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Nature, ISSN 0028-0836, 08/2016, Volume 537, Issue 7618, pp. 63 - 68
Journal Article
ACS Nano, ISSN 1936-0851, 04/2014, Volume 8, Issue 4, pp. 3202 - 3212
Journal Article
Drug Resistance Updates, ISSN 1368-7646, 2011, Volume 14, Issue 3, pp. 191 - 201
Abstract Resistance towards chemotherapy, either primary or acquired, represents a major obstacle in clinical oncology. Three basic categories underlie most... 
Infectious Disease | Hematology, Oncology and Palliative Medicine | HIF-2α | Hypoxia | HIF-1α | Microenvironment | Drug resistance | Autophagy | Cancer | p53 | TRANSCRIPTIONAL ACTIVITY | HIF-1 alpha | HIF-2 alpha | INDUCIBLE FACTOR 1-ALPHA | ENDOTHELIAL-GROWTH-FACTOR | DNA-DAMAGE RESPONSE | HIPPEL-LINDAU PROTEIN | BREAST-CANCER | PROSTATE-CANCER CELLS | FACTOR-I-ALPHA | PHARMACOLOGY & PHARMACY | MULTIDRUG-RESISTANCE | TUMOR-GROWTH | Neoplasms - metabolism | Apoptosis - drug effects | Humans | Gene Expression Regulation, Neoplastic | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Autophagy - drug effects | Tumor Suppressor Protein p53 - genetics | Hypoxia - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Neoplasms - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Antineoplastic Agents - pharmacology | Tumor Microenvironment - drug effects | Cell Hypoxia - drug effects | Basic Helix-Loop-Helix Transcription Factors - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Tumor Suppressor Protein p53 - metabolism | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Mitochondria - metabolism | Mitochondria - drug effects | Neoplasms - drug therapy | Cell Cycle | Signal Transduction - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Cell Hypoxia - genetics | Neoplasms - pathology | Drug Resistance, Neoplasm - drug effects | Chemotherapy | Cell death | Drug interactions | Biochemistry | DNA binding proteins | Tumor proteins | Tumors
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2012, Volume 109, Issue 8, pp. 2784 - 2789
Journal Article
Cancer Research, ISSN 0008-5472, 05/2011, Volume 71, Issue 9, pp. 3364 - 3376
Journal Article
Oncogene, ISSN 0950-9232, 08/2010, Volume 29, Issue 31, pp. 4424 - 4435
Activating transcription factor 4 (ATF4) is a transcription factor induced under severe hypoxia and a component of the PERK pathway involved in the unfolded... 
hypoxia | cancer | autophagy | anoxia | tumour | UPR | CANCER-CELLS | SURVIVAL | TRANSLATIONAL REGULATION | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOPLASMIC-RETICULUM STRESS | CELL-DEATH | CELL BIOLOGY | UNFOLDED PROTEIN RESPONSE | ONCOLOGY | GENETICS & HEREDITY | RESISTANCE | MOLECULAR-CLONING | TUMOR-GROWTH | Neoplasms - metabolism | Oxygen - pharmacology | Cell Hypoxia - physiology | Oligonucleotide Array Sequence Analysis | Humans | Endoplasmic Reticulum - metabolism | Gene Expression Profiling | Autophagy - drug effects | Dose-Response Relationship, Drug | Neoplasms - genetics | Base Sequence | Endoplasmic Reticulum - drug effects | Antineoplastic Agents - pharmacology | Autophagy - genetics | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Unfolded Protein Response - drug effects | Activating Transcription Factor 4 - antagonists & inhibitors | Cell Hypoxia - drug effects | Bortezomib | Unfolded Protein Response - genetics | HCT116 Cells | RNA, Small Interfering - pharmacology | Activating Transcription Factor 4 - genetics | Validation Studies as Topic | HeLa Cells | Neoplasms - pathology | Pyrazines - pharmacology | Activating Transcription Factor 4 - physiology | Boronic Acids - pharmacology | Complications and side effects | Cancer cells | Physiological aspects | Hypoxia | Genetic aspects | Research | Phagocytosis | Proteins | Cellular biology | Gene expression | Binding sites | Cancer
Journal Article