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PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, p. e57208
Background: Traumatic brain injury (TBI) initiates a neuroinflammatory cascade that contributes to neuronal damage and behavioral impairment. Toll-like... 
TOLL-LIKE-RECEPTORS | SIGNALING PATHWAYS | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | MAST-CELLS | SPINAL-CORD-INJURY | NITRIC-OXIDE-SYNTHASE | NF-KAPPA-B | CEREBRAL-ISCHEMIA | EXPRESSION | INNATE IMMUNITY | Nitric Oxide Synthase Type II - biosynthesis | I-kappa B Proteins - immunology | Cerebral Cortex - pathology | MAP Kinase Kinase 4 - immunology | NF-kappa B - metabolism | Brain Injuries - metabolism | Interleukin-1beta - genetics | Tyrosine - analogs & derivatives | Inflammation - metabolism | Tryptases - immunology | NF-KappaB Inhibitor alpha | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - immunology | Brain Injuries - genetics | Poly(ADP-ribose) Polymerases - biosynthesis | Tyrosine - immunology | Mice, Knockout | Tyrosine - metabolism | Cerebral Cortex - immunology | Tryptases - biosynthesis | MAP Kinase Kinase 4 - genetics | Mice | Poly (ADP-Ribose) Polymerase-1 | Poly(ADP-ribose) Polymerases - immunology | Toll-Like Receptor 4 - biosynthesis | NF-kappa B - immunology | Brain Infarction - metabolism | Brain Infarction - pathology | I-kappa B Proteins - metabolism | I-kappa B Proteins - genetics | Cerebral Cortex - metabolism | Glial Fibrillary Acidic Protein | MAP Kinase Kinase 4 - metabolism | Brain Injuries - immunology | Nitric Oxide Synthase Type II - immunology | Nerve Tissue Proteins - biosynthesis | Interleukin-1beta - biosynthesis | Tryptases - genetics | Nerve Tissue Proteins - immunology | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Interleukin-1beta - immunology | Inflammation - immunology | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | NF-kappa B - genetics | Nitric Oxide Synthase Type II - genetics | Brain Infarction - immunology | Inflammation - genetics | Brain Infarction - genetics | Brain Injuries - pathology | Tyrosine - genetics | Brain | Brain damage | Brain research | Neurons | Injuries | Neuroprotection | Animal models | Traumatic brain injury | Bax protein | Bcl-2 protein | Control methods | Kinases | Proteins | Signal transduction | Receptors | Head injuries | Animal tissues | Toll-like receptors | Immune system | Translocation | NF-κB protein | Glial fibrillary acidic protein | Cortex | Poly(ADP-ribose) polymerase | JNK protein | Inflammation | TLR4 protein | IL-1β | Trauma | Nitric-oxide synthase | Chymase | Augmentation | Signaling | Injury prevention | Tryptase | Nitrotyrosine | Apoptosis
Journal Article
Nature Genetics, ISSN 1061-4036, 12/2016, Volume 48, Issue 12, pp. 1564 - 1569
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, p. e85362
Systemic mastocytosis with associated hematologic clonal non-mast cell disease (SM-AHNMD) is a rare and heterogeneous subtype of SM and few studies on this... 
