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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2011, Volume 108, Issue 30, pp. 12455 - 12460
Tuberous sclerosis complex (TSC) is a tumor suppressor syndrome characterized by benign tumors in multiple organs, including the brain and kidney.... 
Cell growth | Kidneys | Cell death | Cell lines | Tuberous sclerosis | Giant cells | Lesions | Heterologous transplantation | Tumors | Cancer | Therapy | Cell survival | Metabolism | Chloroquine | ACTIVATION | cell survival | therapy | MULTIDISCIPLINARY SCIENCES | MTOR PATHWAY | TSC2 | CELL-GROWTH | MODEL | CANCER | P62 | chloroquine | GENE | ANGIOMYOLIPOMA | TUMOR-SUPPRESSOR | metabolism | Microtubule-Associated Proteins - genetics | Sequestosome-1 Protein | Multiprotein Complexes | Cell Survival - genetics | Autophagy - physiology | Mechanistic Target of Rapamycin Complex 1 | Tuberous Sclerosis - pathology | Heat-Shock Proteins - genetics | Genes, p53 | Apoptosis Regulatory Proteins - deficiency | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Autophagy - genetics | Microtubule-Associated Proteins - deficiency | Cell Survival - physiology | Beclin-1 | Heat-Shock Proteins - metabolism | Mice, Inbred C57BL | Mice, SCID | Mice, Knockout | Tuberous Sclerosis - genetics | Proteins - genetics | Animals | Proteins - metabolism | Autophagy-Related Protein 5 | Tuberous Sclerosis - metabolism | Mice, Nude | Adaptor Proteins, Signal Transducing - genetics | Mice | TOR Serine-Threonine Kinases | Adaptor Proteins, Signal Transducing - metabolism | Autophagy (Cytology) | Physiological aspects | Development and progression | Genetic aspects | Research | Carcinogenesis | Genetic disorders | Pathogenesis | Autophagy | Rodents | Medical treatment | Index Medicus | Biological Sciences
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2014, Volume 211, Issue 11, pp. 2249 - 2263
Journal Article
Nature Communications, ISSN 2041-1723, 06/2017, Volume 8, Issue 1, pp. 15816 - 15816
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 01/2008, Volume 358, Issue 2, pp. 140 - 151
Journal Article
Journal Article
Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7413, pp. 647 - 651
Autism spectrum disorders (ASDs) are highly prevalent neurodevelopmental disorders(1), but the underlying pathogenesis remains poorly understood. Recent... 
SURVIVAL | MTORC1 | TUBEROUS SCLEROSIS COMPLEX | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | ULTRASONIC VOCALIZATIONS | DISORDERS | BRAIN | CHILDREN | Autistic Disorder - pathology | Autistic Disorder - physiopathology | TOR Serine-Threonine Kinases - metabolism | Tuberous Sclerosis - complications | Cell Count | Cerebellum - drug effects | TOR Serine-Threonine Kinases - antagonists & inhibitors | Synapses - metabolism | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | Behavior, Animal - drug effects | Vocalization, Animal - drug effects | Purkinje Cells - drug effects | Autistic Disorder - genetics | Grooming - physiology | Tumor Suppressor Proteins - metabolism | Purkinje Cells - metabolism | Maze Learning - physiology | Mice, Inbred C57BL | Grooming - drug effects | Vocalization, Animal - physiology | Cerebellum - physiopathology | Maze Learning - drug effects | Mutation - genetics | Sirolimus - pharmacology | Cerebellum - pathology | Tuberous Sclerosis - genetics | Cell Shape - drug effects | Rotarod Performance Test | Animals | Heterozygote | Mice | Mice, Inbred BALB C | Autistic Disorder - complications | Autism | Complications and side effects | Purkinje cells | Tuberous sclerosis | Physiological aspects | Research | Risk factors | Studies | Proteins | Pathogenesis | Social interaction | Rodents | Ataxia | Behavior | Animal cognition | Index Medicus
Journal Article