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1. Full Text Recent progress in biological activities of synthesized phenothiazines
by Pluta, Krystian and Morak-Młodawska, Beata and Jeleń, Małgorzata
European journal of medicinal chemistry, ISSN 0223-5234, 2011, Volume 46, Issue 8, pp. 3179 - 3189
Multi-drug resistance | Antifungal | Antibacterial | Azaphenothiazines | Anticancer | Phenothiazines | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | General aspects | Pharmacology. Drug treatments | Bones, joints and connective tissue. Antiinflammatory agents | Biological and medical sciences | Medical sciences | Antineoplastic agents | Antibiotics. Antiinfectious agents. Antiparasitic agents | Analgesics - pharmacology | Drug Resistance, Multiple | Humans | Bacteria - drug effects | Cell Membrane Permeability | Trypanocidal Agents - chemistry | Antifungal Agents - chemistry | Structure-Activity Relationship | Anticonvulsants - pharmacology | Antiviral Agents - chemistry | Phenothiazines - pharmacology | Anti-Bacterial Agents - chemistry | Antineoplastic Agents - pharmacology | Immunosuppressive Agents - pharmacology | Antifungal Agents - pharmacology | Rabbits | Antiviral Agents - pharmacology | Anti-Inflammatory Agents - pharmacology | Solubility | Rats | Viruses - drug effects | Antineoplastic Agents - chemistry | Antimalarials - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Antipsychotic Agents - chemistry | Phenothiazines - chemistry | Trypanocidal Agents - pharmacology | Analgesics - chemistry | Anticonvulsants - chemistry | Antimalarials - chemistry | Hydrophobic and Hydrophilic Interactions | Anti-Bacterial Agents - pharmacology | Mice | Antipsychotic Agents - pharmacology | Immunosuppressive Agents - chemistry | Index Medicus
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2. Full Text 9- and 11-substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma
by Maiwald, Franziska and Benítez, Diego and Charquero, Diego and Dar, Mahin Abad and Erdmann, Hanna and Preu, Lutz and Koch, Oliver and Hölscher, Christoph and Loaëc, Nadège and Meijer, Laurent and Comini, Marcelo A and Kunick, Conrad
European journal of medicinal chemistry, ISSN 0223-5234, 08/2014, Volume 83, pp. 274 - 283
Nagana | Chalcones | Cinnamides | Trypanosoma brucei brucei | Paullones | Human trypanosomiasis | Cell Line | Humans | Trypanocidal Agents - toxicity | Trypanocidal Agents - chemistry | Structure-Activity Relationship | Benzazepines - pharmacology | Benzazepines - chemical synthesis | Trypanosoma brucei brucei - drug effects | Trypanosoma brucei brucei - physiology | Trypanosomiasis, African - parasitology | Animals | Trypanocidal Agents - pharmacology | Drug Design | Trypanocidal Agents - chemical synthesis | Macrophages - drug effects | Cell Proliferation - drug effects | Mice | Benzazepines - toxicity | Benzazepines - chemistry | Substitution reactions | Antiparasitic agents | Livestock | Index Medicus | Trypanocidal Agents/chemistry | Trypanocidal Agents/chemical synthesis | Trypanosoma brucei brucei/drug effects | Trypanocidal Agents/pharmacology | Biochemistry, Molecular Biology | Benzazepines/pharmacology | Trypanosomiasis, African/parasitology | Life Sciences | Benzazepines/toxicity | Macrophages/drug effects | Benzazepines/chemistry | Trypanosoma brucei brucei/physiology | Trypanocidal Agents/toxicity | Cell Proliferation/drug effects | Benzazepines/chemical synthesis
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3. Full Text Drug Strategies Targeting CYP51 in Neglected Tropical Diseases
by Choi, Jun Yong and Podust, Larissa M and Roush, William R
Chemical reviews, ISSN 0009-2665, 11/2014, Volume 114, Issue 22, pp. 11242 - 11271
Physical Sciences | Chemistry | Chemistry, Multidisciplinary | Science & Technology | Antifungal Agents - pharmacology | 14-alpha Demethylase Inhibitors - chemistry | Humans | Trypanocidal Agents - chemistry | Antifungal Agents - chemistry | Antifungal Agents - therapeutic use | Animals | 14-alpha Demethylase Inhibitors - pharmacology | Trypanocidal Agents - pharmacology | Chagas Disease - drug therapy | Trypanocidal Agents - therapeutic use | 14-alpha Demethylase Inhibitors - therapeutic use | Tropical Medicine | Antimitotic agents | Drug therapy | Antineoplastic agents | Health aspects | Tropical diseases | Antifungal agents | Medical research | Index Medicus | Review
