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PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, p. e62082
Some potent chemotherapy drugs including tubulin-binding agents had been developed from nature plants, such as podophyllotoxin and paclitaxel. However, poor... 
MITOSIS | ANTIMITOTIC ACTIVITY | MICROTUBULES | NATURAL-PRODUCTS | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | RESISTANCE | TUBULIN | BINDING AGENTS | EXPRESSION | KINASES | Lung Neoplasms - drug therapy | Podophyllotoxin - pharmacology | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Apoptosis - genetics | Endoplasmic Reticulum Stress - genetics | Microtubules - metabolism | Podophyllotoxin - toxicity | Drug Evaluation, Preclinical | Disease Models, Animal | DNA Damage - drug effects | Lung Neoplasms - genetics | M Phase Cell Cycle Checkpoints - drug effects | Endoplasmic Reticulum Stress - drug effects | Antineoplastic Agents, Phytogenic - toxicity | Xenograft Model Antitumor Assays | Animals | Mitosis - drug effects | Signal Transduction - drug effects | Tumor Burden - drug effects | Cell Cycle Checkpoints - drug effects | Models, Biological | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Antineoplastic Agents, Phytogenic - pharmacology | Protein Multimerization - drug effects | Podophyllotoxin - analogs & derivatives | Chemotherapy | Podophyllotoxin | Analysis | Lung cancer | Polymerization | Stress (Physiology) | Tubulins | Health aspects | Apoptosis | Cancer | Drugs | Flow cytometry | Toxicity | Mitosis | Leukemia | DNA damage | Cytotoxicity | Selectivity | Drug development | Kinases | Cancer therapies | Anticancer properties | Metastases | Proteins | Signal transduction | Tubulin | Paclitaxel | Xenografts | Cell cycle | Inhibition | Stains | Deoxyribonucleic acid--DNA | Stresses | Plants (botany) | Hematology | Injection | Survivin | Tumor cell lines | Gene expression | Stress | Aurora B protein | Signaling | Side effects | Cell lines | Colonization | Deoxyribonucleic acid | DNA
Journal Article
Molecular Nutrition & Food Research, ISSN 1613-4125, 07/2011, Volume 55, Issue 7, pp. 999 - 1009
Scope: Sulforaphane (SFN) is an isothiocyanate derived from cruciferous vegetables such as broccoli. The ability of SFN to inhibit histone deacetylase (HDAC)... 
Epigenetics | Isothiocyanate | Prostate cancer | Chemoprevention | Apoptosis | LNCAP | MECHANISM | SUBEROYLANILIDE HYDROXAMIC ACID | ACETYLATION | FOOD SCIENCE & TECHNOLOGY | THERAPY | PATHWAY | GROWTH | INHIBITORS | VEGETABLES | EXPRESSION | Thiocyanates - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - drug effects | Apoptosis - drug effects | Epithelial Cells - drug effects | Humans | Cytosol - drug effects | Male | NAD(P)H Dehydrogenase (Quinone) - genetics | Promoter Regions, Genetic - drug effects | Tubulin - drug effects | Prostate - pathology | Tubulin - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Prostate - drug effects | Thiocyanates - pharmacology | Hyperplasia - drug therapy | Anticarcinogenic Agents - pharmacology | Isothiocyanates | Prostatic Neoplasms - drug therapy | Cell Line | Prostatic Neoplasms - pathology | Histone Deacetylase 6 | Epithelial Cells - pathology | Histone Deacetylases - metabolism | Hyperplasia - pathology | Acetylation - drug effects | NAD(P)H Dehydrogenase (Quinone) - drug effects | Prostate - cytology | Cell Line, Tumor | Cytosol - metabolism | Histone Deacetylase Inhibitors - pharmacology | Histone Deacetylases - drug effects | Histone Deacetylase 2 - metabolism | Histones - metabolism | Cell Cycle - drug effects | apoptosis | isothiocyanate | prostate cancer | chemoprevention | epigenetics
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2012, Volume 7, Issue 5, p. e36831
The present study was to explore the biological responses of the newly compound, MJ-29 in murine myelomonocytic leukemia WEHI-3 cells in vitro and in vivo... 
PERMEABILITY TRANSITION PORE | IMMUNE-RESPONSE | ACUTE LYMPHOBLASTIC-LEUKEMIA | IN-VIVO | BIOLOGY | TUBULIN POLYMERIZATION | DEATH | ANTITUMOR-ACTIVITY | BINDING AGENTS | CANCER | BALB/C MICE | Leukocytes, Mononuclear - metabolism | Reactive Oxygen Species | Apoptosis - drug effects | Calcium - metabolism | Body Weight - drug effects | Male | Leukemia - metabolism | Antineoplastic Agents - administration & dosage | Antigens, CD - metabolism | Antineoplastic Agents - toxicity | Lymphocytes - immunology | Antineoplastic Agents - pharmacology | Macrophages - immunology | Quinazolinones - pharmacology | Cell Survival - drug effects | Unfolded Protein Response - drug effects | Phagocytosis - drug effects | Leukocytes, Mononuclear - drug effects | Endoplasmic Reticulum Stress - drug effects | Leukemia - drug therapy | Mitochondria - drug effects | Organ Size - drug effects | Animals | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | Lymphocytes - drug effects | Cell Line, Tumor | Macrophages - drug effects | Mice | Mice, Inbred BALB C | Leukemia - mortality | Chemotherapy | Immunotherapy | Leukemia | Calpain | B cells | Cancer | Apoptosis | Flow cytometry | Liver | Body weight | Red pulp | Intracellular signalling | Cytotoxicity | Macrophages | Drug resistance | Cancer therapies | Pulp | Proteins | Mitochondria | Animal tissues | Cell cycle | Life sciences | Quinazolinone | Deoxyribonucleic acid--DNA | Spleen | Stresses | Myelomonocytic leukemia | Immune response | Calcium (intracellular) | Permeability | Stress | Cytometry | Monocytes | Lymphocytes B | Infiltration | Annexin V | Viability | Endoplasmic reticulum | Pharmaceuticals | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
Journal Article
New Phytologist, ISSN 0028-646X, 9/2015, Volume 207, Issue 4, pp. 1061 - 1074
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 04/2014, Volume 426, Issue 8, pp. 1848 - 1860
Journal Article
Nature, ISSN 0028-0836, 03/2011, Volume 471, Issue 7336, pp. 110 - 114
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 06/2014, Volume 25, Issue 11, pp. 1715 - 1729
Journal Article