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tropolone - pharmacology (287) 287
tropolone - analogs & derivatives (231) 231
animals (201) 201
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index medicus (115) 115
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pharmacology & pharmacy (91) 91
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tropolone - chemistry (75) 75
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hinokitiol (65) 65
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dose-response relationship, drug (38) 38
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tropolone - metabolism (34) 34
cells, cultured (32) 32
cycloheptanes - pharmacology (32) 32
in vitro techniques (30) 30
tropolone - chemical synthesis (30) 30
monoterpenes (29) 29
catechol o-methyltransferase inhibitors (28) 28
microbiology (28) 28
antineoplastic agents - pharmacology (27) 27
cell line, tumor (27) 27
inhibition (27) 27
apoptosis (26) 26
article (26) 26
enzyme inhibitors - pharmacology (24) 24
microbial sensitivity tests (24) 24
rats, inbred strains (24) 24
anti-bacterial agents - pharmacology (23) 23
cells (22) 22
tropolone - isolation & purification (22) 22
analysis (21) 21
cell survival - drug effects (21) 21
monoterpenes - chemistry (21) 21
time factors (21) 21
anti-infective agents - pharmacology (20) 20
monophenol monooxygenase - metabolism (20) 20
dopamine - metabolism (19) 19
research (19) 19
apoptosis - drug effects (18) 18
catechol o-methyltransferase - metabolism (18) 18
cell biology (18) 18
chemistry, multidisciplinary (18) 18
hinokitiol-related compounds (18) 18
expression (17) 17
β-thujaplicin (17) 17
biotechnology & applied microbiology (16) 16
chemistry, organic (16) 16
gamma-thujaplicin (16) 16
in-vitro (16) 16
iron chelating agents - pharmacology (16) 16
mechanism (16) 16
tyrosinase (16) 16
binding (15) 15
cancer (15) 15
chemistry (15) 15
colchicine - pharmacology (15) 15
magnetic resonance spectroscopy (15) 15
monophenol monooxygenase - antagonists & inhibitors (15) 15
tropolones (15) 15
antifungal agents - pharmacology (14) 14
antineoplastic agents - chemical synthesis (14) 14
antineoplastic agents - chemistry (14) 14
brain - metabolism (14) 14
cell proliferation - drug effects (14) 14
cytotoxicity (14) 14
norepinephrine - metabolism (14) 14
oncology (14) 14
pargyline - pharmacology (14) 14
rnase-h (14) 14
signal transduction - drug effects (14) 14
tropolone - therapeutic use (14) 14
acid (13) 13
beta-dolabrin (13) 13
biological-activity (13) 13
derivatives (13) 13
inhibitors (13) 13
methylation (13) 13
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physiological aspects (13) 13
plant sciences (13) 13
tubulin - metabolism (13) 13
tumor cells, cultured (13) 13
antiviral agents - pharmacology (12) 12
binding sites (12) 12
biosynthesis (12) 12
colchicine - metabolism (12) 12
drug screening assays, antitumor (12) 12
hiv-1 reverse-transcriptase (12) 12
hydroxylated tropolones (12) 12
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1. Full Text Hinokitiol inhibits platelet activation ex vivo and thrombus formation in vivo
by Lin, Kuan H and Kuo, Jinn R and Lu, Wan J and Chung, Chi L and Chou, Duen S and Huang, Shih Y and Lee, Hsiu C and Sheu, Joen R
Biochemical Pharmacology, ISSN 0006-2952, 05/2013, Volume 85, Issue 10, pp. 1478 - 1485
Hinokitiol is a tropolone-related bioactive compound that has been used in hair tonics, cosmetics, and food as an antimicrobial agent. Recently, hinokitiol has... 
