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Nature Immunology, ISSN 1529-2908, 05/2010, Volume 11, Issue 5, pp. 411 - 418
Sensors of pathogens, such as Toll-like receptors (TLRs), detect microbes to activate transcriptional programs that orchestrate adaptive responses to specific... 
UNFOLDED PROTEIN RESPONSE | PATHWAY | ER STRESS | HOST-DEFENSE | ENDOPLASMIC-RETICULUM STRESS | FRANCISELLA-TULARENSIS INFECTION | IMMUNOLOGY | LIVE VACCINE STRAIN | INFLAMMATORY RESPONSE | NEGATIVE REGULATOR | SYSTEMS BIOLOGY | RNA, Small Interfering - genetics | Endoribonucleases - genetics | Tularemia - metabolism | Toll-Like Receptor 2 - genetics | Membrane Glycoproteins - metabolism | Lipopeptides - pharmacology | Transcriptional Activation - drug effects | NADPH Oxidases - metabolism | Tularemia - genetics | Protein Splicing - genetics | Transcriptional Activation - immunology | X-Box Binding Protein 1 | Protein Splicing - drug effects | NADPH Oxidases - genetics | Stress, Physiological - drug effects | TNF Receptor-Associated Factor 6 - genetics | Transcription Factor CHOP - biosynthesis | Transcription Factors - immunology | Cytokines - genetics | Protein-Serine-Threonine Kinases - metabolism | DNA-Binding Proteins - immunology | Endoribonucleases - metabolism | Macrophages - pathology | Stress, Physiological - genetics | Myeloid Differentiation Factor 88 - genetics | Toll-Like Receptor 4 - genetics | Signal Transduction - genetics | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Macrophages - metabolism | Signal Transduction - drug effects | Tunicamycin - pharmacology | Lipopolysaccharides - pharmacology | Toll-Like Receptor 2 - immunology | Mice | Stress, Physiological - immunology | Endoribonucleases - immunology | Transcription Factor CHOP - genetics | NADPH Oxidases - immunology | DNA-Binding Proteins - metabolism | Signal Transduction - immunology | Macrophages - virology | Mice, Mutant Strains | Tularemia - immunology | Membrane Glycoproteins - immunology | Macrophages - immunology | Cytokines - immunology | Cell Line | Francisella tularensis - immunology | Protein Splicing - immunology | Protein-Serine-Threonine Kinases - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Immunity, Innate | NADPH Oxidase 2 | Regulatory Factor X Transcription Factors | Mice, Inbred C3H | Membrane Glycoproteins - genetics | Transcription Factors - metabolism | Animals | TNF Receptor-Associated Factor 6 - metabolism | Macrophages - drug effects | Protein-Serine-Threonine Kinases - immunology | Francisella tularensis - pathogenicity | Myeloid Differentiation Factor 88 - metabolism | Cytokines - biosynthesis | Cell receptors | Transcription factors | Immune response | Physiological aspects | Genetic aspects | Research | Health aspects | Francisella tularensis | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 12/2010, Volume 185, Issue 12, pp. 7562 - 7572
An inadequate innate immune response appears to contribute to the virulence of Francisella tularensis following pulmonary infection. Studies in mice suggest... 
