X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (6619) 6619
Dissertation (70) 70
Book Chapter (27) 27
Magazine Article (4) 4
Book / eBook (3) 3
Web Resource (3) 3
Journal / eJournal (2) 2
Publication (1) 1
Reference (1) 1
Report (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (4432) 4432
humans (2378) 2378
trypanosoma cruzi - drug effects (2311) 2311
trypanosoma cruzi (2091) 2091
mice (1751) 1751
trypanosoma-cruzi (1653) 1653
parasitology (1588) 1588
parasitic diseases (1223) 1223
trypanocidal agents - pharmacology (1180) 1180
microbiology (1168) 1168
biochemistry & molecular biology (1115) 1115
chagas-disease (1053) 1053
chagas disease - drug therapy (1034) 1034
parasites (1004) 1004
chagas disease (999) 999
chagas' disease (995) 995
chemistry, medicinal (968) 968
pharmacology & pharmacy (887) 887
female (831) 831
male (769) 769
protozoa (754) 754
research article (743) 743
in-vitro (734) 734
tropical medicine (704) 704
immunology (681) 681
chagas disease - parasitology (657) 657
chemotherapy (654) 654
antiprotozoal agents - pharmacology (649) 649
research (609) 609
infectious diseases (592) 592
proteins (590) 590
analysis (576) 576
trypanosoma cruzi - growth & development (571) 571
infections (565) 565
benznidazole (563) 563
trypanocidal agents - chemistry (555) 555
health aspects (532) 532
trypanosoma cruzi - enzymology (527) 527
drugs (511) 511
structure-activity relationship (497) 497
trypanosoma (474) 474
arctic medicine. tropical medicine (458) 458
trypanosoma cruzi - metabolism (453) 453
enzymes (452) 452
mice, inbred balb c (447) 447
protozoan proteins - metabolism (447) 447
molecular structure (435) 435
trypanocidal agents - therapeutic use (434) 434
cell line (432) 432
biology (424) 424
cell biology (423) 423
medicine (421) 421
parasitic sensitivity tests (417) 417
tropical diseases (417) 417
dose-response relationship, drug (398) 398
leishmania (396) 396
physiological aspects (396) 396
vector-borne diseases (395) 395
trypanosoma cruzi - immunology (389) 389
inhibitors (387) 387
trypanosoma cruzi - genetics (384) 384
infection (382) 382
expression (361) 361
cells, cultured (357) 357
inhibitory concentration 50 (350) 350
multidisciplinary sciences (347) 347
molecular sequence data (342) 342
chagas disease - immunology (339) 339
derivatives (338) 338
rats (333) 333
trypanosoma cruzi - physiology (332) 332
amino acid sequence (327) 327
enzyme inhibitors - pharmacology (326) 326
metabolism (322) 322
biochemistry (321) 321
trypanosoma-cruzi infection (316) 316
disease models, animal (314) 314
cells (306) 306
protozoan proteins - genetics (306) 306
leishmaniasis (304) 304
public aspects of medicine (304) 304
trypanosoma brucei brucei - drug effects (302) 302
identification (301) 301
drug discovery (300) 300
models, molecular (300) 300
trypanocidal agents - chemical synthesis (300) 300
trypanosoma-brucei (289) 289
antiprotozoal agents - chemistry (285) 285
trypanosoma cruzi - pathogenicity (284) 284
drug design (277) 277
gene expression (277) 277
biology and life sciences (276) 276
disease (276) 276
genetic aspects (272) 272
chemistry, organic (269) 269
apoptosis (265) 265
science (261) 261
kinetics (260) 260
drug resistance (258) 258
trypanosoma brucei (258) 258
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (6573) 6573
Portuguese (262) 262
Spanish (61) 61
German (28) 28
French (21) 21
Japanese (17) 17
Dutch (3) 3
Breton (2) 2
Italian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 09/2013, Volume 57, Issue 9, pp. 4151 - 4163
Journal Article
PloS one, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, p. e85706
.... The chemotherapy for Chagas disease remains a problem; the standard treatment currently relies on a single drug, benznidazole, which unfortunately induces several side effects and it is not successful in the cure of most of the chronic patients... 
