X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (1560) 1560
Publication (227) 227
Book Review (25) 25
Book Chapter (17) 17
Conference Proceeding (7) 7
Book / eBook (1) 1
Data Set (1) 1
Magazine Article (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (1186) 1186
trypanocidal agents - pharmacology (1040) 1040
index medicus (783) 783
humans (648) 648
trypanosoma cruzi - drug effects (466) 466
mice (462) 462
trypanocidal agents - chemistry (458) 458
trypanosoma brucei brucei - drug effects (353) 353
pharmacology & pharmacy (335) 335
chemistry, medicinal (334) 334
parasitology (326) 326
biochemistry & molecular biology (319) 319
trypanocidal agents - therapeutic use (305) 305
chagas disease - drug therapy (260) 260
trypanosomiasis, african - drug therapy (260) 260
chagas-disease (251) 251
trypanosoma cruzi (238) 238
microbiology (229) 229
structure-activity relationship (225) 225
in-vitro (224) 224
chemotherapy (216) 216
parasitic diseases (216) 216
trypanocidal agents - chemical synthesis (215) 215
female (201) 201
male (201) 201
drugs (180) 180
trypanocidal agents - metabolism (158) 158
trypanosoma cruzi - enzymology (149) 149
drug design (147) 147
benznidazole (146) 146
chagas disease (146) 146
parasites (141) 141
drug resistance (139) 139
protozoan proteins - metabolism (137) 137
rats (136) 136
chagas' disease (134) 134
metabolism (134) 134
trypanosoma brucei brucei - enzymology (134) 134
trypanosoma brucei brucei - metabolism (134) 134
trypanosoma-cruzi (133) 133
cell line (132) 132
parasitic sensitivity tests (132) 132
trypanosoma brucei (131) 131
molecular structure (130) 130
human african trypanosomiasis (129) 129
inhibitors (123) 123
dose-response relationship, drug (122) 122
drug discovery (122) 122
trypanocidal agents - pharmacokinetics (122) 122
enzyme inhibitors - pharmacology (121) 121
trypanocidal activity (121) 121
models, molecular (118) 118
chagas disease - parasitology (117) 117
derivatives (116) 116
analysis (111) 111
trypanosomiasis, african - parasitology (111) 111
tropical medicine (110) 110
nitroimidazoles - pharmacology (107) 107
trypanosoma cruzi - metabolism (106) 106
trypanosomiasis (106) 106
chemistry, organic (105) 105
inhibitory concentration 50 (103) 103
kinetics (101) 101
sleeping sickness (101) 101
research article (96) 96
trypanosoma - drug effects (94) 94
trypanocidal agents - administration & dosage (93) 93
mice, inbred balb c (92) 92
blood-stream forms (91) 91
nifurtimox (90) 90
article (87) 87
trypanosoma cruzi - growth & development (87) 87
brucei (86) 86
african trypanosomiasis (85) 85
enzymes (82) 82
disease models, animal (81) 81
cells, cultured (76) 76
protozoa (75) 75
resistance (75) 75
african trypanosomes (74) 74
trypanocidal agents - toxicity (74) 74
research (73) 73
identification (72) 72
cells (70) 70
protozoan proteins - antagonists & inhibitors (70) 70
proteins (69) 69
leishmania (68) 68
trypanosoma brucei brucei - growth & development (67) 67
time factors (65) 65
trypanosomiasis - drug therapy (65) 65
trypanothione reductase (65) 65
cell survival - drug effects (64) 64
inhibition (64) 64
trypanosoma (64) 64
cattle (63) 63
enzyme inhibitors - chemistry (62) 62
infectious diseases (62) 62
molecular sequence data (62) 62
tropical diseases (62) 62
cancer (61) 61
more...
Library Location Library Location
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 44, pp. 18344 - 18353
Apolipoprotein L1 (ApoL1) is a human serum protein conferring resistance to African trypanosomes, and certain ApoL1 variants increase susceptibility to some... 
membrane transporter reconstitution | TRYPANOSOME LYTIC FACTOR | KIDNEY-DISEASE | INSERTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIPID-BINDING PROTEIN | MEMBRANES | AUTOPHAGIC CELL-DEATH | APOL1 RISK VARIANTS | ApoL1 | COLICIN IA | phospholipid vesicle | nephrology | CHANNEL | chloride channel | potassium channel | apolipoprotein L1 | EXPRESSION | Potassium - metabolism | Apolipoprotein L1 - chemistry | Recombinant Fusion Proteins - pharmacology | Cell Membrane Permeability | Fluorescence | Trypanocidal Agents - chemistry | Unilamellar Liposomes - chemistry | Phosphatidylcholines - metabolism | Recombinant Fusion Proteins - metabolism | Cell Membrane - chemistry | Biological Transport | Cell Membrane - metabolism | Protein Stability | Trypanosoma brucei brucei - growth & development | Calcium Signaling | Trypanocidal Agents - metabolism | Cetylpyridinium - metabolism | Apolipoprotein L1 - metabolism | Phosphatidylserines - metabolism | Phosphatidylserines - chemistry | Models, Molecular | Apolipoprotein L1 - genetics | Lethal Dose 50 | Phosphatidylcholines - chemistry | Recombinant Fusion Proteins - chemistry | Apolipoprotein L1 - pharmacology | Trypanosoma brucei brucei - drug effects | Potassium - chemistry | Unilamellar Liposomes - metabolism | Phosphatidic Acids - chemistry | Trypanocidal Agents - pharmacology | Cetylpyridinium - chemistry | Phosphatidic Acids - metabolism | Phosphatidylethanolamines - metabolism | Phosphatidylethanolamines - chemistry | Hydrogen-Ion Concentration | Membrane Biology
Journal Article
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 05/2012, Volume 19, Issue 14, pp. 2176 - 2228
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2016, Volume 121, pp. 387 - 398
Journal Article
PLoS Pathogens, ISSN 1553-7366, 2014, Volume 10, Issue 5, p. e1004114
Trypanosomatid parasites are the causative agents of many neglected tropical diseases and there is currently considerable interest in targeting endogenous... 