Hinokitiol | Platelet activation | MAPK | PLCγ2 | Hydroxyl radical | Occlusion time | CELLS | APOPTOSIS | PROTECTION | 12-LIPOXYGENASE | KINASE | INVOLVEMENT | MECHANISMS | TROPOLONE | SUPPRESSION | PLC gamma 2 | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | Calcium - metabolism | Humans | Proto-Oncogene Proteins c-akt - genetics | Monoterpenes - pharmacology | Thrombin - pharmacology | Platelet Glycoprotein GPIIb-IIIa Complex - metabolism | Phospholipase C gamma - genetics | Platelet Aggregation Inhibitors - pharmacology | Collagen - pharmacology | Platelet Aggregation - drug effects | Hydroxyl Radical - antagonists & inhibitors | Phosphorylation - drug effects | Thrombosis - prevention & control | Blood Platelets - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Phospholipase C gamma - metabolism | Tropolone - analogs & derivatives | Hydroxyl Radical - metabolism | Tropolone - pharmacology | Adenosine Diphosphate - pharmacology | Gene Expression Regulation - drug effects | Thrombosis - metabolism | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Signal Transduction - drug effects | Arachidonic Acid - pharmacology | Mitogen-Activated Protein Kinases - genetics | Mice | Platelet Activation - drug effects | Phospholipase C gamma - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Mitogen-Activated Protein Kinases - metabolism | Genetic research | Medical colleges | Thrombosis | Blood clot
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2. Full Text Inhibition of foamy virus reverse transcriptase by human immunodeficiency virus type 1 RNase H inhibitors
by Corona, Angela and Schneider, Anna and Schweimer, Kristian and Rösch, Paul and Wöhrl, Birgitta M and Tramontano, Enzo
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 2014, Volume 58, Issue 7, pp. 4086 - 4093
RNase H plays an essential role in the replication of human immunodeficiency virus type 1 (HIV-1). Therefore, it is a promising target for drug development.... 
IN-VITRO | DOMAIN | REPLICATION | STRUCTURAL BASIS | ACTIVE-SITE | DIKETO ACID | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | DNA-POLYMERASE | DUAL INHIBITORS | DERIVATIVES | RIBONUCLEASE-H | Anti-HIV Agents - pharmacology | Spumavirus - enzymology | Catalytic Domain | HIV-1 - drug effects | Caproates - pharmacology | HIV Reverse Transcriptase - antagonists & inhibitors | Humans | Tropolone - analogs & derivatives | Reverse Transcriptase Inhibitors - pharmacology | Crystallography, X-Ray | Ribonuclease H - antagonists & inhibitors | Tropolone - pharmacology | Monoterpenes - pharmacology | Pyrroles - pharmacology | Nuclear Magnetic Resonance, Biomolecular | Molecular Docking Simulation | Antiviral Agents
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3. Full Text Multiple signalling pathways mediate fungal elicitor-induced β-thujaplicin biosynthesis in Cupressus lusitanica cell cultures
by Jian Zhao and Kokki Sakai
Journal of Experimental Botany, ISSN 0022-0957, 2/2003, Volume 54, Issue 383, pp. 647 - 656
The biosynthesis of a phytoalexin, β-thujaplicin, in Cupressus lusitanica cell cultures can be stimulated by a yeast elicitor, H2O2, or methyl jasmonate.... 
Cell culture techniques | Signal transduction | Calcium | Reagents | Cultured cells | Cell membranes | Biosynthesis | Cholera | Toxins | Research Papers: Cell and Molecular Biology, Biochemistry and Molecular Physiology | Plant cells | β-thujaplicin | Jasmonate signalling | Cupressus lusitanica | G-proteins | Calcium influx | GTP-BINDING PROTEIN | HETEROTRIMERIC G-PROTEIN | signal transduction | CATHARANTHUS-ROSEUS | calcium influx | OXIDATIVE BURST | beta-thujaplicin | BENZOPHENANTHRIDINE ALKALOID BIOSYNTHESIS | PLASMA-MEMBRANE | PLANT SCIENCES | SOYBEAN CELLS | OCTADECANOID PATHWAY | jasmonate signalling | SUSPENSION-CULTURES | JASMONIC ACID | Tropolone - antagonists & inhibitors | Peptides | Calcium - metabolism | Lanthanum - pharmacology | Cupressus - metabolism | Oxylipins | Cholera Toxin - pharmacology | Monoterpenes - antagonists & inhibitors | Fungi - growth & development | Cupressus - microbiology | Suramin - pharmacology | Lipoxygenase - biosynthesis | Wasp Venoms - pharmacology | Cells, Cultured | Hydrogen Peroxide - pharmacology | Tropolone - analogs & derivatives | Cyclopentanes - pharmacology | Calcimycin - pharmacology | Verapamil - pharmacology | Egtazic Acid - pharmacology | GTP Phosphohydrolases - metabolism | Signal Transduction - drug effects | Monoterpenes - metabolism | Signal Transduction - physiology | Acetates - pharmacology | Calcimycin - antagonists & inhibitors | Plant Growth Regulators - pharmacology | Cupressus - cytology | Tropolone - metabolism | GTP-Binding Proteins - metabolism
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4. Full Text Troponoids can inhibit growth of the human fungal pathogen Cryptococcus neoformans
by Donlin, Maureen J and Zunica, Anthony and Lipnicky, Ashlyn and Garimallaprabhakaran, Aswin K and Berkowitz, Alex J and Grigoryan, Alexandre and Meyers, Marvin J and Tavis, John E and Murellic, Ryan P
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 04/2017, Volume 61, Issue 4
Cryptococcus neoformans is a pathogen that is common in immunosuppressed patients. It can be treated with amphotericin B and fluconazole, but the mortality... 
