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American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 2015, Volume 309, Issue 8, pp. E736 - E746
Metabolomic profiling of obese individuals revealed altered concentrations of many metabolites, especially branched-chain amino acids (BCAA), possibly linked... 
Branched-chain amino acids | Cardiometabolic risk factors | Visceral obesity | HOMEOSTASIS | PHYSIOLOGY | TRYPTOPHAN-METABOLISM | WEIGHT-LOSS | visceral obesity | PATTERNS | branched-chain amino acids | cardiometabolic risk factors | AMINO-ACID-METABOLISM | METABOLOMICS | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | FAT | HUMAN OBESITY | EXPRESSION | Metabolomics | Amino Acids, Branched-Chain - metabolism | Humans | Middle Aged | Gene Expression Profiling | RNA, Messenger - metabolism | Thinness - metabolism | Tryptophan - metabolism | Adipose Tissue - metabolism | Amino Acids - metabolism | Overweight - metabolism | Subcutaneous Fat - metabolism | Adult | Female | Body Fat Distribution | Kynurenine - metabolism | Cardiovascular Diseases - metabolism | Cholesterol, HDL - metabolism | Risk Factors | Insulin Resistance | Cell Size | Adipokines - metabolism | Intra-Abdominal Fat - metabolism | Adipocytes - pathology | Blotting, Western | Obesity - metabolism | Triglycerides - metabolism | Cholesterol, LDL - metabolism | Dyslipidemias - metabolism | 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) - genetics | Blood Glucose - metabolism | 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) - metabolism | Adipose tissues | Metabolic diseases | Amino acids | Metabolites | Health aspects | Risk factors | Enzymes | Tissue | Obesity | Gene expression | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 11, pp. e112945 - e112945
The kynurenine pathway (KP) is the principal route of L-tryptophan (TRP) catabolism leading to the production of kynurenine (KYN), the neuroprotectants,... 
OXIDATIVE STRESS | QUINOLINIC ACID | MAMMALIAN BRAIN | POOR-PROGNOSIS | MULTIDISCIPLINARY SCIENCES | INDOLEAMINE 2,3-DIOXYGENASE | TRYPTOPHAN 2,3-DIOXYGENASE | TUMORAL IMMUNE RESISTANCE | T-CELLS | IDO EXPRESSION | BRAIN-TUMORS | Immunohistochemistry | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Kynurenic Acid - blood | Gene Expression - drug effects | Humans | Kynurenine - biosynthesis | Brain Neoplasms - physiopathology | Picolinic Acids - blood | Quinolinic Acid - blood | Chromatography, High Pressure Liquid | Glial Fibrillary Acidic Protein - metabolism | Kynurenic Acid - metabolism | Carboxy-Lyases - genetics | Tryptophan - metabolism | Brain Neoplasms - metabolism | Picolinic Acids - metabolism | Antigens, CD - metabolism | Glioma - metabolism | Glioma - genetics | Kynurenine - blood | Tryptophan - blood | Carboxy-Lyases - metabolism | Tumor Cells, Cultured | Astrocytes - drug effects | Disaccharides | Cells, Cultured | Brain Neoplasms - genetics | Biosynthetic Pathways | Reverse Transcriptase Polymerase Chain Reaction | Glucuronates | Tryptophan Oxygenase - metabolism | Tryptophan Oxygenase - genetics | Antigens, Differentiation, Myelomonocytic - metabolism | Quinolinic Acid - metabolism | CD11b Antigen - metabolism | Glioma - physiopathology | Interferon-gamma - pharmacology | Astrocytes - metabolism | Tryptophan | Niacinamide | Methyl aspartate | Enzymes | Metabolites | Gliomas | NADPH | Neuroprotection | Brain | Brain tumors | Brain cancer | Glioblastoma | Tryptophan 2,3-dioxygenase | Immunity | DNA repair | Picolinic acid | Rodents | Glioma cells | L-Tryptophan | Kynurenic acid | Quinolinic acid | Deoxyribonucleic acid--DNA | Pyridines | Medical research | Hydroxylase | Adenine | Kynurenine-oxoglutarate transaminase | NAD | Acids | γ-Interferon | Nicotinamide adenine dinucleotide | Catabolism | Nicotinamide | Interferon | Tumors | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Cell Metabolism, ISSN 1550-4131, 02/2018, Volume 27, Issue 2, pp. 378 - 392.e5
The role of tryptophan-kynurenine metabolism in psychiatric disease is well established, but remains less explored in peripheral tissues. Exercise training... 
