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Journal of Experimental Medicine, ISSN 0022-1007, 10/2013, Volume 210, Issue 11, pp. 2435 - 2466
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 01/2017, Volume 16, Issue 1, pp. 25 - 34
AZD6738 is an orally active ATR inhibitor (ATRi) currently in phase I clinical trials. We found in vitro growth inhibitory activity of this ATRi in a panel of... 
CANCER-CELLS | ONCOLOGY | CONSEQUENCES | SENSITIVITY | TUMOR-CELLS | CHECKPOINT | IDENTIFICATION | CHROMOTHRIPSIS | STRESS | DEPENDENT MANNER | RADIATION | Homologous Recombination - drug effects | Tumor Burden - radiation effects | Humans | Tumor Suppressor Protein p53 - genetics | G2 Phase Cell Cycle Checkpoints - radiation effects | G2 Phase Cell Cycle Checkpoints - drug effects | Micronuclei, Chromosome-Defective - drug effects | Inhibitory Concentration 50 | Micronuclei, Chromosome-Defective - radiation effects | Disease Models, Animal | Radiation, Ionizing | DNA Damage - drug effects | Sulfoxides - pharmacology | Homologous Recombination - radiation effects | Radiation-Sensitizing Agents - pharmacology | Tumor Suppressor Protein p53 - metabolism | Pyrimidines - pharmacology | Radiation Tolerance - drug effects | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | DNA Damage - radiation effects | Biotechnology | Mitosis | p53 Protein | DNA damage | Homologous recombination | Cytology | Radiation | Clinical trials | Fluorescence | Homology | Nuclei | Ubiquitination | Radiosensitization | Inhibition | Deoxyribonucleic acid--DNA | BRCA2 protein | Medical research | Radiation effects | CHK1 protein | Breast cancer | Tumor cell lines | Inhibitors | Micronuclei | Cell lines | Nuclei (cytology) | Three dimensional models | Radiation damage | Cancer | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 16, pp. 3314 - 3326
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 10/2014, Volume 20, Issue 19, pp. 5085 - 5096
Purpose: While the addition of radiation to chemotherapy improves survival in patients with locally advanced pancreatic cancer, more effective therapies are... 
POLY(ADP-RIBOSE) POLYMERASE | IN-VITRO | REPLICATION | CHK1 | ONCOLOGY | DNA-DAMAGE | HOMOLOGOUS RECOMBINATION | G CHECKPOINT | RADIATION | HUMAN TUMOR-CELLS | CHECKPOINT KINASE INHIBITOR | Pancreatic Neoplasms - metabolism | Protein-Tyrosine Kinases - metabolism | Tumor Burden - radiation effects | Humans | Radiation | Cell Cycle Proteins - antagonists & inhibitors | Protein-Tyrosine Kinases - genetics | Cell Cycle Proteins - genetics | Female | Tumor Burden - genetics | Nuclear Proteins - genetics | Disease Models, Animal | DNA Damage - drug effects | Cell Survival - drug effects | Pancreatic Neoplasms - pathology | Cell Cycle Proteins - metabolism | Radiation Tolerance - genetics | Nuclear Proteins - metabolism | Pancreatic Neoplasms - genetics | Cell Survival - radiation effects | Piperazines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors | Radiation Tolerance - drug effects | Xenograft Model Antitumor Assays | Phthalazines - pharmacology | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Tumor Burden - drug effects | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Poly (ADP-Ribose) Polymerase-1 | DNA Damage - radiation effects | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus | pancreatic cancer | Wee1 | PARP1 | radiosensitization | homologous recombination repair
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 12/2014, Volume 13, Issue 12, pp. 2955 - 2967
Journal Article
Advanced Materials, ISSN 0935-9648, 01/2016, Volume 28, Issue 2, pp. 245 - 253
In vivo MEO 2 MA@MEO 2 MA‐ co ‐OEGMA‐CuS‐DOX (G‐CuS‐DOX) nanocapsules increase the temperature of tumors from room temperature to 57 °C due to the photothermal... 