TUMOR-NECROSIS-FACTOR | SIGNALING PATHWAYS | INNATE IMMUNE-RESPONSES | INFLAMMATORY RESPONSES | PROTEIN-KINASE PHOSPHATASE-1 | NEGATIVE REGULATION | TOLL-LIKE RECEPTORS | GENE-EXPRESSION | IMMUNOLOGY | PHOSPHOINOSITIDE 3-KINASE | FACTOR-ALPHA | Tularemia - metabolism | Toll-Like Receptor 2 - genetics | Bacterial Vaccines - genetics | Tumor Necrosis Factor-alpha - genetics | Immunity, Innate - genetics | Tularemia - genetics | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - immunology | Inflammation - metabolism | Phosphorylation - genetics | Francisella tularensis - metabolism | Bone Marrow Cells - immunology | Tumor Necrosis Factor-alpha - immunology | Phosphorylation - immunology | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-6 - metabolism | Dual Specificity Phosphatase 1 - genetics | Interleukin-6 - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Enzyme Inhibitors - pharmacology | Myeloid Differentiation Factor 88 - genetics | Signal Transduction - genetics | p38 Mitogen-Activated Protein Kinases - immunology | Toll-Like Receptor 2 - metabolism | Macrophages - metabolism | Proto-Oncogene Proteins c-akt - immunology | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Interleukin-6 - immunology | Toll-Like Receptor 2 - immunology | Mice | Tumor Necrosis Factor-alpha - metabolism | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Tularemia - prevention & control | Phosphatidylinositol 3-Kinases - metabolism | Vaccines, Attenuated - metabolism | Proto-Oncogene Proteins c-akt - genetics | Signal Transduction - immunology | Mice, Mutant Strains | Myeloid Differentiation Factor 88 - immunology | Tularemia - immunology | Bacterial Vaccines - metabolism | Macrophages - immunology | Francisella tularensis - immunology | Mitogen-Activated Protein Kinase 3 - immunology | Immunity, Innate - drug effects | Morpholines - pharmacology | p38 Mitogen-Activated Protein Kinases - genetics | Dual Specificity Phosphatase 1 - immunology | Inflammation - immunology | Phosphatidylinositol 3-Kinases - genetics | Immunity, Innate - immunology | Vaccines, Attenuated - immunology | Animals | Androstadienes - pharmacology | Bacterial Vaccines - immunology | Inflammation - genetics | Dual Specificity Phosphatase 1 - metabolism | Myeloid Differentiation Factor 88 - metabolism | Bone Marrow Cells - metabolism | Vaccines, Attenuated - genetics | Index Medicus | Abridged Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 05/2010, Volume 11, Issue 5, pp. 395 - 402
Inflammasomes regulate the activity of caspase-1 and the maturation of interleukin 1. (IL-1.) and IL-18. AIM2 has been shown to bind DNA and engage the... 
RECOGNITION | TOLL-LIKE RECEPTOR | INDUCIBLE GENES | INNATE IMMUNE-RESPONSE | INFECTION | VACCINIA VIRUS | IMMUNOLOGY | MURINE CYTOMEGALOVIRUS | FRANCISELLA-TULARENSIS | CASPASE-1 ACTIVATION | FAMILY | Tularemia - metabolism | Cytoskeletal Proteins - genetics | Humans | Tularemia - genetics | Caspase 1 - metabolism | Multiprotein Complexes - genetics | Multiprotein Complexes - metabolism | Lymphocyte Activation - genetics | Transcription Factors - immunology | Cytokines - genetics | Macrophages - microbiology | DNA-Binding Proteins | DNA Viruses - pathogenicity | Macrophages - pathology | Killer Cells, Natural - virology | Listeriosis - genetics | Signal Transduction - genetics | DNA Virus Infections - genetics | Viral Load - immunology | Mice, Knockout | Macrophages - metabolism | DNA Virus Infections - immunology | Mice | Killer Cells, Natural - metabolism | Multiprotein Complexes - immunology | DNA Virus Infections - metabolism | Caspase 1 - immunology | Killer Cells, Natural - pathology | Signal Transduction - immunology | Macrophages - virology | Listeriosis - immunology | Tularemia - immunology | Killer Cells, Natural - immunology | Nuclear Proteins - genetics | Macrophages - immunology | Cytokines - immunology | Killer Cells, Natural - microbiology | Cell Line | Francisella tularensis - immunology | Listeriosis - metabolism | Cytokines - metabolism | DNA - immunology | Mice, Inbred C57BL | Nuclear Proteins - metabolism | Transcription Factors - genetics | Immunity, Innate | Nuclear Proteins - immunology | Viral Load - genetics | DNA Viruses - immunology | Transcription Factors - metabolism | Animals | Apoptosis Regulatory Proteins | Caspase 1 - genetics | DNA Viruses - growth & development | CARD Signaling Adaptor Proteins | Francisella tularensis - pathogenicity | Bacterial infections | Immune response | Cytomegalovirus infections | Research | DNA viruses | Health aspects | Risk factors | Index Medicus
