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Journal Article
Molecular cell, ISSN 1097-2765, 10/2017, Volume 68, Issue 1, pp. 210 - 223.e6
.... Here, we present a two-tiered CRISPR-mediated chemical-genetic strategy for target identification... 
CRISPRi | chemical genetics | genome-wide CRISPR screening | rigosertib | microtubules | CRISPRa | drug target identification | drug mechanism of action | Myelodysplastic Syndromes | Genetic Testing | Vinblastine | Tubulin Modulators | Humans | Gene Expression Regulation, Neoplastic | Antineoplastic Agents | Drug Resistance, Neoplasm | Glycine | Lentivirus | Recombinant Fusion Proteins | Journal Article | Tubulin | Small Molecule Libraries | Microtubules | CRISPR-Cas Systems | K562 Cells | RNA, Guide | Colchicine | HeLa Cells | Mutation | Genetic Vectors | Kinesin | Sulfones | PROTEIN | COLCHICINE | SMALL MOLECULES | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENOMIC ASSAYS | TARGETS | RISK MYELODYSPLASTIC SYNDROMES | TUBULIN | INHIBITOR | BINDING AGENTS | CELL BIOLOGY | Colchicine - pharmacology | Glycine - analogs & derivatives | Small Molecule Libraries - pharmacology | RNA, Guide - genetics | RNA, Guide - metabolism | Tubulin Modulators - pharmacology | Tubulin - genetics | Sulfones - pharmacology | Genetic Testing - methods | Recombinant Fusion Proteins - metabolism | Lentivirus - metabolism | Microtubules - metabolism | Tubulin - metabolism | Glycine - chemistry | Microtubules - drug effects | Sulfones - chemistry | Microtubules - ultrastructure | Kinesin - genetics | Lentivirus - genetics | Antineoplastic Agents - pharmacology | Tubulin - chemistry | Myelodysplastic Syndromes - metabolism | Tubulin Modulators - chemistry | Genetic Vectors - chemistry | Genetic Vectors - metabolism | Antineoplastic Agents - chemistry | Kinesin - metabolism | Glycine - pharmacology | Recombinant Fusion Proteins - genetics | Myelodysplastic Syndromes - genetics | Vinblastine - pharmacology | Myelodysplastic Syndromes - pathology | Tubulins | Genomics | Genetic screening | Biochemical genetics | Cells
Journal Article
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2013, Volume 77, Issue 3, pp. 425 - 439
Recent genome-wide association studies have linked common variants in the human genome to Parkinson’s disease (PD) risk. Here we show that the consequences of... 
LOCALIZATION | RETROMER | TRANSPORT | COMPLEX | KINASE | GENE-EXPRESSION | TRAFFICKING | ALPHA | NEURODEGENERATION | MICE | NEUROSCIENCES | rab5 GTP-Binding Proteins - genetics | Immunoprecipitation | Humans | Middle Aged | Cerebral Cortex - pathology | Male | Tubulin - genetics | rab GTP-Binding Proteins - genetics | Green Fluorescent Proteins - genetics | Statistics as Topic | Vesicle-Associated Membrane Protein 2 - genetics | Cerebral Cortex - cytology | Tyrosine 3-Monooxygenase | rab5 GTP-Binding Proteins - metabolism | Tubulin - metabolism | Transfection | Aged, 80 and over | Female | Neurons - metabolism | Parkinson Disease - metabolism | Protein-Serine-Threonine Kinases - metabolism | Animals, Newborn | Synaptosomal-Associated Protein 25 - genetics | rab GTP-Binding Proteins - metabolism | Genetic Predisposition to Disease | Genome-Wide Association Study | Parkinson Disease - pathology | Animals, Genetically Modified | Drosophila | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Rats | Parkinson Disease - genetics | Mutation - genetics | Rats, Sprague-Dawley | Protein Transport - genetics | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Animals | Polymorphism, Single Nucleotide - genetics | Aged | Mice | Synaptosomal-Associated Protein 25 - metabolism | Vesicle-Associated Membrane Protein 2 - metabolism | Parkinson's disease | Neurons | Genomics | Risk factors | Brain | Laboratories | Parkinsons disease | Kinases | Gene expression | Experiments | Defects | Proteins | Pathology | Insects | Neurodegeneration | Gene loci | Mutation
Journal Article
The Journal of cell biology, ISSN 0021-9525, 12/2010, Volume 191, Issue 7, pp. 1315 - 1332
Many protein kinases are activated by a conserved regulatory step involving T-loop phosphorylation. Although there is considerable focus on kinase activator... 