smart nanocapsules | switches | tumors | NIR lasers | chemotherapy | photothermal therapy | DRUG | GRAPHENE OXIDE | POLYMERS | PHYSICS, CONDENSED MATTER | PHYSICS, APPLIED | GOLD NANOCAGES | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | RELEASE | CANCER | CHEMISTRY, MULTIDISCIPLINARY | AGENT | NANOPARTICLES | ABLATION | LIPOSOMES | Neoplasm Transplantation | Tumor Burden - radiation effects | Humans | Carcinoma, Hepatocellular - secondary | Liver Neoplasms - therapy | Antineoplastic Agents - administration & dosage | Nanocapsules - chemistry | Carcinoma, Hepatocellular - diagnostic imaging | Hyperthermia, Induced | Water - chemistry | Liver Neoplasms - pathology | Antineoplastic Agents - pharmacokinetics | Liver Neoplasms - secondary | Doxorubicin - administration & dosage | Cell Survival - drug effects | Low-Level Light Therapy - methods | Combined Modality Therapy | Cell Survival - radiation effects | Liver Neoplasms - diagnostic imaging | Doxorubicin - pharmacokinetics | Animals | Tumor Burden - drug effects | Carcinoma, Hepatocellular - pathology | Cell Line, Tumor | Hydrophobic and Hydrophilic Interactions | Carcinoma, Hepatocellular - therapy | Mice | Chemotherapy | Lasers | Cancer | Tumors | Index Medicus | Drugs | Therapy | Irradiation | Nanostructure | Shrinkage
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 07/2015, Volume 33, Issue 20, pp. 2231 - 2238
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 12/2012, Volume 18, Issue 24, pp. 6668 - 6678
Purpose: This study tested the hypothesis that topical Toll-like receptor (TLR) 7 agonist imiquimod promotes antitumor immunity and synergizes with other... 
ENHANCES TUMOR RESPONSE | IMMUNE-RESPONSE | THERAPY | INHIBITION | ONCOLOGY | IMMUNOTHERAPY | DOXORUBICIN | REGULATORY T-CELLS | RADIOTHERAPY | CHEMOTHERAPY | IMIQUIMOD | Mammary Neoplasms, Experimental - immunology | Neoplasm Transplantation | Cyclophosphamide - administration & dosage | Skin Neoplasms - drug therapy | Skin Neoplasms - radiotherapy | Tumor Burden - radiation effects | Humans | Aminoquinolines - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Chemoradiotherapy | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Histocompatibility Antigens Class I - metabolism | T-Lymphocytes - drug effects | Mammary Neoplasms, Experimental - pathology | Dose Fractionation | Lymph Nodes - drug effects | Mammary Neoplasms, Experimental - drug therapy | Toll-Like Receptor 7 - agonists | T-Lymphocytes - secretion | Cytokines - metabolism | Neoplasm Recurrence, Local - prevention & control | Skin Neoplasms - immunology | Cytokines - secretion | Injections, Intraperitoneal | Membrane Glycoproteins - agonists | Mammary Neoplasms, Experimental - radiotherapy | Histocompatibility Antigens Class I - genetics | Lymph Nodes - immunology | Drug Synergism | Intercellular Adhesion Molecule-1 - metabolism | Animals | Tumor Burden - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Intercellular Adhesion Molecule-1 - genetics | Skin Neoplasms - secondary | Cell Line, Tumor | Immunologic Memory | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Administration, Topical | Index Medicus | radiotherapy | cyclophosphamide | Breast cancer | imiquimod | immunotherapy
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 01/2018, Volume 28, Issue 2, pp. 131 - 140
Aims: Evofosfamide (TH-302) is a hypoxia-activated prodrug (HAP) that releases the DNA-damaging bromo-isophosphoramide mustard (Br-IPM) moiety selectively... 
Original Research Communications | hypoxia | radiation | EPR | TH-302 | hypoxic cytotoxin | ADVANCED CANCER | EFFICACY | SAFETY | OXYGENATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTITUMOR-ACTIVITY | COMBINATION | UTERINE CERVIX | MODELS | NITRONE SPIN TRAPS | ENDOCRINOLOGY & METABOLISM | DNA Damage - drug effects | Cell Survival - drug effects | Cell Hypoxia - drug effects | Cell Hypoxia - radiation effects | Hypoxia - drug therapy | Nitroimidazoles - pharmacology | Prodrugs | Phosphoramide Mustards - pharmacology | Tumor Burden - radiation effects | Humans | Oxidation-Reduction - radiation effects | Hypoxia - radiotherapy | Radiotherapy | Cell Survival - radiation effects | Hypoxia - metabolism | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | Oxidation-Reduction - drug effects | Cell Line, Tumor | Mice | DNA Damage - radiation effects | Disease Models, Animal | Hypoxia | Usage | Research | Electron paramagnetic resonance spectroscopy | Xenotransplantation | Cycles | Surgical implants | Animal models | Transplants & implants | Toxicity | DNA damage | Innovations | Cytotoxicity | Electron spin | Anticancer properties | Fragmentation | Ionizing radiation | Xenografts | Biocompatibility | Redox properties | Deoxyribonucleic acid--DNA | Oxygen | Radiation therapy | Nitroimidazole | Chemotherapy | Antitumor activity | In vivo methods and tests | Mustard | Electron paramagnetic resonance | Kinetics | Solid tumors | Tumors | Index Medicus
Journal Article