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PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 11, p. e112945
The kynurenine pathway (KP) is the principal route of L-tryptophan (TRP) catabolism leading to the production of kynurenine (KYN), the neuroprotectants,... 
QUINOLINIC ACID | INHIBITION | METABOLISM | AMINOTRANSFERASE | MULTIDISCIPLINARY SCIENCES | INDOLEAMINE 2,3-DIOXYGENASE | T-CELL | TUMORAL IMMUNE RESISTANCE | TRYPTOPHAN DEGRADATION | IDO EXPRESSION | BRAIN | Immunohistochemistry | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Kynurenic Acid - blood | Gene Expression - drug effects | Humans | Kynurenine - biosynthesis | Brain Neoplasms - physiopathology | Picolinic Acids - blood | Quinolinic Acid - blood | Chromatography, High Pressure Liquid | Glial Fibrillary Acidic Protein - metabolism | Kynurenic Acid - metabolism | Carboxy-Lyases - genetics | Tryptophan - metabolism | Brain Neoplasms - metabolism | Picolinic Acids - metabolism | Antigens, CD - metabolism | Glioma - metabolism | Glioma - genetics | Kynurenine - blood | Tryptophan - blood | Carboxy-Lyases - metabolism | Tumor Cells, Cultured | Astrocytes - drug effects | Disaccharides | Cells, Cultured | Brain Neoplasms - genetics | Biosynthetic Pathways | Reverse Transcriptase Polymerase Chain Reaction | Glucuronates | Tryptophan Oxygenase - metabolism | Tryptophan Oxygenase - genetics | Antigens, Differentiation, Myelomonocytic - metabolism | Quinolinic Acid - metabolism | CD11b Antigen - metabolism | Glioma - physiopathology | Interferon-gamma - pharmacology | Astrocytes - metabolism | Tryptophan | Niacinamide | Methyl aspartate | Enzymes | Metabolites | Gliomas | Neuroprotection | Brain | Brain tumors | Brain cancer | Glioblastoma | Tryptophan 2,3-dioxygenase | Immunity | DNA repair | Picolinic acid | Rodents | Glioma cells | L-Tryptophan | Kynurenic acid | Quinolinic acid | Deoxyribonucleic acid--DNA | Pyridines | Medical research | Hydroxylase | Adenine | Kynurenine-oxoglutarate transaminase | NAD | Acids | γ-Interferon | Nicotinamide adenine dinucleotide | Catabolism | Nicotinamide | Interferon | Tumors | Deoxyribonucleic acid | DNA
Journal Article
Australian and New Zealand Journal of Psychiatry, ISSN 0004-8674, 2005, Volume 39, Issue 7, pp. 565 - 574
Objective: This is the second of two articles reviewing the modern dietary technique of acute tryptophan depletion (ATD), a method of transiently reducing... 
REMITTED DEPRESSION | ANTIDEPRESSANT-INDUCED REMISSION | PANIC DISORDER | FOCUSED ATTENTION | PSYCHIATRY | SLEEP ELECTROENCEPHALOGRAM | MAJOR DEPRESSION | SEASONAL AFFECTIVE-DISORDER | RAPID DEPLETION | MOOD RESPONSE | clinical | psychopharmacology | serotonin | CATECHOLAMINE DEPLETION | tryptophan | Bipolar Disorder - metabolism | Schizophrenia - metabolism | Disruptive, Impulse Control, and Conduct Disorders - metabolism | Autistic Disorder - metabolism | Serotonin - genetics | Sleep, REM - physiology | Depressive Disorder, Major - metabolism | Humans | Promoter Regions, Genetic - genetics | Tryptophan - metabolism | Sleep Wake Disorders - metabolism | Serotonin Plasma Membrane Transport Proteins - genetics | Tryptophan - deficiency | Female | Surveys and Questionnaires | Monoamine Oxidase Inhibitors - therapeutic use | Monoamine Oxidase Inhibitors - pharmacology | Cognitive Therapy - methods | Premenstrual Syndrome - metabolism | Tryptophan - genetics | Depressive Disorder, Major - therapy | Serotonin Uptake Inhibitors - therapeutic use | Sleep Wake Disorders - diagnosis | Hydroxyindoleacetic Acid - metabolism | Depressive Disorder, Major - genetics | Feeding and Eating Disorders - metabolism | Serotonin - metabolism | Alleles | Alzheimer Disease - metabolism | Serotonin Uptake Inhibitors - pharmacology | Sleep, REM, physiology | Serotonin Uptake Inhibitors, therapeutic use | Eating Disorders, metabolism | Phobic Disorders, metabolism | Sleep Disorders, diagnosis | Male | Bipolar Disorder, metabolism | Premenstrual Syndrome, metabolism | Affect | Serotonin, metabolism | Cognitive Therapy, methods | Autistic Disorder, metabolism | Obsessive-Compulsive Disorder, metabolism | Questionnaires | Schizophrenia, metabolism | Sleep Disorders, metabolism | Alzheimer Disease, metabolism | Hydroxyindoleacetic Acid, metabolism | Serotonin, genetics | Monoamine Oxidase Inhibitors, pharmacology | Depression, therapy | Anxiety, metabolism | Mental Recall | Anxiety, therapy | Aggression | Anxiety, genetics | Tryptophan, genetics | Panic Disorder, metabolism | Depression, metabolism | Serotonin Plasma Membrane Transport Proteins, genetics | Serotonin Uptake Inhibitors, pharmacology | Tryptophan, metabolism | Impulse Control Disorders, metabolism | Tryptophan, deficiency | Depression, genetics | Monoamine Oxidase Inhibitors, therapeutic use
Journal Article
Nature (London), ISSN 1476-4687, 2018, Volume 557, Issue 7707, pp. 724 - 728
Microglia and astrocytes modulate inflammation and neurodegeneration in the central nervous system (CNS)(1-3). Microglia modulate pro-inflammatory and... 
ACTIVATION | ARYL-HYDROCARBON RECEPTOR | MULTIDISCIPLINARY SCIENCES | TGF-ALPHA | CENTRAL-NERVOUS-SYSTEM | SPINAL-CORD-INJURY | DIVERSITY | VEGF-B | EXPRESSION | CNS INFLAMMATION | ENDOTHELIAL GROWTH-FACTOR | Inflammation - pathology | Microglia - metabolism | Central Nervous System - metabolism | Encephalomyelitis, Autoimmune, Experimental - metabolism | Humans | Astrocytes - pathology | Central Nervous System - pathology | Vascular Endothelial Growth Factor B - biosynthesis | Tryptophan - metabolism | Lipopolysaccharide Receptors - metabolism | Inflammation - metabolism | Tryptophan - deficiency | Microglia - pathology | Receptors, Aryl Hydrocarbon - metabolism | Female | Transforming Growth Factor alpha - metabolism | Central Nervous System - microbiology | Disease Models, Animal | Encephalomyelitis, Autoimmune, Experimental - microbiology | Multiple Sclerosis - metabolism | Transforming Growth Factor alpha - biosynthesis | Symbiosis | Inflammation - microbiology | Encephalomyelitis, Autoimmune, Experimental - pathology | ErbB Receptors - metabolism | Mice, Inbred C57BL | Cells, Cultured | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Animals | Vascular Endothelial Growth Factor B - metabolism | Encephalomyelitis, Autoimmune, Experimental - prevention & control | Multiple Sclerosis - pathology | Inflammation - prevention & control | Mice | Astrocytes - metabolism | Physiological aspects | Microbiological research | Metabolites | Transforming growth factors | Astrocytes | Vascular endothelial growth factor | Regulators | Multiple sclerosis | Transcription | Central nervous system | Hydrocarbons | Nervous system | CD14 antigen | Recruitment | Angiogenesis | Signal transduction | Neurotoxicity | Microorganisms | Neurodegeneration | Aromatic compounds | Bone marrow | ErbB-1 protein | Tryptophan | Inflammation | Gene expression | Experimental allergic encephalomyelitis | Microglia | Neurological diseases | Diet | Lymphocytes B | Flora | Spinal cord injuries | Alzheimers disease | Life Sciences | Immunology
Journal Article
Psychoneuroendocrinology, ISSN 0306-4530, 2018, Volume 94, pp. 1 - 10
Journal Article
Nature medicine, ISSN 1546-170X, 2017, Volume 23, Issue 6, pp. 733 - 741
Blood vessels in the central nervous system (CNS) are controlled by neuronal activity. For example, widespread vessel constriction (vessel tone) is induced by... 
