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The Journal of Immunology, ISSN 0022-1767, 08/2005, Volume 175, Issue 3, pp. 1665 - 1676
Independent studies have shown that CD27, 4-1BB, and OX40 can all promote survival of activated CD8+ T cells. We have therefore compared their impact on CD8+... 
B-CELLS | INFLUENZA-A | MURINE CD27 | CD8-T-CELL MEMORY | CLONAL EXPANSION | CD4-T-CELL HELP | IN-VIVO | CD27-CD70 INTERACTIONS | LIGAND | IMMUNOLOGY | MICE LACKING | CD8-Positive T-Lymphocytes - cytology | Genomic Imprinting | Cell Proliferation | Membrane Glycoproteins - biosynthesis | Antigens, CD - genetics | Receptors, Tumor Necrosis Factor - physiology | Orthomyxoviridae Infections - genetics | Lymphocyte Activation - genetics | Membrane Glycoproteins - physiology | CD8-Positive T-Lymphocytes - metabolism | Influenza A virus - immunology | Immunologic Memory - genetics | Antigen-Presenting Cells - metabolism | Receptors, Nerve Growth Factor - biosynthesis | T-Lymphocyte Subsets - transplantation | T-Lymphocyte Subsets - virology | Tumor Necrosis Factor Receptor Superfamily, Member 7 - physiology | Mice, Knockout | Antigens, CD - physiology | Ligands | Mice | CD8-Positive T-Lymphocytes - immunology | Receptors, Nerve Growth Factor - deficiency | Orthomyxoviridae Infections - virology | T-Lymphocyte Subsets - immunology | Antigens, CD - biosynthesis | Tumor Necrosis Factors | Receptors, Nerve Growth Factor - physiology | Adoptive Transfer | Receptors, OX40 | Tumor Necrosis Factor Receptor Superfamily, Member 9 | Immunization, Secondary | Receptors, Tumor Necrosis Factor - deficiency | Tumor Necrosis Factor Receptor Superfamily, Member 7 - biosynthesis | Receptors, Tumor Necrosis Factor - genetics | Antibodies, Viral - biosynthesis | Mice, Inbred C57BL | Tumor Necrosis Factor Receptor Superfamily, Member 7 - genetics | Administration, Intranasal | Antigen-Presenting Cells - immunology | Antigen-Presenting Cells - virology | Receptors, Nerve Growth Factor - genetics | Membrane Glycoproteins - genetics | Animals | CD8-Positive T-Lymphocytes - virology | T-Lymphocyte Subsets - metabolism | Receptors, Tumor Necrosis Factor - biosynthesis | Membrane Glycoproteins - deficiency | Orthomyxoviridae Infections - immunology
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2017, Volume 214, Issue 2, pp. 359 - 380
Aberrant proliferation, symmetric self-renewal, increased survival, and defective differentiation of malignant blasts are key oncogenic drivers in acute... 
MEDICINE, RESEARCH & EXPERIMENTAL | GENE-EXPRESSION SIGNATURE | ACUTE MYELOGENOUS LEUKEMIA | CD27 | DIFFERENTIATION | IMMUNOLOGY | ESTABLISHMENT | WNT | CANCER | CELL-LINE | ASYMMETRIC DIVISION | ACUTE PROMYELOCYTIC LEUKEMIA | Leukemia, Myeloid, Acute - pathology | Protein-Serine-Threonine Kinases - physiology | Blast Crisis - etiology | CD27 Ligand - antagonists & inhibitors | Humans | Middle Aged | Wnt Signaling Pathway - physiology | Antibodies, Monoclonal - therapeutic use | TNF Receptor-Associated Factor 2 - physiology | Tumor Necrosis Factor Receptor Superfamily, Member 7 - genetics | Tumor Necrosis Factor Receptor Superfamily, Member 7 - blood | CD27 Ligand - physiology | Tumor Necrosis Factor Receptor Superfamily, Member 7 - physiology | Tumor Necrosis Factor Receptor Superfamily, Member 7 - antagonists & inhibitors | Animals | Leukemia, Myeloid, Acute - drug therapy | Signal Transduction - physiology | Aged | Mice | Tumor Cells, Cultured | CD27 antigen | Cell proliferation | Deregulation | Wnt protein | Leukemia | CD70 antigen | Signal transduction | Xenografts | Bioindicators | Cell survival | Myeloid leukemia | Gene expression | Survival | Patients | Progenitor cells | Hemopoiesis | Signaling | Tumor necrosis factor | Medical prognosis | Cells (biology) | Stem cells | Monoclonal antibodies | Biomarkers | Aberration | Differentiation | Auditory defects | Acute myeloid leukemia | 304
Journal Article
Journal Article
Journal Article
Journal Article
The Journal of Immunology, ISSN 0022-1767, 03/2008, Volume 180, Issue 5, pp. 2912 - 2921
The role of costimulation has previously been confined to the very early stages of the CD8(+) T cell response. In this study, we demonstrate the requirement... 
TUMOR-NECROSIS-FACTOR | DIFFERENTIATION ANTIGEN | ACTIVATION | SECONDARY EXPANSION | CD8-T-CELL MEMORY | CD4-T-CELL HELP | IN-VIVO | LIGAND | IMMUNOLOGY | EXPRESSION | LYMPHOCYTES | Antibodies, Blocking - metabolism | CD8-Positive T-Lymphocytes - transplantation | CD27 Ligand - antagonists & inhibitors | fas Receptor - deficiency | Apoptosis - genetics | Adoptive Transfer | fas Receptor - biosynthesis | Signal Transduction - immunology | Immunization, Secondary | Time Factors | Peptide Fragments - immunology | CD27 Ligand - metabolism | fas Receptor - genetics | CD8-Positive T-Lymphocytes - metabolism | Influenza A virus - immunology | fas Receptor - physiology | Immunologic Memory - genetics | CD27 Ligand - immunology | Orthomyxoviridae Infections - metabolism | Mice, Inbred C57BL | Peptide Fragments - administration & dosage | Signal Transduction - genetics | Tumor Necrosis Factor Receptor Superfamily, Member 7 - genetics | Tumor Necrosis Factor Receptor Superfamily, Member 7 - physiology | Mice, Knockout | Animals | Apoptosis - immunology | CD8-Positive T-Lymphocytes - virology | Tumor Necrosis Factor Receptor Superfamily, Member 7 - metabolism | Viral Core Proteins - immunology | Mice | Tumor Necrosis Factor Receptor Superfamily, Member 7 - deficiency | Antibodies, Monoclonal - metabolism | CD8-Positive T-Lymphocytes - immunology | Orthomyxoviridae Infections - virology | Orthomyxoviridae Infections - immunology | Viral Core Proteins - administration & dosage
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2017, Volume 214, Issue 2, pp. 269 - 283
The mammalian immune system has evolved over many millennia to be best equipped to protect the host from pathogen infection. In many cases, host and pathogen... 
B-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | CYTOTOXIC T-CELLS | NATURAL-KILLER-CELLS | PRIMARY IMMUNODEFICIENCIES | XIAP DEFICIENCY | ACUTE INFECTIOUS-MONONUCLEOSIS | OF-FUNCTION MUTATIONS | IMMUNOLOGY |