EPIMASTIGOTE | IN-VITRO | POSACONAZOLE | PARTHENOLIDE | MULTIDISCIPLINARY SCIENCES | CHAGAS-DISEASE | SYNERGISTIC ACTIVITY | AUTOPHAGY | NITROKETENE N,S-ARYLAMINOACETALS | DRUG-COMBINATION | CELL-DEATH | Humans | Trypanocidal Agents - toxicity | Trypanocidal Agents - chemistry | Quinoxalines - pharmacology | Parasites - drug effects | Quinoxalines - toxicity | Macaca | Drug Therapy, Combination | Quinoxalines - chemical synthesis | Trypanosoma cruzi - ultrastructure | Cell Membrane - drug effects | Life Cycle Stages - drug effects | Parasites - cytology | Cell Line | Intracellular Space - drug effects | Nitroimidazoles - pharmacology | Cell Size - drug effects | Quinoxalines - chemistry | Animals | Trypanosoma cruzi - growth & development | Trypanocidal Agents - pharmacology | Trypanocidal Agents - chemical synthesis | Trypanosoma cruzi - drug effects | Cell Proliferation - drug effects | Intracellular Space - parasitology | Mice | Parasites - ultrastructure | Toxicity Tests | Trypanosoma cruzi - cytology | Medicine, Experimental | Medical research | Chemotherapy | Chagas' disease | Cell death | Cancer | Drugs | Benznidazole | Nuclear magnetic resonance--NMR | Low concentrations | Toxicity | Cytotoxicity | Parasites | Trypomastigotes | Autophagy | Blood | Tropical diseases | Alterations | Parasitic diseases | Vector-borne diseases | Quinoxaline | Protozoa | Medical treatment | Blood cells | Organelles | Chromatography | Golgi apparatus | Side effects | Epimastigotes | Cell size | Synergistic effect | In vitro methods and tests | Apoptosis | Nuclear magnetic resonance | NMR
Journal Article
PloS one, ISSN 1932-6203, 04/2014, Volume 9, Issue 4, p. e93936
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2012, Volume 122, Issue 7, pp. 2531 - 2542
... T. cruzi parasitemia in blood. CoPP-induced effects did not depend on the adaptive immunity, nor were parasites directly targeted... 
MEDICINE, RESEARCH & EXPERIMENTAL | LABILE IRON | C VIRUS-REPLICATION | INTRACELLULAR GROWTH | RESPIRATORY BURST | IFN-GAMMA | MACROPHAGES | RESPONSE ELEMENTS | IN-VIVO | CHAGAS-DISEASE | HEME OXYGENASE 1 | Chagas Disease - parasitology | Heme Oxygenase-1 - metabolism | Reactive Oxygen Species - metabolism | Oxidative Stress | Respiratory Burst | Antioxidants - metabolism | Protoporphyrins - pharmacology | Parasitemia - drug therapy | Heme Oxygenase-1 - genetics | Ferritins - metabolism | Cation Transport Proteins - metabolism | Ferritins - genetics | Ferrous Compounds - pharmacology | Muscle, Skeletal - parasitology | Heart - parasitology | Cation Transport Proteins - genetics | NF-E2-Related Factor 2 - genetics | Host-Parasite Interactions | Macrophages, Peritoneal - drug effects | Mice, Inbred C57BL | Macrophages, Peritoneal - enzymology | Heme Oxygenase-1 - antagonists & inhibitors | Iron - metabolism | Macrophages, Peritoneal - parasitology | Trypanosoma cruzi - physiology | Antiparasitic Agents - therapeutic use | Animals | NF-E2-Related Factor 2 - metabolism | Antiparasitic Agents - pharmacology | Chagas Disease - drug therapy | Parasitemia - parasitology | Trypanosoma cruzi - drug effects | Mice | Protoporphyrins - therapeutic use | Receptors, Immunologic - metabolism | Oxidative stress | Research | Health aspects | Trypanosomiasis | Risk factors | Trypanosoma cruzi
Journal Article
Scientific reports, ISSN 2045-2322, 2014, Volume 4, Issue 1, pp. 1 - 11
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 09/2017, Volume 60, Issue 17, pp. 7284 - 7299
Journal Article
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 11/2013, Volume 288, Issue 44, pp. 31602 - 31615
Journal Article
PloS one, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, p. e30356
... arylimidamide (AIA - DB1831 (hydrochloride salt) and DB1965 (mesylate salt)) against T. cruzi. These AIAs displayed a high trypanocidal effect in vitro against both relevant... 
BLOOD-SAMPLES | DIAGNOSIS | MANAGEMENT | DNA | BIOLOGY | CHAGAS-DISEASE | TRYPANOCIDAL ACTIVITY | AGENTS | DIAMIDINES | BENZNIDAZOLE | Amidines - adverse effects | Amidines - therapeutic use | Male | Amides - adverse effects | Female | Drug Evaluation, Preclinical | Amides - pharmacology | Chagas Disease - pathology | Cells, Cultured | Mesylates - therapeutic use | Treatment Outcome | Amides - therapeutic use | Mesylates - adverse effects | Pyrimidines - pharmacology | Antiprotozoal Agents - pharmacology | Trypanosoma cruzi - physiology | No-Observed-Adverse-Effect Level | Animals | Antiprotozoal Agents - adverse effects | Trypanosoma cruzi - growth & development | Chagas Disease - mortality | Mesylates - pharmacology | Models, Biological | Pyrimidines - therapeutic use | Chagas Disease - drug therapy | Pyrimidines - adverse effects | Trypanosoma cruzi - drug effects | Amidines - pharmacology | Mice | Antiprotozoal Agents - therapeutic use | Infection | Medicine, Experimental | Medical research | Chagas' disease | Health aspects | Heart | Drugs | Cell culture | Salts | Animal models | Benznidazole | Nifurtimox | Cardiovascular disease | Infections | Selectivity | Parasites | Tropical diseases | Parasitic diseases | Deoxyribonucleic acid--DNA | Vector-borne diseases | Protozoa | Effectiveness | Polymerase chain reaction | Chemistry | Chemotherapy | Morphology | In vivo methods and tests | Intracellular | Molecular biology | Deoxyribonucleic acid
Journal Article
Journal Article