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1. Full Text The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches
by Joerger, Andreas C and Fersht, Alan R
Annual review of biochemistry, ISSN 0066-4154, 6/2016, Volume 85, Issue 1, pp. 375 - 404
cancer therapy | signaling pathways | protein evolution | drug design | p53 family | small-molecule stabilizers | Protein evolution | Signaling pathways | Drug design | Small-molecule stabilizers | P53 family | Cancer therapy | Neoplasms - metabolism | Proto-Oncogene Proteins c-mdm2 - genetics | Antineoplastic Agents, Alkylating - chemical synthesis | Humans | Protein Multimerization | Gene Expression Regulation, Neoplastic | Proto-Oncogene Proteins - chemistry | Molecular Targeted Therapy | Proto-Oncogene Proteins c-mdm2 - chemistry | Tumor Suppressor Protein p53 - genetics | Neoplasms - genetics | Tumor Suppressor Protein p53 - agonists | Drug Design | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Protein Structure, Secondary | Signal Transduction | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Clinical Trials as Topic | Nuclear Proteins - chemistry | Neoplasms - drug therapy | Antineoplastic Agents, Alkylating - therapeutic use | Animals | Nuclear Proteins - antagonists & inhibitors | Molecular Docking Simulation | Tumor Suppressor Protein p53 - chemistry | Mutation | Neoplasms - pathology | Transcription factors | Care and treatment | Health aspects | Methods | Cancer | Medical screening | Tumors | Index Medicus
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2. Full Text Awakening guardian angels: drugging the p53 pathway
by Verma, Chandra S and Fersht, Alan R and Brown, Christopher J and Lain, Sonia and Lane, David P
Nature reviews. Cancer, ISSN 1474-175X, 12/2009, Volume 9, Issue 12, pp. 862 - 873
Life Sciences & Biomedicine | Oncology | Science & Technology | Neoplasms - metabolism | Signal Transduction | Humans | Tumor Suppressor Protein p53 - metabolism | Antineoplastic Agents - chemistry | Drug Delivery Systems | Neoplasms - drug therapy | Genes, p53 | Neoplasms - genetics | Tumor Suppressor Protein p53 - agonists | Drug Design | Antineoplastic Agents - pharmacology | Mutation | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Physiological aspects | Development and progression | Tumor suppressor genes | Research | Drug therapy | Tumors | Index Medicus | Medicin och hälsovetenskap
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3. Full Text Reactivation of p53: from peptides to small molecules
by Brown, Christopher J and Cheok, Chit F and Verma, Chandra S and Lane, David P
Trends in pharmacological sciences (Regular ed.), ISSN 0165-6147, 2010, Volume 32, Issue 1, pp. 53 - 62
Advanced Basic Science | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Peptides - chemistry | Humans | Molecular Conformation | Tumor Suppressor Protein p53 - metabolism | Ubiquitin-Protein Ligases - metabolism | Ubiquitin-Protein Ligases - antagonists & inhibitors | Nuclear Proteins - metabolism | Antineoplastic Agents - chemistry | Tumor Suppressor Protein p53 - genetics | Peptides - pharmacology | Molecular Mimicry | Animals | Nuclear Proteins - antagonists & inhibitors | Tumor Suppressor Protein p53 - agonists | Drug Design | Antineoplastic Agents - pharmacology | Tumor Suppressor Protein p53 - chemistry | ADP-Ribosylation Factors - metabolism | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Mutant Proteins - agonists | Peptides | Tumor proteins | Tumors | Index Medicus
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