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Gastroenterology, ISSN 0016-5085, 2009, Volume 137, Issue 1, pp. 350 - 360.e5
Background & Aims Acute pancreatitis constitutes a life-threatening condition in which pancreatic acinar cells undergo massive cell death. We investigated the... 
Gastroenterology and Hepatology | ACTIVATED PROTEIN-KINASE | INHIBITION | RAT PANCREAS | TRYPSINOGEN ACTIVATION | IN-VIVO | ENDOTOXIN | LIPOPOLYSACCHARIDE | CHRONIC ALCOHOL EXPOSURE | ACINAR-CELLS | GASTROENTEROLOGY & HEPATOLOGY | CELL-DEATH | Caspase 9 - metabolism | Pancreatitis - etiology | Humans | Caspase 3 - metabolism | Endotoxemia - chemically induced | Lysosomes - enzymology | Male | Endotoxemia - pathology | Autophagy | Lipopolysaccharides | Necrosis | Lysosomes - metabolism | Transfection | RNA Interference | Time Factors | Adenosine Triphosphate - metabolism | HMGB1 Protein - metabolism | Pancreatitis, Alcoholic - metabolism | Disease Models, Animal | Pancreas - enzymology | Pancreatitis, Alcoholic - etiology | Cell Line | Acute Disease | Lysosome-Associated Membrane Glycoproteins - metabolism | Ethanol | Down-Regulation | Lysosomal-Associated Membrane Protein 2 - genetics | Pancreas - pathology | Rats | Cathepsin B - metabolism | Pancreas - metabolism | Trypsin - metabolism | Rats, Sprague-Dawley | Animals | Endotoxemia - complications | Pancreatitis, Alcoholic - pathology | Pancreatitis - pathology | Pancreatitis - metabolism | Endotoxemia - metabolism | Lysosomal-Associated Membrane Protein 2 - metabolism | Apoptosis | Chromosomal proteins | Mitogens | Pancreatitis | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Gut, ISSN 0017-5749, 08/2016, Volume 65, Issue 8, pp. 1333 - 1346
Journal Article
Gastroenterology, ISSN 0016-5085, 2012, Volume 143, Issue 5, pp. 1352 - 1360.e7
Background & Aims The signaling mechanisms that regulate trypsinogen activation and inflammation in acute pancreatitis (AP) are unclear. We explored the... 
Gastroenterology and Hepatology | Inflammatory Response | Leukocytes | Signal Transduction | Transcriptional Regulation | RAT | LUNG INJURY | VASCULAR SMOOTH-MUSCLE | NF-ATC | IN-VIVO | CARDIAC-HYPERTROPHY | CALCINEURIN | NUCLEAR FACTOR | GASTROENTEROLOGY & HEPATOLOGY | TRANSCRIPTION FACTOR | T-CELLS | Amylases - blood | Aorta - metabolism | Pancreatitis - genetics | Cell Nucleus - metabolism | Taurocholic Acid | Statistics, Nonparametric | Lung - metabolism | Chemokine CXCL2 - metabolism | Pyrazoles - pharmacology | Trypsinogen - metabolism | Acinar Cells - metabolism | Peroxidase - drug effects | Trypsinogen - drug effects | Amylases - drug effects | NFATC Transcription Factors - metabolism | Neutrophils - drug effects | Neutrophils - physiology | Pancreatitis - chemically induced | NFATC Transcription Factors - drug effects | Animals | Chemokine CXCL2 - drug effects | Spleen - metabolism | Pancreatitis - pathology | Mice | Acinar Cells - drug effects | Pancreatitis - metabolism | NFATC Transcription Factors - antagonists & inhibitors | NFATC Transcription Factors - genetics | Peroxidase - metabolism | Inflammation | Cyclosporine | T cells | Macrophages | Luciferase | Pancreatitis | Trypsin | Cellular signal transduction | Analysis | Index Medicus | Abridged Index Medicus | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Gastroenterologi
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 06/2007, Volume 292, Issue 6, pp. 1804 - 1812
Endoplasmic reticulum (ER) stress leads to the accumulation of misfolded proteins in the ER lumen and initiates the unfolded protein response (UPR). Components... 
Exocrine acini | Pancreas | CHOLECYSTOKININ RECEPTORS | PHYSIOLOGY | UNFOLDED-PROTEIN RESPONSE | INTRACELLULAR-TRANSPORT | RAT | ER STRESS | CERULEIN-INDUCED PANCREATITIS | EXOCRINE PANCREAS | TRANSLATIONAL CONTROL | MESSENGER-RNA | pancreas | exocrine acini | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Transcription Factor CHOP - genetics | Phosphorylation | Basic-Leucine Zipper Transcription Factors - metabolism | Molecular Chaperones - metabolism | eIF-2 Kinase - metabolism | Pancreas, Exocrine - pathology | Sincalide - pharmacology | Endoplasmic Reticulum - metabolism | Male | Neoplasm Proteins - metabolism | Pancreas, Exocrine - drug effects | RNA, Messenger - metabolism | Sincalide - metabolism | X-Box Binding Protein 1 | Amylases - metabolism | Dose-Response Relationship, Drug | Endoplasmic Reticulum - pathology | RNA Splicing | Bombesin - pharmacology | Endoplasmic Reticulum - drug effects | Stress, Physiological - metabolism | Neoplasm Proteins - genetics | DNA-Binding Proteins | Trypsinogen - metabolism | Heat-Shock Proteins - metabolism | Cells, Cultured | Sincalide - analogs & derivatives | Rats | Stress, Physiological - physiopathology | Basic-Leucine Zipper Transcription Factors - genetics | Trypsin - metabolism | Rats, Sprague-Dawley | Regulatory Factor X Transcription Factors | Protein Folding | Animals | Signal Transduction - drug effects | Stress, Physiological - pathology | Pancreas, Exocrine - metabolism | Transcription Factors | Enzyme Activation | Transcription Factor CHOP - metabolism | Proteins | Rodents | Biochemistry | Gene expression | Kinases | Cells | Binding sites | Index Medicus
Journal Article
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 06/2007, Volume 292, Issue 6, pp. G1738 - G1746
We have hypothesized that the colocalization of digestive zymogens with lysosomal hydrolases, which occurs during the early stages of every experimental... 
