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European journal of medicinal chemistry, ISSN 0223-5234, 2011, Volume 46, Issue 8, pp. 3179 - 3189
This review summarizes recent medicinal chemistry investigations in vitro and in vivo in search for new phenothiazines of promising biological activities. New... 
Multi-drug resistance | Antifungal | Antibacterial | Azaphenothiazines | Anticancer | Phenothiazines | DESIGN | CHEMISTRY, MEDICINAL | 10H-PHENOTHIAZINES | ANTITUMOR-ACTIVITY | ANTICANCER ACTIVITY | INHIBITION | RIBOFURANOSIDES | ANTITUBERCULAR ACTIVITY | DERIVATIVES | ANTIMICROBIAL ACTIVITY | Analgesics - pharmacology | Drug Resistance, Multiple | Humans | Bacteria - drug effects | Cell Membrane Permeability | Trypanocidal Agents - chemistry | Antifungal Agents - chemistry | Structure-Activity Relationship | Anticonvulsants - pharmacology | Antiviral Agents - chemistry | Phenothiazines - pharmacology | Anti-Bacterial Agents - chemistry | Antineoplastic Agents - pharmacology | Immunosuppressive Agents - pharmacology | Antifungal Agents - pharmacology | Rabbits | Antiviral Agents - pharmacology | Anti-Inflammatory Agents - pharmacology | Solubility | Rats | Viruses - drug effects | Antineoplastic Agents - chemistry | Antimalarials - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Antipsychotic Agents - chemistry | Phenothiazines - chemistry | Trypanocidal Agents - pharmacology | Analgesics - chemistry | Anticonvulsants - chemistry | Antimalarials - chemistry | Hydrophobic and Hydrophilic Interactions | Anti-Bacterial Agents - pharmacology | Mice | Antipsychotic Agents - pharmacology | Immunosuppressive Agents - chemistry
Journal Article
BMC complementary and alternative medicine, ISSN 1472-6882, 2017, Volume 17, Issue 1, pp. 386 - 16
Background: Plants have served either as a natural templates for the development of new chemicals or a phytomedicine since antiquity. Therefore, the present... 
Cytotoxicity | Antileishmanial | Protein kinase inhibition | Antioxidant | Hep G2 | THP-1 leukemia cell line | ANTIOXIDANT ACTIVITY | PHENOLIC-COMPOUNDS | EXTRACTION SOLVENTS | POLYPHENOLS | GALLIC ACID | ANTIBACTERIAL ACTIVITY | INTEGRATIVE & COMPLEMENTARY MEDICINE | DNA | MEDICINAL-PLANTS | Phenols - isolation & purification | Plant Extracts - chemistry | Plant Extracts - pharmacology | Humans | Flavonoids - therapeutic use | Leishmania - drug effects | Flavonoids - pharmacology | Phytotherapy | Antineoplastic Agents, Phytogenic - therapeutic use | Phenols - pharmacology | Antifungal Agents - pharmacology | alpha-Amylases - antagonists & inhibitors | Solvents | Plant Components, Aerial | Antioxidants - pharmacology | Herbal Medicine | Hep G2 Cells | Hypoglycemic Agents - pharmacology | Neoplasms - drug therapy | Antioxidants - therapeutic use | Trypanocidal Agents - pharmacology | Phenols - therapeutic use | Anti-Bacterial Agents - pharmacology | Flavonoids - isolation & purification | Protein Kinase Inhibitors - pharmacology | Streptomyces - drug effects | Antineoplastic Agents, Phytogenic - pharmacology | Medicine, Traditional | Plant Extracts - therapeutic use | Quercus - chemistry | Medicinal plants | Antioxidants | Usage | Analysis | Medicine, Botanic | Medicine, Herbal | Protein kinases | Health aspects | Fungicides | Glucose kinase | Salt water | Lethality | Glucose | Assaying | Artemia | Coumaric acid | Antifungal activity | Polyphenols | Inhibition | Caffeine | Methanol | Free radicals | Gallic acid | Distilled water | Ethyl acetate | Liquid chromatography | Chemicals | Flavonoids | Minimum inhibitory concentration | Acetic acid | In vitro methods and tests | Toxicity | Colorimetry | Optimization | Metabolites | Polarity | Food | Plants (botany) | Catechin | Chloroform | Diabetes mellitus | Antimicrobial agents | Chlorogenic acid | Pharmacology | Tumor cell lines | High-performance liquid chromatography | Ferulic acid | Herbal medicine | Tea | Amylases | Acids | Protein kinase | Phenols | Cancer | Acetone
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 01/2014, Volume 57, Issue 2, pp. 298 - 308
Journal Article
Journal of inorganic biochemistry, ISSN 0162-0134, 2017, Volume 175, pp. 154 - 166
Journal Article
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 06/2006, Volume 49, Issue 11, pp. 3322 - 3331
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 04/2013, Volume 57, Issue 4, pp. 1638 - 1647
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 12/2012, Volume 55, Issue 24, pp. 10918 - 10936
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 09/2013, Volume 57, Issue 9, pp. 4151 - 4163
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 2/2008, Volume 105, Issue 5, pp. 1448 - 1453
Pteridine reductase (PTR1) is essential for salvage of pterins by parasitic trypanosomatids and is a target for the development of improved therapies. To... 
Enzymes | Molecules | Active sites | Folic acid antagonists | Libraries | Infections | Parasites | Amastigotes | Pteridines | Vero cells | Antifolates | Antitrypanosomatid agents | Drug discovery | THYMIDYLATE SYNTHASE | TRYPANOSOMA-CRUZI | CRYSTAL-STRUCTURE | PTR1 | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | ANTIFOLATE METHOTREXATE | PARASITE LEISHMANIA-MAJOR | antitrypanosomatid agents | drug discovery | PURIFICATION | DIHYDROFOLATE-REDUCTASE | RESISTANCE | antifolates | Oxidoreductases - antagonists & inhibitors | Isonipecotic Acids - chemistry | Parasitic Sensitivity Tests | Isonipecotic Acids - pharmacology | Protozoan Proteins - antagonists & inhibitors | Pteridines - chemistry | Crystallography, X-Ray | Trypanocidal Agents - chemistry | Tetrahydrofolate Dehydrogenase - drug effects | Oxidoreductases - chemistry | Trypanosoma cruzi - enzymology | Enzyme Inhibitors - chemistry | Drug Design | Protozoan Proteins - chemistry | Drug Evaluation, Preclinical | Pteridines - pharmacology | Leishmania major - drug effects | Enzyme Inhibitors - pharmacology | Folic Acid - chemistry | Antiprotozoal Agents - chemistry | Antiprotozoal Agents - pharmacology | Animals | Leishmania major - enzymology | Trypanocidal Agents - pharmacology | Trypanosoma cruzi - drug effects | Thymidylate Synthase - antagonists & inhibitors | Pharmaceutical research | Enzyme inhibitors | Antiparasitic agents | Product development | Research | Oxidoreductases | Chemical properties | Methods | Index Medicus | Biological Sciences
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