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1. Full Text Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial
by Priotto, Gerardo, Dr and Kasparian, Serena, MD and Mutombo, Wilfried, MD and Ngouama, Daniel, MD and Ghorashian, Sara, MD and Arnold, Ute, MD and Ghabri, Salah, PhD and Baudin, Elisabeth, MD and Buard, Vincent, MD and Kazadi-Kyanza, Serge, MD and Ilunga, Médard, MD and Mutangala, Willy, MD and Pohlig, Gabriele, PhD and Schmid, Caecilia, PhD and Karunakara, Unni, PhD and Torreele, Els, PhD and Kande, Victor, MD
Lancet, The, ISSN 0140-6736, 2009, Volume 374, Issue 9683, pp. 56 - 64
Summary Background Human African trypanosomiasis (HAT; sleeping sickness) caused by Trypanosoma brucei gambiense is a fatal disease. Current treatment options... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | 10-DAY MELARSOPROL SCHEDULE | CLINICAL-TRIAL | METABOLISM | EFFICACY | I TRIAL | SLEEPING SICKNESS | DIFLUOROMETHYLORNITHINE | FAILURE | ANGOLA | Trypanosomiasis, African - drug therapy | Trypanocidal Agents - adverse effects | Follow-Up Studies | Humans | Eflornithine - adverse effects | Male | Eflornithine - therapeutic use | Fever - chemically induced | Infection - chemically induced | Seizures - chemically induced | Trypanosomiasis, African - diagnosis | Trypanosomiasis, African - epidemiology | Congo - epidemiology | Adult | Female | Trypanocidal Agents - therapeutic use | Safety | Drug Therapy, Combination | Drug Administration Schedule | Administration, Oral | Kaplan-Meier Estimate | Treatment Outcome | Trypanosoma brucei gambiense | Democratic Republic of the Congo - epidemiology | Animals | Nifurtimox - adverse effects | Infusions, Intravenous | Nifurtimox - therapeutic use | Evaluation | Drug therapy, Combination | Drug therapy | African trypanosomiasis | Drugs | Data analysis | Disease | Research methodology | Clinical trials | Clinical medicine | Tropical diseases | Index Medicus | Abridged Index Medicus
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2. Full Text Clinical features, diagnosis, and treatment of human African trypanosomiasis (sleeping sickness)
by Kennedy, Peter GE, Prof
Lancet Neurology, The, ISSN 1474-4422, 2013, Volume 12, Issue 2, pp. 186 - 194
Summary Human African trypanosomiasis, or sleeping sickness, is caused by infection with parasites of the genus Trypanosoma , transmitted by the tsetse fly.... 
Neurology | HUMAN-SERUM | NERVOUS-SYSTEM | 10-DAY MELARSOPROL SCHEDULE | RISK-FACTORS | MEDIATED ISOTHERMAL AMPLIFICATION | BRUCEI-GAMBIENSE TRYPANOSOMIASIS | LYTIC FACTOR | FOLLOW-UP | RAPID DETECTION | CLINICAL NEUROLOGY | TREATMENT FAILURE | Trypanosomiasis, African - drug therapy | Trypanosomiasis, African - parasitology | Trypanosomiasis, African - diagnosis | Trypanosoma brucei rhodesiense - pathogenicity | Humans | Trypanosoma brucei gambiense - pathogenicity | Trypanosomiasis, African - epidemiology | Trypanosomiasis, African - therapy | Care and treatment | Disease transmission | Diagnosis | Trypanosomiasis | Index Medicus
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3. Full Text Nifurtimox-Eflornithine Combination Therapy for Second-Stage Gambiense Human African Trypanosomiasis: Médecins Sans Frontières Experience in the Democratic Republic of the Congo
by Emilie Alirol and David Schrumpf and Josué Amici Heradi and Andrea Riedel and Catherine de Patoul and Michel Quere and François Chappuis
Clinical Infectious Diseases, ISSN 1058-4838, 1/2013, Volume 56, Issue 2, pp. 195 - 203
Background. Existing diagnostic and treatment tools for human African trypanosomiasis (HAT) are limited. The recent development of nifurtimox-eflornithine... 
