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PLoS ONE, ISSN 1932-6203, 12/2015, Volume 10, Issue 12, p. e0143686
Simvastatin (SIM) is anti-inflammatory. We used low density lipoprotein receptor knockout (LDLR-/-) mice and human aortic smooth muscle cells (HASMCs) as model... 
NADPH OXIDASE | IN-VITRO | MULTIDISCIPLINARY SCIENCES | VASCULAR CALCIFICATION | ENDOTHELIAL-CELLS | AORTIC-STENOSIS | HMG-COA REDUCTASE | CLINICAL-IMPLICATIONS | SMOOTH-MUSCLE-CELLS | CHRONIC KIDNEY-DISEASE | ANGIOTENSIN-CONVERTING ENZYME | Tumor Necrosis Factor-alpha - metabolism | Receptors, LDL - genetics | Down-Regulation | Humans | Tumor Necrosis Factor-alpha - genetics | Male | NF-kappa B - metabolism | Receptors, Tumor Necrosis Factor, Type I - metabolism | Gene Knockout Techniques | Receptors, Tumor Necrosis Factor, Type I - genetics | Simvastatin - pharmacology | Mice, Knockout | Receptors, Tumor Necrosis Factor, Type I - drug effects | Animals | Tumor Necrosis Factor-alpha - drug effects | Diet, High-Fat | Arteriosclerosis - metabolism | Mice | Oxidative Stress - drug effects | Calcinosis - metabolism | Arteriosclerosis - pathology | Transcription factors | Dyslipidemia | Acetylcysteine | Smooth muscle | NAD(P)H oxidase | Signal transduction | Aorta | Inhibition | Tyrosine | Medical research | NF-κB protein | Internal medicine | Simvastatin | Thrombosis | Studies | Nutrition research | Hospitals | Arteriosclerosis | Calcification | Receptor density | Clinical medicine | Calcification (ectopic) | Oxidative stress | Biotechnology | Reactive oxygen species | Hydrogen peroxide | Laboratories | Oxidase | Biology | Activation | High fat diet | Vascular diseases | Msx2 protein | Rodents | Atherosclerosis | Down-regulation | Attenuation | Tumor necrosis factor-TNF | Lipoprotein (low density) receptors | Cardiology | Cbfa-1 protein | Bone morphogenetic protein 2 | Diabetes mellitus | Muscles | Superoxide | Inflammation | Cholesterol | Medicine | Diabetes | Veins & arteries | Bone morphogenetic proteins
Journal Article
European Heart Journal, ISSN 0195-668X, 07/2014, Volume 35, Issue 27, pp. 1782 - 1791
Atherothrombosis is no longer considered solely a disorder of lipoprotein accumulation in the arterial wall. Rather, the initiation and progression of... 
Darapladib | Atherosclerosis | Inflammasome | Inflammation | Colchicine | Salsalate | C reactive protein | Canakinumab | Methotrexate | Interleukin-6 | C-REACTIVE PROTEIN | FUTURE MYOCARDIAL-INFARCTION | CARDIAC & CARDIOVASCULAR SYSTEMS | INTERLEUKIN-1 RECEPTOR ANTAGONIST | RANDOMIZED CLINICAL-TRIAL | SECRETORY PHOSPHOLIPASE A | ACUTE CORONARY SYNDROME | APPARENTLY HEALTHY-MEN | REVERSE CHOLESTEROL TRANSPORT | PLACEBO-CONTROLLED TRIAL | TYPE-2 DIABETES-MELLITUS | Hydroxychloroquine - therapeutic use | Interleukin-6 - antagonists & inhibitors | NLR Family, Pyrin Domain-Containing 3 Protein | Colchicine - therapeutic use | Humans | Cell Adhesion Molecules - antagonists & inhibitors | Methotrexate - therapeutic use | Sirtuins - therapeutic use | Vaccination - methods | Lipoproteins, HDL - drug effects | Interleukin-1 - physiology | Interleukin-6 - physiology | Anti-Inflammatory Agents - therapeutic use | Interleukin-1 - antagonists & inhibitors | Leukotriene Antagonists - therapeutic use | Carrier Proteins - physiology | Adaptive Immunity - physiology | Phospholipase A2 Inhibitors - therapeutic use | Atherosclerosis - drug therapy | Serpins - therapeutic use | C-Reactive Protein - physiology | Antioxidants - therapeutic use | Tumor Necrosis Factor-alpha - drug effects | Signal Transduction - drug effects | Tumor Necrosis Factor-alpha - physiology | Thrombosis - drug therapy | Receptors, Interleukin-1 - antagonists & inhibitors | Review
Journal Article
Gut, ISSN 0017-5749, 02/2013, Volume 62, Issue 2, pp. 220 - 226
Objective The gut microbiota is an environmental regulator of fat storage and adiposity. Whether the microbiota represents a realistic therapeutic target for... 
ENERGY-BALANCE | VANCOMYCIN | HIGH-FAT-DIET | LACTOBACILLUS-SALIVARIUS | INSULIN-RESISTANCE | MOUSE | ENDOTOXEMIA | NECROSIS-FACTOR-ALPHA | MICE | BACTERIOCINS | GASTROENTEROLOGY & HEPATOLOGY | Intestines - drug effects | Probiotics - administration & dosage | Obesity - drug therapy | Bacteriocins - administration & dosage | Tumor Necrosis Factor-alpha - blood | Tumor Necrosis Factor-alpha - genetics | Bacteria - drug effects | Diet, High-Fat - adverse effects | Male | Obesity - microbiology | Inflammation - blood | Intestinal Mucosa - drug effects | Drug Delivery Systems | Vancomycin - pharmacology | Obesity - etiology | Weight Gain - drug effects | Gene Expression | Metagenome - drug effects | Vancomycin - administration & dosage | Mice, Inbred C57BL | Intestinal Mucosa - microbiology | Probiotics - pharmacology | Obesity - metabolism | Blood Glucose - drug effects | Animals | Intestines - microbiology | Tumor Necrosis Factor-alpha - drug effects | Triglycerides - blood | Bacteriocins - pharmacology | Anti-Bacterial Agents - pharmacology | Lactobacillus - physiology | Mice | Anti-Bacterial Agents - administration & dosage | Obesity | Probiotics | Care and treatment | Microbiota (Symbiotic organisms) | Dosage and administration | Research | Vancomycin | Bacteriocins | Studies | Load | Diet | Rodents | Antimicrobial agents | Diabetes | Gene expression | Metabolic disorders | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Gastroenterology and Hepatology | Gastroenterologi
Journal Article
Hypertension, ISSN 0194-911X, 11/2014, Volume 64, Issue 5, pp. 1141 - 1150
Journal Article