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1. Chemotherapeutic strategies against Trypanosoma brucei: Drug targets vs. drug targeting
by Lüscher, A and de Koning, H.P and Mäser, P
Current pharmaceutical design, ISSN 1381-6128, 02/2007, Volume 13, Issue 6, pp. 555 - 567
Drug target | Chemotherapy | Sleeping sickness | Drug resistance | Trypanosoma brucei | Functional genomics | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Trypanosomiasis, African - drug therapy | Trypanosoma brucei brucei - metabolism | Trypanosoma brucei gambiense - metabolism | Humans | Trypanosoma brucei gambiense - pathogenicity | Trypanosoma brucei brucei - genetics | Trypanosoma brucei brucei - drug effects | Trypanosomiasis, African - parasitology | Animals | Antiprotozoal Agents - adverse effects | Trypanosoma brucei gambiense - genetics | Trypanosoma brucei rhodesiense - metabolism | Trypanosoma brucei rhodesiense - pathogenicity | Trypanosoma brucei gambiense - drug effects | Trypanosoma brucei brucei - pathogenicity | Antiprotozoal Agents - administration & dosage | Trypanosoma brucei rhodesiense - drug effects | Trypanosomiasis, African - genetics | Trypanosoma brucei rhodesiense - genetics | Drug Delivery Systems - methods | Index Medicus
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2. Full Text Localization of serum resistance‐associated protein in Trypanosoma brucei rhodesiense and transgenic Trypanosoma brucei brucei
by Bart, Jean‐Mathieu and Cordon‐Obras, Carlos and Vidal, Isabel and Reed, Jennifer and Perez‐Pastrana, Esperanza and Cuevas, Laureano and Field, Mark C and Carrington, Mark and Navarro, Miguel
Cellular microbiology, ISSN 1462-5814, 10/2015, Volume 17, Issue 10, pp. 1523 - 1535
Life Sciences & Biomedicine | Microbiology | Science & Technology | Cell Biology | Membrane Glycoproteins - analysis | Trypanosoma brucei rhodesiense - chemistry | Lysosomes - chemistry | Apolipoproteins - metabolism | Humans | Lipoproteins, HDL - metabolism | Protozoan Proteins - genetics | Trypanosoma brucei brucei - chemistry | Trypanosoma brucei brucei - drug effects | Microscopy, Immunoelectron | Trypanosoma brucei rhodesiense - immunology | Membrane Glycoproteins - genetics | Animals | Apolipoprotein L1 | Endosomes - chemistry | Trypanosoma brucei rhodesiense - drug effects | Protozoan Proteins - analysis | Microscopy, Fluorescence | Trypanosoma brucei brucei - immunology | Genetic engineering | Proteins | Protozoa | Index Medicus
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3. Full Text 9- and 11-substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma
by Maiwald, Franziska and Benítez, Diego and Charquero, Diego and Dar, Mahin Abad and Erdmann, Hanna and Preu, Lutz and Koch, Oliver and Hölscher, Christoph and Loaëc, Nadège and Meijer, Laurent and Comini, Marcelo A and Kunick, Conrad
European journal of medicinal chemistry, ISSN 0223-5234, 08/2014, Volume 83, pp. 274 - 283
Nagana | Chalcones | Cinnamides | Trypanosoma brucei brucei | Paullones | Human trypanosomiasis | Cell Line | Humans | Trypanocidal Agents - toxicity | Trypanocidal Agents - chemistry | Structure-Activity Relationship | Benzazepines - pharmacology | Benzazepines - chemical synthesis | Trypanosoma brucei brucei - drug effects | Trypanosoma brucei brucei - physiology | Trypanosomiasis, African - parasitology | Animals | Trypanocidal Agents - pharmacology | Drug Design | Trypanocidal Agents - chemical synthesis | Macrophages - drug effects | Cell Proliferation - drug effects | Mice | Benzazepines - toxicity | Benzazepines - chemistry | Substitution reactions | Antiparasitic agents | Livestock | Index Medicus | Trypanocidal Agents/chemistry | Trypanocidal Agents/chemical synthesis | Trypanosoma brucei brucei/drug effects | Trypanocidal Agents/pharmacology | Biochemistry, Molecular Biology | Benzazepines/pharmacology | Trypanosomiasis, African/parasitology | Life Sciences | Benzazepines/toxicity | Macrophages/drug effects | Benzazepines/chemistry | Trypanosoma brucei brucei/physiology | Trypanocidal Agents/toxicity | Cell Proliferation/drug effects | Benzazepines/chemical synthesis
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4. Full Text Inhibition of F1‐ATPase from Trypanosoma brucei by its regulatory protein inhibitor TbIF1
by Gahura, Ondřej and Panicucci, Brian and Váchová, Hana and Walker, John E and Zíková, Alena
The FEBS journal, ISSN 1742-464X, 12/2018, Volume 285, Issue 23, pp. 4413 - 4423
ATP synthase | Trypanosoma brucei | enzyme inhibitor | trypanosome | TbIF1 | IF 1 | F1Fo‐ATPase | F‐ATPase | F-ATPase | ATPase | TbIF | Enzyme inhibitors | Analysis | Adenosine triphosphatase | Blood proteins | Protons | Yeast | Amino acids | pH effects | Drug development | Monomers | Proteins | Mitochondria | Glycolysis | Dimers | Membrane potential | Inhibition | Electron transport | Dimerization | ATP | Index Medicus