Cryptococcus neoformans | Antifungal agents | Tropolones | SYNTHETIC ALPHA-HYDROXYTROPOLONES | INFECTIONS | antifungal agents | HEPATITIS-B-VIRUS | tropolones | MICROBIOLOGY | AMPHOTERICIN-B | MENINGITIS | ORGAN TRANSPLANT RECIPIENTS | REPLICATION | HYDROXYLATED TROPOLONES | SYNERGY | PHARMACOLOGY & PHARMACY | RIBONUCLEASE-H ACTIVITY | Antifungal Agents - pharmacology | Microbial Sensitivity Tests | Fluconazole - pharmacology | Humans | Amphotericin B - pharmacology | Tropolone - pharmacology | Cryptococcus neoformans - growth & development | Cryptococcus neoformans - drug effects
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5. Full Text Hormetic and anti-radiation effects of tropolone-related compounds
by Kantoh, Kaori and Ono, Manami and Nakamura, Yuko and Nakamura, Yukio and Hashimoto, Ken and Sakagami, Hiroshi and Wakabayashi, Hidetsugu
In Vivo, ISSN 0258-851X, 11/2010, Volume 24, Issue 6, pp. 843 - 851
We have previously investigated a total of 173 azulene-, tropolone- and azulenequinone-related compounds for their tumor-specificity and anti-inflammatory... 
UV protection | Tropones | Hormesis | MEDICINE, RESEARCH & EXPERIMENTAL | NO PRODUCTION | HINOKITIOL-RELATED COMPOUNDS | GAMMA-THUJAPLICIN | MACROPHAGE-LIKE CELLS | hormesis | TUMOR-SPECIFIC CYTOTOXICITY | STRESS | PHYTOGROWTH-INHIBITORY ACTIVITIES | CONSTITUENTS | Cycloheptanes - pharmacology | Gallic Acid - pharmacology | Humans | Cells, Cultured | Tropolone - analogs & derivatives | Radiation-Protective Agents - chemistry | Structure-Activity Relationship | Tropolone - pharmacology | Antineoplastic Agents - chemistry | Cycloheptanes - chemistry | Dose-Response Relationship, Drug | Ultraviolet Rays | Acetylcysteine - pharmacology | Ascorbic Acid - pharmacology | Radiation-Protective Agents - pharmacology | Female | Tropolone - chemistry | Antineoplastic Agents - pharmacology | Tumor Cells, Cultured | Child | Cytoprotection
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6. Full Text Mode of action and resistance studies unveil new roles for tropodithietic acid as an anticancer agent and the γ-glutamyl cycle as a proton sink
by Maxwell Z. Wilson and Rurun Wang and Zemer Gitai and Mohammad R. Seyedsayamdost
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2016, Volume 113, Issue 6, pp. 1630 - 1635
While we have come to appreciate the architectural complexity of microbially synthesized secondary metabolites, far less attention has been paid to linking... 