Headache | Relapse | Vomiting | Mortality | Clinical trials | Hats | Children | Cerebrospinal fluid | ARTICLES AND COMMENTARIES | African trypanosomiasis | Trypanosome | human african trypanosomiasis | NECT | pharmacovigilance | Democratic Republic of Congo | safety | INFECTIOUS DISEASES | RISK-FACTORS | CLINICAL-TRIAL | CHAGAS-DISEASE | SLEEPING SICKNESS | BRUCEI | MICROBIOLOGY | IMMUNOLOGY | FAILURE | UGANDA | MELARSOPROL TREATMENT | Trypanosomiasis, African - drug therapy | Follow-Up Studies | Humans | Middle Aged | Risk Factors | Child, Preschool | Eflornithine - adverse effects | Infant | Male | Treatment Outcome | Eflornithine - therapeutic use | Trypanosoma brucei gambiense | Young Adult | Medication Adherence | Nifurtimox - adverse effects | Adolescent | Adult | Female | Democratic Republic of the Congo | Drug Therapy, Combination | Child | Nifurtimox - therapeutic use | Cohort Studies
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4. Full Text Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story
by Baker, Nicola and de Koning, Harry P and Mäser, Pascal and Horn, David
Trends in Parasitology, ISSN 1471-4922, 2013, Volume 29, Issue 3, pp. 110 - 118
Melarsoprol and pentamidine represent the two main classes of drugs, the arsenicals and diamidines, historically used to treat the diseases caused by African... 
Infectious Disease | Gastroenterology and Hepatology | MRPA | drug resistance | AQP2 | Trypanosoma brucei | MIP | AT1 | Drug resistance | BRUCEI-GAMBIENSE TRYPANOSOMIASIS | P2 ADENOSINE TRANSPORTER | COMBINATION THERAPY | CROSS-RESISTANCE | SLEEPING SICKNESS | BLOOD-STREAM FORM | NUCLEOSIDE TRANSPORTER | 3 AQUAGLYCEROPORINS | ABC TRANSPORTERS | MULTIDRUG-RESISTANCE | PARASITOLOGY | Trypanosomiasis, African - drug therapy | Humans | Pentamidine - therapeutic use | Melarsoprol - therapeutic use | Phylogeny | Trypanosoma brucei brucei - genetics | Trypanosoma brucei brucei - drug effects | Drug Resistance - genetics | Animals | Trypanocidal Agents - pharmacology | Aquaglyceroporins - genetics | Trypanosoma brucei brucei - classification | Trypanocidal Agents - therapeutic use | Aquaglyceroporins - metabolism | Antiparasitic agents | Livestock | Trypanosomiasis | Aquaporins | drug-resistance
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5. Full Text The animal trypanosomiases and their chemotherapy: A review
by Giordani, Federica and Morrison, Liam J and Rowan, Tim G and De Koning, Harry P and Barrett, Michael P
Parasitology, ISSN 0031-1820, 12/2016, Volume 143, Issue 14, pp. 1862 - 1889
Pathogenic animal trypanosomes affecting livestock have represented a major constraint to agricultural development in Africa for centuries, and their negative... 
Trypanosoma vivax | drug resistance | Trypanosoma brucei | animal trypanosomiases | Trypanosoma congolense | veterinary trypanocide | INCUBATION INFECTIVITY TEST | BRUCEI-GAMBIENSE TRYPANOSOMIASIS | HUMAN AFRICAN TRYPANOSOMIASIS | EFLORNITHINE COMBINATION THERAPY | AXENIC INVITRO CULTIVATION | NATURALLY INFECTED CATTLE | TRYPANOCIDAL DRUG-RESISTANCE | TSETSE-TRANSMITTED TRYPANOSOMES | BLOOD-STREAM FORMS | CENTRAL-NERVOUS-SYSTEM | PARASITOLOGY | Trypanosomiasis - parasitology | Trypanosomiasis, African - drug therapy | Africa - epidemiology | Trypanosomiasis - veterinary | Trypanosoma - classification | Tsetse Flies - parasitology | Trypanosomiasis, Bovine - drug therapy | Trypanosomiasis, African - veterinary | Trypanosomiasis - drug therapy | Trypanosomiasis, African - parasitology | Asia - epidemiology | South America - epidemiology | Animals | Trypanosoma - pathogenicity | Trypanosoma - drug effects | Cattle | Trypanosomiasis, Bovine - epidemiology | Insect Vectors - parasitology | Trypanosomiasis, African - epidemiology | Trypanocidal Agents - therapeutic use | Drug Resistance | Review
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6. Full Text Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness
by Khare, Shilpi and Nagle, Advait S and Biggart, Agnes and Lai, Yin H and Liang, Fang and Davis, Lauren C and Barnes, S. Whitney and Mathison, Casey J. N and Myburgh, Elmarie and Gao, Mu-Yun and Gillespie, J. Robert and Liu, Xianzhong and Tan, Jocelyn L and Stinson, Monique and Rivera, Ianne C and Ballard, Jaime and Yeh, Vince and Groessl, Todd and Federe, Glenn and Koh, Hazel X. Y and Venable, John D and Bursulaya, Badry and Shapiro, Michael and Mishra, Pranab K and Spraggon, Glen and Brock, Ansgar and Mottram, Jeremy C and Buckner, Frederick S and Rao, Srinivasa P. S and Wen, Ben G and Walker, John R and Tuntland, Tove and Molteni, Valentina and Glynne, Richard J and Supek, Frantisek
Nature, ISSN 0028-0836, 08/2016, Volume 537, Issue 7619, pp. 229 - 233
Chagas disease, leishmaniasis and sleeping sickness affect 20 million people worldwide and lead to more than 50,000 deaths annually(1). The diseases are caused... 
