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Journal of Clinical Investigation, ISSN 0021-9738, 04/2012, Volume 122, Issue 4, pp. 1271 - 1282
The cytolcine IL-12 induces IFN-gamma production by T and NK cells. In preclinical models, it contributes to antitumor immunity. However, in clinical testing,... 
CXC CHEMOKINE RECEPTOR-5 | MEDICINE, RESEARCH & EXPERIMENTAL | TUMOR | INTERLEUKIN-12 | INNATE IMMUNE CELLS | ANTIGEN-SPECIFIC CD8 | ANTITUMOR IMMUNITY | HEPATITIS-C | HCV INFECTION | PD-1 EXPRESSION | DISEASE PROGRESSION | T-Lymphocyte Subsets - immunology | Lymphoma, Follicular - metabolism | Prognosis | Humans | Neoplasm Proteins - physiology | Interleukin-12 - physiology | Monocytes - metabolism | Neoplasm Proteins - antagonists & inhibitors | Interleukin-12 - blood | Membrane Proteins - physiology | T-Lymphocyte Subsets - drug effects | Programmed Cell Death 1 Receptor - biosynthesis | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | B-Lymphocytes - metabolism | Interleukin-12 - biosynthesis | Interleukin-12 - pharmacology | Cells, Cultured - drug effects | Lymphoma, Follicular - pathology | Membrane Proteins - genetics | Neoplasm Proteins - biosynthesis | Tumor Cells, Cultured - drug effects | CD4-Positive T-Lymphocytes - metabolism | Kaplan-Meier Estimate | Lymphoma, Follicular - mortality | Transcription Factors - biosynthesis | Tumor Cells, Cultured - metabolism | CD4 Lymphocyte Count | Transcription Factors - genetics | Hepatitis A Virus Cellular Receptor 2 | Monocytes - drug effects | B-Lymphocytes - drug effects | Disease-Free Survival | Membrane Proteins - biosynthesis | T-Lymphocyte Subsets - pathology | Lymphoma, Follicular - immunology | Membrane Proteins - antagonists & inhibitors | T-Lymphocyte Subsets - metabolism | Lipopolysaccharides - pharmacology | Cells, Cultured - metabolism | Programmed Cell Death 1 Receptor - genetics | CD4-Positive T-Lymphocytes - drug effects | Interferon-gamma - biosynthesis | Interferon-gamma - pharmacology | Care and treatment | Interleukin-12 | Genetic aspects | Research | Non-Hodgkin's lymphomas | Diagnosis | Gene expression | T cells | Health aspects
Journal Article
Radiotherapy and Oncology, ISSN 0167-8140, 2011, Volume 99, Issue 3, pp. 287 - 292
Journal Article
Journal Article
Carcinogenesis, ISSN 0143-3334, 03/2010, Volume 31, Issue 3, pp. 481 - 488
As a critical factor in the induction of angiogenesis, vascular endothelial growth factor (VEGF) has become an attractive target for anti-angiogenesis... 
3T3-L1 ADIPOCYTES | DIETARY ANTHOCYANIDIN | INSULIN-RECEPTOR | IN-VITRO | POLYPHENOLS | ONCOLOGY | BIOLOGICAL-ACTIVITY | TUMOR ANGIOGENESIS | GRAPE SEED EXTRACT | CANCER | ENDOTHELIAL GROWTH-FACTOR | Biflavonoids - pharmacology | Neovascularization, Physiologic - drug effects | Plant Extracts - pharmacology | Cells, Cultured - cytology | Humans | Male | Cell Line, Tumor - drug effects | Cell Line, Tumor - transplantation | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Laminin | Proanthocyanidins - pharmacology | Protein Processing, Post-Translational - drug effects | Cattle | Female | Aorta, Thoracic - drug effects | Phosphorylation - drug effects | Catechin - pharmacology | Cells, Cultured - drug effects | Proteoglycans | Cell Line, Tumor - enzymology | Cinnamomum zeylanicum - chemistry | Angiogenesis Inhibitors - pharmacology | Plant Extracts - isolation & purification | Mice, SCID | Chick Embryo | Cell Division - drug effects | Cells, Cultured - enzymology | Xenograft Model Antitumor Assays | Cell Movement - drug effects | Biflavonoids - isolation & purification | Animals | Signal Transduction - drug effects | Breast Neoplasms - pathology | Endothelial Cells - cytology | Collagen | Catechin - isolation & purification | Morphogenesis - drug effects | Angiogenesis Inhibitors - isolation & purification | Mice | Endothelial Cells - enzymology | Drug Combinations | Proanthocyanidins - isolation & purification | Endothelial Cells - drug effects | Index Medicus | Cancer Prevention
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2012, Volume 122, Issue 10, pp. 3603 - 3617
Epithelial ovarian cancers (EOCs) often exhibit morphologic features of embryonic Mullerian duct-derived tissue lineages and colonize peritoneal surfaces that... 
BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | STEM-CELLS | TGF-BETA | HOMEOBOX GENE-EXPRESSION | BONE-MARROW-CELLS | MESENCHYMAL TRANSITION | HUMAN ENDOMETRIUM | STROMAL CELLS | SEX STEROIDS | TUMOR-GROWTH | Vascular Endothelial Growth Factor A - biosynthesis | Epithelial Cells - metabolism | Prognosis | Humans | Ovarian Neoplasms - pathology | Adipose Tissue - cytology | Carcinoma - mortality | Tumor Cells, Cultured - transplantation | Culture Media, Conditioned - pharmacology | Ovarian Neoplasms - mortality | Tumor Microenvironment - physiology | Vascular Endothelial Growth Factor A - genetics | Ovarian Neoplasms - genetics | Tumor Cells, Cultured - pathology | Chemokine CXCL12 - genetics | Peritoneum - cytology | Female | Gene Expression Regulation, Neoplastic - drug effects | Homeodomain Proteins - pharmacology | Carcinoma - pathology | Neoplasm Proteins - genetics | Carcinoma - secondary | Peritoneal Neoplasms - secondary | Tumor Microenvironment - drug effects | Mesenchymal Stromal Cells - drug effects | Interleukin-6 - genetics | Neoplasm Proteins - biosynthesis | Tumor Cells, Cultured - drug effects | Kaplan-Meier Estimate | Epithelial Cells - pathology | Transforming Growth Factor beta2 - physiology | Fibroblasts - pathology | Cell Division - drug effects | Transforming Growth Factor beta2 - biosynthesis | Animals | Cell Differentiation - drug effects | Endothelial Cells - cytology | Mice, Nude | Paracrine Communication - drug effects | Interleukin-6 - biosynthesis | Carcinoma - genetics | Chemokine CXCL12 - biosynthesis | Mice | Mesenchymal Stromal Cells - pathology | Transforming Growth Factor beta2 - genetics | Homeodomain Proteins - physiology | Endothelial Cells - drug effects | Fibroblasts | Physiological aspects | Genetic aspects | Research | Risk factors | Oncogenes | Ovarian cancer
Journal Article
Cancer Science, ISSN 1347-9032, 11/2011, Volume 102, Issue 11, pp. 1958 - 1966
The past decade has seen a dramatic increase in stem cell research that focuses on glioma stem cells (GSC) and their mechanisms of action, revealing multiple... 
INITIATING CELLS | ONCOLOGY | ENDOTHELIAL-CELLS | INHIBITS GROWTH | GENE-EXPRESSION | SELF-RENEWAL | VASCULAR NICHE | PROLIFERATION | ACUTE MYELOID-LEUKEMIA | PREDICT PROGNOSIS | GLIOBLASTOMA CELLS | Neoplastic Stem Cells - drug effects | Humans | Neoplasm Proteins - physiology | Radiation Tolerance | Brain Neoplasms - pathology | DNA Repair - radiation effects | Drug Resistance, Neoplasm | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Glioma - radiotherapy | Intercellular Signaling Peptides and Proteins - physiology | Glioma - pathology | Angiogenesis Inhibitors - therapeutic use | Neoplastic Stem Cells - pathology | Tumor Cells, Cultured - radiation effects | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Brain Neoplasms - radiotherapy | Neoplastic Stem Cells - radiation effects | Cell Hypoxia - drug effects | DNA Repair - drug effects | Tumor Cells, Cultured - drug effects | Angiogenesis Inhibitors - pharmacology | Brain Neoplasms - drug therapy | Cellular Microenvironment - immunology | Signal Transduction - drug effects | Cell Differentiation - drug effects | Models, Biological | Cellular Microenvironment - drug effects | DNA Methylation - drug effects | Glioma - drug therapy | Stem cell research | Gliomas | Brain tumors | Stem cells
Journal Article
Journal Article
The EMBO Journal, ISSN 0261-4189, 12/2006, Volume 25, Issue 24, pp. 5826 - 5839
Journal Article