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1. Full Text Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei
by Mony, Binny M and MacGregor, Paula and Ivens, Alasdair and Rojas, Federico and Cowton, Andrew and Young, Julie and Horn, David and Matthews, Keith
Nature (London), ISSN 0028-0836, 2014, Volume 505, Issue 7485, pp. 681 - 685
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | RNA-Binding Proteins - genetics | Protein Kinases - genetics | Reproducibility of Results | Trypanosoma brucei brucei - metabolism | Gene Expression Regulation | Genome - genetics | Signal Transduction - genetics | Trypanosoma brucei brucei - genetics | Trypanosoma brucei brucei - enzymology | Quorum Sensing - genetics | G1 Phase | Animals | RNA Interference | G1 Phase Cell Cycle Checkpoints | Cell Differentiation | Cyclic AMP - metabolism | Trypanosoma brucei brucei - growth & development | RNA-Binding Proteins - metabolism | Physiological aspects | Genetic research | Genetic aspects | Transduction | Cellular signal transduction | Research | Trypanosoma brucei | Proteins | Flow cytometry | Signal transduction | Genes | Population | Genomes | Parasites | Index Medicus
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2. Full Text Natively Inhibited Trypanosoma brucei Cathepsin B Structure Determined by Using an X-ray Laser
by Lars Redecke and Karol Nass and Daniel P. Deponte and Thomas A. White and Dirk Rehders and Anton Barty and Francesco Stellato and Mengning Liang and Thomas R.M. Barends and Sébastien Boutet and Garth J. Williams and Marc Messerschmidt and M. Marvin Seibert and Andrew Aquila and David Arnlund and Sasa Bajt and Torsten Barth and Michael J. Bogan and Carl Caleman and Tzu-Chiao Chao and R. Bruce Doak and Holger Fleckenstein and Matthias Frank and Raimund Fromme and Lorenzo Galli and Ingo Grotjohann and Mark S. Hunter and Linda C. Johansson and Stephan Kassemeyer and Gergely Katona and Richard A. Kirian and Rudolf Koopmann and Chris Kupitz and Lukas Lomb and Andrew V. Martin and Stefan Mogk and Richard Neutze and Robert L. Shoeman and Jan Steinbrener and Nicusor Timneanu and Dingjie Wang and Uwe Weierstall and Nadia A. Zatsepin and John C. H. Spence and Petra Fromme and Ilme Schlichting and Michael Duszenko and Christian Betzel and Henry N. Chapman and Institutionen för kemi och molekylärbiologi and Naturvetenskapliga fakulteten and Faculty of Sciences and Göteborgs universitet and Gothenburg University and Department of Chemistry and Molecular Biology
Science (American Association for the Advancement of Science), ISSN 0036-8075, 1/2013, Volume 339, Issue 6116, pp. 227 - 230
Enzymes | Electronic structure | Active sites | Lasers | REPORTS | Crystals | Atoms | Biochemistry | Electron density | Molecular biology | Crystal structure | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Amino Acid Sequence | Catalytic Domain | Enzyme Precursors - chemistry | Protozoan Proteins - antagonists & inhibitors | Crystallization | Cathepsin B - antagonists & inhibitors | Cathepsin B - chemistry | Models, Molecular | Molecular Sequence Data | Crystallography, X-Ray | Glycosylation | Trypanosoma brucei brucei - enzymology | Spodoptera | Sf9 Cells | Animals | X-Rays | Protein Conformation | Protozoan Proteins - chemistry | Usage | Physiological aspects | Cathepsins | Microbiological chemistry | Research | Trypanosoma brucei | Health aspects | Lasers in medicine | Protozoa | Proteases | Parasitic diseases | Crystallography | Index Medicus | Inhibitors | Diffraction | X-ray lasers | Activation | Radiation damage | chemistry | Protozoan Proteins | Molecular | Trypanosoma brucei brucei | antagonists & inhibitors | enzymology | Biokemi och molekylärbiologi | Cathepsin B | X-Ray | Biochemistry and Molecular Biology | Models | Enzyme Precursors