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4. Full Text Cloning, Characterization, and Sulfonamide and Thiol Inhibition Studies of an α‑Carbonic Anhydrase from Trypanosoma cruzi, the Causative Agent of Chagas Disease
by Pan, Peiwen and Vermelho, Alane Beatriz and Capaci Rodrigues, Giseli and Scozzafava, Andrea and Tolvanen, Martti E. E and Parkkila, Seppo and Capasso, Clemente and Supuran, Claudiu T
Journal of medicinal chemistry, ISSN 0022-2623, 02/2013, Volume 56, Issue 4, pp. 1761 - 1771
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Chagas Disease - parasitology | Sulfhydryl Compounds - pharmacology | Carbonic Anhydrase Inhibitors - chemistry | Protozoan Proteins - antagonists & inhibitors | Carbonic Anhydrases - genetics | Humans | Molecular Sequence Data | Trypanocidal Agents - chemistry | Structure-Activity Relationship | Phylogeny | Carbonic Anhydrases - chemistry | Protozoan Proteins - genetics | Trypanosoma cruzi - enzymology | Thiadiazoles - chemistry | Cloning, Molecular | Protozoan Proteins - chemistry | Sulfhydryl Compounds - chemistry | Thiadiazoles - pharmacology | Amino Acid Sequence | Sulfonamides - chemistry | Carbonic Anhydrase Inhibitors - chemical synthesis | Carbonic Anhydrase Inhibitors - pharmacology | Sulfhydryl Compounds - chemical synthesis | Sulfonamides - pharmacology | Sulfonamides - chemical synthesis | Thiadiazoles - chemical synthesis | Trypanocidal Agents - pharmacology | Trypanocidal Agents - chemical synthesis | Trypanosoma cruzi - drug effects | Index Medicus
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5. Full Text Novel Antitrypanosomal Agents Based on Palladium Nitrofurylthiosemicarbazone Complexes:  DNA and Redox Metabolism as Potential Therapeutic Targets
by Otero, Lucía and Vieites, Marisol and Boiani, Lucía and Denicola, Ana and Rigol, Carolina and Opazo, Lucía and Olea-Azar, Claudio and Maya, Juan Diego and Morello, Antonio and Krauth-Siegel, R. Luise and Piro, Oscar E and Castellano, Eduardo and González, Mercedes and Gambino, Dinorah and Cerecetto, Hugo
Journal of medicinal chemistry, ISSN 0022-2623, 06/2006, Volume 49, Issue 11, pp. 3322 - 3331
Biological and medical sciences | Antiparasitic agents | Medical sciences | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Oxidative Stress | Dimethyl Sulfoxide - chemistry | Crystallography, X-Ray | Trypanocidal Agents - chemistry | Structure-Activity Relationship | Nitrofurans - pharmacology | Spectroscopy, Fourier Transform Infrared | Thiosemicarbazones - chemistry | Free Radicals - metabolism | Spectrum Analysis, Raman | Molecular Structure | Thiosemicarbazones - pharmacology | Nitrofurans - chemistry | Electron Spin Resonance Spectroscopy | Magnetic Resonance Spectroscopy | Oxidation-Reduction | Trypanosoma cruzi - metabolism | Thiosemicarbazones - chemical synthesis | Palladium | Nitrofurans - chemical synthesis | DNA - chemistry | Animals | Trypanocidal Agents - pharmacology | Organometallic Compounds - chemical synthesis | Electrochemistry | Trypanocidal Agents - chemical synthesis | Trypanosoma cruzi - drug effects | Ligands | Organometallic Compounds - chemistry | NADH, NADPH Oxidoreductases - antagonists & inhibitors | Organometallic Compounds - pharmacology | Index Medicus
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6. Full Text Individual and combined antiparasitic effect of six plant metabolites against Leishmania amazonensis and Trypanosoma cruzi
by Sandjo, Louis P and de Moraes, Milene H and Kuete, Victor and Kamdoum, Blaise C and Ngadjui, Bonaventure T and Steindel, Mario
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 04/2016, Volume 26, Issue 7, pp. 1772 - 1775
Antiparasitic effect | Secondary metabolites | Activity in combination | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Chalcones - chemistry | Plant Extracts - chemistry | Plant Extracts - pharmacology | Humans | Trypanocidal Agents - chemistry | Structure-Activity Relationship | Flavanones - chemistry | Chalcones - pharmacology | Plants - chemistry | Leishmania mexicana - drug effects | Alkaloids - pharmacology | Flavanones - pharmacology | Zanthoxylum - chemistry | Antiprotozoal Agents - chemistry | Leishmaniasis, Cutaneous - drug therapy | Antiprotozoal Agents - pharmacology | Trypanocidal Agents - pharmacology | Antiparasitic Agents - pharmacology | Chagas Disease - drug therapy | Trypanosoma cruzi - drug effects | Moraceae - chemistry | Anthraquinones - pharmacology | Anthraquinones - chemistry | Alkaloids - chemistry | Antiparasitic Agents - chemistry | Rubiaceae - chemistry | Plant metabolites | Index Medicus