Phosphorylation | Phosphatases | Mitosis | Cell nucleus | Cell lines | HeLa cells | Small interfering RNA | Gene expression regulation | Chromosomes | Mitotic spindle apparatus | MITOSIS | SIGNALING PATHWAY | STRUCTURAL BASIS | CENTROSOME | A KINASE | CHROMOSOME SEGREGATION | POLO-LIKE KINASE | MYOSIN PHOSPHATASE | SOMATIC MUTATIONS | DROSOPHILA | CELL BIOLOGY | RNA, Small Interfering - genetics | Microtubule-Associated Proteins - genetics | Antigens, Nuclear - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Phosphoprotein Phosphatases - metabolism | Tubulin - genetics | Telophase - genetics | Protein Subunits - metabolism | Tubulin - metabolism | Holoenzymes - metabolism | Cell Nucleus - pathology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Phosphorylation - drug effects | Nuclear Proteins - genetics | Spindle Apparatus - physiology | Kinesin - antagonists & inhibitors | Protein-Serine-Threonine Kinases - metabolism | Protein Subunits - genetics | Proto-Oncogene Proteins - metabolism | Cell Line | Phosphoric Monoester Hydrolases - genetics | Catalytic Domain - genetics | Cell Cycle Proteins - metabolism | Nuclear Matrix-Associated Proteins - metabolism | Nuclear Proteins - metabolism | Aurora Kinases | Pyrimidines - pharmacology | Fibroblasts - pathology | Mutation - genetics | Kinesin - metabolism | Azepines - pharmacology | Anaphase - genetics | Histones - genetics | Phosphoprotein Phosphatases - genetics | Cell Nucleus - genetics | Mitosis - physiology | Models, Biological | Cyclin B - metabolism | Holoenzymes - genetics | Protein Kinase Inhibitors - pharmacology | Spindle Apparatus - drug effects | HeLa Cells | Histones - metabolism | Cell Nucleus - drug effects | Chromosome Segregation - genetics | Protein Binding - physiology | Spindle (Cell division) | Cellular proteins | Research | Properties | Phosphotransferases
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 3/2002, Volume 99, Issue 6, pp. 3734 - 3739
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2012, Volume 7, Issue 8, p. e42536
Background: Recently, long noncoding RNAs have emerged as pivotal molecules for the regulation of coding genes' expression. These molecules might result from... 
BETA-TUBULIN | ENDOGENOUS SIRNAS | TRANSCRIPTS | RETROPOSITION | MOUSE OOCYTES | BIOLOGY | GENE-EXPRESSION | IDENTIFICATION | MAMMALIAN-CELLS | PSEUDOGENES | INTERFERING RNAS | Microtubule-Associated Proteins - chemistry | Testis - metabolism | Molecular Chaperones - metabolism | Spermatocytes - metabolism | Spermatogenesis - genetics | Microtubule-Associated Proteins - genetics | RNA, Untranslated - metabolism | Chromosomes, Mammalian - genetics | Microtubule-Associated Proteins - metabolism | Genome - genetics | Molecular Sequence Data | Male | Molecular Chaperones - chemistry | RNA, Messenger - metabolism | RNA, Untranslated - genetics | Gene Knockdown Techniques | Gene Expression Regulation, Developmental | Base Sequence | Transcription, Genetic | Amino Acid Sequence | Cell Line | RNA, Messenger - genetics | Molecular Chaperones - genetics | Models, Molecular | Testis - growth & development | Animals | RNA, Antisense - metabolism | Mice | RNA, Antisense - genetics | Animal genetics | RNA | Analysis | Genes | Genomics | Genomes | Genetic aspects | Genetic transcription | Tubulins | Mass spectrometry | Post-transcription | Spermatogenesis | Gene regulation | Proteins | Tubulin | Cell cycle | DNA methylation | Trends | Chromosomes | Dimerization | Maturation | RNA-mediated interference | Cell division | Antisense RNA | Mass spectroscopy | Gene expression | Ribonucleic acid--RNA | Pseudogenes | Microtubules | Regulatory mechanisms (biology) | Cytoskeleton | Mutation | Apoptosis | Ribonucleic acid
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2016, Volume 11, Issue 5, p. e0154943
...) has been conducted among 11 (7%) CAA-developed KD patients to reveal five significant genetic variants passed pre-defined thresholds and resulted in two novel susceptibility... 
NEBULETTE MUTATIONS | RISK-FACTORS | SINGLE | MULTIDISCIPLINARY SCIENCES | MATRIX-METALLOPROTEINASE-9 | LOCI | TNF-ALPHA | MODEL | RETREATMENT | EXPRESSION | LYMPHOCYTES | Coronary Vessels - pathology | Genetic Predisposition to Disease | Genome-Wide Association Study | Humans | Risk Factors | Tumor Necrosis Factor-alpha - genetics | Coronary Aneurysm - complications | Linkage Disequilibrium - genetics | Coronary Aneurysm - genetics | Mucocutaneous Lymph Node Syndrome - genetics | Mucocutaneous Lymph Node Syndrome - complications | Matrix Metalloproteinase 9 - genetics | Polymorphism, Single Nucleotide - genetics | Models, Genetic | Child | Gene Ontology | Kawasaki disease | Physiological aspects | Aneurysms | Development and progression | Genetic aspects | Risk factors | Coronary arteries | Pediatrics | Phosphorylation | Intravenous administration | Laboratories | Pathogenesis | Genomics | Genes | Aneurysm | Cardiovascular disease | Genomes | Arteries | Tubulin | Vasculitis | Coding | DNA methylation | Tumor necrosis factor-TNF | Children | Lesions | Heart diseases | Drug dosages | Informatics | Stretching | Medical research | Immunoglobulins | Threonine | Cardiac muscle | Coronary artery | Knowledge representation | Muscles | Blood vessels | Heredity | Gene expression | Patients | Medicine | Genetic variance | Hospitals | Genotyping | Coronary vessels | Proteomics | Mucocutaneous lymph node syndrome | Mutation | Health risk assessment
Journal Article
Journal Article
Journal Article