CRITERIA | KITD816V | POLYCYTHEMIA-VERA | LINEAGE DISEASES | MULTIDISCIPLINARY SCIENCES | Prognosis | Cell Count | Hematologic Neoplasms - mortality | Humans | Middle Aged | Male | Mastocytosis, Systemic - diagnosis | Mastocytosis, Systemic - genetics | Neutropenia - complications | Neutropenia - diagnosis | Monocytes - pathology | Neutropenia - mortality | Aged, 80 and over | Adult | Female | Proto-Oncogene Proteins c-kit - genetics | Hematologic Neoplasms - complications | Neutropenia - genetics | Proto-Oncogene Proteins c-cbl - genetics | Hematologic Neoplasms - diagnosis | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | DNA-Binding Proteins - genetics | Mastocytosis, Systemic - mortality | Adolescent | Survival Analysis | Aged | Hematologic Neoplasms - genetics | Mutation | Mastocytosis, Systemic - complications | Medical research | Mast cell disease | Analysis | Patient outcomes | Medicine, Experimental | Hemoglobin | Bones | Genetic aspects | Density | Splenomegaly | Mastocytosis | Disease | Laboratories | Liver | Leukemia | Multivariate analysis | Defects | Variables | Chronic myelomonocytic leukemia | Lesions | Neutropenia | Enlargement | Cell survival | Hematology | Patients | Survival | Studies | Monocytes | Medical prognosis | Tryptase | Bone mineral density | Blood diseases | Ascites | Tumors
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 2006, Volume 117, Issue 6, pp. 1411 - 1414
Journal Article
American Journal of Hematology, ISSN 0361-8609, 09/2015, Volume 90, Issue 9, pp. 774 - 777
Journal Article
Nature Genetics, ISSN 1061-4036, 12/2016, Volume 48, Issue 12, pp. 1450 - 1451
Unspecific and unexplained medical complaints can be frustrating to both patients and clinicians. A cause for these complex symptoms and signs may now have... 
DISORDERS | TRYPTASE | IRRITABLE-BOWEL-SYNDROME | GENETICS & HEREDITY | Genetics | Complaints | Genes | Irritable bowel syndrome | Cell adhesion & migration
Journal Article
Journal of Immunology, ISSN 0022-1767, 12/2010, Volume 185, Issue 12, pp. 7681 - 7690
A second-degree epidermal scald burn in mice elicits an inflammatory response mediated by natural IgM directed to nonmuscle myosin with complement activation... 
ISCHEMIA-REPERFUSION INJURY | SKELETAL-MUSCLE | SUBSTRATE-SPECIFICITY | SERINE PROTEASES | TRYPTASE MMCP-6 | ANGIOTENSIN-II GENERATION | TRICHINELLA-SPIRALIS | CARBOXYPEPTIDASE-A | IMMUNOLOGY | BETA-CHYMASES | INNATE IMMUNITY | Leukocyte Elastase - metabolism | Chymases - pharmacology | Leukocyte Elastase - pharmacology | Humans | Chymases - immunology | Immunoglobulin M - metabolism | Burns - enzymology | Serine Endopeptidases - genetics | Serine Endopeptidases - immunology | Epidermis - enzymology | Immunoglobulin M - genetics | Tryptases - immunology | Myosins - immunology | Carboxypeptidases A - immunology | Leukocyte Elastase - genetics | Mast Cells - enzymology | Proto-Oncogene Proteins c-kit | Cicatrix - genetics | Models, Immunological | Tryptases - pharmacology | Mice | Mice, Inbred BALB C | Burns - genetics | Tryptases - metabolism | Cicatrix - immunology | Chymases - metabolism | Serine Endopeptidases - pharmacology | Immunoglobulin M - immunology | Cell Degranulation - genetics | Mice, Mutant Strains | Myosins - metabolism | Tryptases - genetics | Mast Cells - immunology | Epidermis - pathology | Carboxypeptidases A - metabolism | Inflammation | Cell Degranulation - immunology | Myosins - genetics | Chymases - genetics | Animals | Epidermis - immunology | Burns - pathology | Mast Cells - pathology | Cicatrix - enzymology | Carboxypeptidases A - genetics | Cicatrix - pathology | Serine Endopeptidases - metabolism | Burns - immunology | Leukocyte Elastase - immunology | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
Journal Article
Clinical and Experimental Medicine, ISSN 1591-8890, 8/2018, Volume 18, Issue 3, pp. 319 - 323
Mast cells are recognized as critical components of the tumor stromal microenvironment in several solid and hematological malignancies, promoting angiogenesis... 