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5. Full Text Activity of bisnaphthalimidopropyl derivatives against trypanosoma brucei
by Graça, Nuno A. G and Gaspar, Luis and Costa, David M and Loureiro, Inês and Thoo-Lin, Paul Kong and Ramos, Isbaal and Roura, Meritxell and Pruvost, Alain and Pemberton, Ian K and Loukil, Hadjer and Macdougall, Jane and Tavares, Joana and Cordeiro-Da-silva, Anabela
Antimicrobial agents and chemotherapy, ISSN 0066-4804, 04/2016, Volume 60, Issue 4, pp. 2532 - 2536
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Trypanosomiasis, African - drug therapy | Mitochondria, Liver - metabolism | Humans | Microsomes, Liver - metabolism | Neurons - cytology | Structure-Activity Relationship | Hepatocytes - metabolism | Hepatocytes - cytology | Naphthalimides - chemical synthesis | Liver - drug effects | Microsomes, Liver - drug effects | Trypanosomiasis, African - mortality | Inhibitory Concentration 50 | Female | Trypanosomiasis, African - pathology | Neurons - metabolism | Neurons - drug effects | Trypanosoma brucei brucei - growth & development | Hepatocytes - drug effects | Pentamidine - pharmacology | Cell Line | Trypanosoma brucei brucei - metabolism | Drug Stability | Liver - metabolism | Parasite Load | Macrophages - cytology | Trypanosoma brucei brucei - drug effects | Mitochondria, Liver - drug effects | Trypanosomiasis, African - parasitology | Macrophages - metabolism | Animals | Naphthalimides - pharmacology | Trypanocidal Agents - pharmacology | Survival Analysis | Trypanocidal Agents - chemical synthesis | Macrophages - drug effects | Mice | Mice, Inbred BALB C | Primary Cell Culture | Index Medicus
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6. Full Text Development of an Alamar Blue™ viability assay in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427
by Sykes, Melissa L and Avery, Vicky M
The American journal of tropical medicine and hygiene, ISSN 0002-9637, 10/2009, Volume 81, Issue 4, pp. 665 - 674
Public, Environmental & Occupational Health | Life Sciences & Biomedicine | Science & Technology | Tropical Medicine | Biological and medical sciences | Infectious diseases | Medical sciences | Diminazene - pharmacology | Oxazines | Trypanosoma brucei brucei - isolation & purification | Humans | Trypanosoma brucei brucei - drug effects | Xanthenes | Trypanosomiasis, African - parasitology | Sphingosine - analogs & derivatives | Animals | Trypanosomiasis, African - diagnosis | Trypanocidal Agents - pharmacology | Trypanosomiasis, African - blood | Sensitivity and Specificity | Staining and Labeling | Indicators and Reagents | Pentamidine - pharmacology | Index Medicus | Abridged Index Medicus
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7. Full Text An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics
by Scott, Fraser J and Khalaf, Abedawn I and Giordani, Federica and Wong, Pui Ee and Duffy, Sandra and Barrett, Michael and Avery, Vicky M and Suckling, Colin J
European journal of medicinal chemistry, ISSN 0223-5234, 06/2016, Volume 116, pp. 116 - 125
Antiparasitic activity | Minor Groove Binders | African trypanosomiasis | Trypanocidal Agents - pharmacology | Computer Simulation | Humans | Trypanocidal Agents - toxicity | HEK293 Cells | Inhibitory Concentration 50 | Trypanocidal Agents - chemistry | Structure-Activity Relationship | Trypanosoma brucei brucei - drug effects | Drug discovery | Analysis | Therapeutics | Homeopathy | Materia medica and therapeutics | Index Medicus | Research Paper
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8. Full Text High-throughput decoding of antitrypanosomal drug efficacy and resistance
by Alsford, Sam and Eckert, Sabine and Baker, Nicola and Glover, Lucy and Sanchez-Flores, Alejandro and Leung, Ka Fai and Turner, Daniel J and Field, Mark C and Berriman, Matthew and Horn, David
Nature (London), ISSN 0028-0836, 02/2012, Volume 482, Issue 7384, pp. 232 - 236
