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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2014, Volume 111, Issue 38, pp. 13817 - 13821
The recent success of antibody-drug conjugates (ADCs) in the treatment of cancer has led to a revived interest in microtubuledestabilizing agents. Here, we... 
Microtubules | Drug interactions | Antineoplastics | Ligands | Dimers | Breast cancer | Molecular mechanisms of action | Crystallography | Binding sites | Crystal structure | X-ray crystallography | Microtubule-targeting agents | Drug mechanism | microtubule-targeting agents | BETA-TUBULIN | VINCA-DOMAIN | MAYTANSINE | MULTIDISCIPLINARY SCIENCES | RESOLUTION | ANTIMITOTIC AGENTS | MACROCYCLIC LACTONE ANTIBIOTICS | POTENT ANTITUMOR-ACTIVITY | BREAST-CANCER | STRUCTURAL BASIS | RHIZOXIN | drug mechanism | Tubulin Modulators - chemistry | Humans | Polyketides - chemistry | Antineoplastic Agents, Phytogenic - chemistry | Crystallography, X-Ray | Maytansine - therapeutic use | Breast Neoplasms - drug therapy | Tubulin Modulators - therapeutic use | Pyrones - chemistry | Animals | Antibiotics, Antineoplastic - chemistry | Antibiotics, Antineoplastic - therapeutic use | Macrolides - chemistry | Cattle | Maytansine - chemistry | Pyrones - therapeutic use | Female | Microtubules - chemistry | Tubulin - chemistry | Antineoplastic Agents, Phytogenic - therapeutic use | Macrolides - therapeutic use | Polyketides - therapeutic use | Binding Sites | Clinical Trials, Phase I as Topic | Antimitotic agents | Pharmaceutical research | Physiological aspects | Dosage and administration | Research | Tubulins | Antineoplastic agents | Binding sites (Biochemistry) | Biological Sciences
Journal Article
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 04/2016, Volume 75, Issue 4, pp. 644 - 651
Journal Article
Circulation, ISSN 0009-7322, 06/2012, Volume 125, Issue 23, pp. 2873 - 2891
Journal Article
JAMA, ISSN 0098-7484, 09/2014, Volume 312, Issue 10, pp. 1016 - 1023
Journal Article
Circulation, ISSN 0009-7322, 04/2011, Volume 123, Issue 16, pp. 1745 - 1756
Background-Concerns persist regarding the risk of stent thrombosis in the setting of primary percutaneous coronary intervention for ST-segment elevation... 
stents | thrombosis | myocardial infarction | CARDIAC & CARDIOVASCULAR SYSTEMS | RANDOMIZED-TRIALS | BARE-METAL STENTS | ROUTINE CLINICAL-PRACTICE | UNCOATED STENTS | CLOPIDOGREL | IMPLANTATION | LARGE 2-INSTITUTIONAL COHORT | PLATELET INHIBITION | PERIPHERAL VASCULAR DISEASE | ST-SEGMENT ELEVATION | HEMATOLOGY | DRUG-ELUTING STENTS | Recombinant Proteins - therapeutic use | Predictive Value of Tests | Myocardial Infarction - epidemiology | Coronary Thrombosis - epidemiology | Ticlopidine - therapeutic use | Hirudins | Humans | Metals | Middle Aged | Heparin - therapeutic use | Male | Angioplasty, Balloon, Coronary - statistics & numerical data | Drug-Eluting Stents - adverse effects | Angioplasty, Balloon, Coronary - adverse effects | Myocardial Infarction - therapy | Coronary Thrombosis - prevention & control | Drug-Eluting Stents - statistics & numerical data | Female | Drug Therapy, Combination | Platelet Aggregation Inhibitors - therapeutic use | Antithrombins - therapeutic use | Risk Factors | Anticoagulants - therapeutic use | Coronary Restenosis - prevention & control | Treatment Outcome | Paclitaxel - therapeutic use | Ticlopidine - analogs & derivatives | Tubulin Modulators - therapeutic use | Coronary Restenosis - epidemiology | Aged | Peptide Fragments - therapeutic use | Complications and side effects | Care and treatment | Angioplasty | Research | Thrombosis | Heart attack | Stent (Surgery) | Blood clot | Risk factors
Journal Article