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1. Full Text The animal trypanosomiases and their chemotherapy: A review
by Giordani, Federica and Morrison, Liam J and Rowan, Tim G and De Koning, Harry P and Barrett, Michael P
Parasitology, ISSN 0031-1820, 12/2016, Volume 143, Issue 14, pp. 1862 - 1889
Pathogenic animal trypanosomes affecting livestock have represented a major constraint to agricultural development in Africa for centuries, and their negative... 
Trypanosoma vivax | drug resistance | Trypanosoma brucei | animal trypanosomiases | Trypanosoma congolense | veterinary trypanocide | INCUBATION INFECTIVITY TEST | BRUCEI-GAMBIENSE TRYPANOSOMIASIS | HUMAN AFRICAN TRYPANOSOMIASIS | EFLORNITHINE COMBINATION THERAPY | AXENIC INVITRO CULTIVATION | NATURALLY INFECTED CATTLE | TRYPANOCIDAL DRUG-RESISTANCE | TSETSE-TRANSMITTED TRYPANOSOMES | BLOOD-STREAM FORMS | CENTRAL-NERVOUS-SYSTEM | PARASITOLOGY | Trypanosomiasis - parasitology | Trypanosomiasis, African - drug therapy | Africa - epidemiology | Trypanosomiasis - veterinary | Trypanosoma - classification | Tsetse Flies - parasitology | Trypanosomiasis, Bovine - drug therapy | Trypanosomiasis, African - veterinary | Trypanosomiasis - drug therapy | Trypanosomiasis, African - parasitology | Asia - epidemiology | South America - epidemiology | Animals | Trypanosoma - pathogenicity | Trypanosoma - drug effects | Cattle | Trypanosomiasis, Bovine - epidemiology | Insect Vectors - parasitology | Trypanosomiasis, African - epidemiology | Trypanocidal Agents - therapeutic use | Drug Resistance | Review
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2. Full Text The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes
by Capewell, Paul and Cren-Travaillé, Christelle and Marchesi, Francesco and Johnston, Pamela and Clucas, Caroline and Benson, Robert A and Gorman, Taylor-Anne and Calvo-Alvarez, Estefania and Crouzols, Aline and Jouvion, Grégory and Jamonneau, Vincent and Weir, William and Lynn Stevenson, M and O’Neill, Kerry and Cooper, Anneli and Swar, Nono-Raymond Kuispond and Bucheton, Bruno and Ngoyi, Dieudonné Mumba and Garside, Paul and Rotureau, Brice and MacLeod, Annette
eLife, ISSN 2050-084X, 09/2016, Volume 5, Issue 2016
The role of mammalian skin in harbouring and transmitting arthropod-borne protozoan parasites has been overlooked for decades as these pathogens have been... 
SUSPECTS | PARASITEMIA | BRUCEI-GAMBIENSE | BIOLOGY | CNS | SLEEPING-SICKNESS | EXPRESSION | THREAT | Trypanosomiasis, African - parasitology | Trypanosomiasis, African - transmission | Animals | Tsetse Flies - parasitology | Humans | Mice, Inbred C57BL | Skin - parasitology | Mice, Inbred BALB C | Trypanosoma brucei gambiense - isolation & purification | Disease Models, Animal | Skin | Disease transmission | Observations | Trypanosomiasis | Health aspects | Risk factors | Medical research | Parasitology | Immunoglobulins | Biomedical research | Disease | Infections | Inflammation | Parasites | Vectors (Biology) | Experimental infection | Histopathology | Microscopy | Blood parasites | Extravasation | Localization | African trypanosomiasis | Life Sciences | Human health and pathology | Microbiology and Parasitology | Santé publique et épidémiologie
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3. Full Text Clinical features, diagnosis, and treatment of human African trypanosomiasis (sleeping sickness)
by Kennedy, Peter GE, Prof
Lancet Neurology, The, ISSN 1474-4422, 2013, Volume 12, Issue 2, pp. 186 - 194
Summary Human African trypanosomiasis, or sleeping sickness, is caused by infection with parasites of the genus Trypanosoma , transmitted by the tsetse fly.... 