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3. Full Text Lipoamide dehydrogenase is essential for both bloodstream and procyclic Trypanosoma brucei
by Roldán, Angela and Comini, Marcelo A and Crispo, Martina and Krauth‐Siegel, R. Luise
Molecular microbiology, ISSN 0950-382X, 08/2011, Volume 81, Issue 3, pp. 623 - 639
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Mitochondria - enzymology | Virulence Factors - genetics | Trypanosoma brucei brucei - metabolism | Molecular Sequence Data | Mitochondria - metabolism | Trypanosoma brucei brucei - genetics | Trypanosoma brucei brucei - enzymology | Sequence Analysis, DNA | Rodent Diseases - parasitology | Trypanosomiasis, African - parasitology | Animals | Metabolic Networks and Pathways | Gene Deletion | Trypanosoma brucei brucei - pathogenicity | Dihydrolipoamide Dehydrogenase - genetics | Survival Analysis | Dihydrolipoamide Dehydrogenase - metabolism | DNA, Protozoan - genetics | Rodent Diseases - pathology | Trypanosomiasis, African - pathology | Virulence Factors - metabolism | Mice | DNA, Protozoan - chemistry | Disease Models, Animal | Thiols | Messenger RNA | Branched chain amino acids | Analysis | Animal genetic engineering | DNA synthesis | Glucose | Glycine | Dextrose | Enzymes | Amino acids | Parasites | Ribonucleic acid--RNA | Cell cycle | Index Medicus | Dihydrolipoamide Dehydrogenase | Trypanosomiasis, African | Trypanosoma brucei brucei | Virulence Factors | DNA, Protozoan | Life Sciences | Microbiology and Parasitology | Mitochondria | Rodent Diseases
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4. Full Text Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei
by Wyllie, Susan and Foth, Bernardo J and Kelner, Anna and Sokolova, Antoaneta Y and Berriman, Matthew and Fairlamb, Alan H
Journal of antimicrobial chemotherapy, ISSN 0305-7453, 03/2016, Volume 71, Issue 3, pp. 625 - 634
Pharmacology & Pharmacy | Infectious Diseases | Life Sciences & Biomedicine | Microbiology | Science & Technology | Nitroreductases - genetics | Nitroimidazoles - pharmacology | Parasitic Sensitivity Tests | Genome, Protozoan | Trypanosoma brucei brucei - genetics | Trypanosoma brucei brucei - enzymology | Antiprotozoal Agents - pharmacology | Sequence Analysis, DNA | Trypanosoma brucei brucei - drug effects | Nifurtimox - pharmacology | Nitroreductases - metabolism | Polymorphism, Single Nucleotide | Drug Resistance | Genotype & phenotype | Gene expression | Drug resistance | Chromosomes | Cloning | Index Medicus | Original Research
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5. Full Text 3′ adenylation determines mRNA abundance and monitors completion of RNA editing in T. brucei mitochondria
by Aphasizhev, Ruslan and Gershon, Paul D and Aphasizheva, Inna and Etheridge, Ronald D
The EMBO journal, ISSN 0261-4189, 06/2008, Volume 27, Issue 11, pp. 1596 - 1608
polyadenylation | mRNA editing | Trypanosoma | mitochondria | mRNA stability | Mitochondria | Polyadenylation | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Polynucleotide Adenylyltransferase - metabolism | Amino Acid Sequence | Mitochondria - enzymology | Cell Survival | RNA Editing - genetics | Molecular Sequence Data | Mitochondrial Proteins - genetics | Trypanosoma brucei brucei - genetics | Protozoan Proteins - genetics | RNA, Messenger - metabolism | Trypanosoma brucei brucei - enzymology | Polynucleotide Adenylyltransferase - genetics | Animals | Protozoan Proteins - metabolism | Mitochondrial Proteins - metabolism | Mitochondrial Proteins - chemistry | Polynucleotide Adenylyltransferase - chemistry | Kinetics | Parasites | Microbiology | Molecular biology | Ribonucleic acid--RNA | Genomics | Index Medicus