brown fat | inflammation | Rgs14 | Gpr35 | beige fat | adipose tissue | exercise | energy expenditure | kynurenic acid | CELLS | WHITE FAT | PROTEIN | MITOCHONDRIAL BIOGENESIS | ADAPTIVE THERMOGENESIS | FAT SWITCH | BROWN ADIPOCYTES | ENDOCRINOLOGY & METABOLISM | ERK1/2 ACTIVATION | PPAR-GAMMA | MASS-SPECTROMETRY | CELL BIOLOGY | Epididymis - metabolism | Inflammation - pathology | Receptors, G-Protein-Coupled - metabolism | Adipose Tissue, White - metabolism | Body Weight - drug effects | Homeostasis | Male | Gene Expression Profiling | Kynurenic Acid - metabolism | Adipose Tissue - metabolism | Inflammation - metabolism | Subcutaneous Fat - metabolism | Adiposity | Diet, High-Fat | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism | RGS Proteins - metabolism | Transcription, Genetic | Receptors, Adrenergic, beta - metabolism | Physical Conditioning, Animal | Lymphocytes - metabolism | Mice, Inbred C57BL | Adipose Tissue - pathology | Cells, Cultured | Gene Expression Regulation | Animals | Receptors, G-Protein-Coupled - deficiency | Energy Metabolism | Adipocytes - metabolism | Glucose - metabolism | Adipose Tissue, Beige - metabolism | Adipose tissues | Genetically modified animals | Tryptophan | Muscles | Inflammation | Glucose | Gene expression | Dextrose | Membrane proteins | Resveratrol | Physiological aspects | G proteins
Journal Article
Science, ISSN 0036-8075, 1/2009, Volume 323, Issue 5910, pp. 101 - 106
Journal Article
Nature, ISSN 0028-0836, 05/2018, Volume 557, Issue 7707, pp. 724 - 728
Microglia and astrocytes modulate inflammation and neurodegeneration in the central nervous system (CNS)(1-3). Microglia modulate pro-inflammatory and... 
ACTIVATION | ARYL-HYDROCARBON RECEPTOR | MULTIDISCIPLINARY SCIENCES | TGF-ALPHA | CENTRAL-NERVOUS-SYSTEM | SPINAL-CORD-INJURY | DIVERSITY | VEGF-B | EXPRESSION | CNS INFLAMMATION | ENDOTHELIAL GROWTH-FACTOR | Inflammation - pathology | Microglia - metabolism | Central Nervous System - metabolism | Encephalomyelitis, Autoimmune, Experimental - metabolism | Humans | Astrocytes - pathology | Central Nervous System - pathology | Vascular Endothelial Growth Factor B - biosynthesis | Tryptophan - metabolism | Lipopolysaccharide Receptors - metabolism | Inflammation - metabolism | Tryptophan - deficiency | Microglia - pathology | Receptors, Aryl Hydrocarbon - metabolism | Female | Transforming Growth Factor alpha - metabolism | Central Nervous System - microbiology | Disease Models, Animal | Encephalomyelitis, Autoimmune, Experimental - microbiology | Multiple Sclerosis - metabolism | Transforming Growth Factor alpha - biosynthesis | Symbiosis | Inflammation - microbiology | Encephalomyelitis, Autoimmune, Experimental - pathology | ErbB Receptors - metabolism | Mice, Inbred C57BL | Cells, Cultured | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Animals | Vascular Endothelial Growth Factor B - metabolism | Encephalomyelitis, Autoimmune, Experimental - prevention & control | Multiple Sclerosis - pathology | Inflammation - prevention & control | Mice | Astrocytes - metabolism | Physiological aspects | Microbiological research | Metabolites | Transforming growth factors | Astrocytes | Vascular endothelial growth factor | Regulators | Multiple sclerosis | Encephalomyelitis | Transcription | Central nervous system | Hydrocarbons | Nervous system | CD14 antigen | Recruitment | Angiogenesis | Signal transduction | Neurotoxicity | Microorganisms | Neurodegeneration | Aromatic compounds | Bone marrow | ErbB-1 protein | Tryptophan | Inflammation | Gene expression | Experimental allergic encephalomyelitis | Microglia | Neurological diseases | Diet | Lymphocytes B | Flora | Spinal cord injuries | Alzheimers disease | Index Medicus | Life Sciences | Immunology
Journal Article
Psychoneuroendocrinology, ISSN 0306-4530, 08/2018, Volume 94, pp. 1 - 10
Journal Article
Nature Medicine, ISSN 1078-8956, 06/2016, Volume 22, Issue 6, pp. 586 - 597
Astrocytes have important roles in the central nervous system (CNS) during health and disease. Through genome-wide analyses we detected a transcriptional... 
