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Journal Article
NATURE CELL BIOLOGY, ISSN 1465-7392, 01/2018, Volume 20, Issue 1, pp. 58 - 58
Ubiquitylation of the TNFR1 signalling complex (TNF-RSC) controls the activation of RIPK1, a kinase critically involved in mediating multiple TNF... 
CHRONIC INTESTINAL INFLAMMATION | NECROPTOSIS | INDUCED APOPTOSIS | LINEAR UBIQUITIN | PROGRAMMED NECROSIS | KINASE RIP | NF-KAPPA-B | CELL-DEATH | SIGNALING COMPLEX | A20 | CELL BIOLOGY | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Tumor Necrosis Factor-alpha - metabolism | Humans | Tumor Necrosis Factor-alpha - genetics | Apoptosis - genetics | Tumor Necrosis Factor alpha-Induced Protein 3 - metabolism | Receptors, Tumor Necrosis Factor, Type I - metabolism | Phosphoproteins - metabolism | Genes, Lethal | Ubiquitination | HEK293 Cells | Fibroblasts - metabolism | Signal Transduction | Mice, Inbred C57BL | Gene Expression Regulation | Phosphoproteins - genetics | Receptors, Tumor Necrosis Factor, Type I - genetics | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Tumor Necrosis Factor alpha-Induced Protein 3 - genetics | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Carrier Proteins - metabolism | Adaptor Proteins, Signal Transducing - deficiency | Adaptor Proteins, Signal Transducing - genetics | Fibroblasts - cytology | Mice | Receptor-Interacting Protein Serine-Threonine Kinases - deficiency | Cell Line, Transformed | Cellular signal transduction | Research | Gene expression | Tumor necrosis factor | Protein kinases | Tumor necrosis factor receptors | Ubiquitin | Signaling | Licenses | Activation | Lethality | Tumor necrosis factor-α | Kinases | Embryos | Apoptosis | Recruitment
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2018, Volume 115, Issue 39, pp. E9192 - E9200
Journal Article
Nature Cell Biology, ISSN 1465-7392, 09/2017, Volume 19, Issue 10, pp. 1260 - 1273
Although the ubiquitin-editing enzyme A20 is a key player in inflammation and autoimmunity, its role in cancer metastasis remains unknown. Here we show that... 
TGF-BETA | CELL-MIGRATION | INFLAMMATION | GENE-EXPRESSION | TNFAIP3 | NECROSIS-FACTOR-ALPHA | TUMOR-CELLS | MESENCHYMAL TRANSITION | NF-KAPPA-B | TRANSCRIPTION FACTOR | CELL BIOLOGY | Phosphorylation | Humans | Gene Expression Regulation, Neoplastic | Drug Resistance, Neoplasm | Lung Neoplasms - pathology | Tumor Necrosis Factor alpha-Induced Protein 3 - metabolism | Breast Neoplasms - enzymology | Snail Family Transcription Factors - genetics | Transfection | Ubiquitination - drug effects | MCF-7 Cells | RNA Interference | Time Factors | Epithelial-Mesenchymal Transition | HEK293 Cells | Neoplastic Stem Cells - pathology | Female | Protein Stability | Transforming Growth Factor beta1 - pharmacology | Lung Neoplasms - genetics | Lung Neoplasms - enzymology | Snail Family Transcription Factors - metabolism | Signal Transduction | Mice, SCID | Breast Neoplasms - drug therapy | Glycogen Synthase Kinase 3 beta - metabolism | Cell Movement - drug effects | Tumor Necrosis Factor alpha-Induced Protein 3 - genetics | Tumor Necrosis Factor-alpha - pharmacology | Animals | Breast Neoplasms - genetics | Lung Neoplasms - prevention & control | Breast Neoplasms - pathology | Lysine | Mice, Inbred NOD | Mice, Inbred BALB C | Neoplastic Stem Cells - enzymology | Ubiquitin | Residues | Animal models | Cell survival | Mesenchyme | Glycogen | Glycogen synthase kinase 3 | Breast cancer | Metastasis | Kinases | Nuclei | Metastases | Arginine | Lungs | Xenografts | Breast | Cancer
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2036 - 15
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 07/2018, Volume 215, Issue 7, pp. 1839 - 1852
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 03/2017, Volume 76, Issue 3, pp. 585 - 592
Journal Article