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Journal Article
Nature, ISSN 0028-0836, 05/2017, Volume 545, Issue 7652, pp. 60 - 65
Despite the success of monotherapies based on blockade of programmed cell death 1 (PD-1) in human melanoma, most patients do not experience durable clinical... 
CRITERIA | MELANOMA | PEMBROLIZUMAB | IMMUNE CHECKPOINT BLOCKADE | PD-1 BLOCKADE | MULTIDISCIPLINARY SCIENCES | BRAF INHIBITORS | CHRONIC VIRAL-INFECTION | CANCER-THERAPY | IPILIMUMAB | EXHAUSTION | CD8-Positive T-Lymphocytes - cytology | Antibodies, Monoclonal, Humanized - therapeutic use | Melanoma - blood supply | Humans | Ki-67 Antigen - metabolism | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Treatment Outcome | Melanoma - pathology | Phenotype | Antibodies, Monoclonal, Humanized - administration & dosage | Ki-67 Antigen - immunology | Antibodies, Monoclonal, Humanized - pharmacokinetics | Melanoma - immunology | Melanoma - drug therapy | CD8-Positive T-Lymphocytes - metabolism | Female | Programmed Cell Death 1 Receptor - immunology | Antibodies, Monoclonal, Humanized - immunology | CD8-Positive T-Lymphocytes - immunology | Neoplasm Staging | Tumor Burden - immunology | Oncology, Experimental | Melanoma | Physiological aspects | Research | T cells | Tumors | Apoptosis | Cancer | Profiling | PD-1 protein | CD8 antigen | Medical services | Clinical trials | Lymphocytes T | Blood | Metastases | Immunology | Lymphocytes | Immunotherapy | Peripheral blood | Pretreatment | Medical research | Immunoglobulins | T cell receptors | Pharmacology | Patients | Pathology | Cell death | PD-L1 protein | Infiltration | Index Medicus
Journal Article
Cancer Immunology, Immunotherapy, ISSN 0340-7004, 1/2009, Volume 58, Issue 1, pp. 49 - 59
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 06/2013, Volume 73, Issue 12, pp. 3591 - 3603
Tumor progression is facilitated by regulatory T cells (Treg) and restricted by effector T cells. In this study, we document parallel regulation of CD8(+) T... 
DISTINCT MECHANISMS | ONCOLOGY | PROGRAMMED DEATH-1 | IMMUNE ESCAPE | MYELOID-LEUKEMIA | SYNGENEIC MOUSE MODEL | REGULATORY T | GROWTH-FACTOR | CHRONIC VIRAL-INFECTION | ANTITUMOR-ACTIVITY | HUMAN OVARIAN-CANCER | T-Lymphocytes, Regulatory - metabolism | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antibodies, Blocking - pharmacology | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Neoplasms, Experimental - pathology | Flow Cytometry | T-Lymphocytes - metabolism | Neoplasms, Experimental - immunology | CD8-Positive T-Lymphocytes - metabolism | Female | Lymphocytes, Tumor-Infiltrating - metabolism | Cytokines - immunology | Cytokines - metabolism | Cancer Vaccines - administration & dosage | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Neoplasms, Experimental - therapy | CTLA-4 Antigen - metabolism | Lymphocytes, Tumor-Infiltrating - transplantation | Programmed Cell Death 1 Receptor - metabolism | Combined Modality Therapy | CTLA-4 Antigen - immunology | B7-H1 Antigen - immunology | Cancer Vaccines - immunology | B7-H1 Antigen - metabolism | Animals | Antibodies, Blocking - immunology | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | CTLA-4 Antigen - antagonists & inhibitors | Lymphocytes, Tumor-Infiltrating - immunology | Tumor Burden - immunology | Index Medicus
Journal Article
Journal Article
Journal Article
Cancer Immunology, Immunotherapy, ISSN 0340-7004, 11/2013, Volume 62, Issue 11, pp. 1745 - 1756
The role and characteristics of tumor-associated neutrophils (TAN) in cancer are poorly defined. We have recently shown that TAN can have anti-tumorigenic (N1)... 
Immunology | Medicine & Public Health | Tumor microenvironment | Lung cancer | Tumor immunology | Oncology | Cancer Research | Tumor-associated neutrophils | Mesothelioma | CELLS | ACTIVATION | MACROPHAGES | DISTINCT | IMMUNOLOGY | CANCER | NECROSIS-FACTOR | THERAPY | ONCOLOGY | INFLAMMATION | NF-KAPPA-B | INNATE IMMUNITY | Immunohistochemistry | Tumor Necrosis Factor-alpha - metabolism | Neoplasms, Experimental - pathology | Flow Cytometry | Tumor Microenvironment - genetics | Time Factors | Neoplasms, Experimental - immunology | Neoplasms, Experimental - genetics | Tumor Necrosis Factor-alpha - immunology | Antigens, Ly - metabolism | Tumor Burden - genetics | Cytokines - genetics | Neutrophils - metabolism | Antibodies, Monoclonal - immunology | Gene Expression Regulation, Neoplastic - genetics | Cytokines - immunology | Cytotoxicity, Immunologic - genetics | Nitric Oxide - immunology | Cytokines - metabolism | Antibodies, Monoclonal - pharmacology | Mice, Inbred C57BL | Neutrophils - drug effects | Neutrophils - immunology | Gene Expression Regulation, Neoplastic - immunology | Reverse Transcriptase Polymerase Chain Reaction | Disease Progression | Hydrogen Peroxide - metabolism | Tumor Microenvironment - immunology | Animals | Antigens, Ly - immunology | Hydrogen Peroxide - immunology | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Cytotoxicity, Immunologic - immunology | Nitric Oxide - metabolism | Tumor Burden - immunology | Development and progression | Real estate development | Tumors | Index Medicus | Animal models
Journal Article