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Blood, ISSN 0006-4971, 2009, Volume 113, Issue 26, pp. 6716 - 6725
Journal Article
Journal Article
Experimental Hematology, ISSN 0301-472X, 2011, Volume 39, Issue 12, pp. 1171 - 1181
Various agents, including chemotherapeutic drugs, can induce cell senescence. However, the mechanisms involved in the aging pathway, particularly the stress... 
Hematology, Oncology and Palliative Medicine | Advanced Basic Science | PROGENITOR CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | BREAST-TUMOR CELLS | DNA-DAMAGE | BONE-MARROW TRANSPLANTS | HIGH-DOSE CHEMOTHERAPY | ACCELERATED SENESCENCE | IONIZING-RADIATION | STROMAL CELLS | HEMATOLOGY | CELLULAR SENESCENCE | TELOMERE LENGTH | Phosphorylation | Antibiotics, Antineoplastic - toxicity | Telomere - ultrastructure | Cells, Cultured - cytology | Humans | Cellular Senescence - drug effects | Adipocytes - cytology | Telomere - drug effects | Neoplasm Proteins - metabolism | DNA Breaks, Double-Stranded | DNA-Binding Proteins - metabolism | Dose-Response Relationship, Drug | Antineoplastic Agents, Phytogenic - administration & dosage | Mesenchymal Stromal Cells - cytology | Mesenchymal Stromal Cells - ultrastructure | Adult | Bone Marrow Cells - drug effects | Osteoblasts - cytology | Protein-Serine-Threonine Kinases - metabolism | Doxorubicin - administration & dosage | Mesenchymal Stromal Cells - drug effects | Tumor Stem Cell Assay | Cells, Cultured - drug effects | Etoposide - toxicity | Tumor Suppressor Proteins - metabolism | Bone Marrow Cells - cytology | Cell Cycle Proteins - metabolism | Etoposide - administration & dosage | Ataxia Telangiectasia Mutated Proteins | Doxorubicin - toxicity | Antibiotics, Antineoplastic - administration & dosage | Antineoplastic Agents, Phytogenic - toxicity | Cell Differentiation - drug effects | Protein Processing, Post-Translational | Anthracyclines | Chemotherapy | Analysis | DNA | Stem cells | Etoposide | Automated teller machines | Telomerase | Cancer | Index Medicus
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 11/2011, Volume 71, Issue 21, pp. 6857 - 6866
Most ductal breast carcinoma cells are weakly invasive in vitro and in vivo, suggesting that components of their microenvironment may facilitate a transition... 
MIGRATION | TRANSITION | COLLAGEN | ONCOLOGY | BRANCHING MORPHOGENESIS | GENE-EXPRESSION | TUMOR | CELL-LINES | CARCINOMA | IN-SITU | REVEALS | Neoplasm Transplantation | Fibroblasts - physiology | Spheroids, Cellular - transplantation | Cells, Cultured - cytology | Coculture Techniques | Humans | Neoplasm Invasiveness - prevention & control | Culture Media, Conditioned - pharmacology | Tumor Microenvironment - physiology | Spheroids, Cellular - physiology | Cell Movement - physiology | Neovascularization, Pathologic - pathology | Carcinoma, Ductal, Breast - classification | Extracellular Matrix - physiology | cdc42 GTP-Binding Protein - antagonists & inhibitors | Carcinoma, Ductal, Breast - pathology | Female | Breast Neoplasms - classification | Breast - cytology | RNA, Small Interfering - pharmacology | Tumor Cells, Cultured - drug effects | Collagen - physiology | Cells, Cultured - physiology | cdc42 GTP-Binding Protein - physiology | Mice, SCID | Neoplasm Invasiveness - physiopathology | Cell Movement - drug effects | Extracellular Matrix - ultrastructure | Animals | Carcinoma, Intraductal, Noninfiltrating - pathology | Breast Neoplasms - pathology | cdc42 GTP-Binding Protein - genetics | Fibroblasts - cytology | Mice | Protein Kinase Inhibitors - pharmacology | Tumor Cells, Cultured - physiology | Tumor Cells, Cultured - cytology | Index Medicus | microenvironment | Breast cancer | invasion | metastasis | heterogeneity
Journal Article
Carcinogenesis, ISSN 0143-3334, 03/2010, Volume 31, Issue 3, pp. 481 - 488
As a critical factor in the induction of angiogenesis, vascular endothelial growth factor (VEGF) has become an attractive target for anti-angiogenesis... 