MEDICINE, RESEARCH & EXPERIMENTAL | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MYELOID CELLS | BLOOD-BRAIN-BARRIER | BETA | CELL BIOLOGY | RESPONSES | MULTIPLE-SCLEROSIS | REGULATORY T-CELLS | DIFFERENTIATION | NF-KAPPA-B | EXPRESSION | Optical Imaging | Cell Proliferation | Central Nervous System - metabolism | Encephalomyelitis, Autoimmune, Experimental - metabolism | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Immunoblotting | Gene Expression Profiling | Chromatography, High Pressure Liquid | Glial Fibrillary Acidic Protein - metabolism | Interferon Type I - immunology | Suppressor of Cytokine Signaling Proteins | Tryptophan - metabolism | Case-Control Studies | Central Nervous System - immunology | Tryptophanase - metabolism | Gene Knockdown Techniques | Indoles - metabolism | STAT1 Transcription Factor - metabolism | Lactobacillus reuteri | Astrocytes - immunology | Chromatin Immunoprecipitation | Polymerase Chain Reaction | Receptors, Aryl Hydrocarbon - metabolism | Chemokine CCL2 - metabolism | Receptor, Interferon alpha-beta - genetics | Multiple Sclerosis - metabolism | Indican - urine | Serotonin | Gastrointestinal Microbiome | Inflammation | Mice, Knockout | Animals | Interferon-beta - pharmacology | Fluorescent Antibody Technique | Multiple Sclerosis - immunology | T-Lymphocytes - immunology | Mice | Myxovirus Resistance Proteins - metabolism | Receptors, Aryl Hydrocarbon - immunology | Nitric Oxide Synthase Type II - metabolism | Microbiota (Symbiotic organisms) | Astrocytes | Physiological aspects | Tryptophan | Interferon | Genetic aspects | Research | Autoimmunity | Multiple sclerosis | Care and treatment | Encephalomyelitis | Central nervous system | Prevention | Metabolites | Analysis | Dosage and administration | Diagnosis | Health aspects | Nervous system | Microorganisms | Immune system | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 06/2017, Volume 23, Issue 6, pp. 733 - 741
Blood vessels in the central nervous system (CNS) are controlled by neuronal activity. For example, widespread vessel constriction (vessel tone) is induced by... 
MEDICINE, RESEARCH & EXPERIMENTAL | PIAL VESSELS | RAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRACE AMINES | SYNAPTIC-TRANSMISSION | HYPOXIA | CELL BIOLOGY | CENTRAL-NERVOUS-SYSTEM | LOCOMOTOR FUNCTION | CEREBRAL-ARTERIES | RECEPTORS | BRAIN | Capillaries - pathology | Serotonin 5-HT1 Receptor Antagonists - pharmacology | Receptors, Adrenergic, alpha-2 - metabolism | Transcriptome | Capillaries - drug effects | RNA, Messenger - metabolism | Oxygen - metabolism | Hypoxia - metabolism | Receptors, Serotonin, 5-HT1 - metabolism | Spinal Cord Injuries - pathology | Receptor, Serotonin, 5-HT1B - metabolism | Aromatic-L-Amino-Acid Decarboxylases - metabolism | Tyramine - metabolism | Capillaries - metabolism | Locomotion - drug effects | Injections, Spinal | Capillaries - physiopathology | Spinal Cord Injuries - metabolism | Pericytes - metabolism | Vasoconstriction | Rats | Microscopy, Interference | Oxygen Inhalation Therapy | Microscopy, Confocal | Animals | Norepinephrine - metabolism | Tryptamines - metabolism | Serotonin - metabolism | Spinal Cord Injuries - physiopathology | Biogenic Monoamines - metabolism | Locomotion - physiology | Enzymes | Care and treatment | Analysis | Tryptophan | Spinal cord injuries | Dosage and administration | Drug therapy | Health aspects | Noradrenaline | Blood flow | Index Medicus | spinal cord injury | AADC | hypoxia | pericyte | capillary | locomotion | Trace amines | neurovascular coupling | 5-HT1B receptor | motoneurons | ischemia
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 06/2013, Volume 18, Issue 6, pp. 666 - 673
Bacterial colonisation of the intestine has a major role in the post-natal development and maturation of the immune and endocrine systems. These processes are... 
