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European Journal of Medicinal Chemistry, ISSN 0223-5234, 2011, Volume 46, Issue 8, pp. 3179 - 3189
This review summarizes recent medicinal chemistry investigations in vitro and in vivo in search for new phenothiazines of promising biological activities. New... 
Multi-drug resistance | Antifungal | Antibacterial | Azaphenothiazines | Anticancer | Phenothiazines | CHEMISTRY, MEDICINAL | MUSTARD TYPE PHENOTHIAZINES | SULFONE DERIVATIVES | ANTITUMOR-ACTIVITY | ANTICANCER ACTIVITY | ANTIMICROBIAL ACTIVITIES | RIBOFURANOSIDES | N-ACYLPHENOTHIAZINES | ANTITUBERCULAR ACTIVITY | INHIBITORS | MULTIDRUG-RESISTANCE | Analgesics - pharmacology | Drug Resistance, Multiple | Humans | Bacteria - drug effects | Cell Membrane Permeability | Trypanocidal Agents - chemistry | Antifungal Agents - chemistry | Structure-Activity Relationship | Anticonvulsants - pharmacology | Antiviral Agents - chemistry | Phenothiazines - pharmacology | Anti-Bacterial Agents - chemistry | Antineoplastic Agents - pharmacology | Immunosuppressive Agents - pharmacology | Antifungal Agents - pharmacology | Rabbits | Antiviral Agents - pharmacology | Anti-Inflammatory Agents - pharmacology | Solubility | Rats | Viruses - drug effects | Antineoplastic Agents - chemistry | Antimalarials - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Antipsychotic Agents - chemistry | Phenothiazines - chemistry | Trypanocidal Agents - pharmacology | Analgesics - chemistry | Anticonvulsants - chemistry | Antimalarials - chemistry | Hydrophobic and Hydrophilic Interactions | Anti-Bacterial Agents - pharmacology | Mice | Antipsychotic Agents - pharmacology | Immunosuppressive Agents - chemistry
Journal Article
BMC Complementary and Alternative Medicine, ISSN 1472-6882, 08/2017, Volume 17, Issue 1, pp. 386 - 16
Background: Plants have served either as a natural templates for the development of new chemicals or a phytomedicine since antiquity. Therefore, the present... 
Cytotoxicity | Antileishmanial | Protein kinase inhibition | Antioxidant | Hep G2 | THP-1 leukemia cell line | ANTIOXIDANT ACTIVITY | PHENOLIC-COMPOUNDS | EXTRACTION SOLVENTS | POLYPHENOLS | GALLIC ACID | ANTIBACTERIAL ACTIVITY | INTEGRATIVE & COMPLEMENTARY MEDICINE | DNA | MEDICINAL-PLANTS | Phenols - isolation & purification | Plant Extracts - chemistry | Plant Extracts - pharmacology | Humans | Flavonoids - therapeutic use | Leishmania - drug effects | Flavonoids - pharmacology | Phytotherapy | Antineoplastic Agents, Phytogenic - therapeutic use | Phenols - pharmacology | Antifungal Agents - pharmacology | alpha-Amylases - antagonists & inhibitors | Solvents | Plant Components, Aerial | Antioxidants - pharmacology | Herbal Medicine | Hep G2 Cells | Hypoglycemic Agents - pharmacology | Neoplasms - drug therapy | Antioxidants - therapeutic use | Trypanocidal Agents - pharmacology | Phenols - therapeutic use | Anti-Bacterial Agents - pharmacology | Flavonoids - isolation & purification | Protein Kinase Inhibitors - pharmacology | Streptomyces - drug effects | Antineoplastic Agents, Phytogenic - pharmacology | Medicine, Traditional | Plant Extracts - therapeutic use | Quercus - chemistry | Medicinal plants | Antioxidants | Usage | Analysis | Medicine, Botanic | Medicine, Herbal | Protein kinases | Health aspects | Fungicides | Glucose kinase | Salt water | Lethality | Glucose | Assaying | Artemia | Coumaric acid | Antifungal activity | Polyphenols | Inhibition | Caffeine | Methanol | Free radicals | Gallic acid | Distilled water | Ethyl acetate | Liquid chromatography | Chemicals | Flavonoids | Minimum inhibitory concentration | Acetic acid | In vitro methods and tests | Toxicity | Colorimetry | Optimization | Metabolites | Polarity | Food | Plants (botany) | Catechin | Chloroform | Diabetes mellitus | Antimicrobial agents | Chlorogenic acid | Pharmacology | Tumor cell lines | High-performance liquid chromatography | Ferulic acid | Herbal medicine | Tea | Amylases | Acids | Protein kinase | Phenols | Cancer | Acetone
Journal Article
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2017, Volume 40, Issue 11, pp. 1941 - 1947
Journal Article
Journal Article
Journal of Inorganic Biochemistry, ISSN 0162-0134, 09/2015, Volume 150, pp. 38 - 47
Journal Article
by Najib M. El-Sayed and Peter J. Myler and Daniella C. Bartholomeu and Daniel Nilsson and Gautam Aggarwal and Anh-Nhi Tran and Elodie Ghedin and Elizabeth A. Worthey and Arthur L. Delcher and Gaëlle Blandin and Scott J. Westenberger and Elisabet Caler and Gustavo C. Cerqueira and Carole Branched Brian Haas and Atashi Anupama and Erik Arner and Lena Åslund and Philip Attipoe and Esteban Bontempi and Frédéric Bringaud and Peter Burton and Eithon Cadag and David A. Campbell and Mark Carrington and Jonathan Crabtree and Hamid Darban and Jose Franco da Silveira and Pieter de Jong and Kimberly Edwards and Paul T. Englund and Gholam Fazelina and Tamara Feldblyum and Marcela Ferella and Alberto Carlos Frasch and Keith Gull and David Horn and Lihua Hou and Yiting Huang and Ellen Kindlund and Michele Klingbeil and Sindy Kluge and Hean Koo and Daniela Lacerda and Mariano J. Levin and Hernan Lorenzi and Tin Louie and Carlos Renato Machado and Richard McCulloch and Alan McKenna and Yumi Mizuno and Jeremy C. Mottram and Siri Nelson and Stephen Ochaya and Kazutoyo Osoegawa and Grace Pai and Marilyn Parsons and Martin Pentony and Ulf Pettersson and Mihai Pop and Jose Luis Ramirez and Joel Rinta and Laura Robertson and Steven L. Salzberg and Daniel O. Sanchez and Amber Seyler and Reuben Sharma and Jyoti Shetty and Anjana J. Simpson and Ellen Sisk and Martti T. Tammi and Rick Tarleton and Santuza Teixeira and Susan Van Aken and Christy Vogt and Pauline N. Ward and Bill Wickstead and Jennifer Wortman and Owen White and Claire M. Fraser and Kenneth D. Stuart and Björn Andersson and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för genetik och patologi and Uppsala universitet
Science, ISSN 0036-8075, 7/2005, Volume 309, Issue 5733, pp. 409 - 415
Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of... 