Neurology | HUMAN-SERUM | NERVOUS-SYSTEM | 10-DAY MELARSOPROL SCHEDULE | RISK-FACTORS | MEDIATED ISOTHERMAL AMPLIFICATION | BRUCEI-GAMBIENSE TRYPANOSOMIASIS | LYTIC FACTOR | FOLLOW-UP | RAPID DETECTION | CLINICAL NEUROLOGY | TREATMENT FAILURE | Trypanosomiasis, African - drug therapy | Trypanosomiasis, African - parasitology | Trypanosomiasis, African - diagnosis | Trypanosoma brucei rhodesiense - pathogenicity | Humans | Trypanosoma brucei gambiense - pathogenicity | Trypanosomiasis, African - epidemiology | Trypanosomiasis, African - therapy | Care and treatment | Disease transmission | Diagnosis | Trypanosomiasis | Index Medicus
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4. Full Text Antigenic variation in African trypanosomes
by Horn, David
Molecular & Biochemical Parasitology, ISSN 0166-6851, 07/2014, Volume 195, Issue 2, pp. 123 - 129
Studies on Variant Surface Glycoproteins (VSGs) and antigenic variation in the African trypanosome, , have yielded a remarkable range of novel and important... 
Monoallelic | Immune evasion | Silencing | Trans-splicing | In situ | Polycistronic | RNA-POLYMERASE-I | GENE-EXPRESSION SITE | BIOCHEMISTRY & MOLECULAR BIOLOGY | VARIANT-SURFACE-GLYCOPROTEIN | CELL-SURFACE | STABLE EXPRESSION | GENOMIC ENVIRONMENT | DISCONTINUOUS TRANSCRIPTION | POLYCISTRONIC TRANSCRIPTION UNITS | HOMOLOGOUS RECOMBINATION | VSG GENE | PARASITOLOGY | Trypanosomiasis, African - parasitology | Animals | Antigenic Variation | Humans | Trypanosoma brucei brucei - genetics | Variant Surface Glycoproteins, Trypanosoma - genetics | Trypanosoma brucei brucei - immunology | Variant Surface Glycoproteins, Trypanosoma - immunology | Review
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5. Full Text African trypanosomes and brain infection – the unsolved question
by Mogk, Stefan and Boßelmann, Christian M and Mudogo, Celestin N and Stein, Jasmin and Wolburg, Hartwig and Duszenko, Michael
Biological Reviews, ISSN 1464-7931, 08/2017, Volume 92, Issue 3, pp. 1675 - 1687
ABSTRACT African trypanosomes induce sleeping sickness. The parasites are transmitted during the blood meal of a tsetse fly and appear primarily in blood and... 
trypanosomiasis | brain infection | HAT | Trypanosoma brucei | African sleeping sickness | ASTROCYTE-ENDOTHELIAL INTERACTIONS | SLEEPING-SICKNESS | BRUCEI-BRUCEI | CEREBROSPINAL-FLUID | PROGRAMMED CELL-DEATH | TIGHT JUNCTIONS | CIRCUMVENTRICULAR ORGANS | BLOOD-STREAM FORMS | BIOLOGY | CENTRAL-NERVOUS-SYSTEM | CHOROID-PLEXUS | Trypanosomiasis, African - parasitology | Trypanosomiasis, African - transmission | Animals | Central Nervous System - parasitology | Humans | Host-Parasite Interactions | Blood-Brain Barrier - parasitology | Brain - parasitology
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6. Full Text Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans
by Giulio Genovese and David J. Friedman and Michael D. Ross and Laurence Lecordier and Pierrick Uzureau and Barry I. Freedman and Donald W. Bowden and Carl D. Langefeld and Taras K. Oleksyk and Andrea L. Uscinski Knob and Andrea J. Bernhardy and Pamela J. Hicks and George W. Nelson and Benoit Vanhollebeke and Cheryl A. Winkler and Jeffrey B. Kopp and Etienne Pays and Martin R. Pollak
Science, ISSN 0036-8075, 8/2010, Volume 329, Issue 5993, pp. 841 - 845
African Americans have higher rates of kidney disease than European Americans. Here, we show that, in African Americans, focal segmental glomerulosclerosis... 