antibiotic | VIBRIO-ANGUILLARUM | CELLS | mode of action | roseobacter | PHAEOBACTER-GALLAECIENSIS | NATURAL-PRODUCTS | MULTIDISCIPLINARY SCIENCES | CLADE | anticancer agent | MEDIATED GROWTH-INHIBITION | POLYETHER IONOPHORES | MOLECULES | tropodithietic acid | MARINE ROSEOBACTER LINEAGE | MONENSIN | Protons | Metabolomics | Escherichia coli - drug effects | Tropolone - analogs & derivatives | Antiporters - metabolism | Dimethyl Sulfoxide - pharmacology | Genetic Loci | Tropolone - pharmacology | Nucleotides - metabolism | Time-Lapse Imaging | Dictyostelium - drug effects | Models, Biological | Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology | Flagella - drug effects | Antineoplastic Agents - pharmacology | Glutamic Acid - metabolism | Nigericin - pharmacology | Drug Resistance, Neoplasm - drug effects | Biological Sciences | Physical Sciences
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7. Full Text Synergistic interactions between hepatitis B virus RNase H antagonists and other inhibitors
by Lomonosova, Elena and Zlotnick, Adam and Tavis, John E
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 03/2017, Volume 61, Issue 3
Combination therapies are standard for management of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections; however, no such therapies are... 
Antiviral combination | RNase H | Synergy | Hepatitis B virus | Viral replication | ANTIVIRAL AGENTS | LIFE-CYCLE | synergy | antiviral combination | hepatitis B virus | MICROBIOLOGY | DNA-SYNTHESIS | VIRAL RIBONUCLEASE H | viral replication | ANGSTROM RESOLUTION | IN-VITRO | REPLICATION | HYDROXYLATED TROPOLONES | MICHAELIS-MENTEN | PHARMACOLOGY & PHARMACY | HIV-1 REVERSE-TRANSCRIPTASE | Hepatitis B virus - growth & development | Allosteric Regulation | Humans | Deoxycytidine - pharmacology | Ribonuclease H - antagonists & inhibitors | Viral Proteins - metabolism | Dose-Response Relationship, Drug | Tetrazolium Salts | Isoquinolines - pharmacology | Thiazoles | Ribonuclease H - genetics | Virus Replication - drug effects | Antiviral Agents - pharmacology | Gene Expression | Tropolone - analogs & derivatives | Viral Proteins - genetics | Viral Proteins - antagonists & inhibitors | Tropolone - pharmacology | Hep G2 Cells | Drug Synergism | Hepatitis B virus - drug effects | Hepatitis B virus - genetics | Lamivudine - pharmacology | Kinetics | Drug Combinations | Ribonuclease H - metabolism
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8. Full Text Anti-duck virus hepatitis mechanisms of Bush Sophora Root polysaccharide and its sulfate verified by intervention experiments
by Chen, Yun and Zeng, Ling and Xiong, Wen and Song, Meiyun and Du, Hongxu and Wang, Yixuan and Wang, Deyun and Ming, Ke and Wu, Yi and Hu, Yuanliang and Liu, Jiaguo
Virus Research, ISSN 0168-1702, 06/2015, Volume 204, pp. 58 - 67
In our previous study, Bush Sophora Root polysaccharide (BSRPS) and its sulfate (sBSRPS) exhibited anti-duck virus hepatitis (DVH) abilities as well as... 
Duck virus hepatitis | Immuno-enhancement | Bush Sophora Root polysaccharide | Intervention experiment | Anti-oxidative | VIROLOGY | HINOKITIOL | INFECTION | MICE | DAMAGE | Liver - pathology | Poultry Diseases - pathology | Hepatitis, Viral, Animal - drug therapy | Sophora - chemistry | Picornaviridae Infections - drug therapy | Picornaviridae Infections - virology | Monoterpenes - pharmacology | Liver - drug effects | Tacrolimus - pharmacology | Hepatitis, Viral, Animal - virology | Immunosuppressive Agents - pharmacology | Picornaviridae Infections - pathology | Hepatitis, Viral, Animal - pathology | Ducks - virology | Tropolone - analogs & derivatives | Sulfates - pharmacology | Antioxidants - pharmacology | Poultry Diseases - virology | Random Allocation | Tropolone - pharmacology | Poultry Diseases - drug therapy | Polysaccharides - pharmacology | Animals | Hepatitis Virus, Duck - drug effects | Plant Roots - chemistry | Virus diseases | Hepatitis | Polysaccharides | Sulfates
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9. Full Text Effect of donor atom identity on metal-binding pharmacophore coordination
by Dick, Benjamin L and Patel, Ashay and McCammon, J. Andrew and Cohen, Seth M
Journal of Biological Inorganic Chemistry, ISSN 0949-8257, 06/2017, Volume 22, Issue 4, pp. 605 - 613
The inhibition and binding of three metal-binding pharmacophores (MBPs), 2-hydroxycyclohepta-2,4,6-trien-1-one (tropolone), 2-mercaptopyridine-N-oxide... 