MECHANISM | NITROGEN-CONTAINING BISPHOSPHONATES | TRYPANOSOMA-CRUZI | MICROBIOLOGY | CRYSTALLOGRAPHY | MODEL | FARNESYL DIPHOSPHATE SYNTHASE | IN-VITRO | VIROLOGY | ISOPRENOID BIOSYNTHESIS | INHIBITORS | CHOLESTEROL-BIOSYNTHESIS | PARASITOLOGY | Polyisoprenyl Phosphates - chemistry | Sesquiterpenes - metabolism | Humans | Cercopithecus aethiops | Crystallography, X-Ray | Trypanocidal Agents - chemistry | Trypanosoma cruzi - enzymology | Farnesyl-Diphosphate Farnesyltransferase - chemistry | Enzyme Inhibitors - chemistry | Trypanocidal Agents - therapeutic use | Vero Cells | Molecular Targeted Therapy - methods | Trypanocidal Agents - metabolism | Sesquiterpenes - chemistry | Enzyme Inhibitors - metabolism | Quinuclidines - pharmacology | Enzyme Inhibitors - pharmacology | Models, Molecular | Diphosphonates - metabolism | Enzyme Inhibitors - therapeutic use | Polyisoprenyl Phosphates - metabolism | Farnesyl-Diphosphate Farnesyltransferase - metabolism | Animals | Trypanocidal Agents - pharmacology | Farnesyl-Diphosphate Farnesyltransferase - antagonists & inhibitors | Diphosphonates - chemistry | Chagas Disease - drug therapy | Protein Binding | Quinuclidines - chemistry | Quinuclidines - metabolism | Diphosphonates - pharmacology | Phosphonates | Physiological aspects | Squalene | Chagas' disease | Diagnosis | Research | Drug therapy | Health aspects | Research & development | Protozoa | R&D | Disease | Sterols | Ligands | Biosynthesis | Parasites | Tropical diseases | Cholesterol
Journal Article
PLoS Pathogens, ISSN 1553-7366, 12/2009, Volume 5, Issue 12, pp. e1000685 - e1000685
Apolipoprotein L-I (apoL1) is a human-specific serum protein that kills Trypanosoma brucei through ionic pore formation in endosomal membranes of the parasite.... 
PROTEIN | MICROBIOLOGY | HYDROPHOBIC CLUSTER-ANALYSIS | HUMAN SERUM | VIROLOGY | GENE | BLOOD-STREAM FORMS | LYTIC FACTOR | RESISTANCE | GAMBIENSE | EXPRESSION | CULTIVATION | PARASITOLOGY | Trypanosoma brucei rhodesiense - physiology | Pore Forming Cytotoxic Proteins - genetics | Lipoproteins, HDL - genetics | Membrane Glycoproteins - metabolism | Humans | Lipoproteins, HDL - metabolism | Molecular Sequence Data | Lipoproteins, HDL - pharmacology | Trypanosoma brucei brucei - physiology | Thermodynamics | Protozoan Proteins - metabolism | Trypanosoma brucei rhodesiense - metabolism | Apolipoproteins - genetics | DNA Mutational Analysis | Amino Acid Sequence | Cell Survival - drug effects | Trypanocidal Agents - metabolism | Pore Forming Cytotoxic Proteins - metabolism | Trypanosoma brucei brucei - metabolism | Apolipoproteins - pharmacology | Apolipoproteins - metabolism | Mice, Transgenic | Papio anubis | Lipoproteins, HDL - physiology | Leucine Zippers - genetics | Sequence Alignment | Animals | Trypanocidal Agents - pharmacology | Apolipoprotein L1 | Pore Forming Cytotoxic Proteins - pharmacology | Protein Binding | Mice | Mutation | Apolipoproteins - physiology | Genetic aspects | Research | Gene mutations | Apolipoproteins | Trypanosoma brucei | Health aspects | Proteins | Cluster analysis | Enzymes | E coli | Cloning | Parasites | Gene expression | Experiments
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2018, Volume 61, Issue 13, pp. 5643 - 5663
Journal Article
Journal Article
Mini-Reviews in Medicinal Chemistry, ISSN 1389-5575, 11/2016, Volume 16, Issue 17, pp. 1374 - 1391
Journal Article
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 2017, Volume 45, Issue 14, pp. 8378 - 8391
Journal Article
Molecular Microbiology, ISSN 0950-382X, 11/2013, Volume 90, Issue 4, pp. 665 - 679
Journal Article