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 10/2012, Volume 19, Issue 10, pp. 1709 - 1721
Journal Article
Infection and Immunity, ISSN 0019-9567, 01/2013, Volume 81, Issue 1, pp. 201 - 208
Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
5,10-METHENYLTETRAHYDROFOLATE SYNTHETASE | AIM2 INFLAMMASOME | INFECTIOUS DISEASES | INFLAMMASOME ACTIVATION | ESCHERICHIA-COLI | RECEPTOR | MELANOMA 2 | IMMUNOLOGY | VIRULENCE | IMMUNE RECOGNITION | CYTOPLASMIC DNA | INNATE IMMUNITY | Phagosomes - microbiology | Interleukin-18 - immunology | Tularemia - metabolism | Inflammasomes - metabolism | Macrophage Activation - genetics | Folic Acid - immunology | Tularemia - genetics | Caspase 1 - metabolism | Caspase 1 - immunology | Vaccines, Attenuated - metabolism | Mutation - immunology | Carbon-Nitrogen Ligases - genetics | Phagosomes - immunology | Tularemia - microbiology | Francisella tularensis - metabolism | Interleukin-1beta - metabolism | Tularemia - immunology | Bacterial Vaccines - metabolism | Francisella tularensis - genetics | Intramolecular Transferases - immunology | Macrophages - immunology | Macrophages - microbiology | Francisella tularensis - immunology | Intramolecular Transferases - genetics | Carbon-Nitrogen Ligases - metabolism | Macrophage Activation - immunology | Mice, Inbred C57BL | Phagosomes - metabolism | Interleukin-1beta - immunology | Mutation - genetics | Inflammasomes - genetics | Intramolecular Transferases - metabolism | Macrophages - metabolism | Vaccines, Attenuated - immunology | Animals | Bacterial Vaccines - immunology | Inflammasomes - immunology | Virulence - immunology | Carbon-Nitrogen Ligases - immunology | Folic Acid - metabolism | Mice | Folic Acid - genetics | Interleukin-18 - metabolism | Index Medicus | Cellular Microbiology | Pathogen-Host Cell Molecular Interactions
Journal Article
Nature Immunology, ISSN 1529-2908, 05/2010, Volume 11, Issue 5, pp. 385 - 393
Francisella tularensis, the causative agent of tularemia, infects host macrophages, which triggers production of the proinflammatory cytokines interleukin 1... 
PHAGOSOMAL ESCAPE | ACTIVATION | CASPASE-1 | ASC PYROPTOSOME | IMMUNOLOGY | NF-KAPPA-B | PATHOGEN RECOGNITION | NALP3 INFLAMMASOME | CYTOPLASMIC DNA | CELL-DEATH | PYRIN | L-Lactate Dehydrogenase - metabolism | Tularemia - metabolism | Humans | Protein Multimerization | Tularemia - genetics | Caspase 1 - metabolism | Multiprotein Complexes - genetics | Caspase 1 - immunology | Interleukin-1beta - genetics | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | Multiprotein Complexes - metabolism | L-Lactate Dehydrogenase - immunology | Tularemia - immunology | Calcium Signaling - immunology | Interleukin-1beta - biosynthesis | Nuclear Proteins - genetics | Macrophages - immunology | DNA-Binding Proteins | Interferon Regulatory Factor-3 - immunology | Francisella tularensis - immunology | Macrophages - pathology | Cells, Cultured | Interleukin-1beta - immunology | Nuclear Proteins - metabolism | Immunity, Innate | Nuclear Proteins - immunology | Mice, Knockout | Macrophages - metabolism | Animals | L-Lactate Dehydrogenase - genetics | Caspase 1 - genetics | Interferon Regulatory Factor-3 - metabolism | Francisella tularensis - pathogenicity | Mice | Multiprotein Complexes - immunology | Interleukins | Bacterial proteins | Tularemia | Physiological aspects | Causes of | Genetic aspects | Research | Health aspects | Francisella tularensis | Index Medicus
Journal Article
Journal Article
PLoS Pathogens, ISSN 1553-7366, 01/2014, Volume 10, Issue 1, pp. e1003893 - e1003893
Journal Article
Journal Article
Journal Article