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Nature Reviews Rheumatology, ISSN 1759-4790, 04/2017, Volume 13, Issue 4, pp. 217 - 233
TNF blockers are highly efficacious at dampening inflammation and reducing symptoms in rheumatic diseases such as rheumatoid arthritis, psoriatic arthritis and... 
LIGAND 1A TL1A | COLLAGEN-INDUCED ARTHRITIS | FIBROBLAST-LIKE SYNOVIOCYTES | TUMOR-NECROSIS-FACTOR | SYSTEMIC-LUPUS-ERYTHEMATOSUS | LYMPHOTOXIN-BETA-RECEPTOR | SYNOVIAL FIBROBLASTS | CD4(+) T-CELLS | CD40 LIGAND | MONOCLONAL-ANTIBODY | RHEUMATOLOGY | Fas Ligand Protein - metabolism | Rheumatic Diseases - drug therapy | OX40 Ligand - metabolism | CD27 Ligand - antagonists & inhibitors | Dendritic Cells - immunology | Humans | Lymphotoxin-alpha - metabolism | Molecular Targeted Therapy | 4-1BB Ligand - antagonists & inhibitors | TNF-Related Apoptosis-Inducing Ligand - antagonists & inhibitors | CD40 Ligand - metabolism | CD27 Ligand - metabolism | Cell Death | Rheumatic Diseases - immunology | Signal Transduction | Lymphocyte Activation | Tumor Necrosis Factors - metabolism | 4-1BB Ligand - metabolism | Immune Tolerance | Tumor Necrosis Factor Ligand Superfamily Member 15 - metabolism | TNF-Related Apoptosis-Inducing Ligand - metabolism | Tumor Necrosis Factor Ligand Superfamily Member 14 - metabolism | Tumor Necrosis Factors - immunology | OX40 Ligand - antagonists & inhibitors | Cytokine TWEAK | Fas Ligand Protein - antagonists & inhibitors | Animals | Tumor Necrosis Factor Ligand Superfamily Member 15 - antagonists & inhibitors | T-Lymphocytes - immunology | Tumor Necrosis Factor Ligand Superfamily Member 14 - antagonists & inhibitors | CD40 Ligand - antagonists & inhibitors | Lymphotoxin-alpha - antagonists & inhibitors | Tumor Necrosis Factors - antagonists & inhibitors | Care and treatment | Cytokines | Tumor necrosis factor | Rheumatic diseases | Development and progression | Genetic aspects | Health aspects
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 136, Issue 3, pp. 757 - 768
Background Pulmonary fibrosis is characterized by excessive accumulation of collagen and α-smooth muscle actin in the lung. The key molecules that promote... 
Allergy and Immunology | bronchial epithelial cell | Pulmonary fibrosis | TNFSF14 | TSLP | HVEM | LIGHT | asthma | IPF | CHEMOKINES | MECHANISMS | IMMUNOLOGY | TNF | PATHOGENESIS | ATOPIC-DERMATITIS | ALLERGY | EXPRESSION | Humans | Pulmonary Fibrosis - genetics | Receptors, Virus - genetics | Actins - immunology | Tumor Necrosis Factor Ligand Superfamily Member 14 - genetics | Actins - genetics | Bleomycin | Female | Collagen - genetics | Cytokines - genetics | Cytokines - immunology | Cell Line | Lung - pathology | Tumor Necrosis Factor Ligand Superfamily Member 14 - immunology | Signal Transduction | Collagen - immunology | Gene Expression Regulation | Pulmonary Fibrosis - immunology | Epithelial Cells - pathology | Pulmonary Fibrosis - pathology | Fibroblasts - pathology | Mice, Knockout | Animals | Lymphotoxin beta Receptor - genetics | Epithelial Cells - immunology | Herpesviridae - immunology | Protein Binding | Pulmonary Fibrosis - chemically induced | Receptors, Virus - immunology | Fibroblasts - immunology | Mice | Lung - immunology | Lymphotoxin beta Receptor - immunology | Medical colleges | Tumor necrosis factor | Collagen | Respiratory tract diseases | Muscle proteins | Tumors | Disease | Smooth muscle | Inflammation | Experiments | Allergies | Proteins | Immunology | Lungs | Transgenic animals | Rodents | Light | Fibroblasts | Tumor necrosis factor-TNF | Laboratory animals
Journal Article
Immunological Reviews, ISSN 0105-2896, 11/2011, Volume 244, Issue 1, pp. 169 - 187
The tumor necrosis factor (TNF) receptor superfamily member herpesvirus entry mediator (HVEM) (TNFRSF14) regulates T‐cell immune responses by activating both... 
