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Journal of Biological Chemistry, ISSN 0021-9258, 09/2009, Volume 284, Issue 38, pp. 25697 - 25703
Journal Article
BioMetals, ISSN 0966-0844, 4/2017, Volume 30, Issue 2, pp. 313 - 320
Gold compounds form a new class of promising metal-based drugs with a number of potential therapeutic applications, particularly in the fields of anticancer... 
Life Sciences | Biochemistry, general | Cysteine proteases | Gold compounds | Microbiology | Enzyme inhibition | Plant Physiology | Parasitic protozoa | Pharmacology/Toxicology | Medicine/Public Health, general | Cell Biology | DRUG-SENSITIVITY | TRYPANOSOMA-BRUCEI-RHODESIENSE | ASSAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | IN-VITRO | LEISHMANIA-MEXICANA | CATHEPSIN-L | ROLES | PARASITE | Cysteine Endopeptidases - chemistry | Plasmodium falciparum - enzymology | Fibroblasts - enzymology | Protozoan Proteins - antagonists & inhibitors | Humans | Cathepsin B - chemistry | Plasmodium falciparum - drug effects | Trypanosoma brucei brucei - enzymology | Trypanosoma cruzi - enzymology | Leishmania infantum - growth & development | Cysteine Proteinase Inhibitors - chemical synthesis | Inhibitory Concentration 50 | Trypanosoma brucei rhodesiense - growth & development | Antiprotozoal Agents - chemical synthesis | Protozoan Proteins - chemistry | Trypanosoma brucei brucei - growth & development | Cell Line | Organogold Compounds - chemical synthesis | Cathepsin B - antagonists & inhibitors | Proteasome Endopeptidase Complex - chemistry | Recombinant Proteins - chemistry | Macrophages - cytology | Cathepsin L - antagonists & inhibitors | Antiprotozoal Agents - pharmacology | Trypanosoma brucei brucei - drug effects | Leishmania infantum - enzymology | Macrophages - enzymology | Animals | Trypanosoma cruzi - growth & development | Organogold Compounds - pharmacology | Cysteine Proteinase Inhibitors - pharmacology | Fibroblasts - drug effects | Leishmania infantum - drug effects | Trypanosoma cruzi - drug effects | Macrophages - drug effects | Fibroblasts - cytology | Mice | Trypanosoma brucei rhodesiense - drug effects | Plasmodium falciparum - growth & development | Cathepsin L - chemistry | Trypanosoma brucei rhodesiense - enzymology | Cysteine | Biological products | Protease inhibitors | Proteases | Parasitic diseases | Antiparasitic agents | Technical education | Cystine | Gold | Enzymes | Antimicrobial agents | Cancer therapies | Pharmaceuticals
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2010, Volume 285, Issue 49, pp. 37964 - 37975
Using a pharmacological inhibitor of Hsp90 in cultured malarial parasite, we have previously implicated Plasmodium falciparum Hsp90 (PfHsp90) as a drug target... 
CELLS | HSP90 MOLECULAR CHAPERONE | ATPASE ACTIVITY | INHIBITION | HEAT-SHOCK-PROTEIN-90 | PLASMODIUM-FALCIPARUM | HUMAN ERYTHROCYTES | GELDANAMYCIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | EXPRESSION | Malaria, Falciparum - enzymology | Plasmodium falciparum - enzymology | Malaria, Falciparum - genetics | Protozoan Proteins - antagonists & inhibitors | Trypanosoma - genetics | Humans | Plasmodium berghei - genetics | Trypanosomiasis - enzymology | Protozoan Proteins - genetics | Protozoan Proteins - metabolism | Plasmodium berghei - enzymology | Plasmodium falciparum - genetics | HSP90 Heat-Shock Proteins - genetics | Trypanosoma - enzymology | Disease Models, Animal | Protein Structure, Tertiary | Malaria, Falciparum - drug therapy | Trypanosomiasis - genetics | Enzyme Inhibitors - pharmacology | Adenosine Triphosphatases - metabolism | Lactams, Macrocyclic - pharmacology | Antiprotozoal Agents - pharmacology | Benzoquinones - pharmacology | Trypanosomiasis - drug therapy | Adenosine Triphosphatases - antagonists & inhibitors | Acetylation - drug effects | Animals | HSP90 Heat-Shock Proteins - antagonists & inhibitors | HSP90 Heat-Shock Proteins - metabolism | Adenosine Triphosphatases - genetics | Mice | Hsp90 | Trypanosoma evansi | Molecular Bases of Disease | Plasmodium falciparum | Parasitology | Post-translational Modification | Protozoan | Geldanamycin | Preclinical Study | Protein-Drug Interactions | Heat Shock Protein
Journal Article
Wiley Interdisciplinary Reviews: RNA, ISSN 1757-7004, 01/2019, Volume 10, Issue 1, pp. e1511 - n/a
Journal Article
Journal Article
Archives of Biochemistry and Biophysics, ISSN 0003-9861, 10/2017, Volume 632, pp. 175 - 191
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2016, Volume 109, pp. 173 - 186
Journal Article