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ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, ISSN 0066-4804, 06/2019, Volume 63, Issue 6
The protozoan parasite Trypanosoma brucei is the causative agent of human African trypanosomiasis (HAT). The disease is fatal if it remains untreated, whereas... 
TARGET | CROSS-RESISTANCE | MICROBIOLOGY | MECHANISMS | indirubins | kinase inhibition | FLAGELLUM | POTENT | drug discovery | GSK3 | ACCURATE DOCKING | SELECTIVE INHIBITORS | PHARMACOLOGY & PHARMACY | AFRICAN TRYPANOSOMIASIS | Trypanosoma brucei | DERIVATIVES | MOTILITY
Journal Article
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2015, Volume 290, Issue 32, pp. 19987 - 19998
The eukaryotic protozoan parasite Trypanosoma brucei is the causative agent of human African trypanosomiasis. Polyamine biosynthesis is essential in T. brucei,... 
YEAST | FACTOR EF-P | HUMAN AFRICAN TRYPANOSOMIASIS | BLOOD-STREAM FORMS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HOMOLOG | ACTIN CYTOSKELETON | CELL-GROWTH | HYPUSINE MODIFICATION | SACCHAROMYCES-CEREVISIAE | POLYAMINE METABOLISM | RNA, Protozoan - genetics | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | Proteome - genetics | Protozoan Proteins - antagonists & inhibitors | Humans | Molecular Sequence Data | Protozoan Proteins - genetics | RNA, Messenger - metabolism | Gene Knockdown Techniques | Peptides - metabolism | Protozoan Proteins - metabolism | RNA, Messenger - antagonists & inhibitors | Escherichia coli - metabolism | Lysine - metabolism | Microfilament Proteins - metabolism | Flagella - genetics | Peptide Initiation Factors - antagonists & inhibitors | Microfilament Proteins - genetics | RNA-Binding Proteins - antagonists & inhibitors | Recombinant Proteins - metabolism | Amino Acid Sequence | Lysine - analogs & derivatives | Flagella - ultrastructure | Trypanosoma brucei brucei - metabolism | RNA, Messenger - genetics | RNA, Protozoan - antagonists & inhibitors | Recombinant Proteins - genetics | Trypanosoma brucei brucei - genetics | Peptide Initiation Factors - metabolism | Sequence Homology, Amino Acid | Peptide Initiation Factors - genetics | RNA, Protozoan - metabolism | Trypanosoma brucei brucei - ultrastructure | Sequence Alignment | Animals | Flagella - metabolism | Escherichia coli - genetics | Protein Processing, Post-Translational | Proteome - metabolism | RNA-Binding Proteins - metabolism | RNA, Small Interfering - metabolism | parasite metabolism | polyamine | spermidine | hypusine | Microbiology | eukaryotic initiation factor 5A (eIF5A) | Trypanosoma brucei
Journal Article
Journal Article
Journal Article
Cell Host & Microbe, ISSN 1931-3128, 06/2016, Volume 19, Issue 6, pp. 837 - 848
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2012, Volume 109, Issue 27, pp. 10996 - 11001
Journal Article
Molecular & Biochemical Parasitology, ISSN 0166-6851, 03/2016, Volume 206, Issue 1-2, pp. 13 - 19
The trace element selenium is found in polypeptides as selenocysteine, the 21 amino acid that is co-translationally inserted into proteins at a UGA codon. In... 
Infection | Selenocysteine | Thiol | Sulfur metabolism | Selenocysteine synthase | OXIDATIVE STRESS | PHYSIOLOGICAL ROLES | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLYOXALASE-II | BRUCEI-BRUCEI | TRYPANOTHIONE | SELENIUM | MONOTHIOL GLUTAREDOXIN-1 | THIOREDOXIN REDUCTASE | EXPRESSION | METHYLGLYOXAL | PARASITOLOGY | Transferases - deficiency | Selenocysteine - metabolism | Kinetoplastida - classification | Proteome - genetics | Selenoproteins - genetics | Databases, Genetic | Data Mining | Kinetoplastida - drug effects | Phylogeny | Protozoan Proteins - genetics | Transferases - genetics | Protozoan Proteins - metabolism | Kinetoplastida - growth & development | Gene Deletion | Trypanosomiasis, African - pathology | Host-Parasite Interactions | Kinetoplastida - metabolism | Trypanosoma brucei brucei - growth & development | Pyruvaldehyde - pharmacology | Trypanosoma brucei brucei - metabolism | Gene Expression Regulation | Hydrogen Peroxide - pharmacology | Trypanosoma brucei brucei - drug effects | Trypanosomiasis, African - parasitology | Animals | Selenoproteins - deficiency | Trypanosoma brucei brucei - classification | Mice | Proteome - metabolism | Kinetoplastida | Parasitology | Transferases | Hydrogen Peroxide | Proteome | Trypanosomiasis, African | Protozoan Proteins | Trypanosoma brucei brucei | Life Sciences | Microbiology and Parasitology | Selenoproteins | Pyruvaldehyde
Journal Article