asthma | cancer | cytokines | autoimmunity | T cells | inflammation | Autoimmunity | Inflammation | Cytokines | Asthma | Cancer | DECOY RECEPTOR-3 | T-LYMPHOCYTE ATTENUATOR | IMMUNOLOGY | VERSUS-HOST-DISEASE | CUTTING EDGE | MHC CLASS-I | B-LYMPHOCYTE | LYMPHOTOXIN-BETA-RECEPTOR | NK-CELL ACTIVATION | SIMPLEX-VIRUS | GLYCOPROTEIN-D | Tumor Necrosis Factor-alpha - metabolism | Antigens, CD - immunology | Humans | Tumor Necrosis Factor-alpha - genetics | Lymphotoxin-alpha - metabolism | Antigens, CD - genetics | Lymphotoxin-alpha - immunology | Tumor Necrosis Factor Ligand Superfamily Member 14 - genetics | Antigens, CD - metabolism | Lymphotoxin beta Receptor - metabolism | Lymphotoxin-alpha - genetics | Signal Transduction - immunology | T-Lymphocytes - metabolism | Gene Expression - immunology | Tumor Necrosis Factor-alpha - immunology | Viral Envelope Proteins - metabolism | Herpesvirus 1, Human - immunology | Receptors, Immunologic - immunology | Receptors, Tumor Necrosis Factor, Member 14 - immunology | Receptors, Tumor Necrosis Factor, Member 14 - genetics | GPI-Linked Proteins - immunology | Tumor Necrosis Factor Ligand Superfamily Member 14 - immunology | Lymphocyte Activation | Immunity, Innate | Protein Binding - immunology | Tumor Necrosis Factor Ligand Superfamily Member 14 - metabolism | GPI-Linked Proteins - metabolism | Herpes Simplex - immunology | Mice, Knockout | Herpes Simplex - metabolism | Receptor Cross-Talk - immunology | Herpes Simplex - virology | Receptors, Tumor Necrosis Factor, Member 14 - metabolism | Animals | Lymphotoxin beta Receptor - genetics | T-Lymphocytes - immunology | Viral Envelope Proteins - immunology | Mice | Receptors, Immunologic - genetics | Receptors, Immunologic - metabolism | GPI-Linked Proteins - genetics | Lymphotoxin beta Receptor - immunology | Immunoglobulins | Analysis
Journal Article
Immunological Reviews, ISSN 0105-2896, 05/2009, Volume 229, Issue 1, pp. 192 - 215
The tumor necrosis factor receptor family member 4‐1BB plays a key role in the survival of activated and memory CD8+ T cells. Depending on the disease model,... 
regulatory T cells | bidirectional signaling | T‐cell memory | costimulation | agonistic antibody therapy | Regulatory T cells | T-cell memory | Costimulation | Bidirectional signaling | Agonistic antibody therapy | BCL-X-L | NECROSIS-FACTOR RECEPTOR | HUMAN DENDRITIC CELLS | IFN-GAMMA | BONE-MARROW | IMMUNOLOGY | CD8 T-CELLS | EX-VIVO EXPANSION | CD137 INDUCES PROLIFERATION | NF-KAPPA-B | MONOCLONAL-ANTIBODY LEADS | 4-1BB Ligand - genetics | Antigen-Presenting Cells - metabolism | Tumor Necrosis Factor Ligand Superfamily Member 14 - immunology | Cytokines - metabolism | Infection - immunology | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - immunology | Humans | Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology | 4-1BB Ligand - metabolism | Hematopoietic Stem Cells - metabolism | Tumor Necrosis Factor Receptor Superfamily, Member 9 - metabolism | Tumor Necrosis Factor Ligand Superfamily Member 14 - metabolism | Antigen-Presenting Cells - immunology | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - metabolism | Signal Transduction - immunology | Hematopoietic Stem Cells - immunology | Animals | T-Lymphocytes - metabolism | Immunologic Memory | T-Lymphocytes - immunology | 4-1BB Ligand - immunology | Cytokines - immunology | T cells | Laws, regulations and rules | Analysis
Journal Article
Structure, ISSN 0969-2126, 2011, Volume 19, Issue 2, pp. 162 - 171
Decoy Receptor 3 (DcR3), a secreted member of the Tumor Necrosis Factor (TNF) receptor superfamily, neutralizes three different TNF ligands: FasL, LIGHT, and... 