Angiogenesis | Medicine & Public Health | Hematology | Pancreatic ductal adenocarcinoma | Internal Medicine | Oncology | Mast cells | PLUS GEMCITABINE | CANCER-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | CARCINOMA CELLS | TRIAL | CARCINOGENESIS | INFLAMMATION | GENERATION | GROWTH-FACTOR | CROSSTALK | TUMOR MICROENVIRONMENT | Tryptases - metabolism | Interleukin-13 - antagonists & inhibitors | Humans | Pancreatic Neoplasms - blood supply | Gene Expression Regulation, Neoplastic | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Angiopoietin-1 - metabolism | Vascular Endothelial Growth Factor A - genetics | Platelet-Derived Growth Factor - genetics | Carcinoma, Pancreatic Ductal - genetics | Neovascularization, Pathologic - pathology | Pancreatic Neoplasms - drug therapy | Interleukin-13 - genetics | Tumor Microenvironment - genetics | Tryptases - antagonists & inhibitors | Mast Cells - metabolism | Angiogenesis Inhibitors - therapeutic use | Fibroblast Growth Factor 2 - metabolism | Neovascularization, Pathologic - prevention & control | Tryptases - genetics | Tumor Microenvironment - drug effects | Neoplasm Invasiveness | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - genetics | Interleukin-13 - metabolism | Carcinoma, Pancreatic Ductal - pathology | Mast Cells - drug effects | Angiopoietin-1 - antagonists & inhibitors | Disease Progression | Angiopoietin-1 - genetics | Carcinoma, Pancreatic Ductal - drug therapy | Cell Movement - drug effects | Fibroblast Growth Factor 2 - antagonists & inhibitors | Platelet-Derived Growth Factor - metabolism | Fibroblast Growth Factor 2 - genetics | Mast Cells - pathology | Neovascularization, Pathologic - genetics | Carcinoma, Pancreatic Ductal - blood supply | Platelet-Derived Growth Factor - antagonists & inhibitors | Adenocarcinoma | Medical colleges | Neurosciences | Analysis | Pancreatic cancer | Development and progression | Growth factors | Cells | Cell proliferation | Fibroblast growth factor 2 | Fibroblast growth factor | Platelet-derived growth factor | Leukocyte migration | Angiopoietin | Interleukin 13 | Metastases | Histamine | Pancreatic carcinoma | Tryptase | Degranulation | Vascular endothelial growth factor | Cell migration
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2015, Volume 125, Issue 6, pp. 2317 - 2334
Mast cells (MCs) have been identified in various tumors; however, the role of these cells in tumorigenesis remains controversial. Here, we quantified MCs in... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | C-KIT GENE | TUMOR PROGRESSION | INFLAMMATION | MOUSE MODEL | DEFICIENT | LUNG ADENOCARCINOMA | FACTOR-KAPPA-B | MICE | PROMOTES | Tryptases - metabolism | Colonic Neoplasms - genetics | Adenocarcinoma - pathology | Lung Neoplasms - diet therapy | Colonic Neoplasms - drug therapy | Humans | Lung Neoplasms - metabolism | Pleural Cavity - metabolism | Lung Neoplasms - pathology | Male | Interleukin-1beta - genetics | Pleural Effusion, Malignant - genetics | Proto-Oncogene Proteins c-kit - metabolism | Pleural Effusion, Malignant - pathology | Proto-Oncogene Proteins c-kit - antagonists & inhibitors | Colonic Neoplasms - metabolism | Pleural Effusion, Malignant - drug therapy | Adenocarcinoma - metabolism | Interleukin-1beta - metabolism | Mast Cells - metabolism | Proto-Oncogene Proteins c-kit - genetics | Adenocarcinoma - genetics | Benzamides - pharmacology | Tryptases - genetics | Lung Neoplasms - genetics | Pleural Effusion, Malignant - metabolism | Mice, Transgenic | Pyrimidines - pharmacology | Mice, SCID | Adenocarcinoma - drug therapy | Imatinib Mesylate | Piperazines - pharmacology | Animals | Colonic Neoplasms - pathology | Mast Cells - pathology | Cell Line, Tumor | Mice, Inbred NOD | Mice | Protein Kinase Inhibitors - pharmacology | Pleural Cavity - pathology | Studies | Flow cytometry | Rodents | Mortality | Melanoma | Cancer therapies | Tumors | Cancer | Angiogenesis | Oncology | Immunology | Cardiology | Vascular Biology
Journal Article
Journal Article
Seminars in Immunopathology, ISSN 1863-2297, 1/2012, Volume 34, Issue 1, pp. 133 - 149
Journal Article