SYSTEM | POSACONAZOLE | GENE | TRYPANOSOMA-CRUZI | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | RANDOMIZED-TRIAL | INFECTION | CURE | BORTEZOMIB | BENZNIDAZOLE | Triazoles - adverse effects | Trypanosomiasis, African - drug therapy | Chagas Disease - parasitology | Species Specificity | Chymotrypsin - metabolism | Triazoles - chemistry | Humans | Kinetoplastida - drug effects | Molecular Targeted Therapy | Pyrimidines - chemistry | Proteasome Endopeptidase Complex - drug effects | Inhibitory Concentration 50 | Female | Molecular Structure | Disease Models, Animal | Triazoles - therapeutic use | Proteasome Inhibitors - pharmacology | Leishmaniasis - drug therapy | Proteasome Inhibitors - classification | Pyrimidines - pharmacology | Kinetoplastida - enzymology | Proteasome Inhibitors - adverse effects | Proteasome Inhibitors - therapeutic use | Triazoles - pharmacology | Trypanosomiasis, African - parasitology | Animals | Pyrimidines - therapeutic use | Chagas Disease - drug therapy | Pyrimidines - adverse effects | Chymotrypsin - antagonists & inhibitors | Leishmaniasis - parasitology | Mice | Care and treatment | Leishmaniasis | Chagas' disease | Proteins | Protozoa | Cell growth | Inhibitor drugs | Parasitic diseases | Parasites | Drug therapy
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7. Full Text Specific Cell Targeting Therapy Bypasses Drug Resistance Mechanisms in African Trypanosomiasis
by Unciti-Broceta, Juan D and Arias, José L and Maceira, José and Soriano, Miguel and Ortiz-González, Matilde and Hernández-Quero, José and Muñóz-Torres, Manuel and de Koning, Harry P and Magez, Stefan and Garcia-Salcedo, José A
PLoS Pathogens, ISSN 1553-7366, 06/2015, Volume 11, Issue 6, pp. e1004942 - e1004942
African trypanosomiasis is a deadly neglected disease caused by the extracellular parasite Trypanosoma brucei. Current therapies are characterized by high drug... 
LEISHMANIA-INFANTUM | PENTAMIDINE | DIAMIDINE DRUGS | CHITOSAN | CROSS-RESISTANCE | BRUCEI | MICROBIOLOGY | DELIVERY | NUCLEOSIDE TRANSPORTER | NANOPARTICLES | VIROLOGY | EXPRESSION | PARASITOLOGY | Trypanosomiasis, African - drug therapy | Mice, Inbred C57BL | Chitosan - administration & dosage | Drug Carriers - administration & dosage | Drug Resistance - drug effects | Pentamidine - administration & dosage | Trypanocidal Agents - pharmacokinetics | Pentamidine - pharmacokinetics | Antibodies, Protozoan - administration & dosage | Animals | Chitosan - pharmacokinetics | Nanoparticles - therapeutic use | Inhibitory Concentration 50 | Female | Drug Carriers - pharmacokinetics | Electrophoretic Mobility Shift Assay | Mice | Real-Time Polymerase Chain Reaction | Molecular Targeted Therapy - methods | Disease Models, Animal | Trypanocidal Agents - administration & dosage | Index Medicus | Drug delivery systems | Immunoglobulins | Parasites | Drug resistance | Experiments | Molecular weight | Chemotherapy | Parasitic diseases | Polyethylene glycol | Mutation | Drug dosages | Thermal cycling | Binding sites
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8. Full Text Scyx-7158, an orally-active benzoxaborole for the treatment of stage 2 human african trypanosomiasis
by Jacobs, Robert T and Nare, Bakela and Wring, Stephen A and Orr, Matthew D and Chen, Daitao and Sligar, Jessica M and Jenks, Matthew X and Noe, Robert A and Bowling, Tana S and Mercer, Luke T and Rewerts, Cindy and Gaukel, Eric and Owens, Jennifer and Parham, Robin and Randolph, Ryan and Beaudet, Beth and Bacchi, Cyrus J and Yarlett, Nigel and Plattner, Jacob J and Freund, Yvonne and Ding, Charles and Akama, Tsutomu and Zhang, Y.-K and Brun, Reto and Kaiser, Marcel and Scandale, Ivan and Don, Robert
PLoS Neglected Tropical Diseases, ISSN 1935-2727, 06/2011, Volume 5, Issue 6, p. e1151
Background: Human African trypanosomiasis (HAT) is an important public health problem in sub-Saharan Africa, affecting hundreds of thousands of individuals. An... 