Proteins | Haplotypes | Retrotransposons | DNA | Mucins | Genomes | Parasitism | Research Articles | Parasites | Eukaryotic cells | Membrane proteins | AFRICAN TRYPANOSOMES | MULTILOCUS ENZYME ELECTROPHORESIS | NON-LTR RETROTRANSPOSONS | RNA INTERFERENCE RNAI | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | PARASITE PLASMODIUM-FALCIPARUM | AMPLIFIED POLYMORPHIC DNA | CLONE CL BRENER | NUCLEOTIDE-SEQUENCE | TRANS-SIALIDASE | Chagas Disease - parasitology | Multigene Family | Genome, Protozoan | Humans | Genes, Protozoan | Protozoan Proteins - genetics | DNA, Mitochondrial - genetics | Membrane Proteins - physiology | Recombination, Genetic | Protozoan Proteins - chemistry | Trypanocidal Agents - therapeutic use | Telomere - genetics | Signal Transduction | Membrane Proteins - genetics | Retroelements | Trypanosoma cruzi - genetics | DNA Replication | Meiosis | Protozoan Proteins - physiology | Sequence Analysis, DNA | Trypanosoma cruzi - physiology | Animals | Membrane Proteins - chemistry | Trypanocidal Agents - pharmacology | DNA Repair | Chagas Disease - drug therapy | Repetitive Sequences, Nucleic Acid | DNA, Protozoan - genetics | Trypanosoma cruzi - chemistry | Genetic aspects | Trypanosoma cruzi | Eukaryotes | Disease | Genomics | Genes | Parasitic protozoa | DNA repair | Chagas Disease/drug therapy/parasitology | Research Support; U.S. Gov't; P.H.S | Telomere/genetics | Recombination; Genetic | Repetitive Sequences; Nucleic Acid | Biology | Membrane Proteins/chemistry/genetics/physiology | Research Support; N.I.H.; Extramural | Trypanocidal Agents/pharmacology/therapeutic use | Genetics | Research Support; Non-U.S. Gov't | Biologi | Natural Sciences | Genes; Protozoan | Biological Sciences | DNA; Protozoan/genetics | Genome; Protozoan | Sequence Analysis; DNA | Genetik | Protozoan Proteins/chemistry/genetics/physiology | Naturvetenskap | Biologiska vetenskaper | Cell and molecular biology | Trypanosoma cruzi/chemistry/genetics/physiology | DNA; Mitochondrial/genetics | Cell- och molekylärbiologi
Journal Article
Molecules, ISSN 1420-3049, 12/2017, Volume 22, Issue 12, p. 2220
The synthesis of four cymantrene-5-fluorouracil derivatives (1-4) and two cymantrene-adenine derivatives (5 and 6) is reported. All of the compounds were... 
Cymantrene | Antibacterial activity | Antitrypanosomal activity | Bioorganometallics | Anticancer activity | Nucleobases | antibacterial activity | ORGANOMETALLIC COMPOUNDS | CELLS | TRYPANOSOMA-BRUCEI | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | bioorganometallics | ANTIBACTERIAL | FERROCENYL | AUTOPHAGY | CHEMISTRY, MULTIDISCIPLINARY | BREAST-CANCER | cymantrene | nucleobases | BLOOD-STREAM FORMS | BIOLOGICAL-ACTIVITY | antitrypanosomal activity | anticancer activity | Adenine - chemical synthesis | Staphylococcus epidermidis - drug effects | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Escherichia coli - drug effects | Humans | Structure-Activity Relationship | Autophagy - drug effects | Fluorouracil - chemical synthesis | Antineoplastic Agents - pharmacology | Drug Evaluation, Preclinical | Cell Survival - drug effects | Adenine - analogs & derivatives | Fluorouracil - analogs & derivatives | Adenine - pharmacology | Trypanosoma brucei brucei - drug effects | Anti-Bacterial Agents - chemical synthesis | Trypanocidal Agents - pharmacology | Organometallic Compounds - chemical synthesis | Cell Line, Tumor | Trypanocidal Agents - chemical synthesis | Anti-Bacterial Agents - pharmacology | Fluorouracil - pharmacology | Oxidative Stress - drug effects | Staphylococcus aureus - drug effects | Organometallic Compounds - pharmacology | Biotechnology | Oxidative stress | Antimicrobial activity | 5-Fluorouracil | Clinical isolates | Cytotoxicity | Vancomycin | Drug resistance | Crystallography | Autophagy | Antibacterial materials | Anticancer properties | X-ray crystallography | Methicillin | Synthesis | E coli | Bacteria | Strains (organisms) | Crystal structure | Crystallization | Adenine | Tumor cell lines | Derivatives | Antitumor activity | Uracil | Phagocytosis | Cancer | Apoptosis
Journal Article