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tubercidin - pharmacology (391) 391
animals (380) 380
tubercidin - analogs & derivatives (306) 306
humans (189) 189
mice (133) 133
biochemistry & molecular biology (132) 132
rats (112) 112
adenosine - pharmacology (109) 109
index medicus (107) 107
adenosine - analogs & derivatives (106) 106
male (99) 99
tubercidin (95) 95
tubercidin - chemistry (95) 95
cell line (87) 87
kinetics (86) 86
adenosine (82) 82
adenosine - metabolism (82) 82
enzyme inhibitors - pharmacology (79) 79
adenosine kinase - antagonists & inhibitors (72) 72
pharmacology & pharmacy (71) 71
ribonucleosides - pharmacology (65) 65
tubercidin - metabolism (65) 65
methylation (64) 64
female (63) 63
cells, cultured (55) 55
in vitro techniques (54) 54
structure-activity relationship (53) 53
nucleosides (52) 52
adenine - analogs & derivatives (51) 51
tubercidin - chemical synthesis (50) 50
adenosine kinase (49) 49
adenine - pharmacology (45) 45
dose-response relationship, drug (45) 45
analogs (43) 43
molecular structure (43) 43
chemistry, medicinal (42) 42
antiviral agents - pharmacology (41) 41
binding sites (37) 37
phosphorylation (37) 37
inhibitors (35) 35
thioinosine - analogs & derivatives (35) 35
chemistry, organic (34) 34
models, molecular (34) 34
adenosylhomocysteinase (32) 32
chemistry (32) 32
homocysteine - pharmacology (32) 32
inhibition (32) 32
metabolism (32) 32
research article (32) 32
adenosine deaminase inhibitors (31) 31
adenosine kinase - metabolism (31) 31
nucleotides (31) 31
adenosine triphosphate - metabolism (30) 30
base sequence (30) 30
isomerism (30) 30
homocysteine - analogs & derivatives (29) 29
dna (28) 28
article (27) 27
disease models, animal (27) 27
molecular sequence data (27) 27
research (27) 27
thioinosine - pharmacology (27) 27
tubercidin - therapeutic use (27) 27
aminoglycosides (26) 26
cell division - drug effects (26) 26
cricetinae (26) 26
hydrolases - antagonists & inhibitors (26) 26
magnetic resonance spectroscopy (26) 26
cells (25) 25
crystallography, x-ray (25) 25
virus replication - drug effects (25) 25
antiviral activity (24) 24
neurosciences (24) 24
rats, inbred strains (24) 24
antiviral agents - chemical synthesis (23) 23
cell biology (23) 23
dipyridamole - pharmacology (23) 23
expression (23) 23
receptors (23) 23
binding (22) 22
protein binding (22) 22
proteins (22) 22
substrate specificity (22) 22
toyocamycin - pharmacology (22) 22
derivatives (21) 21
drug resistance (21) 21
s-adenosylhomocysteine - metabolism (21) 21
s-adenosylhomocysteine hydrolase (21) 21
cattle (20) 20
deoxyadenosines - pharmacology (20) 20
mutation (20) 20
nucleoside (20) 20
3-deazaadenosine (19) 19
activation (19) 19
antineoplastic agents - pharmacology (19) 19
biological transport - drug effects (19) 19
cell survival - drug effects (19) 19
dna - chemistry (19) 19
formycins - pharmacology (19) 19
hydrogen bonding (19) 19
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European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2020, Volume 188, p. 112018
African trypanosomiasis, a deadly infectious disease caused by the protozoan Trypanosoma brucei spp., is spread to new hosts by bites of infected tsetse flies.... 
Trypanosoma brucei | Inosine nucleoside analogues | Parasite nucleoside transporter | ACID RELATED-COMPOUNDS | CHEMISTRY, MEDICINAL | TRYPANOSOMA-BRUCEI | PURINE | ADENOSINE | GLYCOSYLATION | BIOLOGICAL-ACTIVITY | INOSINE ANALOGS | TUBERCIDIN | RESISTANCE | SUBSTRATE RECOGNITION MOTIFS
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2012, Volume 53, Issue 5, pp. 484 - 486
Several 1′-substituted analogs of Tubercidin C-nucleosides were prepared using a highly convergent synthesis. Good to high diastereoselectivity was achieved... 