IN-VITRO | DRUG DISCOVERY | EFLORNITHINE COMBINATION THERAPY | GAMBIENSE SLEEPING SICKNESS | BORIC-ACID | BRUCEI | AGENTS | DECARBOXYLASE INHIBITORS | MODEL | PARASITOLOGY | TROPICAL MEDICINE | P-GLYCOPROTEIN | Trypanosomiasis, African - drug therapy | Parasitic Sensitivity Tests | Administration, Oral | Benzamides - pharmacokinetics | Boron Compounds - pharmacokinetics | Treatment Outcome | Boron Compounds - administration & dosage | Antiprotozoal Agents - pharmacokinetics | Benzamides - administration & dosage | Animals | Antiprotozoal Agents - adverse effects | Rodent Diseases - drug therapy | Trypanosoma - drug effects | Primate Diseases - drug therapy | Antiprotozoal Agents - administration & dosage | Primates | Boron Compounds - adverse effects | Female | Mice | Benzamides - adverse effects | Disease Models, Animal | Brain | Physiological aspects | Diagnosis | Drug therapy | Biological assay | Trypanosoma brucei | Health aspects | African trypanosomiasis | Methods | Blood-brain barrier | Rodents | Clinical trials | Infections | Experiments | Drug dosages | Public health
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9. Full Text Management of trypanosomiasis and leishmaniasis
by Barrett, Michael P and Croft, Simon L
British Medical Bulletin, ISSN 0007-1420, 12/2012, Volume 104, Issue 1, pp. 175 - 196
The current treatments for human African trypanosomiasis (HAT), Chagas disease and leishmaniasis (collectively referred to as the kinetoplastid diseases) are... 
Chagas disease | human African trypanosomiasis | leishmaniasis | antiprotozoal drug development | antiprotozoal drug treatment | EFFICACY | DRUG DISCOVERY | CHAGAS-DISEASE | SLEEPING SICKNESS | RANDOMIZED-TRIAL | LIPOSOMAL AMPHOTERICIN-B | CUTANEOUS LEISHMANIASIS | MEDICINE, GENERAL & INTERNAL | BRUCEI-GAMBIENSE | VISCERAL LEISHMANIASIS | Trypanosomiasis, African - drug therapy | Africa - epidemiology | Humans | Pentamidine - therapeutic use | Benzamides - therapeutic use | Nitroimidazoles - therapeutic use | Trypanosomiasis, African - diagnosis | Benzamides - pharmacology | Drug Therapy, Combination | Pentamidine - pharmacology | Triazoles - therapeutic use | Boron Compounds - pharmacology | Leishmaniasis - diagnosis | Nitroimidazoles - pharmacology | Administration, Oral | Amphotericin B - pharmacology | India - epidemiology | Leishmaniasis - drug therapy | Antiprotozoal Agents - pharmacology | Triazoles - pharmacology | Chagas Disease - diagnosis | Chagas Disease - drug therapy | Amphotericin B - therapeutic use | Antiprotozoal Agents - therapeutic use | Boron Compounds - therapeutic use
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10. Full Text The human african trypanosomiasis control and surveillance programme of the world health organization 2000-2009: The way forward
by Simarro, Pere P and Diarra, Abdoulaye and Postigo, Jose A. Ruiz and Franco, José R and Jannin, Jean G
PLoS Neglected Tropical Diseases, ISSN 1935-2735, 02/2011, Volume 5, Issue 2, p. e1007
TRIAL | EFLORNITHINE | COMBINATION THERAPY | GAMBIENSE SLEEPING SICKNESS | NIFURTIMOX | PARASITOLOGY | TROPICAL MEDICINE | UGANDA | Endemic Diseases | Geography | Trypanosomiasis, African - drug therapy | World Health Organization | Humans | Trypanosomiasis, African - epidemiology | Trypanosomiasis, African - prevention & control | Communicable Disease Control - methods | Communicable Disease Control - organization & administration | Incidence
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