3T3-L1 ADIPOCYTES | DIETARY ANTHOCYANIDIN | INSULIN-RECEPTOR | IN-VITRO | POLYPHENOLS | ONCOLOGY | BIOLOGICAL-ACTIVITY | TUMOR ANGIOGENESIS | GRAPE SEED EXTRACT | CANCER | ENDOTHELIAL GROWTH-FACTOR | Biflavonoids - pharmacology | Neovascularization, Physiologic - drug effects | Plant Extracts - pharmacology | Cells, Cultured - cytology | Humans | Male | Cell Line, Tumor - drug effects | Cell Line, Tumor - transplantation | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Laminin | Proanthocyanidins - pharmacology | Protein Processing, Post-Translational - drug effects | Cattle | Female | Aorta, Thoracic - drug effects | Phosphorylation - drug effects | Catechin - pharmacology | Cells, Cultured - drug effects | Proteoglycans | Cell Line, Tumor - enzymology | Cinnamomum zeylanicum - chemistry | Angiogenesis Inhibitors - pharmacology | Plant Extracts - isolation & purification | Mice, SCID | Chick Embryo | Cell Division - drug effects | Cells, Cultured - enzymology | Xenograft Model Antitumor Assays | Cell Movement - drug effects | Biflavonoids - isolation & purification | Animals | Signal Transduction - drug effects | Breast Neoplasms - pathology | Endothelial Cells - cytology | Collagen | Catechin - isolation & purification | Morphogenesis - drug effects | Angiogenesis Inhibitors - isolation & purification | Mice | Endothelial Cells - enzymology | Drug Combinations | Proanthocyanidins - isolation & purification | Endothelial Cells - drug effects | Index Medicus | Cancer Prevention
Journal Article
Blood, ISSN 0006-4971, 11/2001, Volume 98, Issue 10, pp. 3006 - 3015
Prostratin is a unique phorbol ester that stimulates protein kinase C activity but is nontumor promoting. Remarkably, prostratin is also able to inhibit de... 
PROMYELOCYTIC LEUKEMIA | NONPROMOTING PHORBOL | ACTIVE ANTIRETROVIRAL THERAPY | TRANSCRIPTION | LEUKEMIA-CELL LINE | CD4(+) T-CELLS | HIV-1-INFECTED PATIENTS | HUMAN-IMMUNODEFICIENCY-VIRUS | ESTABLISHMENT | HEMATOLOGY | CD-1 MOUSE SKIN | Myeloid Cells - cytology | Proviruses - physiology | Tetradecanoylphorbol Acetate - pharmacology | Oligonucleotide Array Sequence Analysis | Leukemia, Monocytic, Acute - pathology | Monocytes - cytology | Virus Latency | Cells, Cultured - cytology | Humans | Receptors, CCR5 - genetics | Gene Expression Profiling | Receptors, CCR5 - biosynthesis | Viral Load | Dose-Response Relationship, Drug | RNA, Messenger - biosynthesis | HIV-1 - physiology | Protein Kinase C - metabolism | Phorbol Esters - pharmacology | Myeloid Cells - drug effects | Receptors, CXCR4 - genetics | CD4 Antigens - genetics | HIV Infections - blood | Cells, Cultured - drug effects | HIV-1 - drug effects | Lymphocyte Activation | HIV Infections - virology | Tumor Cells, Cultured - drug effects | HL-60 Cells - drug effects | Enzyme Activation - drug effects | Antiretroviral Therapy, Highly Active | Drug Synergism | Gene Expression Regulation - drug effects | Monocytes - drug effects | HL-60 Cells - cytology | Virus Activation - drug effects | Receptors, CXCR4 - biosynthesis | Cell Differentiation - drug effects | HIV Infections - drug therapy | CD4 Antigens - biosynthesis | Tumor Cells, Cultured - cytology | Index Medicus | Abridged Index Medicus
Journal Article
Scientific Reports, ISSN 2045-2322, 06/2016, Volume 6, Issue 1, pp. 28375 - 28375
Multicellular tumor spheroids embedded in a matrix represent invaluable tools to analyze cell invasion. Spheroid sizes and invasiveness are the main... 
MIGRATION | TUMOR | IN-VITRO | MODEL | MULTIDISCIPLINARY SCIENCES | Reproducibility of Results | Cell Proliferation | Cell Culture Techniques - instrumentation | Neoplasm Invasiveness | Humans | Spheroids, Cellular - pathology |