Haplotypes | Kidneys | Focal segmental glomerulosclerosis | REPORTS | Diabetic nephropathies | African Americans | Disease risk | Kidney diseases | Chromosomes | Genetic mutation | Genotypes | 9 GENE MYH9 | POLYMORPHISMS | POSITIVE SELECTION | MULTIDISCIPLINARY SCIENCES | NATURAL-SELECTION | RHODESIENSE | HUMAN SERUM | STAGE RENAL-DISEASE | GENOME | Sequence Deletion | Lipoproteins, HDL - genetics | Lipoproteins, HDL - blood | Glomerulosclerosis, Focal Segmental - genetics | Humans | Lipoproteins, HDL - metabolism | Myosin Heavy Chains - genetics | Kidney Failure, Chronic - ethnology | Molecular Motor Proteins - genetics | Case-Control Studies | Trypanosoma brucei rhodesiense - metabolism | Apolipoproteins - genetics | Glomerulosclerosis, Focal Segmental - ethnology | Trypanosomiasis, African - genetics | Recombinant Proteins - metabolism | Genetic Predisposition to Disease | Genetic Association Studies | Apolipoproteins - metabolism | Gene Frequency | Africa | Selection, Genetic | African Americans - genetics | Logistic Models | Apolipoproteins - blood | Immunity, Innate | Linkage Disequilibrium | Kidney Failure, Chronic - genetics | Trypanosomiasis, African - parasitology | Alleles | Apolipoprotein L1 | Hypertension - complications | Polymorphism, Single Nucleotide | Cohort Studies | Kidney Failure, Chronic - etiology | Genetic aspects | Demographic aspects | Health aspects | Proteins | Mutation | Population genetics
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7. Full Text Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness
by Khare, Shilpi and Nagle, Advait S and Biggart, Agnes and Lai, Yin H and Liang, Fang and Davis, Lauren C and Barnes, S. Whitney and Mathison, Casey J. N and Myburgh, Elmarie and Gao, Mu-Yun and Gillespie, J. Robert and Liu, Xianzhong and Tan, Jocelyn L and Stinson, Monique and Rivera, Ianne C and Ballard, Jaime and Yeh, Vince and Groessl, Todd and Federe, Glenn and Koh, Hazel X. Y and Venable, John D and Bursulaya, Badry and Shapiro, Michael and Mishra, Pranab K and Spraggon, Glen and Brock, Ansgar and Mottram, Jeremy C and Buckner, Frederick S and Rao, Srinivasa P. S and Wen, Ben G and Walker, John R and Tuntland, Tove and Molteni, Valentina and Glynne, Richard J and Supek, Frantisek
Nature, ISSN 0028-0836, 08/2016, Volume 537, Issue 7619, pp. 229 - 233
Chagas disease, leishmaniasis and sleeping sickness affect 20 million people worldwide and lead to more than 50,000 deaths annually(1). The diseases are caused... 
