOLOGY | DYSFUNCTION | CHEMISTRY, MULTIDISCIPLINARY | CELL-DEATH | INDUCED HEPATOTOXICITY
Journal Article
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