Colocalization | Cathepsin B | Lysosomes | Trypsinogen activation | PHYSIOLOGY | cathepsin B | RATS | colocalization | SUPRAMAXIMAL STIMULATION | PROTEASE INHIBITOR | ACINI | trypsinogen activation | ENZYMES | CERULEIN | lysosomes | SECRETION | GASTROENTEROLOGY & HEPATOLOGY | CATHEPSIN-B | Actins - metabolism | Lysosomes - enzymology | JNK Mitogen-Activated Protein Kinases - metabolism | NF-kappa B - metabolism | Pancreatitis - prevention & control | Amylases - metabolism | Time Factors | Chemokine CCL2 - metabolism | Secretory Vesicles - enzymology | Interleukin-6 - metabolism | Disease Models, Animal | Pancreas - enzymology | Severity of Illness Index | Trypsinogen - metabolism | Acute Disease | Dipeptides - pharmacology | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Cathepsin B - antagonists & inhibitors | Pancreas - drug effects | Pancreas - pathology | Cathepsin B - metabolism | Pancreas - metabolism | Pancreatitis - chemically induced | Trypsin - metabolism | Arylsulfatases - metabolism | Pancreatitis - enzymology | Protein Transport | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Pancreatitis - pathology | Mice | Enzyme Activation | Pancreatitis - metabolism | Ceruletide | Mitogen-Activated Protein Kinase 1 - metabolism | Proteins | Protease inhibitors | Pancreas | Digestive system | Chemical compounds | Medical disorders | Index Medicus
Journal Article
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 10/2012, Volume 303, Issue 8, pp. G894 - G903
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2007, Volume 104, Issue 52, pp. 20884 - 20889
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 08/2010, Volume 246, Issue 3, pp. 154 - 162
Pancreatitis caused by activation of digestive zymogens in the exocrine pancreas is a serious chronic health problem in alcoholic patients. However, mechanism... 
Deer mice | ER stress | Fatty acid ethyl esters | Alcoholic pancreatitis | Apoptosis | RAT PANCREAS | ALDEHYDE DEHYDROGENASE | CHOLESTEROL ESTERASE | LIVER-DISEASE | METABOLIC BASIS | ACID ETHYL-ESTERS | TRYPSINOGEN ACTIVATION | PHARMACOLOGY & PHARMACY | ENDOPLASMIC-RETICULUM | ACINAR-CELLS | TOXICOLOGY | INDUCED CYTOTOXICITY | Liver - pathology | Acetaldehyde - metabolism | Lipase - blood | Liver - enzymology | Pancreatitis, Alcoholic - enzymology | Ethanol - toxicity | Endoplasmic Reticulum - metabolism | Male | HSP70 Heat-Shock Proteins - blood | Ethanol - blood | Ethyl Ethers - metabolism | Liver - drug effects | Pancreatitis, Alcoholic - metabolism | Alcohol Dehydrogenase - deficiency | Membrane Proteins - metabolism | Membrane Proteins - blood | Fatty Acids - metabolism | Disease Models, Animal | Pancreas - enzymology | Alcohol Dehydrogenase - metabolism | Oligopeptides - blood | Acetaldehyde - blood | Liver - metabolism | Pancreas - drug effects | Pancreas - pathology | Cathepsin B - metabolism | Lipase - metabolism | Oligopeptides - metabolism | Pancreas - metabolism | HSP70 Heat-Shock Proteins - metabolism | Animals | Pancreatitis, Alcoholic - pathology | Cathepsin B - blood | Mice | Pancreatitis, Alcoholic - blood | Evaluation | Alcohol, Denatured | Analysis | Pancreatitis | Physiological aspects | Cathepsins | Alcohol | Lipase | Fatty acids | Organic compounds | Index Medicus | Alcohol dehydrogenase | ALCOHOL DEHYDROGENASE | APOPTOSIS | DIGESTIVE SYSTEM | PANCREAS | 60 APPLIED LIFE SCIENCES | STRESSES | ENDOPLASMIC RETICULUM | HYDROXY COMPOUNDS | GLANDS | ENZYMES | ENDOCRINE GLANDS | VERTEBRATES | MICE | MAMMALS | ANIMALS | INJURIES | RODENTS | ORGANIC COMPOUNDS | SYMPTOMS | HEMIACETAL DEHYDROGENASES | DIGESTIVE SYSTEM DISEASES | ALCOHOLS | ORGANS | DISEASES | INFLAMMATION | ETHANOL | PROTEINS | BODY | PATHOLOGICAL CHANGES | CELL CONSTITUENTS | OXIDOREDUCTASES
Journal Article