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7. Full Text 3-Trifluoromethylquinoxaline N,N′-Dioxides as Anti-Trypanosomatid Agents. Identification of Optimal Anti-T. cruzi Agents and Mechanism of Action Studies
by Benitez, Diego and Cabrera, Mauricio and Hernández, Paola and Boiani, Lucía and Lavaggi, María L and Di Maio, Rossanna and Yaluff, Gloria and Serna, Elva and Torres, Susana and Ferreira, María E and Vera de Bilbao, Ninfa and Torres, Enrique and Pérez-Silanes, Silvia and Solano, Beatriz and Moreno, Elsa and Aldana, Ignacio and López de Ceráin, Adela and Cerecetto, Hugo and González, Mercedes and Monge, Antonio
Journal of medicinal chemistry, ISSN 0022-2623, 05/2011, Volume 54, Issue 10, pp. 3624 - 3636
Chemistry, Pharmaceutical - methods | Models, Chemical | Trypanosoma cruzi - metabolism | Humans | Quinoxalines - chemistry | Parasitemia - drug therapy | Quinoxalines - pharmacology | Cyclic N-Oxides - chemistry | Animals | Trypanocidal Agents - pharmacology | Mutagenicity Tests | Drug Design | Inhibitory Concentration 50 | Mice | Quinoxalines - chemical synthesis | Toxicity Tests | Electrons | Index Medicus
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8. Full Text An efficient synthesis of new caffeine-based chalcones, pyrazolines and pyrazolo[3,4-b][1,4]diazepines as potential antimalarial, antitrypanosomal and antileishmanial agents
by Insuasty, Braulio and Ramírez, Juan and Becerra, Diana and Echeverry, Carlos and Quiroga, Jairo and Abonia, Rodrigo and Robledo, Sara M and Vélez, Iván Darío and Upegui, Yulieth and Muñoz, July A and Ospina, Victoria and Nogueras, Manuel and Cobo, Justo
European journal of medicinal chemistry, ISSN 0223-5234, 03/2015, Volume 93, pp. 401 - 413
Chalcones | Antimicrobial activity | Pyrazolines | Diazepines | Caffeine | Chalcones - chemistry | Chemistry Techniques, Synthetic | Humans | Trypanocidal Agents - toxicity | Trypanocidal Agents - chemistry | Caffeine - toxicity | Structure-Activity Relationship | Plasmodium falciparum - drug effects | Antimalarials - pharmacology | Pyrazoles - chemistry | Azepines - chemistry | Trypanocidal Agents - pharmacology | U937 Cells | Caffeine - chemistry | Antimalarials - chemistry | Caffeine - pharmacology | Inhibitory Concentration 50 | Leishmania - drug effects | Trypanocidal Agents - chemical synthesis | Trypanosoma cruzi - drug effects | Caffeine - chemical synthesis | Antimalarials - toxicity | Antimalarials - chemical synthesis | Malaria | Formic acid | Organic acids | Resveratrol | Index Medicus
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9. Full Text Design, synthesis and cruzain docking of 3-(4-substituted-aryl)-1,2,4-oxadiazole- N-acylhydrazones as anti- Trypanosoma cruzi agents
by dos Santos Filho, José Mauricio and Leite, Ana Cristina Lima and Oliveira, Boaz Galdino de and Moreira, Diogo Rodrigo Magalhães and Lima, Milena S and Soares, Milena Botelho Pereira and Leite, Lucia Fernanda C.C
Bioorganic & medicinal chemistry, ISSN 0968-0896, 2009, Volume 17, Issue 18, pp. 6682 - 6691
Cruzain | Oxadiazole | Privileged structures | Molecular docking | Trypanosoma cruzi | N-Acylhydrazone | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Antiparasitic agents | Medical sciences | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Cysteine Endopeptidases - chemistry | Oxadiazoles - administration & dosage | Parasitic Sensitivity Tests | Trypanocidal Agents - chemistry | Structure-Activity Relationship | Cysteine Endopeptidases - metabolism | Protozoan Proteins - metabolism | Oxadiazoles - pharmacology | Protozoan Proteins - chemistry | Oxadiazoles - chemistry | Trypanocidal Agents - administration & dosage | Cell Survival - drug effects | Oxadiazoles - chemical synthesis | Trypanosoma cruzi - metabolism | Hydrazones - administration & dosage | Models, Molecular | Hydrazones - chemical synthesis | Spleen - cytology | Hydrazones - chemistry | Hydrazones - pharmacology | Animals | Trypanocidal Agents - pharmacology | Chagas Disease - drug therapy | Protein Binding | Trypanocidal Agents - chemical synthesis | Trypanosoma cruzi - drug effects | Mice | Mice, Inbred BALB C | Lead compounds | Index Medicus