CUTANEOUS LEISHMANIASIS | CRUZI | POSACONAZOLE | HUMAN AFRICAN TRYPANOSOMIASIS | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | RANDOMIZED-TRIAL | BRUCEI | INFECTION | BORTEZOMIB | BENZNIDAZOLE | Triazoles - adverse effects | Trypanosomiasis, African - drug therapy | Chagas Disease - parasitology | Species Specificity | Chymotrypsin - metabolism | Triazoles - chemistry | Humans | Kinetoplastida - drug effects | Molecular Targeted Therapy | Pyrimidines - chemistry | Proteasome Endopeptidase Complex - drug effects | Inhibitory Concentration 50 | Female | Molecular Structure | Disease Models, Animal | Triazoles - therapeutic use | Proteasome Inhibitors - pharmacology | Leishmaniasis - drug therapy | Proteasome Inhibitors - classification | Pyrimidines - pharmacology | Kinetoplastida - enzymology | Proteasome Inhibitors - adverse effects | Proteasome Inhibitors - therapeutic use | Triazoles - pharmacology | Trypanosomiasis, African - parasitology | Animals | Pyrimidines - therapeutic use | Chagas Disease - drug therapy | Pyrimidines - adverse effects | Chymotrypsin - antagonists & inhibitors | Leishmaniasis - parasitology | Mice | Care and treatment | Leishmaniasis | Chagas' disease | Proteins | Protozoa | Cell growth | Inhibitor drugs | Parasitic diseases | Parasites | Drug therapy
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8. Full Text Trypanosoma brucei Parasites Occupy and Functionally Adapt to the Adipose Tissue in Mice
by Trindade, Sandra and Rijo-Ferreira, Filipa and Carvalho, Tânia and Pinto-Neves, Daniel and Guegan, Fabien and Aresta-Branco, Francisco and Bento, Fabio and Young, Simon A and Pinto, Andreia and Van Den Abbeele, Jan and Ribeiro, Ruy M and Dias, Sérgio and Smith, Terry K and Figueiredo, Luisa M and Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Cell Host & Microbe, ISSN 1931-3128, 06/2016, Volume 19, Issue 6, pp. 837 - 848
is an extracellular parasite that causes sleeping sickness. In mammalian hosts, trypanosomes are thought to exist in two major niches: early in infection, they... 
African trypanosomes | fat | fatty acid β-oxidation | metabolism | transcriptome | mouse infection | CHRONIC INFECTIONS | TRANSMISSION | VIROLOGY | METABOLISM | IN-VIVO | DISEASE | TRANSCRIPTION | DYNAMICS | SLEEPING SICKNESS | RECEPTOR | MICROBIOLOGY | PARASITOLOGY | Adipose Tissue - parasitology | Oxidation-Reduction | Mice, Inbred C57BL | Adipose Tissue - pathology | Transcriptome | Male | Trypanosoma brucei brucei - genetics | Protozoan Proteins - genetics | Life Cycle Stages | Trypanosoma brucei brucei - physiology | Trypanosomiasis, African - parasitology | Myristic Acid - metabolism | Animals | Protozoan Proteins - metabolism | Trypanosomiasis, African - blood | Base Sequence | Trypanosomiasis, African - pathology | Mice | Trypanosoma brucei brucei - growth & development | Disease Models, Animal | Adipose tissues | Enzymes | Neurosciences | Analysis | Physiological aspects | Genetic transcription | Fatty acids | BASIC BIOLOGICAL SCIENCES | biological science
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9. Full Text A meta-analysis of the prevalence of African animal trypanosomiasis in Nigeria from 1960 to 2017
by Odeniran, Paul Olalekan and Ademola, Isaiah Oluwafemi
Parasites and Vectors, ISSN 1756-3305, 05/2018, Volume 11, Issue 1, pp. 280 - 12
Background: African animal trypanosomiasis is an economically significant disease that affects the livestock industry in Nigeria. It is caused by several... 
Trypanosomes | Livestock | Prevalence | Tsetse | Nigeria | JOS PLATEAU | BOVINE TRYPANOSOMIASIS | TSETSE-FLIES | GLOSSINA | BENUE STATE | TROPICAL MEDICINE | NSUKKA AREA | TRADE-CATTLE ROUTE | INFECTION-RATES | LOCAL-GOVERNMENT AREA | PARASITOLOGY | ANAMBRA | Tsetse Flies - parasitology | Trypanosoma - genetics | Risk Factors | Trypanosomiasis, African - veterinary | Trypanosomiasis, Bovine - parasitology | Swine Diseases - epidemiology | Livestock - parasitology | Swine Diseases - parasitology | Trypanosomiasis, African - parasitology | Swine Diseases - diagnosis | Animals | Trypanosomiasis, African - diagnosis | Cattle | Swine | Trypanosomiasis, Bovine - epidemiology | Insect Vectors - parasitology | Trypanosomiasis, African - epidemiology | Nigeria - epidemiology | Polymerase Chain Reaction | Trypanosomiasis, Bovine - diagnosis | Trypanosomiasis | Sentinel health events | Methods | Distribution
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