NECROSIS-FACTOR RECEPTOR | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR | TNF SUPERFAMILY | T-CELL | FACTOR-ALPHA | TL1A | CELL BIOLOGY | BIOPHYSICS | LIGHT-MEDIATED APOPTOSIS | FACTOR SUPERFAMILY | LIGAND | Fas Ligand Protein - metabolism | Receptors, Tumor Necrosis Factor, Member 6b - metabolism | Humans | Molecular Conformation | Molecular Sequence Data | Crystallography, X-Ray | Fas Ligand Protein - immunology | Signal Transduction - immunology | Receptors, Tumor Necrosis Factor, Member 6b - immunology | Cloning, Molecular | Receptors, Tumor Necrosis Factor, Member 6b - genetics | Tumor Necrosis Factor Ligand Superfamily Member 15 - genetics | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Amino Acid Sequence | Mutagenesis, Site-Directed | Tumor Necrosis Factor Ligand Superfamily Member 14 - immunology | Cells, Cultured | Crystallization | Recombinant Proteins - genetics | Tumor Necrosis Factor Ligand Superfamily Member 15 - metabolism | Tumor Necrosis Factor Ligand Superfamily Member 14 - metabolism | Tumor Necrosis Factor Ligand Superfamily Member 15 - immunology | Animals | Drosophila melanogaster | Index Medicus | Decoys | Stoichiometry | Receptors | Ligands | Strategy | Biochemistry | Invariants | Crystal structure | ATOMS | CRYSTAL STRUCTURE | MUTAGENESIS | MATERIALS SCIENCE | SPECIFICITY | AFFINITY
Journal Article
Immunological Reviews, ISSN 0105-2896, 11/2011, Volume 244, Issue 1, pp. 115 - 133
Members of the tumor necrosis factor receptor superfamily (TNFRSF) participate prominently in B‐cell maturation and function. In particular, B‐cell activating... 
BAFF | B cell | CD40 | BCMA | NF‐κB | TACI | NF-κB | FORKHEAD TRANSCRIPTION FACTOR | SYSTEMIC-LUPUS-ERYTHEMATOSUS | HUMORAL IMMUNE-RESPONSES | COMMON VARIABLE IMMUNODEFICIENCY | IMMUNOLOGY | KINASE-C-DELTA | GERMINAL CENTER FORMATION | NF-?B | ACTIVATING FACTOR-RECEPTOR | NON-HODGKIN-LYMPHOMA | X-LINKED IMMUNODEFICIENCY | NF-KAPPA-B | Cell Proliferation | Humans | NF-kappa B - immunology | NF-kappa B - metabolism | Transmembrane Activator and CAML Interactor Protein - metabolism | Signal Transduction - immunology | CD40 Antigens - metabolism | B-Cell Activating Factor - immunology | B-Lymphocyte Subsets - immunology | CD40 Antigens - genetics | B-Cell Activation Factor Receptor - genetics | B-Lymphocytes - metabolism | B-Cell Activation Factor Receptor - immunology | B-Cell Maturation Antigen - immunology | Tumor Necrosis Factor Ligand Superfamily Member 13 - immunology | Gene Expression | Mice, Transgenic | Cell Survival - immunology | Immunity, Innate | Tumor Necrosis Factor Ligand Superfamily Member 13 - metabolism | Transmembrane Activator and CAML Interactor Protein - genetics | B-Cell Activation Factor Receptor - metabolism | Animals | B-Cell Activating Factor - metabolism | B-Cell Maturation Antigen - metabolism | B-Lymphocytes - immunology | B-Lymphocyte Subsets - metabolism | NF-kappa B - genetics | B-Cell Activating Factor - genetics | Neoplasms - immunology | Autoimmune Diseases | Tumor Necrosis Factor Ligand Superfamily Member 13 - genetics | Mice | B-Cell Maturation Antigen - genetics | Transmembrane Activator and CAML Interactor Protein - immunology | CD40 Antigens - immunology | Autoimmunity | Antigens | Tumor necrosis factor | Tumors | Necrosis
Journal Article