X-ray crystallography | Computational chemistry | Ligand binding | Density functional theory | Metalloenzyme | ACTIVE-SITE | CHELATORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | MODEL | CHEMISTRY, INORGANIC & NUCLEAR | DENSITY | CARBONIC-ANHYDRASE-II | MATRIX-METALLOPROTEINASE INHIBITORS | AFFINITY | HISTONE DEACETYLASE INHIBITORS | ENERGIES | Carbonic Anhydrase Inhibitors - chemistry | Pyridines - chemistry | Humans | Thiones - chemistry | Tropolone - analogs & derivatives | Carbonic Anhydrase II - metabolism | Models, Molecular | Crystallography, X-Ray | Carbonic Anhydrase Inhibitors - chemical synthesis | Carbonic Anhydrase Inhibitors - pharmacology | Tropolone - pharmacology | Zinc - chemistry | Carbonic Anhydrase II - antagonists & inhibitors | Quantum Theory | Organometallic Compounds - chemical synthesis | Organometallic Compounds - chemistry | Tropolone - chemistry | Molecular Structure | Pyridines - pharmacology | Thiones - pharmacology | Zinc - pharmacology | Carbonic Anhydrase II - genetics | Organometallic Compounds - pharmacology | Density functionals | Beta lactamases | Specific gravity | Analysis
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10. Full Text Evaluation physical characteristics and comparison antimicrobial and anti-inflammation potentials of dental root canal sealers containing hinokitiol in vitro
by Shih, Yin-Hua and Lin, Dan-Jae and Chang, Kuo-Wei and Hsia, Shih-Min and Ko, Shun-Yao and Lee, Shyh-Yuan and Hsue, Shui-Sang and Wang, Tong-Hong and Chen, Yi-Ling and Shieh, Tzong-Ming
PLoS ONE, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, p. e94941
Hinokitiol displays potent antimicrobial activity. It has been used in toothpaste and oral-care gel to improve the oral lichen planus and reduce halitosis. The... 
LYSYL OXIDASE | ZINC OXIDE-EUGENOL | CELLS | CALCIUM HYDROXIDE | MESSENGER-RNA | ANTIBACTERIAL ACTIVITY | MULTIDISCIPLINARY SCIENCES | ENTEROCOCCUS-FAECALIS | BETA-THUJAPLICIN | CANCER | ENDODONTIC SEALERS | Anti-Infective Agents - pharmacology | Humans | Pit and Fissure Sealants - chemistry | RNA, Messenger - metabolism | Monoterpenes - pharmacology | Cyclooxygenase 2 - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Anti-Infective Agents - chemistry | Aggregatibacter actinomycetemcomitans - drug effects | Root Canal Filling Materials - chemistry | Fibroblasts - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Methicillin-Resistant Staphylococcus aureus - drug effects | RNA, Messenger - genetics | Cells, Cultured | Tropolone - analogs & derivatives | Streptococcus mutans - drug effects | Tropolone - pharmacology | Pit and Fissure Sealants - pharmacology | Fibroblasts - drug effects | Cyclooxygenase 2 - metabolism | Protein-Lysine 6-Oxidase - metabolism | Monoterpenes - chemistry | Root Canal Filling Materials - pharmacology | Tropolone - chemistry | Protein-Lysine 6-Oxidase - genetics | Antimicrobial activity | Calcium | Toxicity | Sealing compounds | Cytotoxicity | mRNA | Physical tests | Drug resistance | Lichen planus | Antiinfectives and antibacterials | Eugenol | Prostaglandin endoperoxide synthase | Methicillin | Dental restorative materials | Biological effects | Microorganisms | Off odor | Working hours | Physical characteristics | Fibroblasts | Tumor necrosis factor-TNF | Zinc oxide | Inhibition | Hypoxia-inducible factors | Sealers | Toothpaste | Bacterial infections | Staphylococcus infections | Antimicrobial agents | Inflammation | Dentistry | Gene expression | Lysyl oxidase | Film thickness | Physical properties | Slaked lime | Zinc | Zinc oxides | Oral hygiene | Liquid oxygen | Hypoxia | Root canals | Cyclooxygenase-2 | Synergistic effect | Calcium hydroxide
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11. Full Text Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones
by Budihas, Scott R and Gorshkova, Inna and Gaidamakov, Sergei and Wamiru, Antony and Bona, Marion K and Parniak, Michael A and Crouch, Robert J and McMahon, James B and Beutler, John A and Le Grice, Stuart F.J
Nucleic Acids Research, ISSN 0305-1048, 2005, Volume 33, Issue 4, pp. 1249 - 1256
High-throughput screening of a National Cancer Institute library of pure natural products identified the hydroxylated tropolone derivatives beta-thujaplicinol... 