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10. Full Text Design, Synthesis, and Evaluation of Hydroxamic Acid Derivatives as Promising Agents for the Management of Chagas Disease
by Rodrigues, Giseli Capaci and Feijó, Daniel Ferreira and Bozza, Marcelo Torres and Pan, Peiwen and Vullo, Daniela and Parkkila, Seppo and Supuran, Claudiu T and Capasso, Clemente and Aguiar, Alcino Palermo and Vermelho, Alane Beatriz
Journal of medicinal chemistry, ISSN 0022-2623, 01/2014, Volume 57, Issue 2, pp. 298 - 308
Chagas Disease - parasitology | Carbonic Anhydrase Inhibitors - chemistry | Humans | Hydroxamic Acids - chemistry | Trypanocidal Agents - chemistry | Structure-Activity Relationship | Isoxazoles - chemical synthesis | Trypanosoma cruzi - enzymology | Carbonic Anhydrases - metabolism | Protease Inhibitors - pharmacology | Isoenzymes - metabolism | Drug Design | Hydroxamic Acids - pharmacology | Macrophages, Peritoneal - drug effects | Peptide Hydrolases - metabolism | Protease Inhibitors - chemistry | Carbonic Anhydrase Inhibitors - chemical synthesis | Carbonic Anhydrase Inhibitors - pharmacology | Isoxazoles - chemistry | Macrophages, Peritoneal - parasitology | Isoxazoles - pharmacology | Animals | Trypanosoma cruzi - growth & development | Trypanocidal Agents - pharmacology | Chagas Disease - drug therapy | Cell Line, Tumor | Trypanocidal Agents - chemical synthesis | Trypanosoma cruzi - drug effects | Mice | Mice, Inbred BALB C | Protease Inhibitors - chemical synthesis | Hydroxamic Acids - chemical synthesis | Isoenzymes - antagonists & inhibitors | Index Medicus
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11. Full Text Novel 3‑Nitrotriazole-Based Amides and Carbinols as Bifunctional Antichagasic Agents
by Papadopoulou, Maria V and Bloomer, William D and Lepesheva, Galina I and Rosenzweig, Howard S and Kaiser, Marcel and Aguilera-Venegas, Benjamín and Wilkinson, Shane R and Chatelain, Eric and Ioset, Jean-Robert
Journal of medicinal chemistry, ISSN 0022-2623, 02/2015, Volume 58, Issue 3, pp. 1307 - 1319
Amides - pharmacology | Cell Line | Chagas Disease - parasitology | Parasitic Sensitivity Tests | Methanol - pharmacology | Amides - chemical synthesis | Triazoles - chemistry | Rats | Trypanocidal Agents - chemistry | Methanol - analogs & derivatives | Structure-Activity Relationship | Dose-Response Relationship, Drug | Animals | Trypanocidal Agents - pharmacology | Chagas Disease - drug therapy | Amides - chemistry | Trypanocidal Agents - chemical synthesis | Trypanosoma cruzi - drug effects | Mice | Mice, Inbred BALB C | Molecular Structure | Trypanosoma brucei rhodesiense - drug effects | Methanol - chemistry | Index Medicus
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12. Full Text Facile Synthesis of a Series of Non-Symmetric Thioethers Including a Benzothiazole Moiety and Their Use as Efficient In Vitro anti-Trypanosoma cruzi Agents
by Avila-Sorrosa, Alcives and Tapia-Alvarado, Jazz D and Nogueda-Torres, Benjamin and Fabiola Chacon-Vargas, Karla and Diaz-Cedillo, Francisco and Elena Vargas-Diaz, Maria and Morales-Morales, David
Molecules (Basel, Switzerland), ISSN 1420-3049, 09/2019, Volume 24, Issue 17, p. 3077
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Chemistry Techniques, Synthetic | Parasitic Sensitivity Tests | Trypanocidal Agents - pharmacology | Sulfides - chemistry | Benzothiazoles - chemistry | Inhibitory Concentration 50 | Trypanosoma cruzi - drug effects | Trypanocidal Agents - chemistry | Molecular Structure | Structure-Activity Relationship | Sulfides - pharmacology | Protons | Drugs | Protozoa | Nuclear magnetic resonance--NMR | Fluorine | Benzothiazole | Parasite resistance | Cytotoxicity | Spectra | Parasites | Drug development | Mammals | Organic chemistry | Side effects | Synthesis | Aromatic compounds | Benzene | ThioeThers | Scientific imaging | Diagnostic systems | Mass spectrometry | Index Medicus | Chagas disease | neglected diseases | benzothiazole derivatives | non-symmetric thioethers | Trypanosoma cruzi
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