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Clinical Cancer Research, ISSN 1078-0432, 07/2017, Volume 23, Issue 14, pp. 3711 - 3720
Purpose: To explore whether a cross-talk exists between PARP inhibition and PD-L1/PD-1 immune checkpoint axis, and determine whether blockade of PD-L1/PD-1... 
CELL LUNG-CANCER | BREAST-CANCER | OVEREXPRESSION | ACTIVATION | THERAPY | PEMBROLIZUMAB | ONCOLOGY | OVARIAN-CANCER | PROVIDES | COMBINATION | CHEMOTHERAPY | Tumor Microenvironment - drug effects | Poly (ADP-Ribose) Polymerase-1 - immunology | Breast Neoplasms - immunology | Humans | Poly(ADP-ribose) Polymerase Inhibitors - immunology | Lymphocytes, Tumor-Infiltrating - drug effects | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Breast Neoplasms - drug therapy | Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors | Poly(ADP-ribose) Polymerase Inhibitors - administration & dosage | Tumor Microenvironment - immunology | Xenograft Model Antitumor Assays | Immunosuppression | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cell Line, Tumor | Female | Mice | Gene Expression Regulation, Neoplastic - drug effects | Programmed Cell Death 1 Receptor - immunology | Programmed Cell Death 1 Receptor - genetics | Lymphocytes, Tumor-Infiltrating - immunology | Cell culture | Flow cytometry | Biotechnology | Animal models | PD-1 protein | Immunoblotting | Lymphocytes T | Immunity | Anticancer properties | Lymphocytes | Xenografts | Tumor-infiltrating lymphocytes | Tumor cells | Poly(ADP-ribose) polymerase | Breast cancer | Tumor cell lines | Inhibitors | Immune checkpoint | Experimental design | PD-L1 protein | Cell lines | Breast | In vivo methods and tests | Tumors | Cancer
Journal Article
Cancer Research, ISSN 0008-5472, 04/2007, Volume 67, Issue 7, pp. 2912 - 2915
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2019, Volume 116, Issue 4, pp. 1361 - 1369
Interleukin-1 beta (IL-1 beta) is abundant in the tumor microenvironment, where this cytokine can promote tumor growth, but also antitumor activities. We... 
Antitumor immunity | Breast cancer | Anti–PD-1 | IL-1β | Immunotherapy | INTERLEUKIN-1 | RECRUITMENT | IMMUNE CONTEXTURE | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | breast cancer | IL-1 beta | anti-PD-1 | antitumor immunity | CHEMOTHERAPY | MICROENVIRONMENT | CYTOKINE RELEASE SYNDROME | INFLAMMATION | immunotherapy | REGULATORY T-CELLS | SUPPRESSOR-CELLS | Tumor Necrosis Factor-alpha - metabolism | Granzymes - pharmacology | Immunosuppression - methods | Humans | Monocytes - metabolism | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Interferon-gamma - metabolism | Colony-Stimulating Factors - metabolism | Breast Neoplasms - metabolism | Inflammation - metabolism | CD8-Positive T-Lymphocytes - metabolism | Dendritic Cells - drug effects | Female | Antineoplastic Agents - pharmacology | Dendritic Cells - metabolism | Interleukin-1beta - antagonists & inhibitors | Tumor Microenvironment - drug effects | Antibodies, Monoclonal - pharmacology | Mice, Inbred C57BL | Breast Neoplasms - drug therapy | Mice, Knockout | Monocytes - drug effects | Macrophages - metabolism | Animals | Cell Differentiation - drug effects | CD8-Positive T-Lymphocytes - drug effects | Cell Line, Tumor | Macrophages - drug effects | Mice | Mice, Inbred BALB C | CD11b Antigen - metabolism | PD-1 protein | CD8 antigen | Interleukin | Macrophages | Immunity | Metastases | Anticancer properties | Recruitment | Granzyme B | Lymphocytes | Colony-stimulating factor | Inhibition | CD11b antigen | Dendritic cells | Secretion | Medical immunity | Macrophage colony-stimulating factor | Interleukin 12 | Inflammation | Tumor necrosis factor-α | Monocytes | Immunosuppression | Lymphocytes B | γ-Interferon | Interleukin 10 | Differentiation | Monocyte chemoattractant protein 1 | Tumors | Cancer | Biological Sciences | PNAS Plus | anti–PD-1
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2013, Volume 123, Issue 6, pp. 2355 - 2357
Journal Article