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Trends in Parasitology, ISSN 1471-4922, 11/2003, Volume 19, Issue 11, pp. 488 - 494
Journal Article
Nature, ISSN 0028-0836, 04/2010, Volume 464, Issue 7289, pp. 728 - 732
African sleeping sickness or human African trypanosomiasis, caused by Trypanosoma brucei spp., is responsible for similar to 30,000 deaths each year. Available... 
VARIANT SURFACE GLYCOPROTEIN | AFRICAN TRYPANOSOMES | TRYPANOSOMA-BRUCEI | SUBSTRATE PROTEINS | MYRISTOYL-COA | MULTIDISCIPLINARY SCIENCES | COMPLEXES | TRAFFICKING | DRUG TARGET | ENDOCYTOSIS | LEISHMANIA | Acyltransferases - antagonists & inhibitors | Trypanosomiasis, African - drug therapy | Pyrazoles - therapeutic use | Humans | Antiparasitic Agents - metabolism | Aminopyridines - metabolism | Acyltransferases - metabolism | Trypanosoma brucei brucei - enzymology | Aminopyridines - chemistry | Pyrazoles - chemistry | Aminopyridines - therapeutic use | Time Factors | Enzyme Inhibitors - chemistry | Female | Molecular Structure | Trypanosoma brucei brucei - growth & development | Pyrazoles - pharmacology | Enzyme Inhibitors - metabolism | Sulfonamides - chemistry | Enzyme Inhibitors - pharmacology | Rats | Enzyme Assays | Pyrazoles - metabolism | Sulfonamides - pharmacology | Enzyme Inhibitors - therapeutic use | Trypanosoma brucei brucei - drug effects | Antiparasitic Agents - therapeutic use | Trypanosomiasis, African - parasitology | Animals | Sulfonamides - therapeutic use | Aminopyridines - pharmacology | Antiparasitic Agents - pharmacology | Sulfonamides - metabolism | Mice | Antiparasitic Agents - chemistry | Post-translational modification | Usage | Control | Care and treatment | Enzyme inhibitors | Transferases | Physiological aspects | Genetic aspects | Research | Health aspects | Trypanosomiasis | Proteins | Data collection | Enzymes | Human | Inhibitors | Peptides | Central nervous system | Sicknesses | Trypanosome | PARASITES | TRYPANOSOMIASIS | BASIC BIOLOGICAL SCIENCES | SAFETY | SUBSTRATES | VALIDATION | CENTRAL NERVOUS SYSTEM | IN VIVO | 60 APPLIED LIFE SCIENCES | DISEASES | PEPTIDES | TRYPANOSOMA | ENZYMES | IN VITRO | DRUGS | TARGETS | MICE | PROTEINS | TRYPANOSOMES | LEAD COMPOUNDS
Journal Article
Molecules, ISSN 1420-3049, 01/2017, Volume 22, Issue 1, p. 79
This review presents an survey to the biological importance of sesquiterpene lactones (SLs) in the fight against four infectious neglected tropical diseases... 
Neglected tropical diseases | Schistosomiasis | Secondary metabolites | Computer-Aided drug design | Sesquiterpene lactones | Sleeping sickness | Chagas disease | QSAR studies | Leishmaniasis | IN-SILICO | TRYPANOSOMA-CRUZI | SCHISTOSOMA-MANSONI | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHAGAS-DISEASE | leishmaniasis | SODIUM STIBOGLUCONATE | computer-aided drug design | CHEMISTRY, MULTIDISCIPLINARY | INTRALESIONAL MEGLUMINE ANTIMONIATE | neglected tropical diseases | secondary metabolites | MOLECULAR DESCRIPTORS | NEURAL-NETWORKS | LEISHMANICIDAL ACTIVITIES | sesquiterpene lactones | schistosomiasis | QUANTITATIVE STRUCTURE | sleeping sickness | Trypanosomiasis, African - drug therapy | Sesquiterpenes - chemistry | Humans | Models, Molecular | Leishmaniasis - drug therapy | Neglected Diseases - drug therapy | Antiprotozoal Agents - chemistry | Schistosomiasis - drug therapy | Antiprotozoal Agents - pharmacology | Schistosoma - drug effects | Lactones - pharmacology | Animals | Trypanosoma - drug effects | Chagas Disease - drug therapy | Drug Design | Leishmania - drug effects | Molecular Docking Simulation | Computer-Aided Design | Sesquiterpenes - pharmacology | Quantitative Structure-Activity Relationship | Lactones - chemistry | Vector-borne diseases | Molecular structure | Toxicity | Pharmacology | Structure-activity relationships | Drug development | Chemical compounds | Biological activity | Tropical diseases | Molecular docking | Lactones | Organic chemistry | Infectious diseases | Computer aided design--CAD | Chagas' disease | African trypanosomiasis
Journal Article
Journal Article
Clinical Infectious Diseases, ISSN 1058-4838, 12/2007, Volume 45, Issue 11, pp. 1435 - 1442
Journal Article
Molecular & Biochemical Parasitology, ISSN 0166-6851, 03/2016, Volume 206, Issue 1-2, pp. 67 - 74
Trypanosomatids are the causative agents of African sleeping sickness, Chagas' disease, and the different forms of leishmaniasis. This family of protozoan... 
Drug | Trypanothione synthetase | Inhibitor | Trypanosoma | Leishmania | Trypanothione reductase | LEISHMANIA-INFANTUM | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHAGAS-DISEASE | BRUCEI | ESSENTIAL ENZYME | DISCOVERY | TRYPAREDOXIN | SYNTHETASE | DRUG TARGET | INHIBITORS | PARASITOLOGY | Trypanosomiasis, African - drug therapy | Chagas Disease - parasitology | Amide Synthases - antagonists & inhibitors | Protozoan Proteins - antagonists & inhibitors | Trypanosoma - genetics | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Molecular Targeted Therapy | Protozoan Proteins - genetics | Amide Synthases - metabolism | Sulfhydryl Compounds - metabolism | Leishmania - enzymology | Protozoan Proteins - metabolism | Leishmania - drug effects | Antiprotozoal Agents - chemical synthesis | NADH, NADPH Oxidoreductases - metabolism | Trypanosoma - enzymology | NADH, NADPH Oxidoreductases - genetics | Gene Expression | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Leishmaniasis - drug therapy | Trypanosoma - growth & development | Antiprotozoal Agents - pharmacology | Trypanosomiasis, African - parasitology | Animals | High-Throughput Screening Assays | Trypanosoma - drug effects | Chagas Disease - drug therapy | Leishmaniasis - parasitology | NADH, NADPH Oxidoreductases - antagonists & inhibitors | Amide Synthases - genetics | Leishmania - growth & development | Leishmania - genetics | Chemotherapy | Thiols | Cancer
Journal Article
Journal Article
Journal Article
Journal Article
Current Opinion in Pharmacology, ISSN 1471-4892, 2012, Volume 12, Issue 5, pp. 562 - 566
Highlights ► New drug candidates are being clinically tested against malaria and sleeping sickness. ► For malaria these are the synthetic peroxide OZ439 and... 
Internal Medicine | Medical Education | TRYPANOSOMIASIS | FEXINIDAZOLE | INFECTIONS | POTENT | SPIROINDOLONES | PHARMACOLOGY & PHARMACY | CANDIDATE | CURE | Antiparasitic Agents - therapeutic use | Trypanosomiasis, African - drug therapy |