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Physicochemical properties. Structure-activity relationships | General pharmacology | Pharmacology. Drug treatments | Biological and medical sciences | Antiparasitic agents | Medical sciences | Antibiotics. Antiinfectious agents. Antiparasitic agents | Lysosomes - drug effects | Trypanosomiasis, African - drug therapy | Melarsoprol - pharmacology | Trypanosoma brucei brucei - metabolism | Endocytosis - drug effects | Humans | Trypanosoma brucei brucei - cytology | Eflornithine - pharmacology | Glycosylation - drug effects | Trypanosoma brucei brucei - enzymology | Trypanosoma brucei brucei - drug effects | Drug Resistance - genetics | Nifurtimox - pharmacology | High-Throughput Screening Assays | Lysosomes - metabolism | RNA Interference | Trypanocidal Agents - pharmacology | Aquaglyceroporins - deficiency | Trypanocidal Agents - therapeutic use | Trypanosomiasis, African - genetics | Suramin - pharmacology | Aquaglyceroporins - metabolism | Pentamidine - pharmacology | Chemotherapy | Care and treatment | Research | Drug resistance | Health aspects | Trypanosomiasis | Cancer | Proteins | Studies | Toxicity | Genomes | Biosynthesis | Genetic testing | Deoxyribonucleic acid--DNA | Index Medicus
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9. Full Text Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei
by Wyllie, Susan and Foth, Bernardo J and Kelner, Anna and Sokolova, Antoaneta Y and Berriman, Matthew and Fairlamb, Alan H
Journal of antimicrobial chemotherapy, ISSN 0305-7453, 03/2016, Volume 71, Issue 3, pp. 625 - 634
Pharmacology & Pharmacy | Infectious Diseases | Life Sciences & Biomedicine | Microbiology | Science & Technology | Nitroreductases - genetics | Nitroimidazoles - pharmacology | Parasitic Sensitivity Tests | Genome, Protozoan | Trypanosoma brucei brucei - genetics | Trypanosoma brucei brucei - enzymology | Antiprotozoal Agents - pharmacology | Sequence Analysis, DNA | Trypanosoma brucei brucei - drug effects | Nifurtimox - pharmacology | Nitroreductases - metabolism | Polymorphism, Single Nucleotide | Drug Resistance | Genotype & phenotype | Gene expression | Drug resistance | Chromosomes | Cloning | Index Medicus | Original Research
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10. Full Text Adaptation of Trypanosoma rhodesiense to hypohaptoglobinaemic serum requires transcription of the APOL1 resistance gene in a RNA polymerase I locus
by Lecordier, Laurence and Uzureau, Pierrick and Tebabi, Patricia and Brauner, Jonathan and Benghiat, Fleur Samantha and Vanhollebeke, Benoit and Pays, Etienne
Molecular microbiology, ISSN 0950-382X, 08/2015, Volume 97, Issue 3, pp. 397 - 407
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Adaptation, Physiological | Trypanosoma brucei rhodesiense - physiology | Haptoglobins - analysis | Humans | Membrane Glycoproteins - biosynthesis | Trypanosoma brucei gambiense - growth & development | Gene Expression Regulation | Receptors, Cell Surface - metabolism | RNA Polymerase I - metabolism | Trypanosoma brucei brucei - genetics | Trypanosoma brucei brucei - drug effects | Trypanosoma brucei gambiense - genetics | Trypanosoma brucei gambiense - drug effects | Apolipoprotein L1 | Lipoproteins, HDL - toxicity | Trypanosoma brucei rhodesiense - growth & development | Transcription, Genetic | Trypanosoma brucei rhodesiense - drug effects | Trypanosoma brucei rhodesiense - genetics | Apolipoproteins - toxicity | Trypanosoma brucei brucei - growth & development | Serum - chemistry | Hemoglobin | Glycoproteins | Parasites | RNA polymerase | Apolipoproteins | Gene expression | Index Medicus
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11. Full Text Selenoproteins of African trypanosomes are dispensable for parasite survival in a mammalian host
by Bonilla, Mariana and Krull, Erika and Irigoín, Florencia and Salinas, Gustavo and Comini, Marcelo A
Molecular and biochemical parasitology, ISSN 0166-6851, 03/2016, Volume 206, Issue 1-2, pp. 13 - 19
Infection | Selenocysteine | Thiol | Sulfur metabolism | Selenocysteine synthase | Biochemistry & Molecular Biology | Parasitology | Life Sciences & Biomedicine | Science & Technology | Transferases - deficiency | Selenocysteine - metabolism | Kinetoplastida - classification | Proteome - genetics | Selenoproteins - genetics | Databases, Genetic | Data Mining | Kinetoplastida - drug effects | Phylogeny | Protozoan Proteins - genetics | Transferases - genetics | Protozoan Proteins - metabolism | Kinetoplastida - growth & development | Gene Deletion | Trypanosomiasis, African - pathology | Host-Parasite Interactions | Kinetoplastida - metabolism | Trypanosoma brucei brucei - growth & development | Pyruvaldehyde - pharmacology | Trypanosoma brucei brucei - metabolism | Gene Expression Regulation | Hydrogen Peroxide - pharmacology | Trypanosoma brucei brucei - drug effects | Trypanosomiasis, African - parasitology | Animals | Selenoproteins - deficiency | Trypanosoma brucei brucei - classification | Mice | Proteome - metabolism | Index Medicus | Kinetoplastida | Transferases | Hydrogen Peroxide | Proteome | Trypanosomiasis, African | Protozoan Proteins | Trypanosoma brucei brucei | Life Sciences | Microbiology and Parasitology | Selenoproteins | Pyruvaldehyde
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