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European journal of cancer (1990), ISSN 0959-8049, 2016, Volume 56, pp. 131 - 143
.... To fully understand the biological behaviour of tumours, it is essential to understand the microenvironment in which cancer cells exist, and how they manipulate the surrounding stroma to promote the malignant phenotype... 
Hematology, Oncology and Palliative Medicine | Tumour microenvironment | Ovarian cancer | LYMPHOCYTE-ASSOCIATED ANTIGEN-4 | INFILTRATING LYMPHOCYTES | PHASE-II | OPEN-LABEL | RECURRENT OVARIAN | MYELOID CELLS | MAINTENANCE THERAPY | ONCOLOGY | CD8(+) T-LYMPHOCYTES | MACROPHAGE POLARIZATION | EPITHELIAL OVARIAN | Neoplasms, Glandular and Epithelial - blood supply | Humans | Neovascularization, Pathologic | Ovarian Neoplasms - pathology | Neoplasms, Glandular and Epithelial - metabolism | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Neoplasms, Glandular and Epithelial - immunology | Angiogenesis Inhibitors - therapeutic use | Female | Ovarian Neoplasms - metabolism | Ovarian Neoplasms - blood supply | Ovarian Neoplasms - drug therapy | Fibroblasts - metabolism | Tumor Microenvironment - drug effects | Neoplasms, Glandular and Epithelial - pathology | Endothelial Cells - metabolism | Fibroblasts - pathology | Animals | Signal Transduction - drug effects | Tumor Burden - drug effects | Fibroblasts - drug effects | Neoplasms, Glandular and Epithelial - drug therapy | Carcinoma, Ovarian Epithelial | Cell Proliferation - drug effects | Endothelial Cells - pathology | Endothelial Cells - drug effects | Ovarian Neoplasms - immunology | Chemotherapy | Relapse | RNA | Metastasis | Health aspects | Diseases | Cancer | tumor microenvironment
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 2018, Volume 215, Issue 3, pp. 895 - 910
.... We hypothesized that factors present in the human tumor microenvironment (TME) drive drug resistance... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | CYCLIN D1 | PHOSPHORYLATION | ANTIESTROGEN RESISTANCE | TRANSCRIPTION | ENDOCRINE THERAPY | FIBROBLAST-GROWTH-FACTOR | INHIBITORS | IMMUNOLOGY | EXPRESSION | CARCINOMA | Cyclin D1 - metabolism | Receptors, Estrogen - metabolism | Apoptosis - drug effects | Humans | Fibroblast Growth Factor 2 - pharmacology | Phosphatidylinositol 3-Kinases - metabolism | Molecular Targeted Therapy | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Breast Neoplasms - metabolism | Neoplasm Recurrence, Local - pathology | Female | Tumor Microenvironment - drug effects | Cytokines - metabolism | Signal Transduction | Treatment Outcome | Mechanistic Target of Rapamycin Complex 1 - antagonists & inhibitors | Transcriptome - genetics | Down-Regulation - drug effects | Mechanistic Target of Rapamycin Complex 1 - metabolism | Up-Regulation - drug effects | Animals | Bcl-2-Like Protein 11 - metabolism | Breast Neoplasms - pathology | Cell Cycle Checkpoints - drug effects | Models, Biological | Receptors, Fibroblast Growth Factor - metabolism | Cell Line, Tumor | Ligands | Cell Proliferation - drug effects | Mice | Drug Resistance, Neoplasm - drug effects | Fibroblast growth factor 2 | Fibroblast growth factor | Xenotransplantation | Estrogens | Estrogen | Extracellular signal-regulated kinase | Estrogen receptors | Breast cancer | Drug resistance | Cyclin D1 | Patients | 1-Phosphatidylinositol 3-kinase | Proteins | Screening | Signaling | Receptors | Down-regulation | Xenografts | Inhibition | Tumors | Cancer | Constitution | Fibroblast growth factor receptors | 307
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 3, p. e92248
... [3], [4]. Unfortunately, drug failures are often not identified until late in development. Therefore, the earlier identification of ineffective and toxic... 
CANCER-CELLS | CARCINOMA-CELLS | CROSS-TALK | GROWTH-FACTOR RECEPTOR | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | ERLOTINIB RESISTANCE | C-MET ANTIBODY | MULTICELLULAR SPHEROIDS | KINASE INHIBITORS | ANTICANCER DRUGS | Proto-Oncogene Proteins c-met - metabolism | Lung Neoplasms - drug therapy | Humans | Spheroids, Cellular - pathology | Lung Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Hepatocyte Growth Factor - pharmacology | Cell Culture Techniques - methods | Receptor, Epidermal Growth Factor - metabolism | Antineoplastic Agents - pharmacology | Spheroids, Cellular - drug effects | Phosphorylation - drug effects | Tumor Cells, Cultured | Tumor Microenvironment - drug effects | Cell Survival - drug effects | Reproducibility of Results | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Treatment Outcome | Drug Discovery | Cell Movement - drug effects | Protein Kinase Inhibitors - therapeutic use | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Ligands | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Epidermal Growth Factor - pharmacology | Epidermal growth factor | Health aspects | Lung cancer | Tumors | Monomolecular films | Cell proliferation | Drugs | Self assembly | Cell culture | Flow cytometry | Biotechnology | Phosphorylation | Systematic review | Drug development | Kinases | Tissues | Pharmaceutical industry | Growth factors | Epidermal growth factor receptors | Hepatocyte growth factor | Research & development--R&D | Tumor cells | Pharmacology | Tumor cell lines | Chemical compounds | Spheroids | Studies | Cytometry | Self-assembly | Inhibitors | Lungs | Monolayers | Mutation | Three dimensional models | Cell migration | Research & development | R&D
Journal Article