Tubercidin | Chelation | C-nucleosides | Stereoselective | NUCLEOPHILES | CHEMISTRY, ORGANIC | OXOCARBENIUM IONS | PARALLEL SYNTHESIS
Journal Article
PloS one, ISSN 1932-6203, 2016, Volume 11, Issue 5, pp. e0154862 - e0154862
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 10/2019, Volume 62, Issue 19, pp. 8847 - 8865
Trypanosoma cruzi is the causative pathogen of Chagas disease and the main culprit for cardiac-related mortality in Latin-America triggered by an infective... 
PHASE | CHEMISTRY, MEDICINAL | CHAGAS-DISEASE | TUBERCIDIN | INFECTION | GLYCOSYLATION | ANTITUMOR
Journal Article
ChemMedChem, ISSN 1860-7179, 09/2014, Volume 9, Issue 9, pp. 2186 - 2192
Human equilibrative nucleoside transporter 1 (hENT1) is a prototypical nucleoside transporter protein ubiquitously expressed on the cell surface of almost all... 
nucleosides | nucleoside transporter inhibition | 7‐deazapurine nucleosides | antiproliferative agents | nitrogen heterocycles | 7-deazapurine nucleosides | DIMROTH-REARRANGEMENT | ACID RELATED-COMPOUNDS | CHEMISTRY, MEDICINAL | PYRROLOPYRIMIDINE NUCLEOSIDES | ENZYME-INHIBITION | ADENOSINE-KINASE-INHIBITORS | SUGAR-MODIFIED ANALOGS | IN-VITRO | ANTIBIOTICS TUBERCIDIN | ANTIVIRAL ACTIVITY | PHARMACOLOGY & PHARMACY | DERIVATIVES | Purines - chemical synthesis | Tubercidin - chemistry | Antibiotics, Antineoplastic - pharmacology | Toyocamycin - analogs & derivatives | Antineoplastic Agents - chemical synthesis | Humans | Toyocamycin - chemical synthesis | Purine Nucleosides - chemical synthesis | Membrane Transport Modulators - chemical synthesis | Alkylation | Tubercidin - pharmacology | Antibiotics, Antineoplastic - chemistry | Membrane Transport Modulators - pharmacology | Toyocamycin - pharmacology | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Equilibrative Nucleoside Transporter 1 - antagonists & inhibitors | Pyrimidine Nucleosides - pharmacology | Pyrimidine Nucleosides - chemical synthesis | Prevention | Virus diseases | Isocyanates | Therapeutics | Homeopathy | Materia medica and therapeutics | Cancer | Cell growth | Adenosine | Derivatives | Antiproliferation
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 10/2014, Volume 2014, Issue 28, pp. 6314 - 6320
Adenosine analogue nucleosides are a fundamental part of medicinal chemistry. Tubercidin is a well‐known example, but its application is limited due to high... 
Nucleosides | Cytotoxicity | Medicinal chemistry | Anticancer agents | Fluorine | ANOMERIC CONFIGURATION | TOYOCAMYCIN | DESIGN | CHEMISTRY, ORGANIC | GLYCOSYLATION | RIBOFURANOSYL CHLORIDES | INHIBITION | TUBERCIDIN | RIBONUCLEOSIDES | Adenosine | Fluorides
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 03/2019, Volume 10, Issue 1, pp. 1421 - 14
Journal Article
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 03/2009, Volume 53, Issue 3, pp. 926 - 934
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 01/2008, Volume 52, Issue 1, pp. 211 - 219
Journal Article
Synthesis, ISSN 0039-7881, 05/2011, Volume 2011, Issue 9, pp. 1442 - 1446
Journal Article
Current Organic Chemistry, ISSN 1385-2728, 04/2016, Volume 20, Issue 8, pp. 830 - 838
Tubercidin represents one of the most widely recognized nucleosides isolated from natural sources. The major structural difference between adenosine and... 
Tubercidin | Natural product | Nucleosides | Antibiotic | Synthesis | antibiotic | synthesis | SALT GLYCOSYLATION PROCEDURE | PURINE | PYRROLOPYRIMIDINE NUCLEOSIDES | natural product | ADENOSINE | CHEMISTRY, ORGANIC | IDENTIFICATION | nucleosides | POTENT | VIRUS-RNA REPLICATION | ANTIVIRAL ACTIVITY | INHIBITOR | DERIVATIVES
Journal Article