germ-free | microbiota | anxiety | serotonin | recolonisation | central nervous system | NERVOUS-SYSTEM | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | DEVELOPMENTAL ROLE | NEUROSCIENCES | MATERNAL SEPARATION MODEL | ANXIETY BEHAVIOR | TRYPTOPHAN-HYDROXYLASE ISOFORM | ANIMAL-MODELS | MICE | STRESS | IRRITABLE-BOWEL-SYNDROME | Tumor Necrosis Factor-alpha - metabolism | Body Weight | Male | Receptors, Serotonin - genetics | Tryptophan - metabolism | Microbiota | Serotonin Plasma Membrane Transport Proteins - genetics | Hippocampus - microbiology | Female | Brain-Derived Neurotrophic Factor - metabolism | Tryptophan Hydroxylase - metabolism | Disease Models, Animal | Stress, Psychological - blood | Gastrointestinal Tract - microbiology | Gene Expression Regulation - physiology | Hydroxyindoleacetic Acid - metabolism | Sex Characteristics | Gastrointestinal Tract - metabolism | Receptors, Serotonin - metabolism | Stress, Psychological - microbiology | Tryptophan Hydroxylase - genetics | Serotonin Plasma Membrane Transport Proteins - metabolism | Stress, Psychological - pathology | Hippocampus - metabolism | Animals | Analysis of Variance | Serotonin - metabolism | Lipopolysaccharides - pharmacology | Mice | Physiological aspects | Homeostasis | Research | Hippocampus (Brain) | Serotonin | Animal behavior | Index Medicus
Journal Article
International immunology, ISSN 0953-8178, 12/2014, Volume 26, Issue 12, pp. 673 - 684
Indoleamine 2,3-dioxygenase (IDO) suppresses adaptive immunity by inhibiting T-cell proliferation and altering glucose metabolism. The tumor suppressor p53... 
GCN2 kinase | indoleamine 2 | proliferation | T cells | aerobic glycolysis | 3-dioxygenase | glutaminolysis | p53 | CANCER-CELLS | ACTIVATION | P53-INDUCIBLE REGULATOR | TOLERANCE | IMMUNOLOGY | TRYPTOPHAN CATABOLISM | GLUTAMINE-METABOLISM | INHIBITION | ARYL-HYDROCARBON RECEPTOR | indoleamine 2,3-dioxygenase | EXPRESSION | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | L-Lactate Dehydrogenase - metabolism | Leukocytes, Mononuclear - metabolism | TOR Serine-Threonine Kinases - metabolism | Tumor Suppressor Protein p53 - antagonists & inhibitors | Humans | Middle Aged | Glucose Transporter Type 1 - metabolism | Male | Intracellular Signaling Peptides and Proteins - metabolism | Healthy Volunteers | Lymphocyte Culture Test, Mixed | Mechanistic Target of Rapamycin Complex 1 | Toluene - analogs & derivatives | Multiprotein Complexes - metabolism | Lymphocyte Activation - immunology | T-Lymphocytes - metabolism | Isoenzymes - metabolism | Mitochondrial Proteins - metabolism | T-Lymphocytes - drug effects | Tryptophan - analogs & derivatives | Leukocytes, Mononuclear - immunology | Lactic Acid - biosynthesis | Adult | Female | Toluene - pharmacology | Leukocytes, Mononuclear - drug effects | Benzothiazoles - pharmacology | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Carrier Proteins - metabolism | Glucose - metabolism | Glucosephosphate Dehydrogenase - metabolism | Glycolysis | T-Lymphocytes - immunology | Cell Proliferation - drug effects | Tryptophan - pharmacology | Enzyme Activation | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | Index Medicus
Journal Article