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Biophysical Journal, ISSN 0006-3495, 02/2017, Volume 112, Issue 3, pp. 524a - 524a
Journal Article
2008
Source: National Library of New Zealand Te Puna Matauranga o Aotearoa, licensed by the Department of Internal Affairs for re-use under the Creative Commons... 
Tryptophan | Biochemistry
eJournal
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 09/2012, Volume 109, Issue 37, pp. 14912 - 14917
Toxicity of aggregation-prone proteins is thought to play an important role in aging and age-related neurological diseases like Parkinson and Alzheimer's... 
Protein metabolism | Neurons | Medical genetics | Huntington disease | Homeostasis | Parkinson disease | Metabolic diseases | Gene expression regulation | Alzheimers disease | Human genetics | LIFE-SPAN | PROTEOTOXICITY | HEAT-SHOCK-FACTOR | Huntington | ALPHA-SYNUCLEIN | UMCG Approved | CAENORHABDITIS-ELEGANS | KYNURENINE 3-MONOOXYGENASE | IN-VIVO | longevity | C-ELEGANS | LEWY BODIES | PARKINSONS-DISEASE | Longevity | MULTIDISCIPLINARY SCIENCES | Tryptophan Oxygenase - antagonists & inhibitors | Animals, Genetically Modified | alpha-Synuclein - toxicity | Computational Biology | Tryptophan - chemistry | Immunoblotting | DNA Primers - genetics | Longevity - genetics | Reverse Transcriptase Polymerase Chain Reaction | Tryptophan - metabolism | Tryptophan Oxygenase - metabolism | Caenorhabditis elegans | Tandem Mass Spectrometry | Fertility - genetics | Animals | Peptides - metabolism | Aging - physiology | RNA Interference | Homeostasis - physiology | Amyloid beta-Peptides - metabolism | Chromatography, Liquid | Aging - metabolism | Proteins | Tryptophan | Physiological aspects | Aging | Research | Health aspects | Index Medicus | Peptides | Neurons and Cognition | Psychology and behavior | Neurobiology | Tryptophan Oxygenase | DNA Primers | Life Sciences | Fertility | Amyloid beta-Peptides | Cognitive Sciences | alpha-Synuclein | Biological Sciences
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 11, p. e112945
The kynurenine pathway (KP) is the principal route of L-tryptophan (TRP) catabolism leading to the production of kynurenine (KYN), the neuroprotectants,... 
QUINOLINIC ACID | INHIBITION | METABOLISM | AMINOTRANSFERASE | MULTIDISCIPLINARY SCIENCES | INDOLEAMINE 2,3-DIOXYGENASE | T-CELL | TUMORAL IMMUNE RESISTANCE | TRYPTOPHAN DEGRADATION | IDO EXPRESSION | BRAIN | Immunohistochemistry | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Kynurenic Acid - blood | Gene Expression - drug effects | Humans | Kynurenine - biosynthesis | Brain Neoplasms - physiopathology | Picolinic Acids - blood | Quinolinic Acid - blood | Chromatography, High Pressure Liquid | Glial Fibrillary Acidic Protein - metabolism | Kynurenic Acid - metabolism | Carboxy-Lyases - genetics | Tryptophan - metabolism | Brain Neoplasms - metabolism | Picolinic Acids - metabolism | Antigens, CD - metabolism | Glioma - metabolism | Glioma - genetics | Kynurenine - blood | Tryptophan - blood | Carboxy-Lyases - metabolism | Tumor Cells, Cultured | Astrocytes - drug effects | Disaccharides | Cells, Cultured | Brain Neoplasms - genetics | Biosynthetic Pathways | Reverse Transcriptase Polymerase Chain Reaction | Glucuronates | Tryptophan Oxygenase - metabolism | Tryptophan Oxygenase - genetics | Antigens, Differentiation, Myelomonocytic - metabolism | Quinolinic Acid - metabolism | CD11b Antigen - metabolism | Glioma - physiopathology | Interferon-gamma - pharmacology | Astrocytes - metabolism | Tryptophan | Niacinamide | Methyl aspartate | Enzymes | Metabolites | Gliomas | Neuroprotection | Brain | Brain tumors | Brain cancer | Glioblastoma | Tryptophan 2,3-dioxygenase | Immunity | DNA repair | Picolinic acid | Rodents | Glioma cells | L-Tryptophan | Kynurenic acid | Quinolinic acid | Deoxyribonucleic acid--DNA | Pyridines | Medical research | Hydroxylase | Adenine | Kynurenine-oxoglutarate transaminase | NAD | Acids | γ-Interferon | Nicotinamide adenine dinucleotide | Catabolism | Nicotinamide | Interferon | Tumors | Deoxyribonucleic acid | DNA
Journal Article
Current Biology, ISSN 0960-9822, 2011, Volume 21, Issue 11, pp. 961 - 966
Journal Article
Clinical science (1979), ISSN 1470-8736, 2016, Volume 130, Issue 15, pp. 1327 - 1333
Journal Article
Molecular psychiatry, ISSN 1476-5578, 2008, Volume 14, Issue 5, pp. 511 - 522
Although elevated activity of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) has been proposed to mediate comorbid depression in... 
Kynurenine | Minocycline | Tryptophan | 1-methyltryptophan | Forced-swim test | Tail suspension test | tail suspension test | forced-swim test | DENDRITIC CELLS | KYNURENINE PATHWAY | PSYCHIATRY | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | kynurenine | NEUROSCIENCES | INTERFERON-ALPHA | QUINOLINIC ACID | CANCER-PATIENTS | minocycline | TRYPTOPHAN DEGRADATION | EXPRESSION | tryptophan | BRAIN | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Minocycline - pharmacology | Kynurenine - adverse effects | Motor Activity - drug effects | Male | Chromatography, High Pressure Liquid | Dose-Response Relationship, Drug | Kynurenine - blood | Tryptophan - blood | Time Factors | Minocycline - therapeutic use | Tryptophan - analogs & derivatives | Depression - chemically induced | Behavior, Animal - drug effects | Swimming | Disease Models, Animal | Enzyme Inhibitors - pharmacology | Enzyme Activation - drug effects | Hindlimb Suspension - methods | Enzyme Inhibitors - therapeutic use | Mice, Inbred ICR | Gene Expression Regulation - drug effects | Animals | Lipopolysaccharides - pharmacology | Cytokinins - metabolism | Mice | Tryptophan - pharmacology | Tryptophan - therapeutic use | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | Depression - blood | Mediators | Depression, Mental | Indole | Physiological aspects | Development and progression | Inflammation | Research | Enzyme activation | Life Sciences | serotonin | interferon-γ | tumor necrosis factor-α | depression | interleukin-1β | forced swim test
Journal Article
Nature (London), ISSN 1476-4687, 2011, Volume 478, Issue 7368, pp. 197 - 203
Journal Article
Nature communications, ISSN 2041-1723, 2019, Volume 10, Issue 1, pp. 1476 - 15
Journal Article