STRAND TRANSFER-REACTIONS | RNASE-H | DOMAIN | ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | HINOKITIOL | Cuticle | plant biomechanics | tomato | CLEAVAGE | cracking | TRACT | ripening | Lycopersicon esculentum | BIOLOGICAL-ACTIVITY | SITES | stiffening | fruit growth | epidermis | Anti-HIV Agents - pharmacology | Coumarins - metabolism | Benzocycloheptenes - chemistry | Benzocycloheptenes - pharmacology | HIV-1 - drug effects | Tropolone - analogs & derivatives | Reverse Transcriptase Inhibitors - pharmacology | Pyranocoumarins | Ribonuclease H - antagonists & inhibitors | Tropolone - pharmacology | Reverse Transcriptase Inhibitors - chemistry | Coumarins - pharmacology | Anti-HIV Agents - chemistry | HIV-1 - enzymology | Tropolone - chemistry | Reverse Transcriptase Inhibitors - metabolism | Anti-HIV Agents - metabolism | Binding Sites | Ribonuclease H - metabolism
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12. Full Text Efficacy and cytotoxicity in cell culture of novel α-hydroxytropolone inhibitors of hepatitis B virus ribonuclease H
by Lomonosova, Elena and Daw, Jil and Garimallaprabhakaran, Aswin K and Agyemang, Nana B and Ashani, Yashkumar and Murelli, Ryan P and Tavis, John E
Antiviral Research, ISSN 0166-3542, 08/2017, Volume 144, pp. 164 - 172
Chronic Hepatitis B virus (HBV) infection is a major worldwide public health problem. Current direct-acting anti-HBV drugs target the HBV DNA polymerase... 
Antiviral | QSAR | HBV | RNaseH | Tropolones | MECHANISM | DRUG DISCOVERY | PREDICTION | MEDICINAL CHEMISTRY | IN-VITRO | REPLICATION | VIROLOGY | HYDROXYLATED TROPOLONES | REDUCTASE | PHARMACOLOGY & PHARMACY | INFECTION | MOLECULAR-DYNAMICS SIMULATIONS | Hepatitis B virus - enzymology | Cell Line | Virus Replication - drug effects | Antiviral Agents - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Tropolone - analogs & derivatives | Ribonuclease H - antagonists & inhibitors | Structure-Activity Relationship | Tropolone - pharmacology | Hepatitis B virus - physiology | Microbial Sensitivity Tests | Hepatitis B virus - drug effects | Cell Culture Techniques
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13. Full Text Compounds that select against the tetracycline-resistance efflux pump
by Stone, Laura K and Baym, Michael and Lieberman, Tami D and Chait, Remy and Clardy, Jon and Kishony, Roy
Nature Chemical Biology, ISSN 1552-4450, 11/2016, Volume 12, Issue 11, pp. 902 - 904
We developed a competition-based screening strategy to identify compounds that invert the selective advantage of antibiotic resistance. Using our assay, we... 