MEDICINE, RESEARCH & EXPERIMENTAL | PIAL VESSELS | RAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRACE AMINES | SYNAPTIC-TRANSMISSION | HYPOXIA | CELL BIOLOGY | CENTRAL-NERVOUS-SYSTEM | LOCOMOTOR FUNCTION | CEREBRAL-ARTERIES | RECEPTORS | BRAIN | Capillaries - pathology | Serotonin 5-HT1 Receptor Antagonists - pharmacology | Receptors, Adrenergic, alpha-2 - metabolism | Transcriptome | Capillaries - drug effects | RNA, Messenger - metabolism | Oxygen - metabolism | Hypoxia - metabolism | Receptors, Serotonin, 5-HT1 - metabolism | Spinal Cord Injuries - pathology | Receptor, Serotonin, 5-HT1B - metabolism | Aromatic-L-Amino-Acid Decarboxylases - metabolism | Tyramine - metabolism | Capillaries - metabolism | Locomotion - drug effects | Injections, Spinal | Capillaries - physiopathology | Spinal Cord Injuries - metabolism | Pericytes - metabolism | Vasoconstriction | Rats | Microscopy, Interference | Oxygen Inhalation Therapy | Microscopy, Confocal | Animals | Norepinephrine - metabolism | Tryptamines - metabolism | Serotonin - metabolism | Spinal Cord Injuries - physiopathology | Biogenic Monoamines - metabolism | Locomotion - physiology | Enzymes | Care and treatment | Analysis | Tryptophan | Spinal cord injuries | Dosage and administration | Drug therapy | Health aspects | Noradrenaline | Blood flow | spinal cord injury | AADC | hypoxia | pericyte | capillary | locomotion | Trace amines | neurovascular coupling | 5-HT1B receptor | motoneurons | ischemia
Journal Article
Cell host & microbe, ISSN 1931-3128, 2018, Volume 23, Issue 6, pp. 716 - 724
Journal Article
Journal of the neurological sciences, ISSN 0022-510X, 2012, Volume 323, Issue 1-2, pp. 1 - 8
...), Parkinson's disease (PD), Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS). Several studies have demonstrated that altered kynurenine metabolism plays an important role in the pathogenesis of this group of diseases... 
Neurology | Aging | Alzheimer's disease (AD) | Amyotrophic lateral sclerosis (ALS) | Huntington's disease (HD) | Parkinson's disease (PD) | Kynurenine pathway | TRYPTOPHAN-METABOLISM | ACID | ALZHEIMERS-DISEASE | INDOLEAMINE 2,3-DIOXYGENASE | DISORDERS | NEUROSCIENCES | CLINICAL NEUROLOGY | QUINOLINATE LEVELS | CELL-DEATH | 3-MONOOXYGENASE | BRAIN | PARKINSONS-DISEASE | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Neuroprotective Agents - therapeutic use | Microglia - metabolism | Kynurenine - therapeutic use | Humans | Neurodegenerative Diseases - prevention & control | Parkinson Disease - drug therapy | Kynurenic Acid - metabolism | Molecular Targeted Therapy | Neurodegenerative Diseases - drug therapy | Quinolinic Acid - antagonists & inhibitors | Tryptophan - metabolism | Amyotrophic Lateral Sclerosis - drug therapy | Inflammation - metabolism | Neuroprotective Agents - pharmacology | Alzheimer Disease - prevention & control | Neurons - metabolism | Parkinson Disease - metabolism | Kynurenine - metabolism | Huntington Disease - drug therapy | Receptors, G-Protein-Coupled - drug effects | Receptors, G-Protein-Coupled - physiology | Receptors, N-Methyl-D-Aspartate - drug effects | Kynurenine - pharmacology | Enzyme Inhibitors - pharmacology | Alzheimer Disease - drug therapy | Neurodegenerative Diseases - metabolism | Enzyme Inhibitors - therapeutic use | Huntington Disease - metabolism | Kynurenine - analogs & derivatives | Receptors, N-Methyl-D-Aspartate - physiology | Parkinson Disease - prevention & control | Animals | Quinolinic Acid - metabolism | Alzheimer Disease - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Neurotoxins - metabolism | Kynurenic Acid - antagonists & inhibitors | Aging - metabolism | Enzymes | Nervous system diseases | Enzyme inhibitors | Parkinson's disease | Metabolites | Huntington's chorea | Analysis | Physiological aspects | Tryptophan | Amyotrophic lateral sclerosis | Health aspects | Alzheimer's disease | Index Medicus
Journal Article
Nature communications, ISSN 2041-1723, 2019, Volume 10, Issue 1, pp. 1476 - 15
Journal Article