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6. Full Text High-throughput decoding of antitrypanosomal drug efficacy and resistance
by Alsford, Sam and Eckert, Sabine and Baker, Nicola and Glover, Lucy and Sanchez-Flores, Alejandro and Leung, Ka Fai and Turner, Daniel J and Field, Mark C and Berriman, Matthew and Horn, David
Nature (London), ISSN 0028-0836, 02/2012, Volume 482, Issue 7384, pp. 232 - 236
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Physicochemical properties. Structure-activity relationships | General pharmacology | Pharmacology. Drug treatments | Biological and medical sciences | Antiparasitic agents | Medical sciences | Antibiotics. Antiinfectious agents. Antiparasitic agents | Lysosomes - drug effects | Trypanosomiasis, African - drug therapy | Melarsoprol - pharmacology | Trypanosoma brucei brucei - metabolism | Endocytosis - drug effects | Humans | Trypanosoma brucei brucei - cytology | Eflornithine - pharmacology | Glycosylation - drug effects | Trypanosoma brucei brucei - enzymology | Trypanosoma brucei brucei - drug effects | Drug Resistance - genetics | Nifurtimox - pharmacology | High-Throughput Screening Assays | Lysosomes - metabolism | RNA Interference | Trypanocidal Agents - pharmacology | Aquaglyceroporins - deficiency | Trypanocidal Agents - therapeutic use | Trypanosomiasis, African - genetics | Suramin - pharmacology | Aquaglyceroporins - metabolism | Pentamidine - pharmacology | Chemotherapy | Care and treatment | Research | Drug resistance | Health aspects | Trypanosomiasis | Cancer | Proteins | Studies | Toxicity | Genomes | Biosynthesis | Genetic testing | Deoxyribonucleic acid--DNA | Index Medicus
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7. Full Text Structures of MERS1, the 5 ' processing enzyme of mitochondrial mRNAs in Trypanosoma brucei
by Schumacher, Maria A and Henderson, Max and Zeng, Wenjie
RNA (Cambridge), ISSN 1355-8382, 01/2020, Volume 26, Issue 1, pp. 69 - 82
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | RNA, Protozoan - genetics | RNA, Mitochondrial - chemistry | Sequence Alignment | RNA, Messenger - genetics | RNA, Mitochondrial - genetics | Models, Molecular | RNA, Messenger - chemistry | Trypanosoma brucei brucei - genetics | Nucleic Acid Conformation | RNA, Protozoan - chemistry | Trypanosoma brucei brucei - enzymology | RNA - metabolism | Protozoa | Enzymes | Glutamic acid | Mitochondria | Guanosine triphosphate | Hydrolase | Guanine | Binding sites | Conformation | Index Medicus | kinetoplastid | Trypanosoma brucei | MERS1 | Nudix hydrolase | mRNA processing
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8. Full Text 'Gestalt,' Composition and Function of the Trypanosoma brucei Editosome
by Göringer, H. Ulrich
Annual review of microbiology, ISSN 0066-4227, 10/2012, Volume 66, pp. 65 - 82
African trypanosome | RNA editing | mitochondrial gene expression | guide RNA | Fundamental and applied biological sciences. Psychology | Microbiology | Biological and medical sciences | Mitochondria - genetics | Trypanosoma brucei brucei - metabolism | RNA Editing | Gene Expression Regulation | Multienzyme Complexes - metabolism | Uridine - metabolism | Mitochondria - metabolism | Uridine - genetics | Trypanosoma brucei brucei - genetics | Trypanosoma brucei brucei - enzymology | Multienzyme Complexes - chemistry | Physiological aspects | Genetic aspects | Research | RNA | Gene expression | Trypanosoma brucei | Index Medicus
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