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Journal Article
Nature, ISSN 0028-0836, 2013, Volume 504, Issue 7479, pp. 296 - 300
Journal Article
Nature, ISSN 0028-0836, 01/2013, Volume 493, Issue 7433, pp. 542 - 546
Journal Article
Cell Reports, ISSN 2211-1247, 05/2013, Volume 3, Issue 5, pp. 1339 - 1345
Journal Article
Nature, ISSN 0028-0836, 02/2011, Volume 470, Issue 7334, pp. 409 - 413
The mature gut renews continuously and rapidly throughout adult life, often in a damage-inflicting micro-environment. The major driving force for self-renewal... 
COLON-CANCER | INTESTINAL EPITHELIUM | TUMOR SUPPRESSION | MULTIDISCIPLINARY SCIENCES | LENTIVIRAL VECTOR | MOUSE MODEL | CELL-CYCLE ARREST | ONCOGENE-INDUCED SENESCENCE | CANCER PROGRESSION | TUMORIGENESIS | EXPRESSION | Intestinal Mucosa - metabolism | Cell Proliferation | Adenoma - genetics | Colorectal Neoplasms - genetics | Homeodomain Proteins - metabolism | Humans | Casein Kinase Ialpha - genetics | Male | Loss of Heterozygosity | Wnt Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - deficiency | Tumor Suppressor Protein p53 - genetics | Adenoma - metabolism | Genes, APC | Adenoma - enzymology | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Cellular Senescence | Neoplasm Invasiveness - pathology | Tumor Suppressor Proteins - deficiency | Intestinal Mucosa - enzymology | Tumor Suppressor Proteins - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Fibroblasts | Female | Genes, Tumor Suppressor | Colorectal Neoplasms - metabolism | Cell Line | Colorectal Neoplasms - enzymology | Tumor Suppressor Proteins - metabolism | Signal Transduction | Casein Kinase Ialpha - deficiency | Tumor Suppressor Protein p53 - metabolism | Tumor Suppressor Protein p53 - deficiency | beta Catenin - metabolism | Disease Progression | Homeodomain Proteins - genetics | Mice, Knockout | Animals | Cell Transformation, Neoplastic | Adenoma - pathology | Cell Line, Tumor | Mice | DNA Damage | Colorectal Neoplasms - pathology | Casein Kinase Ialpha - metabolism | Intestinal Mucosa - pathology
Journal Article
Nature, ISSN 0028-0836, 06/2016, Volume 534, Issue 7607, pp. 341 - 346
Chronic myeloid leukaemia (CML) arises after transformation of a haemopoietic stem cell (HSC) by the protein-tyrosine kinase BCR-ABL. Direct inhibition of... 
CD34(+) CELLS | INHIBITION | MICROARRAY | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | IMATINIB | TUMOR | COMBINATION | CANCER | EXPRESSION | CHRONIC MYELOID-LEUKEMIA | Antigens, CD34 - metabolism | Tumor Suppressor Protein p53 - antagonists & inhibitors | Neoplastic Stem Cells - drug effects | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Transcriptome | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Acetamides - pharmacology | Male | Neoplasm Proteins - metabolism | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Imatinib Mesylate - therapeutic use | Acetamides - therapeutic use | Neoplastic Stem Cells - metabolism | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Imidazolines - therapeutic use | Neoplastic Stem Cells - pathology | Female | Cell Death - drug effects | Hematopoietic Stem Cells - drug effects | Reproducibility of Results | Imatinib Mesylate - pharmacology | Tumor Suppressor Protein p53 - metabolism | Imidazolines - pharmacology | Hematopoietic Stem Cells - metabolism | Tumor Suppressor Protein p53 - deficiency | Proto-Oncogene Proteins c-myc - metabolism | Neoplastic Stem Cells - transplantation | Azepines - therapeutic use | Azepines - pharmacology | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Hematopoietic Stem Cells - cytology | Proto-Oncogene Proteins c-myc - deficiency | Proteomics | Proto-Oncogene Proteins c-myc - antagonists & inhibitors | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Mice | Proto-Oncogene Proteins c-myc - genetics | Fusion Proteins, bcr-abl - metabolism | Molecular targeted therapy | Cancer cells | Stem cells | Development and progression | Genetic aspects | Chronic myeloid leukemia | Tumor proteins | Properties | Health aspects | Methods | Proteins | Transcription factors | Leukemia | Cell cycle | Kinases | Cancer therapies | Apoptosis
Journal Article
Journal Article