COMBINATIONS | FITNESS | ELEMENT | ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTIBIOTIC-RESISTANCE | STAPHYLOCOCCUS-AUREUS | MULTIDRUG-RESISTANCE | DISCOVERY | Disulfiram - chemistry | Escherichia coli - drug effects | Tropolone - analogs & derivatives | Structure-Activity Relationship | Tropolone - pharmacology | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Monoterpenes - pharmacology | Anti-Bacterial Agents - chemistry | Escherichia coli - metabolism | Escherichia coli Proteins - genetics | Monoterpenes - chemistry | Tropolone - chemistry | Anti-Bacterial Agents - pharmacology | Molecular Structure | Escherichia coli Proteins - antagonists & inhibitors | Tetracycline Resistance - drug effects | Disulfiram - pharmacology | Bacteria | Antimicrobial agents | Antibiotics | Drug resistance | Chemical compounds
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14. Full Text Anti-inflammatory effects of hinokitiol on human corneal epithelial cells: An in vitro study
by Ye, J and Xu, Y.-F and Lou, L.-X and Jin, K and Miao, Q and Ye, X and Xi, Y
Eye (Basingstoke), ISSN 0950-222X, 07/2015, Volume 29, Issue 7, pp. 964 - 971
Purpose This study assessed the anti-inflammatory effect and mechanism of action of hinokitiol in human corneal epithelial (HCE) cells. Methods HCE cells were... 
TUMOR-NECROSIS-FACTOR | INTERLEUKIN-1 RECEPTOR ANTAGONIST | 2-PERCENT REBAMIPIDE OPC-12759 | SJOGRENS-SYNDROME | OPHTHALMOLOGY | SODIUM HYALURONATE | INFLAMMATORY CYTOKINES | NF-KAPPA-B | DRY EYE SYNDROME | DIQUAFOSOL OPHTHALMIC SOLUTION | CONJUNCTIVAL EPITHELIUM | Interleukin-8 - genetics | Anti-Infective Agents - pharmacology | Humans | Dimethyl Sulfoxide - pharmacology | Gene Expression Profiling | Interleukin-1beta - genetics | Epithelium, Corneal - pathology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Monoterpenes - pharmacology | Interleukin-1beta - metabolism | Epithelium, Corneal - drug effects | Interleukin-8 - metabolism | Interleukin-6 - metabolism | Real-Time Polymerase Chain Reaction | Cell Line | NF-kappa B - antagonists & inhibitors | Poly I-C - pharmacology | Enzyme-Linked Immunosorbent Assay | Interleukin-6 - genetics | Cell Survival | RNA, Messenger - genetics | Tropolone - analogs & derivatives | Tropolone - pharmacology | Blotting, Western | Epithelium, Corneal - metabolism | Laboratory Study
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15. Full Text SIRT1, a Class III Histone Deacetylase, Regulates LPS-Induced Inflammation in Human Keratinocytes and Mediates the Anti-Inflammatory Effects of Hinokitiol
by Lee, Ju-Hee and Lee, You-Jin and Moon, Ji-Hong and Park, Sang-Youel
Journal of Investigative Dermatology, ISSN 0022-202X, 06/2017, Volume 137, Issue 6, pp. 1257 - 1266
Skin inflammation is a response of the immune system to infection and injury. In this study, we report that hinokitiol, a tropolone-related natural compound... 
REDOX REGULATION | ACETYLATION | IN-VIVO | GENE-EXPRESSION | ACUTE LUNG INJURY | BETA-THUJAPLICIN | EPIDERMAL-KERATINOCYTES | CELL-GROWTH | NF-KAPPA-B | TRANSCRIPTION FACTOR | DERMATOLOGY | Immunohistochemistry | Sirtuin 1 - metabolism | Inflammation - pathology | Cells, Cultured - drug effects | Anti-Inflammatory Agents - pharmacology | Cells, Cultured - cytology | Humans | Real-Time Polymerase Chain Reaction - methods | Tropolone - analogs & derivatives | Keratinocytes - cytology | Tropolone - pharmacology | Monoterpenes - pharmacology | Drug Interactions | Analysis of Variance | Keratinocytes - drug effects | Lipopolysaccharides - pharmacology | Sirtuin 1 - drug effects | Inflammation - prevention & control
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